Advances in neurobiology最新文献_第2页

Synaptic Cell Adhesion: A Structural Perspective. 突触细胞粘附：结构视角。

Advances in neurobiology Pub Date : 2026-01-01 DOI: 10.1007/978-3-032-12594-1_6

Sumit J Bandekar, Szymon P Kordon, Demet Araç

{"title":"Synaptic Cell Adhesion: A Structural Perspective.","authors":"Sumit J Bandekar, Szymon P Kordon, Demet Araç","doi":"10.1007/978-3-032-12594-1_6","DOIUrl":"10.1007/978-3-032-12594-1_6","url":null,"abstract":"Cell adhesion molecules (CAMs) play critical roles in mediating intercellular interactions in the context of the nervous system, such as guiding neuronal development, synapse formation and maturation, and synaptic plasticity. In addition to their extracellular adhesive roles, most CAMs induce intracellular signaling events and scaffold large protein complexes through intracellular domains. The molecular biology of how CAMs regulate synaptic development and function has been hugely advanced by decades of structural biology. These structures have illuminated multiple modes of CAM regulation, including how alternative splicing regulates CAM homotypic and heterotypic interactions. CAMs are diverse in size and contain a variety of adhesion domain classes such as immunoglobulin (Ig), leucine-rich repeats (LRR), and laminin G/neurexin/sex hormone (LNS). In this chapter, we detail structures of key synaptic adhesion complexes, including a mechanistic explanation of how these structures have informed functional work. Detailing the structural basis of synaptic adhesion provides a foundation for deciphering the complex interactions underlying neuronal connectivity and function in health and disease.","PeriodicalId":7360,"journal":{"name":"Advances in neurobiology","volume":"48 ","pages":"151-190"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13225310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146016976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formation, Organization, and Maintenance of Synaptic Vesicle Pools: From Molecules to Structure and Dynamics. 突触囊泡池的形成、组织和维护：从分子到结构和动力学。

Advances in neurobiology Pub Date : 2026-01-01 DOI: 10.1007/978-3-032-12594-1_3

Natali L Chanaday

引用次数: 0

Impairment of Oligodendroglial Lineage Cells: An Important Player in the Pathogenesis of Psychiatric Disorders. 少突胶质谱系细胞损伤：精神疾病发病机制中的重要角色。

Advances in neurobiology Pub Date : 2025-01-01 DOI: 10.1007/978-3-031-87919-7_15

Shengyang Beina, Guangdan Yu, Nan-Xin Huang, Lan Xiao

引用次数: 0

Assessing Exercise and Fitness-Related Brain Health Using Multi-modal Magnetic Resonance Imaging Outcomes. 使用多模态磁共振成像结果评估运动和健身相关的大脑健康。

Advances in neurobiology Pub Date : 2025-01-01 DOI: 10.1007/978-981-95-0066-6_14

J Carson Smith, Daniel D Callow, Gabriel S Pena, Jeremy J Purcell

{"title":"Assessing Exercise and Fitness-Related Brain Health Using Multi-modal Magnetic Resonance Imaging Outcomes.","authors":"J Carson Smith, Daniel D Callow, Gabriel S Pena, Jeremy J Purcell","doi":"10.1007/978-981-95-0066-6_14","DOIUrl":"10.1007/978-981-95-0066-6_14","url":null,"abstract":"Several magnetic resonance imaging (MRI)-based modalities have provided insight into how acute and chronic exercise and physical activity impact brain health. Structural MRI-based measures provide information regarding brain volume and cortical thickness, diffusion-weighted imaging measures provide indices of white matter and gray microstructure, and cerebrovascular effects that may be assessed through measures of regional cerebral blood flow, and brain activation and neural networks can be indexed using task-based and connectivity-based functional MRI, respectively. In this chapter, a series of studies are described in which these multi-modal MRI outcomes, along with indices of neurocognitive function, have been documented after a brief walking exercise intervention in healthy older adults and those diagnosed with mild cognitive impairment. Finally, we provide some additional insight into the neurophysiological mechanisms that may be foundational for these effects, but are yet not measurable in humans. Multi-modal neuroimaging is a non-invasive method in humans to assess the potential mechanisms whereby acute and chronic exercise may exert benefits to brain function and neural networks related to cognition that may protect older adults from age-related cognitive decline and dementia.","PeriodicalId":7360,"journal":{"name":"Advances in neurobiology","volume":"44 ","pages":"253-280"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enriched Exercise Environment Boosting Exercise Effects on the Brain: Beneficial Effects of Music. 丰富的运动环境促进运动对大脑的影响：音乐的有益作用。

