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Histamine: A key compound in red light-enhanced Fusarium verticillioides resistance in maize 组胺：红光增强玉米抗黄萎病抗性的关键化合物

IF 23.7

iMeta Pub Date : 2025-04-07 DOI: 10.1002/imt2.70020

Xuanjun Feng, Dan Zheng, Weixiao Zhang, Huihui Xiao, Huarui Guan, Hao Xiong, Li Jia, Xuemei Zhang, Wenming Wang, Haiyang Wang, Yanli Lu

{"title":"Histamine: A key compound in red light-enhanced Fusarium verticillioides resistance in maize","authors":"Xuanjun Feng, Dan Zheng, Weixiao Zhang, Huihui Xiao, Huarui Guan, Hao Xiong, Li Jia, Xuemei Zhang, Wenming Wang, Haiyang Wang, Yanli Lu","doi":"10.1002/imt2.70020","DOIUrl":"https://doi.org/10.1002/imt2.70020","url":null,"abstract":"In this study, we demonstrate that red light is the most critical light component for promoting healthy maize growth during Fusarium verticillioides infection. Red light receptors PHYTOCHROME B (PHYB) and C (PHYC) play essential roles in maize defense against this pathogen. Overexpression of PHYC in maize enhances resistance to F. verticillioides. Additionally, we identified two defense-related gene networks and some metabolites that reliant on PHYCs, involving key contributors such as WRKY transcription factors and metabolites like histamine and thiamine. Notably, the application of 50 μM histamine significantly boosts resistance, particularly under high-density conditions, marking the first report of the role of histamine in disease resistance in plants.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture>\u0000 </div>\u0000 </figure>","PeriodicalId":73342,"journal":{"name":"iMeta","volume":"4 2","pages":""},"PeriodicalIF":23.7,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/imt2.70020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HLF and PPARα axis regulates metabolic-associated fatty liver disease through extracellular vesicles derived from the intestinal microbiota HLF和PPARα轴通过来自肠道微生物群的细胞外囊泡调节代谢相关的脂肪肝疾病

IF 23.7

iMeta Pub Date : 2025-04-07 DOI: 10.1002/imt2.70022

Xingzhen Yang, Jiale Wang, Xinyu Qi, Menglong Hou, Mengkuan Liu, Yang Xiao, Siqi Liu, Jinfeng Zhou, Jingsu Yu, Yang Wang, Guo Chen, Lin Yu, Khongorzul Batchuluun, Batbold Batsaikhan, Turtushikh Damba, Yuehui Liang, Xue Liang, Jie Ma, Yunxiao Liang, Yixing Li, Lei Zhou

{"title":"HLF and PPARα axis regulates metabolic-associated fatty liver disease through extracellular vesicles derived from the intestinal microbiota","authors":"Xingzhen Yang, Jiale Wang, Xinyu Qi, Menglong Hou, Mengkuan Liu, Yang Xiao, Siqi Liu, Jinfeng Zhou, Jingsu Yu, Yang Wang, Guo Chen, Lin Yu, Khongorzul Batchuluun, Batbold Batsaikhan, Turtushikh Damba, Yuehui Liang, Xue Liang, Jie Ma, Yunxiao Liang, Yixing Li, Lei Zhou","doi":"10.1002/imt2.70022","DOIUrl":"https://doi.org/10.1002/imt2.70022","url":null,"abstract":"Metabolic-associated fatty liver disease (MAFLD) has become increasingly widespread. The intestine is the primary site of lipid absorption and is important for the homeostasis of lipid metabolism. However, the mechanism underlying the participation of the intestinal tract in the development of MAFLD requires additional investigation. In this study, analysis of the single-cell transcriptome of intestinal tissue from cynomolgus monkeys found that hepatic leukemia factor (HLF) participated in the genetic regulation of intestinal lipid absorption. Results obtained from normal and intestine-specific Hlf-knockout mice confirmed that HLF alleviated intestinal barrier disorders by inhibiting peroxisome proliferator-activated receptor alpha (PPARα) expression. The HLF/PPARα axis alleviated MAFLD by mediating gut microbiota-derived extracellular vesicles (fEVs), thereby inhibiting hepatocyte ferroptosis. Lipidomics and functional experiments verified that taurochenodeoxycholic acid (TCDCA), a conjugated bile acid contained in the fEVs, had a key role in the process. In conclusion, intestinal HLF activity was mediated by fEVs and identified as a novel therapeutic target for MAFLD.","PeriodicalId":73342,"journal":{"name":"iMeta","volume":"4 2","pages":""},"PeriodicalIF":23.7,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/imt2.70022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two telomere-to-telomere pig genome assemblies and pan-genome analyses provide insights into genomic structural landscape and genetic adaptations 两个端粒到端粒的猪基因组组装和泛基因组分析提供了基因组结构景观和遗传适应的见解

