Gut microbiome (Cambridge, England)最新文献_第3页

Microbiota and probiotics: chances and challenges - a symposium report. 微生物群和益生菌:机遇和挑战-研讨会报告

Gut microbiome (Cambridge, England) Pub Date : 2023-03-27 eCollection Date: 2023-01-01 DOI: 10.1017/gmb.2023.4

Carrie Helen Stevenson Ruxton, Chiyuki Kajita, Paola Rocca, Bruno Pot

{"title":"Microbiota and probiotics: chances and challenges - a symposium report.","authors":"Carrie Helen Stevenson Ruxton, Chiyuki Kajita, Paola Rocca, Bruno Pot","doi":"10.1017/gmb.2023.4","DOIUrl":"10.1017/gmb.2023.4","url":null,"abstract":"The 10th International Yakult Symposium was held in Milan, Italy, on 13-14 October 2022. Two keynote lectures covered the crewed journey to space and its implications for the human microbiome, and how current regulatory systems can be adapted and updated to ensure the safety of microorganisms used as probiotics or food processing ingredients. The remaining lectures were split into sections entitled \"Chances\" and \"Challenges.\" The \"Chances\" section explored opportunities for the science of probiotics and fermented foods to contribute to diverse areas of health such as irritable bowel syndrome, major depression, Parkinson's disease, immune dysfunction, infant colic, intensive care, respiratory infections, and promoting healthy longevity. The \"Challenges\" section included selecting appropriate clinical trial participants and methodologies to minimise heterogeneity in responses, how to view probiotics in the context of One Health, adapting regulatory frameworks, and understanding how substances of bacterial origin can cross the blood-brain barrier. The symposium provided evidence from cutting-edge research that gut eubiosis is vital for human health and, like space, the microbiota deserves further exploration of its vast potential.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":" ","pages":"e6"},"PeriodicalIF":0.0,"publicationDate":"2023-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11406417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42603753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The gut microbiota is an emerging target for improving brain health during ageing. 肠道微生物群是改善老年期大脑健康的一个新兴目标。

Gut microbiome (Cambridge, England) Pub Date : 2023-01-01 Epub Date: 2022-12-12 DOI: 10.1017/gmb.2022.11

Marcus Boehme, Katherine Elizabeth Guzzetta, Caroline Wasén, Laura Michelle Cox

引用次数: 0

Association of Habitual Intake of Probiotic Supplements and Yogurt with Characteristics of the Gut Microbiome in the Multiethnic Cohort Adiposity Phenotype Study. 多民族肥胖表型研究中益生菌补充剂和酸奶的习惯性摄入与肠道微生物组特征的关系

Gut microbiome (Cambridge, England) Pub Date : 2023-01-01 Epub Date: 2023-07-13 DOI: 10.1017/gmb.2023.10

Weiwen Chai, Gertraud Maskarinec, Unhee Lim, Carol J Boushey, Lynne R Wilkens, V Wendy Setiawan, Loïc Le Marchand, Timothy W Randolph, Isaac C Jenkins, Johanna W Lampe, Meredith A J Hullar

{"title":"Association of Habitual Intake of Probiotic Supplements and Yogurt with Characteristics of the Gut Microbiome in the Multiethnic Cohort Adiposity Phenotype Study.","authors":"Weiwen Chai, Gertraud Maskarinec, Unhee Lim, Carol J Boushey, Lynne R Wilkens, V Wendy Setiawan, Loïc Le Marchand, Timothy W Randolph, Isaac C Jenkins, Johanna W Lampe, Meredith A J Hullar","doi":"10.1017/gmb.2023.10","DOIUrl":"10.1017/gmb.2023.10","url":null,"abstract":"Consumption of probiotics and/or yogurt could be a solution for restoring the balance of the gut microbiota. This study examined associations of regular intake of probiotic supplements or yogurt with the gut microbiota among a diverse population of older adults (N=1,861; 60-72 years). Fecal microbial composition was obtained from 16S rRNA gene sequencing (V1-V3 region). General Linear Models were used to estimate the associations of probiotic supplement or yogurt intake with microbiome measures adjusting for covariates. Compared to non-yogurt consumers (N=1,023), regular yogurt consumers (≥once/week, N=818) had greater Streptococcus (β=0.29, P=0.0003) and lower Odoribacter (β=-0.33, P<0.0001) abundance. The directions of the above associations were consistent across the five ethnic groups but stronger among Japanese Americans (Streptococcus: β=0.56, P=0.0009; Odoribacter: β=-0.62, P=0.0005). Regular intake of probiotic supplements (N=175) was not associated with microbial characteristics (i.e., alpha diversity and the abundance of 152 bacteria genera). Streptococcus is one of the predominant bacteria genera in yogurt products, which may explain the positive association between yogurt consumption and Streptococcus abundance. Our analyses suggest that changes in Odoribacter were independent of changes in Streptococcus abundance. Future studies may investigate whether these microbial genera and their sub-level species mediate potential pathways between yogurt consumption and health.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10927272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45518410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The gut microbiome in children with mood, anxiety, and neurodevelopmental disorders: An umbrella review 患有情绪、焦虑和神经发育障碍儿童的肠道微生物群:综述