Advances in neurobiology Pub Date : 2025-01-01 DOI: 10.1007/978-981-95-0066-6_19

Kazuya Suwabe, Takemune Fukuie, Hideaki Soya

{"title":"Enriched Exercise Environment Boosting Exercise Effects on the Brain: Beneficial Effects of Music.","authors":"Kazuya Suwabe, Takemune Fukuie, Hideaki Soya","doi":"10.1007/978-981-95-0066-6_19","DOIUrl":"10.1007/978-981-95-0066-6_19","url":null,"abstract":"Physical exercise is a potential medicine for cognitive function and mental health; however, regular exercise is more difficult than taking a pill every day. Developing an exercise environment that promotes a positive affective response to exercise and exercise benefits on the brain may encourage people to participate in physical activities. Listening to music while exercising is a promising candidate for such an \"enriched exercise environment.\" This chapter reviews the studies demonstrating the beneficial effects of music on enhancing mood and cognitive function in both acute and chronic settings. Furthermore, the underlying neural mechanisms involved in the effects of exercise with music are discussed from the following three perspectives: (1) musical reward and pleasure, (2) rhythmic entrainment, and (3) sensory distraction. In addition, the concept of groove, which is \"the pleasurable sensation of wanting to move the body to music\" was used to explore the characteristics of music that are compatible with exercise. Finally, individual variations on whether combining exercises with music are appropriate and the considerations that should be addressed for implementation in the field are discussed.","PeriodicalId":7360,"journal":{"name":"Advances in neurobiology","volume":"44 ","pages":"343-369"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Healthy Cognitive Aging Through Movement: A Practical Approach of Light-Intensity Aerobic Dance for Older Adults. 通过运动实现健康的认知衰老：老年人轻强度有氧舞蹈的实用方法。

Advances in neurobiology Pub Date : 2025-01-01 DOI: 10.1007/978-981-95-0066-6_21

Kazuki Hyodo, Hideaki Soya

引用次数: 0

The Ins and Outs of Dopamine Transporter Gene Manipulation: In Vivo Models of DAT Dysfunction. 多巴胺转运体基因操作的来龙去脉：DAT功能障碍的体内模型。

