与西方人群相比,中国人群前列腺癌中嵌合 RNA 的图谱分析揭示了相似之处和不同之处

IF 23.7 Q1 MICROBIOLOGY
iMeta Pub Date : 2025-03-13 DOI:10.1002/imt2.70014
Qiong Wang, Shunli Yu, Jirong Jie, Justin Elfman, Zhi Xiong, Sandeep Singh, Samir Lalani, Yiwei Wang, Kaiwen Li, Bisheng Cheng, Ze Gao, Xu Gao, Hui Li, Hai Huang
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引用次数: 0

摘要

染色体重排产生的嵌合 RNA 多年来一直被确认为癌症标志物和治疗靶点。最近,相邻基因之间的反式拼接和顺式拼接也被证明会产生嵌合 RNA。它们通过编码融合蛋白、作为长非编码 RNA 或环状 RNA 或改变亲代基因表达来影响肿瘤进展。在这里,我们分析了癌症基因组图谱和中国前列腺癌基因组与表观基因组图谱中的嵌合 RNA,确定了中西方前列腺癌队列之间的异同。我们证实了癌症上皮细胞、癌症相关成纤维细胞、肿瘤相关巨噬细胞和 T 细胞之间不同的嵌合 RNA 表达模式。我们揭示了这些嵌合体如何影响肿瘤细胞生长、基质细胞转化以及微环境中的细胞间通讯。这项综合研究为中国 PCa 患者建立了嵌合转录组图谱,突出了人群特异性差异,并提出了具有诊断、预后和治疗潜力的经过验证的嵌合 RNA。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Profiling chimeric RNA in prostate cancer in Chinese cohorts reveals similarities and differences compared to Western populations

Profiling chimeric RNA in prostate cancer in Chinese cohorts reveals similarities and differences compared to Western populations

Chimeric RNAs from chromosomal rearrangements have long been validated as cancer markers and therapeutic targets for many years. Recently, trans-splicing and cis-splicing between adjacent genes are also shown to generate chimeric RNAs. They influence tumor progression by coding fusion proteins, acting as long noncoding or circular RNAs, or altering parental gene expression. Here, we analyzed chimeric RNAs from The Cancer Genome Atlas and Chinese Prostate Cancer Genome and Epigenome Atlas, identifying similarities and differences between Western and Chinese prostate cancer (PCa) cohorts. We confirmed distinct chimeric RNA expression patterns among cancer epithelial cells, cancer-associated fibroblasts, tumor-associated macrophages, and T cells. We unraveled how these chimeras impact tumor cell growth, stromal cell transformation, and intercellular communication within the microenvironment. This comprehensive study establishes a chimeric transcriptome atlas for Chinese PCa patients, highlights population-specific disparities, and presents validated chimeric RNAs with diagnostic, prognostic, and therapeutic potential.

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CiteScore
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