iMeta最新文献

{"title":"Gut microbiota in treating inflammatory digestive diseases: Current challenges and therapeutic opportunities","authors":"Yongpeng Shi,&nbsp;Zeran Chen,&nbsp;Tingyu Fang,&nbsp;Xingyao Chen,&nbsp;Youpeng Deng,&nbsp;Hao Qin,&nbsp;Min Lian,&nbsp;Juntao Shen,&nbsp;Yuru Zong,&nbsp;Huikuan Chu,&nbsp;Constanze Hoebinger,&nbsp;Hao Guo,&nbsp;Zhongshang Yuan,&nbsp;Jie Zheng,&nbsp;Yongjian Zhou,&nbsp;Yue Pan,&nbsp;Beatriz G. Mendes,&nbsp;Sonja Lang,&nbsp;Tim Hendrikx,&nbsp;Suling Zeng,&nbsp;Hailong Cao,&nbsp;Ling Yang,&nbsp;Lianmin Chen,&nbsp;Peng Chen,&nbsp;Lei Dai,&nbsp;Hua Wang,&nbsp;Shi Yin,&nbsp;Shu Zhu,&nbsp;Xiong Ma,&nbsp;Bernd Schnabl,&nbsp;Hanqing Chen,&nbsp;Yi Duan","doi":"10.1002/imt2.265","DOIUrl":"https://doi.org/10.1002/imt2.265","url":null,"abstract":"<p>Accumulating evidence indicates that the gut microbiota is intricately involved in the initiation and progression of human diseases, forming a multidirectional regulatory axis centered on intestinal microbiota. This article illustrates the challenges in exploring the role of the gut microbiota in inflammatory digestive diseases, such as metabolic dysfunction-associated steatotic liver disease (MASLD) and inflammatory bowel disease (IBD), and summarizes the existing microbiome-focused treatment strategies (probiotics, prebiotics, symbiotics, fecal microbiota transplantation, and bacteriophages therapy), emerging technologies (gut microbiome-on-a-chip and artificial intelligence), as well as possible future research directions. Taken together, these therapeutic strategies and technologies present both opportunities and challenges, which require researchers and clinicians to test the rationality and feasibility of various therapeutic modalities in continuous practice.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":73342,"journal":{"name":"iMeta","volume":"4 1","pages":""},"PeriodicalIF":23.7,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/imt2.265","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut Bifidobacterium pseudocatenulatum protects against fat deposition by enhancing secondary bile acid biosynthesis","authors":"Andong Zha,&nbsp;Ming Qi,&nbsp;Yuankun Deng,&nbsp;Hao Li,&nbsp;Nan Wang,&nbsp;Chengming Wang,&nbsp;Simeng Liao,&nbsp;Dan Wan,&nbsp;Xia Xiong,&nbsp;Peng Liao,&nbsp;Jing Wang,&nbsp;Yulong Yin,&nbsp;Bi'e Tan","doi":"10.1002/imt2.261","DOIUrl":"10.1002/imt2.261","url":null,"abstract":"<p>Gut microbiome is crucial for lipid metabolism in humans and animals. However, how specific gut microbiota and their associated metabolites impact fat deposition remains unclear. In this study, we demonstrated that the colonic microbiome of lean and obese pigs differentially contributes to fat deposition, as evidenced by colonic microbiota transplantation experiments. Notably, the higher abundance of <i>Bifidobacterium pseudocatenulatum</i> was significantly associated with lower backfat thickness in lean pigs. Microbial-derived lithocholic acid (LCA) species were also significantly enriched in lean pigs and positively correlated with the abundance of <i>B. pseudocatenulatum</i>. In a high-fat diet (HFD)-fed mice model, administration of live <i>B. pseudocatenulatum</i> decreased fat deposition and enhances colonic secondary bile acid biosynthesis. Importantly, pharmacological inhibition of the bile salt hydrolase (BSH), which mediates secondary bile acid biosynthesis, impaired the anti-fat deposition effect of <i>B. pseudocatenulatum</i> in antibiotic-pretreated, HFD-fed mice. Furthermore, dietary LCA also decreased fat deposition in HFD-fed rats and obese pig models. These findings provide mechanistic insights into the anti-fat deposition role of <i>B. pseudocatenulatum</i> and identify BSH as a potential target for preventing excessive fat deposition in humans and animals.