Advances in neurobiology最新文献_第9页

Auditory Biomarkers of Neuropsychiatric Disorders in Nonhuman Primates. 非人灵长类神经精神疾病的听觉生物标志物

Advances in neurobiology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-69491-2_9

Monica N O'Connell, Annamaria Barczak

{"title":"Auditory Biomarkers of Neuropsychiatric Disorders in Nonhuman Primates.","authors":"Monica N O'Connell, Annamaria Barczak","doi":"10.1007/978-3-031-69491-2_9","DOIUrl":"https://doi.org/10.1007/978-3-031-69491-2_9","url":null,"abstract":"Animal models of neuropsychiatric disorders with appropriate biomarkers can greatly inform the neurobiological basis of disorder-related deficits of cognitive and/or sensory processes. Given the genetic, physiologic, and behavioral similarities between humans and nonhuman primates (NHPs), NHP studies are monumentally important for preclinical translational research. Capitalizing on the NHP's similarities with human systems provides one of the best opportunities to gain detailed insight into the mechanisms underlying disorder-related symptoms and to accumulate a foundation of information for the development of therapeutic interventions. Here, we discuss how results from NHP studies have provided insight into the generation and modulation of select auditory biomarkers of schizophrenia including auditory steady-state responses and mismatch negativity. Since neuro-oscillatory activity has been shown to be relatively preserved across species, we highlight how incorporating the analysis of local and network-level oscillations from multiple nodes across different pathways involved in auditory processing has been used to further the precision of translational comparisons across species.","PeriodicalId":7360,"journal":{"name":"Advances in neurobiology","volume":"40 ","pages":"219-234"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142674889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene Expression at the Tripartite Synapse: Bridging the Gap Between Neurons and Astrocytes. 三方突触的基因表达：弥合神经元与星形胶质细胞之间的鸿沟

Advances in neurobiology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-64839-7_5

Gillian Imrie, Madison B Gray, Vishnuvasan Raghuraman, Isabella Farhy-Tselnicker

{"title":"Gene Expression at the Tripartite Synapse: Bridging the Gap Between Neurons and Astrocytes.","authors":"Gillian Imrie, Madison B Gray, Vishnuvasan Raghuraman, Isabella Farhy-Tselnicker","doi":"10.1007/978-3-031-64839-7_5","DOIUrl":"10.1007/978-3-031-64839-7_5","url":null,"abstract":"Astrocytes, a major class of glial cells, are an important element at the synapse where they engage in bidirectional crosstalk with neurons to regulate numerous aspects of neurotransmission, circuit function, and behavior. Mutations in synapse-related genes expressed in both neurons and astrocytes are central factors in a vast number of neurological disorders, making the proteins that they encode prominent targets for therapeutic intervention. Yet, while the roles of many of these synaptic proteins in neurons are well established, the functions of the same proteins in astrocytes are largely unknown. This gap in knowledge must be addressed to refine therapeutic approaches. In this chapter, we integrate multiomic meta-analysis and a comprehensive overview of current literature to show that astrocytes express an astounding number of genes that overlap with the neuronal and synaptic transcriptomes. Further, we highlight recent reports that characterize the expression patterns and potential novel roles of these genes in astrocytes in both physiological and pathological conditions, underscoring the importance of considering both cell types when investigating the function and regulation of synaptic proteins.","PeriodicalId":7360,"journal":{"name":"Advances in neurobiology","volume":"39 ","pages":"95-136"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142071750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intracranial Pressure and Its Related Parameters in the Management of Severe Pediatric Traumatic Brain Injury. 严重小儿创伤性脑损伤治疗中的颅内压及其相关参数。

Advances in neurobiology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-69832-3_1

Vincent Y Wang

引用次数: 0

Hippocampal Engrams and Contextual Memory. 海马刻痕与情境记忆

Advances in neurobiology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-62983-9_4

