Gut microbiome (Cambridge, England)最新文献

The effect of probiotics, prebiotics and synbiotics on gut microbial community profile in overweight and obese Latin American and Caribbean populations: a systematic review of human trials.

Gut microbiome (Cambridge, England) Pub Date : 2025-01-17 eCollection Date: 2025-01-01 DOI: 10.1017/gmb.2024.12

Manahil M Bineid, Litai Liu, Eduard F Ventura, Sakshi Bansal, Katherine Curi-Quinto, Juana Del Valle-Mendoza, Gemma E Walton, Karani Santhanakrishnan Vimaleswaran

{"title":"The effect of probiotics, prebiotics and synbiotics on gut microbial community profile in overweight and obese Latin American and Caribbean populations: a systematic review of human trials.","authors":"Manahil M Bineid, Litai Liu, Eduard F Ventura, Sakshi Bansal, Katherine Curi-Quinto, Juana Del Valle-Mendoza, Gemma E Walton, Karani Santhanakrishnan Vimaleswaran","doi":"10.1017/gmb.2024.12","DOIUrl":"10.1017/gmb.2024.12","url":null,"abstract":"Oral supplementation with probiotics, prebiotics, and synbiotics is a novel potential complementary therapy for addressing overweight and obesity through gut microbiota modulation. This systematic review provides a comprehensive summary of the existing evidence to guide future research. Literature searches were conducted in four databases to identify human trials published until May 2024 that examined the impact of probiotic, prebiotic, or synbiotic interventions on faecal microbiota composition changes in overweight and obese participants from Latin American and Caribbean populations (LACPs). Of the 13,090 identified records, five randomised controlled trials (RCTs) from Brazil, Mexico, and Chile met the inclusion criteria for this review. The included RCTs evaluated different forms of therapies over short-term interventions (6 or 8 weeks), with sample sizes ranging from 21 to 39 participants across the studies. Variations in the reported outcomes were observed due to differences in supplement formulation, dosage, population characteristics, and methodological heterogeneity. The findings indicate that the available data are inadequate to establish definitive conclusions regarding the impact of biotic treatments on gut microbiota profiles in LACP. Further research with larger sample sizes and precise microbiota analysis is required to elucidate the implications of dietary interventions on gut microbiota in obesity and related disorders.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":"6 ","pages":"e2"},"PeriodicalIF":0.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11810601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Partially hydrolyzed guar gum attenuates symptoms and modulates the gut microbiota in a model of SARS-CoV-2 infection. 在 SARS-CoV-2 感染模型中，部分水解瓜尔豆胶可减轻症状并调节肠道微生物群。

Gut microbiome (Cambridge, England) Pub Date : 2025-01-14 eCollection Date: 2025-01-01 DOI: 10.1017/gmb.2024.7

Jiayue Yang, Isaiah Song, Misa Saito, Tenagy Hartanto, Takeshi Ichinohe, Shinji Fukuda

{"title":"Partially hydrolyzed guar gum attenuates symptoms and modulates the gut microbiota in a model of SARS-CoV-2 infection.","authors":"Jiayue Yang, Isaiah Song, Misa Saito, Tenagy Hartanto, Takeshi Ichinohe, Shinji Fukuda","doi":"10.1017/gmb.2024.7","DOIUrl":"10.1017/gmb.2024.7","url":null,"abstract":"The coronavirus disease 2019 (COVID-19) pandemic has caused health issues worldwide. Studies have suggested that modulation of the gut microbiota could attenuate the severity of COVID-19 symptoms. In light of this, we explored the effects of the prebiotic dietary fibre partially hydrolyzed guar gum (PHGG) on SARS-CoV-2 infection in a Syrian hamster model, hypothesizing that modulation of the gut microbiome and intestinal metabolites through PHGG administration would improve COVID-19 disease outcomes. Eight hamsters each were assigned to the PHGG administration and control groups. The PHGG group was given a diet supplemented with 5% PHGG for two weeks. Consequently, PHGG improved the host survival rate to 100% compared to 25% of the control group (P = 0.003) and attenuated morbid weight loss. Another non-infected set of hamsters was used for the analysis of the gut microbiome composition with 16S rRNA amplicon sequencing, serum, and faecal metabolites with GC-MS and LC-MS. PHGG altered the gut microbiome composition and increased the relative abundances of Ileibacterium, Bifidobacterium, and Prevotella. Furthermore, it elevated the concentrations of faecal valeric acid, propionic acid, ursodeoxycholic acid, and serum deoxycholic acid. Taken together, our data suggest that the prebiotic PHGG modulates gut metabolites and has the potential to reduce COVID-19 morbidity.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":"6 ","pages":"e1"},"PeriodicalIF":0.0,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11810603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GutBugDB: a web resource to predict the human gut microbiome-mediated biotransformation of biotic and xenobiotic molecules. GutBugDB：预测人类肠道微生物介导的生物和异种生物分子生物转化的网络资源。