</p>","PeriodicalId":73342,"journal":{"name":"iMeta","volume":"3 6","pages":""},"PeriodicalIF":23.7,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EGDB: A comprehensive multi-omics database for energy grasses and the epigenomic atlas of pearl millet","authors":"Lin Luo,&nbsp;Dongmei Lin,&nbsp;Jinhui Li,&nbsp;Hao Chen,&nbsp;Qi Qu,&nbsp;Lin Zhang,&nbsp;Yuan Luo,&nbsp;Jiaming Chen,&nbsp;Dingkun Jiang,&nbsp;Peitao Lü,&nbsp;Wenjun Zhu,&nbsp;Hui Lin,&nbsp;Ensi Shao,&nbsp;Haidong Yan,&nbsp;Yarong Jin,&nbsp;Guodong Lu,&nbsp;Zhanxi Lin,&nbsp;LuLu Xun,&nbsp;Fangjie Zhu,&nbsp;Linkai Huang,&nbsp;Jiajing Xiao","doi":"10.1002/imt2.263","DOIUrl":"https://doi.org/10.1002/imt2.263","url":null,"abstract":"<p>Given the key role of energy grasses in biomass energy, electricity, biofuels, and carbon sequestration, the Energy Grass Omics Database (EGDB) integrates germplasm data with genomics, transcriptomics, epigenomics, and phenomics data to support functional genomic research on diverse energy grass species. EGDB also currently supplies the largest epigenetic data set of energy grasses: a high-resolution chromatin modification, chromatin accessibility, and gene expression landscape of pearl millet to provide insights into regulatory traits essential for sustainable energy production.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":73342,"journal":{"name":"iMeta","volume":"4 1","pages":""},"PeriodicalIF":23.7,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/imt2.263","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pangenome and genome variation analyses of pigs unveil genomic facets for their adaptation and agronomic characteristics","authors":"Dong Li,&nbsp;Yulong Wang,&nbsp;Tiantian Yuan,&nbsp;Minghao Cao,&nbsp;Yulin He,&nbsp;Lin Zhang,&nbsp;Xiang Li,&nbsp;Yifan Jiang,&nbsp;Ke Li,&nbsp;Jingchun Sun,&nbsp;Guangquan Lv,&nbsp;Guosheng Su,&nbsp;Qishan Wang,&nbsp;Yuchun Pan,&nbsp;Xinjian Li,&nbsp;Yu Jiang,&nbsp;Gongshe Yang,&nbsp;Martien A. M. Groenen,&nbsp;Martijn F. L. Derks,&nbsp;Rongrong Ding,&nbsp;Xiangdong Ding,&nbsp;Taiyong Yu","doi":"10.1002/imt2.257","DOIUrl":"10.1002/imt2.257","url":null,"abstract":"<p>The development of a comprehensive pig graph pangenome assembly encompassing 27 genomes represents the most extensive collection of pig genomic data to date. Analysis of this pangenome reveals the critical role of structural variations in driving adaptation and defining breed-specific traits. Notably, the study identifies <i>BTF3</i> as a key candidate gene governing intramuscular fat deposition and meat quality in pigs. These findings underscore the power of pangenome approaches in uncovering novel genomic features underlying economically important agricultural traits. Collectively, these results demonstrate the value of leveraging large-scale, multi-genome analyses for advancing our understanding of livestock genomes and accelerating genetic improvement.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":73342,"journal":{"name":"iMeta","volume":"3 6","pages":""},"PeriodicalIF":23.7,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive lung microbial gene and genome catalogs assist the mechanism survey of Mesomycoplasma hyopneumoniae strains causing pig lung lesions","authors":"Jingquan Li,&nbsp;Fei Huang,&nbsp;Yunyan Zhou,&nbsp;Tao Huang,&nbsp;Xinkai Tong,&nbsp;Mingpeng Zhang,&nbsp;Jiaqi Chen,&nbsp;Zhou Zhang,&nbsp;Huipeng Du,&nbsp;Zifeng Liu,&nbsp;Meng Zhou,&nbsp;Yiwen Xiahou,&nbsp;Huashui Ai,&nbsp;Congying Chen,&nbsp;Lusheng Huang","doi":"10.1002/imt2.258","DOIUrl":"10.1002/imt2.258","url":null,"abstract":"<p>Understanding the community structure of the lower respiratory tract microbiome is crucial for elucidating its roles in respiratory tract diseases. However, there are few studies about this topic due to the difficulty in obtaining microbial samples from both healthy and disease individuals. Here, using 744 high-depth metagenomic sequencing data of lower respiratory tract microbial samples from 675 well-phenotyped pigs, we constructed a lung microbial gene catalog containing the largest scale of 10,031,593 nonredundant genes to date, 44.8% of which are novel. We obtained 356 metagenome-assembled genomes (MAGs) which were further clustered into 256 species-level genome bins with 41.8% being first reported in the current databases. Based on these data sets and through integrated analysis of the isolation of the related bacterial strains, in vitro infection, and RNA sequencing, we identified and confirmed that <i>Mesomycoplasma hyopneumoniae</i> (<i>M. hyopneumoniae</i>) MAG_47 and its adhesion-related virulence factors (VFs) were associated with lung lesions in pigs. Differential expression levels of adhesion- and immunomodulation-related VFs likely determined the heterogenicity of adhesion and pathogenicity among <i>M. hyopneumoniae</i> strains. <i>M. hyopneumoniae</i> adhesion activated several pathways, including nuclear factor kappa-light-chain-enhancer of activated B, mitogen-activated protein kinase, cell apoptosis, T helper 1 and T helper 2 cell differentiation, tumor necrosis factor signaling, interleukin-6/janus kinase 2/signal transducer and activator of transcription signaling, and response to reactive oxygen species, leading to cilium loss, epithelial cell‒cell barrier disruption, and lung tissue lesions. Finally, we observed the similar phylogenetic compositions of the lung microbiome between humans with <i>Mycoplasma pneumoniae</i> and pigs infected with <i>M. hyopneumoniae</i>. The results provided important insights into pig lower respiratory tract microbiome and its relationship with lung health.