IF 23.7

iMeta Pub Date : 2025-04-03 DOI: 10.1002/imt2.70013

Wencheng Zong, Li Chen, Dongjie Zhang, Yuebo Zhang, Jinbu Wang, Xinhua Hou, Jie Chai, Yalong An, Ming Tian, Xinmiao He, Chengyi Song, Jun He, Xin Liu, Ligang Wang, Enrico D'Alessandro, Lixian Wang, Yulong Yin, Mingzhou Li, Di Liu, Jinyong Wang, Longchao Zhang

引用次数: 0

The impact of school heavy metal exposure on children's gut microbiota: The mediating role of environmental microorganisms 学校重金属暴露对儿童肠道菌群的影响：环境微生物的中介作用

IF 23.7

iMeta Pub Date : 2025-03-25 DOI: 10.1002/imt2.70021

Yuchen Zou, Menglong Li, Tuerxunayi Abudumijiti, Huiming He, Mengying Guan, Yeerlin Asihaer, Miao Li, Nourhan M. Khattab, Mushui Shu, Yifei Hu

{"title":"The impact of school heavy metal exposure on children's gut microbiota: The mediating role of environmental microorganisms","authors":"Yuchen Zou, Menglong Li, Tuerxunayi Abudumijiti, Huiming He, Mengying Guan, Yeerlin Asihaer, Miao Li, Nourhan M. Khattab, Mushui Shu, Yifei Hu","doi":"10.1002/imt2.70021","DOIUrl":"https://doi.org/10.1002/imt2.70021","url":null,"abstract":"Heavy metals are toxic and harmful pollutants that can affect the school environment and the exposed children's health. This study collected dust samples and children's fecal specimens, and performed gene sequencing. We used eXtreme Gradient Boosting to determine the impact of heavy metals on environmental microorganisms and gut microbiota, while using the relative length of the quadrant and Fourth-corner analysis to explore the relationship among the three components. We found heavy metal pollution existed in the classroom environment, with lead and copper significantly affecting environmental microorganisms' community structure. Although nonsignificant associations were observed between heavy metals and gut microbiota, Fourth-corner analysis revealed the associations were significantly mediated by environmental microorganisms. Both heavy metals and microorganisms in the environment can disrupt the microbial community structure in the intestines of exposed children.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture>\u0000 </div>\u0000 </figure>","PeriodicalId":73342,"journal":{"name":"iMeta","volume":"4 2","pages":""},"PeriodicalIF":23.7,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/imt2.70021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MDIPID: Microbiota-drug interaction and disease phenotype interrelation database MDIPID：微生物-药物相互作用和疾病表型相互关系数据库

IF 23.7

iMeta Pub Date : 2025-03-21 DOI: 10.1002/imt2.70019

Jiayi Yin, Hui Ma, Yuting Qi, Qingwei Zhao, Su Zeng, Fengcheng Li, Feng Zhu

{"title":"MDIPID: Microbiota-drug interaction and disease phenotype interrelation database","authors":"Jiayi Yin, Hui Ma, Yuting Qi, Qingwei Zhao, Su Zeng, Fengcheng Li, Feng Zhu","doi":"10.1002/imt2.70019","DOIUrl":"https://doi.org/10.1002/imt2.70019","url":null,"abstract":"The intricate bidirectional relationships among microbiota, microbial proteins, drugs, and diseases are essential for advancing precision medicine and minimizing adverse drug reactions. However, there are currently no data resources that comprehensively describe these valuable interactions. Therefore, the Microbiota-Drug Interaction and Disease Phenotype Interrelation Database (MDIPID) database was developed in this study. MDIPID is distinctive in its ability to elucidate the complex interactions among microbiota, microbial proteins, drugs/substances, and disease phenotypes, thereby providing a comprehensive interconnected network that facilitates the identification of microbial therapy targets and advances personalized medicine. This comprehensive resource is expected to become a popular repository for researchers aiming to identify microbial therapeutic targets, predict drug efficacy, and develop new therapies, thereby facilitating the advancement of personalized medicine. MDIPID can be accessed free without any login requirement at: https://idrblab.org/mdipid/.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture>\u0000 </div>\u0000 </figure>","PeriodicalId":73342,"journal":{"name":"iMeta","volume":"4 2","pages":""},"PeriodicalIF":23.7,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/imt2.70019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New insights into genome assembly at the chromosome-level of Prunus tomentosa in evolution and cold tolerance 毛李染色体水平基因组组装在进化和耐寒性中的新见解