Gut microbiome (Cambridge, England) Pub Date : 2025-01-09 eCollection Date: 2025-01-01 DOI: 10.1017/gmb.2024.15

Usha Longwani, Ashok K Sharma, Aditya S Malwe, Shubham K Jaiswal, Vineet K Sharma

{"title":"GutBugDB: a web resource to predict the human gut microbiome-mediated biotransformation of biotic and xenobiotic molecules.","authors":"Usha Longwani, Ashok K Sharma, Aditya S Malwe, Shubham K Jaiswal, Vineet K Sharma","doi":"10.1017/gmb.2024.15","DOIUrl":"10.1017/gmb.2024.15","url":null,"abstract":"There has been a growing recognition of the significant role played by the human gut microbiota in altering the bioavailability as well as the pharmacokinetic and pharmacodynamic aspects of orally ingested xenobiotic and biotic molecules. The determination of species-specific contributions to the metabolism of biotic and xenobiotic molecules has the potential to aid in the development of new therapeutic and nutraceutical molecules that can modulate human gut microbiota. Here we present \"GutBugDB,\" an open-access digital repository that provides information on potential gut microbiome-mediated biotransformation of biotic and xenobiotic molecules using the predictions from the GutBug tool. This database is constructed using metabolic proteins from 690 gut bacterial genomes and 363,872 protein enzymes assigned with their EC numbers (with representative Expasy ID and domains present). It provides information on gut microbiome enzyme-mediated metabolic biotransformation for 1439 FDA-approved drugs and nutraceuticals. GutBugDB is publicly available at https://metabiosys.iiserb.ac.in/gutbugdb/.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":"6 ","pages":"e3"},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11810598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pro-inflammatory and hyperinsulinaemic dietary patterns are associated with specific gut microbiome profiles: a TwinsUK cohort study. 促炎和高胰岛素血症饮食模式与特定肠道微生物群特征相关：TwinsUK队列研究

Gut microbiome (Cambridge, England) Pub Date : 2024-12-05 eCollection Date: 2024-01-01 DOI: 10.1017/gmb.2024.14

Ni Shi, Sushma Nepal, Rachel Hoobler, Cristina Menni, Mary C Playdon, Daniel Spakowicz, Philippa M Wells, Claire J Steves, Steven K Clinton, Fred K Tabung

{"title":"Pro-inflammatory and hyperinsulinaemic dietary patterns are associated with specific gut microbiome profiles: a TwinsUK cohort study.","authors":"Ni Shi, Sushma Nepal, Rachel Hoobler, Cristina Menni, Mary C Playdon, Daniel Spakowicz, Philippa M Wells, Claire J Steves, Steven K Clinton, Fred K Tabung","doi":"10.1017/gmb.2024.14","DOIUrl":"10.1017/gmb.2024.14","url":null,"abstract":"Metabolic dietary patterns, including the Empirical Dietary Index for Hyperinsulinaemia (EDIH) and Empirical Dietary Inflammatory Pattern (EDIP), are known to impact multiple chronic diseases, but the role of the colonic microbiome in mediating such relationships is poorly understood. Among 1,610 adults with faecal 16S rRNA data in the TwinsUK cohort, we identified the microbiome profiles for EDIH and EDIP (from food frequency questionnaires) cross-sectionally using elastic net regression. We assessed the association of the dietary pattern-related microbiome profile scores with circulating biomarkers in multivariable-adjusted linear regression. In addition, we used PICRUSt2 to predict biological pathways associated with the enriched microbiome profiles, and further screened pathways for associations with the dietary scores in linear regression analyses. Microbiome profile scores developed with 32 (EDIH) and 15 (EDIP) genera were associated with higher insulin and homeostatic model assessment of insulin resistance. Six genera were associated with both dietary scores: Ruminococcaceae_UCG-008, Lachnospiraceae_UCG-008, Defluviitaleaceae_UCG-011 Anaeroplasma, inversely and Negativibacillus, Streptococcus, positively. Further, pathways in fatty acid biosynthesis, sugar acid degradation, and mevalonate metabolism were associated with insulinaemic and inflammatory diets. Dietary patterns that exert metabolic effects on insulin and inflammation may influence chronic disease risk by modulating gut microbial composition and function.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":"5 ","pages":"e12"},"PeriodicalIF":0.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11658949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Has the two decades of research on the gut microbiome resulted in making healthier choices? 二十年来对肠道微生物组的研究是否导致了更健康的选择？