</p>","PeriodicalId":73342,"journal":{"name":"iMeta","volume":"3 6","pages":""},"PeriodicalIF":23.7,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating gut and IgA-coated microbiota to identify Blautia as a probiotic for enhancing feed efficiency in chickens","authors":"Chunlin Xie,&nbsp;Jiaheng Cheng,&nbsp;Peng Chen,&nbsp;Xia Yan,&nbsp;Chenglong Luo,&nbsp;Hao Qu,&nbsp;Dingming Shu,&nbsp;Jian Ji","doi":"10.1002/imt2.264","DOIUrl":"https://doi.org/10.1002/imt2.264","url":null,"abstract":"<p>This study explores the role of IgA-coated bacteria in improving feed efficiency in chickens, offering a novel perspective for probiotic screening. Chickens with high feed efficiency were found to have a greater abundance of Gram-positive bacteria, while low feed efficiency chickens exhibited higher levels of Gram-negative bacteria and potential pathogens. Through fecal microbiota transplantation (FMT) and integrating analysis of cecal and IgA-coated microbiota, we precisely identified <i>Blautia</i> as a key genus linked to improved feed efficiency. Further validation demonstrated that <i>Blautia coccoides</i>, a representative species of this genus, enhances feed efficiency and activates B cells to produce Immunoglobulin A (IgA), both in vivo and in vitro. Our findings provide new insights into the potential of IgA-coated bacteria as functional probiotics, offering a promising strategy for enhancing feed efficiency in animal production.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":73342,"journal":{"name":"iMeta","volume":"4 1","pages":""},"PeriodicalIF":23.7,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/imt2.264","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the diversity dynamics and network stability of alkaline phosphomonoesterase-producing bacteria in modulating maize yield","authors":"Lijun Chen,&nbsp;Guofan Zhu,&nbsp;Alberto Pascual-Garcia,&nbsp;Francisco Dini-Andreote,&nbsp;Jie zheng,&nbsp;Xiaoyue Wang,&nbsp;Shungui Zhou,&nbsp;Yuji Jiang","doi":"10.1002/imt2.260","DOIUrl":"10.1002/imt2.260","url":null,"abstract":"<p>Phosphorus, as a nonrenewable resource, plays a crucial role in crop development and productivity. However, the extent to which straw amendments contribute to the dynamics of soil alkaline phosphomonoesterase (ALP)-producing bacterial community and functionality over an extended period remains elusive. Here, we conducted a 7-year long-term field experiment consisting of a no-fertilizer control, a chemical fertilizer treatment, and three straw (straw, straw combined with manure, and straw biochar) treatments. Our results indicated that straw amendments significantly improved the succession patterns of the ALP-producing bacterial diversity. Simultaneously, straw amendments significantly increased the network stability of the ALP-producing bacteria over time, as evidenced by higher network robustness, a higher ratio of negative to positive cohesion, and lower network vulnerability. High dynamic and stability of ALP-producing bacterial community generated high ALP activity which further increased soil Phosphorus (P) availability as well as maize productivity.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":73342,"journal":{"name":"iMeta","volume":"3 6","pages":""},"PeriodicalIF":23.7,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptome-wide association identifies KLC1 as a regulator of mitophagy in non-syndromic cleft lip with or without palate","authors":"Shu Lou,&nbsp;Guirong Zhu,&nbsp;Changyue Xing,&nbsp;Shushu Hao,&nbsp;Junyan Lin,&nbsp;Jiayi Xu,&nbsp;Dandan Li,&nbsp;Yifei Du,&nbsp;Congbo Mi,&nbsp;Lian Sun,&nbsp;Lin Wang,&nbsp;Meilin Wang,&nbsp;Mulong Du,&nbsp;Yongchu Pan","doi":"10.1002/imt2.262","DOIUrl":"10.1002/imt2.262","url":null,"abstract":"<p>This study investigated pathogenic genes associated with non-syndromic cleft lip with or without cleft palate (NSCL/P) through transcriptome-wide association studies (TWAS). By