Gut microbiome (Cambridge, England) Pub Date : 2023-01-01 DOI: 10.1017/gmb.2023.16

Kaitlin Romano, Ashka N Shah, Anett Schumacher, Clare Zasowski, Tianyi Zhang, Glyneva Bradley-Ridout, Kaitlyn Merriman, John Parkinson, Peter Szatmari, Susan C Campisi, Daphne J Korczak

{"title":"The gut microbiome in children with mood, anxiety, and neurodevelopmental disorders: An umbrella review","authors":"Kaitlin Romano, Ashka N Shah, Anett Schumacher, Clare Zasowski, Tianyi Zhang, Glyneva Bradley-Ridout, Kaitlyn Merriman, John Parkinson, Peter Szatmari, Susan C Campisi, Daphne J Korczak","doi":"10.1017/gmb.2023.16","DOIUrl":"https://doi.org/10.1017/gmb.2023.16","url":null,"abstract":"Abstract Research on the gut microbiome and mental health among children and adolescents is growing. This umbrella review provides a high-level overview of current evidence syntheses to amalgamate current research and inform future directions. Searches were conducted across seven databases for peer-reviewed pediatric (<18 years) review literature. Studies reporting gut microbiome composition and/or biotic supplementation on depression, bipolar disorder, anxiety, attention deficit hyperactivity disorder, autism spectrum disorder (ASD), or obsessive-compulsive disorder (OCD) were included. Deduplication and screening took place in Covidence. A sensitivity analysis was conducted to assess the degree of primary study overlap. Among the 39 included review studies, 23 (59%) were observational and 16 (41%) were interventional. Most reviews (92%) focused on ASD. Over half (56%) of the observational and interventional reviews scored low or critically low for methodological quality. A higher abundance of Clostridium clusters and a lower abundance of Bifidobacterium were consistently observed in ASD studies. Biotic supplementation was associated with ASD symptom improvement. Gut microbiome-mental health evidence syntheses in child and youth depression, anxiety, bipolar disorder, and OCD are lacking. Preliminary evidence suggests an association between specific microbiota and ASD symptoms, with some evidence supporting a role for probiotic supplementation ASD therapy.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":"298 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135595975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MetaFunc: Taxonomic and Functional Analyses of High Throughput Sequencing for Microbiomes MetaFunc:微生物组高通量测序的分类和功能分析

Gut microbiome (Cambridge, England) Pub Date : 2023-01-01 DOI: 10.1017/gmb.2022.12

Arielle Kae Sulit, Tyler Kolisnik, Frank A Frizelle, Rachel Purcell, Sebastian Schmeier

{"title":"MetaFunc: Taxonomic and Functional Analyses of High Throughput Sequencing for Microbiomes","authors":"Arielle Kae Sulit, Tyler Kolisnik, Frank A Frizelle, Rachel Purcell, Sebastian Schmeier","doi":"10.1017/gmb.2022.12","DOIUrl":"https://doi.org/10.1017/gmb.2022.12","url":null,"abstract":"Abstract The identification of functional processes taking place in microbiome communities augment traditional microbiome taxonomic studies, giving a more complete picture of interactions taking place within the community. While there are applications that perform functional annotation on metagenomes or metatranscriptomes, very few of these are able to link taxonomic identity to function or are limited by their input types or databases used. Here we present MetaFunc, a workflow which takes RNA sequences as input reads, and from these (1) identifies species present in the microbiome sample and (2) provides gene ontology annotations associated with the species identified. In addition, MetaFunc allows for host gene analysis, mapping the reads to a host genome, and separating these reads, prior to microbiome analyses. Differential abundance analysis for microbe taxonomies, and differential gene expression analysis and gene set enrichment analysis may then be carried out through the pipeline. A final correlation analysis between microbial species and host genes can also be performed. Finally, MetaFunc builds an R shiny application that allows users to view and interact with the microbiome results. In this paper, we showed how MetaFunc can be applied to metatranscriptomic datasets of colorectal cancer.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135077882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Towards the characterization of sustainable diet’s gut microbiota composition and functions 可持续饮食肠道菌群组成及功能的研究

Gut microbiome (Cambridge, England) Pub Date : 2023-01-01 DOI: 10.1017/gmb.2023.13

