Gut microbiome (Cambridge, England)最新文献

Pro-inflammatory and hyperinsulinaemic dietary patterns are associated with specific gut microbiome profiles: a TwinsUK cohort study.

Gut microbiome (Cambridge, England) Pub Date : 2024-12-05 eCollection Date: 2024-01-01 DOI: 10.1017/gmb.2024.14

Ni Shi, Sushma Nepal, Rachel Hoobler, Cristina Menni, Mary C Playdon, Daniel Spakowicz, Philippa M Wells, Claire J Steves, Steven K Clinton, Fred K Tabung

{"title":"Pro-inflammatory and hyperinsulinaemic dietary patterns are associated with specific gut microbiome profiles: a TwinsUK cohort study.","authors":"Ni Shi, Sushma Nepal, Rachel Hoobler, Cristina Menni, Mary C Playdon, Daniel Spakowicz, Philippa M Wells, Claire J Steves, Steven K Clinton, Fred K Tabung","doi":"10.1017/gmb.2024.14","DOIUrl":"https://doi.org/10.1017/gmb.2024.14","url":null,"abstract":"Metabolic dietary patterns, including the Empirical Dietary Index for Hyperinsulinaemia (EDIH) and Empirical Dietary Inflammatory Pattern (EDIP), are known to impact multiple chronic diseases, but the role of the colonic microbiome in mediating such relationships is poorly understood. Among 1,610 adults with faecal 16S rRNA data in the TwinsUK cohort, we identified the microbiome profiles for EDIH and EDIP (from food frequency questionnaires) cross-sectionally using elastic net regression. We assessed the association of the dietary pattern-related microbiome profile scores with circulating biomarkers in multivariable-adjusted linear regression. In addition, we used PICRUSt2 to predict biological pathways associated with the enriched microbiome profiles, and further screened pathways for associations with the dietary scores in linear regression analyses. Microbiome profile scores developed with 32 (EDIH) and 15 (EDIP) genera were associated with higher insulin and homeostatic model assessment of insulin resistance. Six genera were associated with both dietary scores: Ruminococcaceae_UCG-008, Lachnospiraceae_UCG-008, Defluviitaleaceae_UCG-011 Anaeroplasma, inversely and Negativibacillus, Streptococcus, positively. Further, pathways in fatty acid biosynthesis, sugar acid degradation, and mevalonate metabolism were associated with insulinaemic and inflammatory diets. Dietary patterns that exert metabolic effects on insulin and inflammation may influence chronic disease risk by modulating gut microbial composition and function.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":"5 ","pages":"e12"},"PeriodicalIF":0.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11658949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Has the two decades of research on the gut microbiome resulted in making healthier choices?

Gut microbiome (Cambridge, England) Pub Date : 2024-12-02 eCollection Date: 2024-01-01 DOI: 10.1017/gmb.2024.13

M Andrea Azcarate-Peril

引用次数: 0

"Gut" to grips with the science of the microbiome - a symposium report.

Gut microbiome (Cambridge, England) Pub Date : 2024-11-29 eCollection Date: 2024-01-01 DOI: 10.1017/gmb.2024.8

Yvonne E Finnegan, Holly R Neill, Emily J Prpa, Bruno Pot

{"title":"\"Gut\" to grips with the science of the microbiome - a symposium report.","authors":"Yvonne E Finnegan, Holly R Neill, Emily J Prpa, Bruno Pot","doi":"10.1017/gmb.2024.8","DOIUrl":"https://doi.org/10.1017/gmb.2024.8","url":null,"abstract":"The latest Yakult Science Study Day was held virtually on 2 November 2023. Aimed at healthcare professionals, researchers, and students, a variety of experts explored the latest gut microbiome research and what it means in practice. The morning sessions discussed the role of the microbiome in health and disease, the rapid advancements in DNA sequencing and implications for personalised nutrition, the current state of evidence on health benefits associated with fermented foods, prebiotics and probiotics and the challenges involved in interpreting research in this area. The afternoon session considered the emerging research on the microbiota-gut-brain axis in mediating effects of food on mood, the bidirectional impact of menopause on the gut microbiota, and the interplay between the gut and skin with implications for the treatment of rare and common skin disorders. The session ended with an update on the use of faecal microbiota transplant in both research and clinical practice. Undoubtedly, the gut microbiome is emerging as a key conductor of human health, both in relation to gastrointestinal and non-gastrointestinal outcomes. As research continues to elucidate mechanisms of action and confirm their effects in human trials, the gut microbiome should be a key consideration within a holistic approach to health moving forward.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":"5 ","pages":"e11"},"PeriodicalIF":0.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11658944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors underlying the association between Streptococcus gallolyticus, subspecies gallolyticus infection and colorectal cancer: a mini review.