Gut microbiome (Cambridge, England) Pub Date : 2024-12-02 eCollection Date: 2024-01-01 DOI: 10.1017/gmb.2024.13

M Andrea Azcarate-Peril

引用次数: 0

"Gut" to grips with the science of the microbiome - a symposium report. "肠道 "掌握微生物组科学--专题讨论会报告。

Gut microbiome (Cambridge, England) Pub Date : 2024-11-29 eCollection Date: 2024-01-01 DOI: 10.1017/gmb.2024.8

Yvonne E Finnegan, Holly R Neill, Emily J Prpa, Bruno Pot

{"title":"\"Gut\" to grips with the science of the microbiome - a symposium report.","authors":"Yvonne E Finnegan, Holly R Neill, Emily J Prpa, Bruno Pot","doi":"10.1017/gmb.2024.8","DOIUrl":"10.1017/gmb.2024.8","url":null,"abstract":"The latest Yakult Science Study Day was held virtually on 2 November 2023. Aimed at healthcare professionals, researchers, and students, a variety of experts explored the latest gut microbiome research and what it means in practice. The morning sessions discussed the role of the microbiome in health and disease, the rapid advancements in DNA sequencing and implications for personalised nutrition, the current state of evidence on health benefits associated with fermented foods, prebiotics and probiotics and the challenges involved in interpreting research in this area. The afternoon session considered the emerging research on the microbiota-gut-brain axis in mediating effects of food on mood, the bidirectional impact of menopause on the gut microbiota, and the interplay between the gut and skin with implications for the treatment of rare and common skin disorders. The session ended with an update on the use of faecal microbiota transplant in both research and clinical practice. Undoubtedly, the gut microbiome is emerging as a key conductor of human health, both in relation to gastrointestinal and non-gastrointestinal outcomes. As research continues to elucidate mechanisms of action and confirm their effects in human trials, the gut microbiome should be a key consideration within a holistic approach to health moving forward.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":"5 ","pages":"e11"},"PeriodicalIF":0.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11658944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors underlying the association between Streptococcus gallolyticus, subspecies gallolyticus infection and colorectal cancer: a mini review. 溶胆链球菌、溶胆链球菌亚种感染与结直肠癌相关因素综述

Gut microbiome (Cambridge, England) Pub Date : 2024-11-04 eCollection Date: 2024-01-01 DOI: 10.1017/gmb.2024.11

David Michael Warner, Arunab Harish Mehta

{"title":"Factors underlying the association between Streptococcus gallolyticus, subspecies gallolyticus infection and colorectal cancer: a mini review.","authors":"David Michael Warner, Arunab Harish Mehta","doi":"10.1017/gmb.2024.11","DOIUrl":"10.1017/gmb.2024.11","url":null,"abstract":"Streptococcus gallolyticus, subspecies gallolyticus (Sgg) is a gram-positive bacterium associated with infective endocarditis and colorectal cancer (CRC). Sgg has features that allow the bacterium to thrive in the colorectal tumor microenvironment and further progress the development of CRC to facilitate its survival. Sgg contains 3 pili that facilitate colonic cell adhesion and translocation through phase variation. Sgg also contains bile salt hydrolase and a bacteriocin called gallocin with substantially increased activity in bile acids, which facilitates its growth in the bile acid-rich adenomatous colorectal microenvironment. Sgg also uses tumor metabolites as an energy source. Sgg also possesses tannase, which metabolizes gallotannin to be used as a carbon source and reduces the anti-apoptotic effects of tannins, driving CRC progression. Sgg also interferes with a variety of oncogenic cell signaling pathways, including the Wnt/β-catenin pathway through mechanisms that are not fully elucidated. Increased β-catenin signaling also enhances adhesion via increased expression of the extracellular matrix and increases bile acid concentrations in the lumen through downregulation of an apical bile acid transporter. Finally, Sgg induces biotransformation of toxic substrates in CRC cells, which leads to formation of toxic intermediates and DNA adducts, promoting further progression of CRC.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":"5 ","pages":"e9"},"PeriodicalIF":0.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11658940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seeding and feeding milestones: the role of human milk microbes and oligosaccharides in the temporal development of infant gut microbiota. 播种和喂养里程碑：人乳微生物和低聚糖在婴儿肠道菌群发育中的作用。

Gut microbiome (Cambridge, England) Pub Date : 2024-05-31 eCollection Date: 2024-01-01 DOI: 10.1017/gmb.2024.5

Martha F Endika, David J M Barnett, Cynthia E Klostermann, Noortje Kok, Henk A Schols, Arjen Nauta, Ilja C W Arts, John Penders, Koen Venema, Hauke Smidt