Mariana Lares-Michel, Zyanya Reyes-Castillo, Fatima Ezzahra Housni

{"title":"Towards the characterization of sustainable diet’s gut microbiota composition and functions","authors":"Mariana Lares-Michel, Zyanya Reyes-Castillo, Fatima Ezzahra Housni","doi":"10.1017/gmb.2023.13","DOIUrl":"https://doi.org/10.1017/gmb.2023.13","url":null,"abstract":"Abstract The gut microbiome is a key element for health preservation and disease prevention. Nevertheless, defining a healthy gut microbiome is complex since it is modulated by several factors, such as host genetics, sex, age, geographical zone, drug use, and, especially, diet. Although a healthy diet has proven to increase microbial alpha and beta diversity and to promote the proliferation of health-related bacteria, considering the current environmental and nutritional crisis, such as climate change, water shortage, loss of diversity, and the obesity pandemic, it should be highlighted that a healthy diet is not always sustainable. Sustainable diets are dietary patterns that promote all dimensions of people’s health and well-being while exerting low pressure on the environment, and being accessible, affordable, safe, equitable, and culturally acceptable. Examples of diets that tend to be sustainable are the Planetary Health Diet of the EAT-Lancet Commission or territorial diets such as the Mediterranean and the Traditional Mexican diet (milpa diet), adapted to specific contexts. These diets are principally plant-based but include small or moderate amounts of animal-based foods. Characterising the effects of sustainable diets on gut microbiota is urgent to ensure that the benefits for human health are aligned with environmental preservation and respect the sociocultural aspects of individuals.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135360957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut physiology meets microbiome science. 肠道生理学与微生物组科学的结合。

Gut microbiome (Cambridge, England) Pub Date : 2022-12-12 eCollection Date: 2023-01-01 DOI: 10.1017/gmb.2022.10

Hannelore Daniel

{"title":"Gut physiology meets microbiome science.","authors":"Hannelore Daniel","doi":"10.1017/gmb.2022.10","DOIUrl":"https://doi.org/10.1017/gmb.2022.10","url":null,"abstract":"Research on the gut microbiome has gained high popularity and almost every disease has meanwhile been linked to alterations in microbiome composition. Typically assessed via stool samples, the microbiome displays a huge diversity with a multitude of environmental parameters already identified as contributing to its character. Despite impressive scientific progress, normal microbiome diversity remains largely unexplained and it is tempting to speculate some of the yet unexplained variance is hidden in normal gut physiology. Although a few genome/phenome-wide associations studies have recently highlighted physiological parameters such as stool frequency, known as contributing to microbiome diversity, there is a large knowledge base from decades of basic research on gut functions that can be explored for possible links to stool features and microbiome characteristics. And, when extrapolating findings from faecal samples to the biology in the intestinal lumen or the mucosal microenvironment, gut anatomy and physiology features need to be considered. Similarly, differences in anatomy and physiology between rodents and humans need attention when discussing findings in animals in relation to human physiology and nutrition.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":"4 ","pages":"e1"},"PeriodicalIF":0.0,"publicationDate":"2022-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11406389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142302554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determining the metabolic fate of human milk oligosaccharides: it may just be more complex than you think? 确定母乳低聚糖的代谢命运：它可能比你想象的更复杂？

Gut microbiome (Cambridge, England) Pub Date : 2022-09-07 eCollection Date: 2022-01-01 DOI: 10.1017/gmb.2022.8

Peter Philip James Jackson, Anisha Wijeyesekera, Robert Adrian Rastall

引用次数: 0

Modulating the gut microenvironment as a treatment strategy for irritable bowel syndrome: a narrative review. 调节肠道微环境作为肠易激综合征的治疗策略:叙述性回顾

Gut microbiome (Cambridge, England) Pub Date : 2022-08-25 eCollection Date: 2022-01-01 DOI: 10.1017/gmb.2022.6

Cristina Iribarren, Lujain Maasfeh, Lena Öhman, Magnus Simrén

引用次数: 0

The microbiome in adult acute appendicitis. 成人急性阑尾炎的微生物组

Gut microbiome (Cambridge, England) Pub Date : 2022-08-04 eCollection Date: 2022-01-01 DOI: 10.1017/gmb.2022.7

Mei Sze Lee, Arielle Sulit, Frank Frizelle, Rachel Purcell

{"title":"The microbiome in adult acute appendicitis.","authors":"Mei Sze Lee, Arielle Sulit, Frank Frizelle, Rachel Purcell","doi":"10.1017/gmb.2022.7","DOIUrl":"10.1017/gmb.2022.7","url":null,"abstract":"Acute appendicitis is a common acute surgical emergency; however, the pathogenesis of adult appendicitis remains poorly understood. The microbiome is increasingly thought to play a key role in inflammatory disease of the bowel and similarly, may play a role in appendicitis. This study aimed to characterise the microbiome of adult acute appendicitis in a prospective cohort. We recruited 60 adults with acute appendicitis and 20 healthy controls. Rectal swabs were taken from each patient. After DNA extraction, 16S rRNA amplicon sequencing was carried out for analysis of diversity and taxonomic abundance. Phylogenetic sequencing of the samples indicated that there is a difference between the microbial composition of those with acute appendicitis and healthy controls, with a statistically significant decrease in alpha diversity in rectal swabs of appendicitis patients compared to healthy controls. At the genus level, we saw an increased abundance of potential pathogens, for example, Parvimonas and Acinetobacter, and a decrease in commensal taxa such as Faecalibacterium, Blautia and Lachnospiraceae in appendicitis patients compared to healthy controls. There was a reduction in diversity and loss of commensals in the microbiome of those with acute appendicitis, which may play a role in the cascade leading to acute appendicitis or the result of this.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":" ","pages":"e8"},"PeriodicalIF":0.0,"publicationDate":"2022-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11406380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47023191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0