Gut microbiome (Cambridge, England) Pub Date : 2024-11-04 eCollection Date: 2024-01-01 DOI: 10.1017/gmb.2024.11

David Michael Warner, Arunab Harish Mehta

{"title":"Factors underlying the association between Streptococcus gallolyticus, subspecies gallolyticus infection and colorectal cancer: a mini review.","authors":"David Michael Warner, Arunab Harish Mehta","doi":"10.1017/gmb.2024.11","DOIUrl":"https://doi.org/10.1017/gmb.2024.11","url":null,"abstract":"Streptococcus gallolyticus, subspecies gallolyticus (Sgg) is a gram-positive bacterium associated with infective endocarditis and colorectal cancer (CRC). Sgg has features that allow the bacterium to thrive in the colorectal tumor microenvironment and further progress the development of CRC to facilitate its survival. Sgg contains 3 pili that facilitate colonic cell adhesion and translocation through phase variation. Sgg also contains bile salt hydrolase and a bacteriocin called gallocin with substantially increased activity in bile acids, which facilitates its growth in the bile acid-rich adenomatous colorectal microenvironment. Sgg also uses tumor metabolites as an energy source. Sgg also possesses tannase, which metabolizes gallotannin to be used as a carbon source and reduces the anti-apoptotic effects of tannins, driving CRC progression. Sgg also interferes with a variety of oncogenic cell signaling pathways, including the Wnt/β-catenin pathway through mechanisms that are not fully elucidated. Increased β-catenin signaling also enhances adhesion via increased expression of the extracellular matrix and increases bile acid concentrations in the lumen through downregulation of an apical bile acid transporter. Finally, Sgg induces biotransformation of toxic substrates in CRC cells, which leads to formation of toxic intermediates and DNA adducts, promoting further progression of CRC.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":"5 ","pages":"e9"},"PeriodicalIF":0.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11658940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Megasphaera elsdenii, a commensal member of the gut microbiota, is associated with elevated gas production during in vitro fermentation. Megasphaera elsdenii 是肠道微生物群的共生成员，与体外发酵过程中气体产生量的增加有关。

Gut microbiome (Cambridge, England) Pub Date : 2023-12-21 eCollection Date: 2024-01-01 DOI: 10.1017/gmb.2023.18

Erasme Mutuyemungu, Hollman A Motta-Romero, Qinnan Yang, Sujun Liu, Sean Liu, Mukti Singh, Devin J Rose

{"title":"Megasphaera elsdenii, a commensal member of the gut microbiota, is associated with elevated gas production during in vitro fermentation.","authors":"Erasme Mutuyemungu, Hollman A Motta-Romero, Qinnan Yang, Sujun Liu, Sean Liu, Mukti Singh, Devin J Rose","doi":"10.1017/gmb.2023.18","DOIUrl":"https://doi.org/10.1017/gmb.2023.18","url":null,"abstract":"Megasphaera elsdenii has been correlated with gas production by human faecal microbiota during fermentation. The objective of this study was to determine the role of M. elsdenii in gas production by the microbiome. Kidney beans and sweet potatoes were subjected to in vitro digestion and dialysis followed by fermentation with ten faecal microbiomes: three with detectable M. elsdenii (Me_D) and seven with no detectable M. elsdenii (Me_ND). Me_D microbiomes produced more gas than the Me_ND microbiomes (p < 0.001). Me_D microbiomes produced more gas during fermentation of sweet potatoes than kidney beans (p < 0.001), while the opposite was true for the Me_ND microbiomes (p < 0.001). Among amplicon sequence variants that were associated with gas production, M. elsdenii had the strongest association (p < 0.001). Me_D microbiomes consumed more acetate and produced more butyrate than Me_ND microbiomes (p < 0.001). Gas production by M. elsdenii was confirmed by fermentation of sweet potatoes and acetate with human and rumen M. elsdenii isolates. The human isolate produced gas on sweet potatoes and acetate. This study suggests that M. elsdenii may be involved in gas production during the fermentation of flatulogenic foods through utilisation of undigestible substrates or cross-feeding on acetate.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":"5 ","pages":"e1"},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11406407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142302556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrogen gas and the gut microbiota are potential biomarkers for the development of experimental colitis in mice 氢气和肠道微生物群是小鼠实验性结肠炎发展的潜在生物标志物

Gut microbiome (Cambridge, England) Pub Date : 2023-11-06 DOI: 10.1017/gmb.2023.17

Yuta Fujiki, Takahisa Tanaka, Kyosuke Yakabe, Natsumi Seki, Masahiro Akiyama, Ken Uchida, Yun-Gi Kim

引用次数: 0

GUT METABOLOMIC PROFILES IN PEDIATRIC ULCERATIVE COLITIS PATIENTS PRIOR TO AND AFTER RECEIVING FECAL MICROBIOTA TRANSPLANTS 儿童溃疡性结肠炎患者接受粪便菌群移植前后的肠道代谢组学特征

Gut microbiome (Cambridge, England) Pub Date : 2023-10-06 DOI: 10.1017/gmb.2023.15

Parastou S. Khalessi Hosseini, Beibei Wang, Yihui Luan, Fengzhu Sun, Sonia Michail

引用次数: 0

The butyrate-producing and spore-forming bacterial genus Coprococcus as a potential biomarker for neurological disorders. 产丁酸盐和形成孢子的细菌属粪原球菌作为神经系统疾病的潜在生物标志物