Krithika Vasudevan, James E Hassell, Stephen Maren

{"title":"Hippocampal Engrams and Contextual Memory.","authors":"Krithika Vasudevan, James E Hassell, Stephen Maren","doi":"10.1007/978-3-031-62983-9_4","DOIUrl":"10.1007/978-3-031-62983-9_4","url":null,"abstract":"Memories are not formed in a vacuum and often include rich details about the time and place in which events occur. Contextual stimuli promote the retrieval of events that have previously occurred in the encoding context and limit the retrieval of context-inappropriate information. Contexts that are associated with traumatic or harmful events both directly elicit fear and serve as reminders of aversive events associated with trauma. It has long been appreciated that the hippocampus is involved in contextual learning and memory and is central to contextual fear conditioning. However, little is known about the underlying neuronal mechanisms underlying the encoding and retrieval of contextual fear memories. Recent advancements in neuronal labeling methods, including activity-dependent tagging of cellular ensembles encoding memory (\"engrams\"), provide unique insight into the neural substrates of memory in the hippocampus. Moreover, these methods allow for the selective manipulation of memory ensembles. Attenuating or erasing fear memories may have considerable therapeutic value for patients with post-traumatic stress disorder or other trauma- or stressor-related conditions. In this chapter, we review the role of the hippocampus in contextual fear conditioning in rodents and explore recent work implicating hippocampal ensembles in the encoding and retrieval of aversive memories.","PeriodicalId":7360,"journal":{"name":"Advances in neurobiology","volume":"38 ","pages":"45-66"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141615643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulatory Processes in Craniofacial Pain States. 颅面疼痛状态的调节过程

Advances in neurobiology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-45493-6_6

Barry J Sessle

{"title":"Modulatory Processes in Craniofacial Pain States.","authors":"Barry J Sessle","doi":"10.1007/978-3-031-45493-6_6","DOIUrl":"10.1007/978-3-031-45493-6_6","url":null,"abstract":"Pain is a common symptom associated with many disorders affecting the craniofacial tissues that include the teeth and their supporting structures, the jaw, face and tongue muscles, and the temporomandibular joint. Most acute craniofacial pain states are easily recognized and readily treated, but chronic craniofacial pain states (e.g., temporomandibular disorders [TMD], trigeminal neuropathies, and some headaches) may be especially challenging to manage successfully. This chapter provides an overview of the processes that underlie craniofacial pain, with a focus on the pain-modulatory mechanisms operating in craniofacial tissues and in the central nervous system (CNS), including the role of endogenous chemical processes such as those involving opioids. The chapter outlines in particular findings from preclinical studies that have provided substantial information about the neural as well as nonneural (e.g., glial) processes involved in the initiation, transmission, and modulation of nociceptive signals in the trigeminal system, and also draws attention to their clinical correlates. The increased understanding gained from these preclinical studies of how nociceptive signals can be modulated will contribute to improvements in presently available therapeutic approaches to manage craniofacial pain as well as to the development of novel analgesic approaches.","PeriodicalId":7360,"journal":{"name":"Advances in neurobiology","volume":"35 ","pages":"107-124"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141316489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physical Exercise as an Intervention for Depression: Evidence for Efficacy and Mu-Opioid Receptors as a Mechanism of Action. 体育锻炼作为抑郁症的干预措施：疗效证据与作为作用机制的缪阿片受体

Advances in neurobiology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-45493-6_11

Colleen Pettrey, Patrick L Kerr, T O Dickey

引用次数: 0

The Foundational Science of Endogenous Opioids and Their Receptors. 内源性阿片类药物及其受体的基础科学。

Advances in neurobiology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-45493-6_2

Simona Tache, Patrick L Kerr, Cristian Sirbu

引用次数: 0

Unveiling Transcriptional and Epigenetic Mechanisms Within Engram Cells: Insights into Memory Formation and Stability. 揭示恩格拉姆细胞内的转录和表观遗传机制：洞察记忆的形成和稳定性

Advances in neurobiology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-62983-9_7

Miguel Fuentes-Ramos, Ángel Barco

引用次数: 0

The Role of Prefrontal Ensembles in Memory Across Time: Time-Dependent Transformations of Prefrontal Memory Ensembles. 前额叶组合在跨时空记忆中的作用：前额叶记忆组合随时间的变化。

Advances in neurobiology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-62983-9_5

Zachary Zeidler, Laura DeNardo

引用次数: 0

Box-Counting Fractal Analysis: A Primer for the Clinician. 盒式计数分形分析：临床医师入门手册

Advances in neurobiology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-47606-8_2

Audrey L Karperien, Herbert F Jelinek

引用次数: 0