IF 23.7

iMeta Pub Date : 2025-03-20 DOI: 10.1002/imt2.70016

Songtao Jiu, Muhammad Aamir Manzoor, Zhengxin Lv, Baozheng Chen, Shaoqin Shen, Yan Xu, Moyang Liu, Chengwei Li, Xunju Liu, Yanhong Fu, Qijing Zhang, Ruie Liu, Xinyu Zhang, Shiping Wang, Xiaoming Song, Yang Dong, Caixi Zhang

{"title":"New insights into genome assembly at the chromosome-level of Prunus tomentosa in evolution and cold tolerance","authors":"Songtao Jiu, Muhammad Aamir Manzoor, Zhengxin Lv, Baozheng Chen, Shaoqin Shen, Yan Xu, Moyang Liu, Chengwei Li, Xunju Liu, Yanhong Fu, Qijing Zhang, Ruie Liu, Xinyu Zhang, Shiping Wang, Xiaoming Song, Yang Dong, Caixi Zhang","doi":"10.1002/imt2.70016","DOIUrl":"https://doi.org/10.1002/imt2.70016","url":null,"abstract":"This study assembled a high-quality chromosome-level genome of Prunus tomentosa, offering a vital resource for elucidating its genetic architecture, evolutionary relationships, and facilitating genome-assisted breeding efforts. Multi-omics integration revealed PtIMP3 and PtMIOX1L as key factors in cold tolerance of P. tomentosa. PtIMP3 drives the conversion of glucose-6-phosphate to myo-inositol, while PtMIOX1L catalyzes myo-inositol to d-glucuronic acid. Specifically, the high expression abundance of PtIMP3 and low expression abundance of PtMIOX1L resulted in high endogenous inositol levels in P. tomentosa. The application of myo-inositol enhanced the cold tolerance of cherry rootstocks by modulating reactive oxygen species concentrations and maintaining a stable relative water content. This finding supports the superior performance of P. tomentosa in adapting to extreme low-temperatures environmental conditions. These insights advance strategies for improving cold tolerance in horticultural crops, bridging fundamental research with practical applications in developing climate-resilient crops.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture>\u0000 </div>\u0000 </figure>","PeriodicalId":73342,"journal":{"name":"iMeta","volume":"4 2","pages":""},"PeriodicalIF":23.7,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/imt2.70016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut microbiota in cancer: From molecular mechanisms to precision medicine applications 癌症中的肠道微生物群：从分子机制到精准医疗应用

IF 23.7

iMeta Pub Date : 2025-03-19 DOI: 10.1002/imt2.70017

Weihua Xiao, Qiong Chen, Chunjiao Liu, Yueer Yu, Tianliang Liu, Yang Jin, Haifen Ma, Shifu Chen, Chao Jiang

引用次数: 0

Tidyplots empowers life scientists with easy code-based data visualization Tidyplots为生命科学家提供了简单的基于代码的数据可视化

IF 23.7

iMeta Pub Date : 2025-03-19 DOI: 10.1002/imt2.70018

Jan Broder Engler

引用次数: 0

Preconception maternal gut dysbiosis affects enteric nervous system development and disease susceptibility in offspring via the GPR41–GDNF/RET/SOX10 signaling pathway 孕前母体肠道生态失调通过GPR41-GDNF /RET/SOX10信号通路影响子代肠道神经系统发育和疾病易感性