Gut microbiome (Cambridge, England) Pub Date : 2023-08-30 eCollection Date: 2023-01-01 DOI: 10.1017/gmb.2023.14

Fleur Notting, Walter Pirovano, Wilbert Sybesma, Remco Kort

{"title":"The butyrate-producing and spore-forming bacterial genus Coprococcus as a potential biomarker for neurological disorders.","authors":"Fleur Notting, Walter Pirovano, Wilbert Sybesma, Remco Kort","doi":"10.1017/gmb.2023.14","DOIUrl":"10.1017/gmb.2023.14","url":null,"abstract":"The host-intestinal microbiome interaction has gained much scientific attention in the past two decades, boosted by advances in DNA sequencing and cultivation techniques. An accumulating amount of evidence shows that gut microbes play crucial roles in gut homeostasis, immune system education, and are associated with quality-of-life indicators. Beneficial health factors are associated with the digestion of dietary fibres in the colon and the subsequent production of short-chain fatty acids, including acetate, propionate, and butyrate. Coprococcus is a butyrate-producing genus in the phylum Firmicutes, and its abundance is inversely correlated with several neuropsychological and neurodegenerative disorders. Case-control studies provide strong evidence of decreased abundance of Coprococcus spp. in depressed individuals. The species Coprococcus eutactus has the unique capacity to use two separate pathways for butyrate synthesis and has been found to be depleted in children with delayed language development and adults with Parkinson's disease. The combined literature on Coprococcus and the gut microbiota-brain axis points towards enhanced butyrate production and reduced colonisation of pathogenic clades as factors explaining its association with health effects. The genus Coprococcus is a promising candidate for a mental health biomarker and an interesting lead for novel dietary-based preventive therapies for specific neurological disorders.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":" ","pages":"e16"},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11406416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46753227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk of bias assessment tool for systematic review and meta-analysis of the gut microbiome. 用于肠道微生物组系统综述和荟萃分析的偏倚风险评估工具

Gut microbiome (Cambridge, England) Pub Date : 2023-08-18 eCollection Date: 2023-01-01 DOI: 10.1017/gmb.2023.12

Thomas Lampeter, Charles Love, Trien T Tang, Aditi S Marella, Hayden Y Lee, Armani Oganyan, Devin Moffat, Anisha Kareem, Matthew Rusling, Aubrey Massmann, Melanie Orr, Christian Bongiorno, Li-Lian Yuan

引用次数: 0

Multiomics characterisation of the zoo-housed gorilla gut microbiome reveals bacterial community compositions shifts, fungal cellulose-degrading, and archaeal methanogenic activity. 动物园饲养的大猩猩肠道微生物组的多组学特征揭示了细菌群落组成变化，真菌纤维素降解和古细菌产甲烷活性

Gut microbiome (Cambridge, England) Pub Date : 2023-07-19 eCollection Date: 2023-01-01 DOI: 10.1017/gmb.2023.11

Isabel M Houtkamp, Martine van Zijll Langhout, Mark Bessem, Walter Pirovano, Remco Kort

{"title":"Multiomics characterisation of the zoo-housed gorilla gut microbiome reveals bacterial community compositions shifts, fungal cellulose-degrading, and archaeal methanogenic activity.","authors":"Isabel M Houtkamp, Martine van Zijll Langhout, Mark Bessem, Walter Pirovano, Remco Kort","doi":"10.1017/gmb.2023.11","DOIUrl":"10.1017/gmb.2023.11","url":null,"abstract":"We carried out a comparative analysis between the bacterial microbiota composition of zoo-housed western lowland gorillas and their wild counterparts through 16S rRNA gene amplicon sequencing. In addition, we characterised the carbohydrate-active and methanogenic potential of the zoo-housed gorilla (ZHG) microbiome through shotgun metagenomics and RNA sequencing. The ZHG microbiota showed increased alpha diversity in terms of bacterial species richness and a distinct composition from that of the wild gorilla microbiota, including a loss of abundant fibre-degrading and hydrogenic Chloroflexi. Metagenomic analysis of the CAZyome indicated predominant oligosaccharide-degrading activity, while RNA sequencing revealed diverse cellulase and hemi-cellulase activities in the ZHG gut, contributing to a total of 268 identified carbohydrate-active enzymes. Metatranscriptome analysis revealed a substantial contribution of 38% of the transcripts from anaerobic fungi and archaea to the gorilla microbiome. This activity originates from cellulose-degrading and hydrogenic fungal species belonging to the class Neocallimastigomycetes, as well as from methylotrophic and hydrogenotrophic methanogenic archaea belonging to the classes Thermoplasmata and Methanobacteria, respectively. Our study shows the added value of RNA sequencing in a multiomics approach and highlights the contribution of eukaryotic and archaeal activities to the gut microbiome of gorillas.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":" ","pages":"e12"},"PeriodicalIF":0.0,"publicationDate":"2023-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11406404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41930133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0