Advances in neurobiology Pub Date : 2025-01-01 DOI: 10.1007/978-3-031-96364-3_10

Adele Stewart, Randy D Blakely

{"title":"The Ins and Outs of Dopamine Transporter Gene Manipulation: In Vivo Models of DAT Dysfunction.","authors":"Adele Stewart, Randy D Blakely","doi":"10.1007/978-3-031-96364-3_10","DOIUrl":"10.1007/978-3-031-96364-3_10","url":null,"abstract":"The clinical efficacy of psychostimulant drugs, which target monoamine transporters, in treating attention-deficit/hyperactivity disorders (ADHDs) has stimulated interest on the role of transporter proteins like the dopamine (DA) transporter (DAT) in neurotransmission as well as the potential utility of DAT knockout organisms as models for neuropsychiatric disorders. Indeed, the study of DAT-deficient worms, flies, fish, mice, and rats has revealed a conserved role for DAT in the control of motor behavior as well as repetitive behavior, threat aversion, social behavior, and cognition in mammals. However, the disconnect between phenotypes observed in DAT-deficient model organisms and humans, which exhibit an early-onset syndrome characterized by Parkinsonism/dystonia and premature death, challenges the construct validity of DAT knockout models with respect to modeling neurobehavioral disorders. As an alternate approach, several groups have utilized coding variants in the SLC6A3 gene linked to psychiatric conditions, which display divergent molecular phenotypes. This chapter reviews the development and characterization of models of DAT gene deletion and mutation with a particular emphasis on comparing/contrasting the functional impact of DAT deficiency to DAT dysregulation triggered by neuropsychiatric disorder-linked DAT mutants in vivo. Ultimately, the study of DAT knockout and mutant models has revealed novel functions for DA in the mammalian brain, uncovered a dynamic interplay between the monoaminergic systems, highlighted sex differences in the DA system that determine the behavioral trajectory of DAT deregulation, and allowed for the screening of potential leads for therapeutics to treat disorders linked to aberrant dopaminergic neurotransmission.","PeriodicalId":7360,"journal":{"name":"Advances in neurobiology","volume":"46 ","pages":"235-270"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Overview of Oligodendrocyte Metabolism. 少突胶质细胞代谢综述。

Advances in neurobiology Pub Date : 2025-01-01 DOI: 10.1007/978-3-031-87919-7_7

Qi Han, Jin Cheng

引用次数: 0

Oligodendroglia in Ageing and Age-Dependent Neurodegenerative Diseases. 衰老和年龄依赖性神经退行性疾病中的少突胶质细胞。

Advances in neurobiology Pub Date : 2025-01-01 DOI: 10.1007/978-3-031-87919-7_13

Jianqin Niu, Alexei Verkhratsky, Arthur Butt, Chenju Yi

引用次数: 0

Seeing Is Believing: Insights into Myelination and Remyelination in Zebrafish. 眼见为实：洞察斑马鱼的髓鞘形成和再髓鞘形成。

Advances in neurobiology Pub Date : 2025-01-01 DOI: 10.1007/978-3-031-87919-7_4

Peng Liu, Qiang Chen, Cheng He

{"title":"Seeing Is Believing: Insights into Myelination and Remyelination in Zebrafish.","authors":"Peng Liu, Qiang Chen, Cheng He","doi":"10.1007/978-3-031-87919-7_4","DOIUrl":"https://doi.org/10.1007/978-3-031-87919-7_4","url":null,"abstract":"Myelin is the lipid-rich insulating layer that wraps axons, providing trophic support and ensuring rapid propagation of the electrical impulses that underlie nervous system function. In the CNS, myelin is produced by mature oligodendrocytes (OLs) that arise from oligodendrocyte precursor cells (OPCs). Myelination is regulated by a variety of molecules, including growth factors, hormones, and extracellular molecules, which activate signaling cascades that drive cellular maturation. Key signaling molecules and downstream pathways that control myelination have been identified in cell culture and rodent models. Although much is known about the development of OL and its progenitor cell in vitro and in vivo, how CNS myelin is dynamically formed through OL processes is still unclear. Zebrafish share significant genetic and physiological similarities with mammals, including humans, making them a relevant model for studying complex biological processes like myelination. Due to its transparent larval development, zebrafish facilitates live imaging studies, enabling dynamic visualizations of cellular and molecular processes in real-time studies. In this chapter, we reviewed the latest insights into OL development and myelin formation, with a particular emphasis on the mechanisms regulating dynamic myelination in zebrafish. We highlight the dynamic extension and retraction of myelin sheath segments and the role of neuronal activity in regulating the developmental myelination in zebrafish. In addition, we also discussed the mechanisms of Ranvier node positioning and axon targeting of myelin sheaths in the spinal cord of zebrafish larvae. Finally, we reviewed the recent progress of zebrafish as a demyelinating disease model for drug discovery of pharmacological compounds favoring myelin regeneration.","PeriodicalId":7360,"journal":{"name":"Advances in neurobiology","volume":"43 ","pages":"81-95"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0