integrating expression quantitative trait loci (eQTL) data with genome-wide association study (GWAS) data, we identified key susceptibility genes, including <i>KLC1</i>. Notably, the variant rs12884809 G&gt;A was associated with an increased risk of NSCL/P by enhancing the binding of the transcription factor ELK1 to the <i>KLC1</i> promoter, thereby activating its expression. This alteration in <i>KLC1</i> expression subsequently impacted mitophagy, leading to significant changes in cellular behavior and zebrafish morphology. Our findings illuminate the genetic mechanisms underlying NSCL/P and provide valuable insights for future prevention strategies and a deeper understanding of this condition.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":73342,"journal":{"name":"iMeta","volume":"3 6","pages":""},"PeriodicalIF":23.7,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term probiotic supplementation affects the diversity, genetics, growth, and interactions of the native gut microbiome","authors":"Xin Shen,&nbsp;Hao Jin,&nbsp;Feiyan Zhao,&nbsp;Lai-Yu Kwok,&nbsp;Zhixin Zhao,&nbsp;Zhihong Sun","doi":"10.1002/imt2.253","DOIUrl":"10.1002/imt2.253","url":null,"abstract":"<p>The precise mechanisms through which probiotics interact with and reshape the native gut microbiota, especially at the species and genetic levels, remain underexplored. This study employed a high-dose probiotic regimen of <i>Bifidobacterium animalis</i> subsp. <i>lactis</i> [200 billion colony forming units (CFU)/day] over 7 days among healthy participants. Weekly fecal samples were collected for metagenomic sequencing analysis. We found that probiotic intake can significantly enhance the diversity of the gut microbiome and impact single nucleotide variations, growth rates, and network interactions of the resident intestinal bacteria. These adaptive changes in the gut microbiota indicate the swift evolutionary responses of native bacteria to the ecological disturbance presented by probiotic supplementation. Notably, the microbial community appears to undergo rapid and multifaceted ecological adjustments, potentially preceding longer-term evolutionary changes. This knowledge lays the groundwork for further exploration into the mechanisms underlying probiotic-mediated modulation of the gut microbiome, highlighting the necessity of encompassing ecological and evolutionary perspectives in the design and optimization of probiotic applications.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":73342,"journal":{"name":"iMeta","volume":"3 6","pages":""},"PeriodicalIF":23.7,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The long-term intake of milk fat does not significantly increase the blood lipid burden in normal and high-fat diet-fed mice","authors":"Guang-Xu Ren,&nbsp;Liang He,&nbsp;Yong-Xin Liu,&nbsp;Yu-Ke Fei,&nbsp;Xiao-Fan Liu,&nbsp;Qiu-Yi Lu,&nbsp;Xin Chen,&nbsp;Zhi-Da Song,&nbsp;Jia-Qi Wang","doi":"10.1002/imt2.256","DOIUrl":"10.1002/imt2.256","url":null,"abstract":"<p>After 10 weeks of feeding C57BL/6J mice with a normal diet (ND) or a high-fat diet (HFD), a 7-week intervention with milk fat and whole milk was conducted to assess their long-term effects on host blood lipid levels. The results showed that milk fat and whole milk did not significantly elevate low-density lipoprotein cholesterol (LDL-C) in either ND- or HFD-fed mice. In ND mice, milk fat and whole milk improved gut microbiota diversity and Amplicon Sequence Variants. Key bacterial genera, such as <i>Blautia</i>, <i>Romboutsia</i>, and <i>Prevotellaceae_NK3B31_group</i>, were identified as bidirectional regulators of LDL-C and high-density lipoprotein cholesterol (HDL-C). Six unique metabolites were also linked to LDL-C and HDL-C regulation. Furthermore, an optimized machine learning model accurately predicted LDL-C (<i>R</i>² = 0.96) and HDL-C (<i>R</i>² = 0.89) based on gut microbiota data, with 80% of the top predictive features being gut metabolites influenced by milk fat and whole milk. These findings indicate that the long-term intake of milk fat does not significantly increase the blood lipid burden, and machine learning algorithms based on gut microbiota and metabolites offer novel insights for early lipid assessment and personalized nutrition strategies.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":73342,"journal":{"name":"iMeta","volume":"3 6","pages":""},"PeriodicalIF":23.7,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}