IF 23.7

iMeta Pub Date : 2025-03-18 DOI: 10.1002/imt2.70012

Cunzheng Zhang, Yuzhu Chen, Ruqiao Duan, Yiming Zhang, Haonan Zheng, Jindong Zhang, Tao Zhang, Jingxian Xu, Kailong Li, Fei Pei, Liping Duan

{"title":"Preconception maternal gut dysbiosis affects enteric nervous system development and disease susceptibility in offspring via the GPR41–GDNF/RET/SOX10 signaling pathway","authors":"Cunzheng Zhang, Yuzhu Chen, Ruqiao Duan, Yiming Zhang, Haonan Zheng, Jindong Zhang, Tao Zhang, Jingxian Xu, Kailong Li, Fei Pei, Liping Duan","doi":"10.1002/imt2.70012","DOIUrl":"https://doi.org/10.1002/imt2.70012","url":null,"abstract":"Maternal health, specifically changes in the gut microbiota, can profoundly impact offspring health; however, our understanding of how gut microbiota alterations during the preconception period influence the offspring remains limited. In this study, we investigated the impact and mechanisms of preconception maternal gut dysbiosis on the development of the enteric nervous system (ENS) in mice. We found that preconception maternal exposure to antibiotics led to the abnormal development of the ENS in offspring, increasing their susceptibility to water avoidance stress at the adult stage. Metagenomic, targeted metabolomic, and transcriptomic analyses revealed that preconception antibiotic exposure disrupted the expression of genes crucial for embryonic ENS development by altering maternal gut microbiota composition. Multi-omics analysis combined with Limosilactobacillus reuteri and propionate gestational supplementation demonstrated that the maternal gut microbiota and metabolites may influence embryonic ENS development via the GPR41–GDNF/RET/SOX10 signaling pathway. Our findings highlight the critical importance of maintaining a healthy maternal gut microbiota before conception to support normal ENS development in offspring.","PeriodicalId":73342,"journal":{"name":"iMeta","volume":"4 2","pages":""},"PeriodicalIF":23.7,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/imt2.70012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143827048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phenotyping, genome-wide dissection, and prediction of maize root architecture for temperate adaptability 表型分析、全基因组解剖和玉米根系结构对温带适应性的预测

IF 23.7

iMeta Pub Date : 2025-03-13 DOI: 10.1002/imt2.70015

Weijun Guo, Fanhua Wang, Jianyue Lv, Jia Yu, Yue Wu, Hada Wuriyanghan, Liang Le, Li Pu

{"title":"Phenotyping, genome-wide dissection, and prediction of maize root architecture for temperate adaptability","authors":"Weijun Guo, Fanhua Wang, Jianyue Lv, Jia Yu, Yue Wu, Hada Wuriyanghan, Liang Le, Li Pu","doi":"10.1002/imt2.70015","DOIUrl":"https://doi.org/10.1002/imt2.70015","url":null,"abstract":"Root System Architecture (RSA) plays an essential role in influencing maize yield by enhancing anchorage and nutrient uptake. Analyzing maize RSA dynamics holds potential for ideotype-based breeding and prediction, given the limited understanding of the genetic basis of RSA in maize. Here, we obtained 16 root morphology-related traits (R-traits), 7 weight-related traits (W-traits), and 108 slice-related microphenotypic traits (S-traits) from the meristem, elongation, and mature zones by cross-sectioning primary, crown, and lateral roots from 316 maize lines. Significant differences were observed in some root traits between tropical/subtropical and temperate lines, such as primary and total root diameters, root lengths, and root area. Additionally, root anatomy data were integrated with genome-wide association study (GWAS) to elucidate the genetic architecture of complex root traits. GWAS identified 809 genes associated with R-traits, 261 genes linked to W-traits, and 2577 key genes related to 108 slice-related traits. We confirm the function of a candidate gene, fucosyltransferase5 (FUT5), in regulating root development and heat tolerance in maize. The different FUT5 haplotypes found in tropical/subtropical and temperate lines are associated with primary root features and hold promising applications in molecular breeding. Furthermore, we performed machine learning prediction models of RSA using root slice traits, achieving high prediction accuracy. Collectively, our study offers a valuable tool for dissecting the genetic architecture of RSA, along with resources and predictive models beneficial for molecular design breeding and genetic enhancement.","PeriodicalId":73342,"journal":{"name":"iMeta","volume":"4 2","pages":""},"PeriodicalIF":23.7,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/imt2.70015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0