{"title":"Seeding and feeding milestones: the role of human milk microbes and oligosaccharides in the temporal development of infant gut microbiota.","authors":"Martha F Endika, David J M Barnett, Cynthia E Klostermann, Noortje Kok, Henk A Schols, Arjen Nauta, Ilja C W Arts, John Penders, Koen Venema, Hauke Smidt","doi":"10.1017/gmb.2024.5","DOIUrl":"https://doi.org/10.1017/gmb.2024.5","url":null,"abstract":"Breastfeeding represents a strong selective factor for shaping the infant gut microbiota. Besides providing nutritional requirements for the infant, human milk is a key source of oligosaccharides, human milk oligosaccharides (HMOs), and diverse microbes in early life. This study aimed to evaluate the influence of human milk microbiota and oligosaccharides on the composition of infant faecal microbiota at one, three, and nine months postpartum. We profiled milk microbiota, HMOs, and infant faecal microbiota from 23 mother-infant pairs at these time points. The predominant genera in milk samples were Streptococcus, Staphylococcus, and an unclassified Enterobacteriaceae genus-level taxon (Enterobacteriaceae uncl.), whereas the infant faecal microbiota was predominated by Bifidobacterium, Bacteroides, and Enterobacteriaceae uncl. Mother-infant dyads frequently shared bacterial amplicon sequence variants (ASVs) belonging to the genera Bifidobacterium, Streptococcus, Enterobacteriaceae uncl., Veillonella, Bacteroides, and Haemophilus. The individual HMO concentrations in the milk showed either no change or decreased over the lactation period, except for 3-fucosyllactose (3-FL), which increased. Neither maternal secretor status nor HMO concentrations were significantly associated with microbiota composition at the different ages or the bacterial ASVs of maternal milk and infant faeces. This study suggests an age-dependent role of milk microbes in shaping the gut microbiota, while variations in HMO concentrations show limited influence.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":"5 ","pages":"e7"},"PeriodicalIF":0.0,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142959733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Megasphaera elsdenii, a commensal member of the gut microbiota, is associated with elevated gas production during in vitro fermentation. Megasphaera elsdenii 是肠道微生物群的共生成员，与体外发酵过程中气体产生量的增加有关。

Gut microbiome (Cambridge, England) Pub Date : 2023-12-21 eCollection Date: 2024-01-01 DOI: 10.1017/gmb.2023.18

Erasme Mutuyemungu, Hollman A Motta-Romero, Qinnan Yang, Sujun Liu, Sean Liu, Mukti Singh, Devin J Rose

{"title":"Megasphaera elsdenii, a commensal member of the gut microbiota, is associated with elevated gas production during in vitro fermentation.","authors":"Erasme Mutuyemungu, Hollman A Motta-Romero, Qinnan Yang, Sujun Liu, Sean Liu, Mukti Singh, Devin J Rose","doi":"10.1017/gmb.2023.18","DOIUrl":"https://doi.org/10.1017/gmb.2023.18","url":null,"abstract":"Megasphaera elsdenii has been correlated with gas production by human faecal microbiota during fermentation. The objective of this study was to determine the role of M. elsdenii in gas production by the microbiome. Kidney beans and sweet potatoes were subjected to in vitro digestion and dialysis followed by fermentation with ten faecal microbiomes: three with detectable M. elsdenii (Me_D) and seven with no detectable M. elsdenii (Me_ND). Me_D microbiomes produced more gas than the Me_ND microbiomes (p < 0.001). Me_D microbiomes produced more gas during fermentation of sweet potatoes than kidney beans (p < 0.001), while the opposite was true for the Me_ND microbiomes (p < 0.001). Among amplicon sequence variants that were associated with gas production, M. elsdenii had the strongest association (p < 0.001). Me_D microbiomes consumed more acetate and produced more butyrate than Me_ND microbiomes (p < 0.001). Gas production by M. elsdenii was confirmed by fermentation of sweet potatoes and acetate with human and rumen M. elsdenii isolates. The human isolate produced gas on sweet potatoes and acetate. This study suggests that M. elsdenii may be involved in gas production during the fermentation of flatulogenic foods through utilisation of undigestible substrates or cross-feeding on acetate.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":"5 ","pages":"e1"},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11406407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142302556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrogen gas and the gut microbiota are potential biomarkers for the development of experimental colitis in mice 氢气和肠道微生物群是小鼠实验性结肠炎发展的潜在生物标志物

Gut microbiome (Cambridge, England) Pub Date : 2023-11-06 DOI: 10.1017/gmb.2023.17

Yuta Fujiki, Takahisa Tanaka, Kyosuke Yakabe, Natsumi Seki, Masahiro Akiyama, Ken Uchida, Yun-Gi Kim

引用次数: 0