Gut microbiome (Cambridge, England)最新文献

A Lactobacillus delbrueckii subsp. bulgaricus fermented skimmed milk powder has limited effects on gastrointestinal health in healthy individuals with mild-to-moderate gastrointestinal symptoms: results from a randomised controlled trial. 一种德尔布鲁氏乳杆菌亚种。保加利亚发酵脱脂奶粉对有轻度至中度胃肠道症状的健康人的胃肠道健康影响有限：一项随机对照试验的结果

Gut microbiome (Cambridge, England) Pub Date : 2026-07-31 eCollection Date: 2026-01-01 DOI: 10.1017/gmb.2026.10031

Martina Rooney, Clíona Ní Chonnacháin, Bernadette Finnerty, Grace Bennett, Éimear Gregory, Conor Carey, Monica Mechoud, Ram Raj Panthi, Harsh Mathur, Eoin G Murphy, Tom Beresford, Paul D Cotter, Alice Lucey, Emma L Feeney

{"title":"A Lactobacillus delbrueckii subsp. bulgaricus fermented skimmed milk powder has limited effects on gastrointestinal health in healthy individuals with mild-to-moderate gastrointestinal symptoms: results from a randomised controlled trial.","authors":"Martina Rooney, Clíona Ní Chonnacháin, Bernadette Finnerty, Grace Bennett, Éimear Gregory, Conor Carey, Monica Mechoud, Ram Raj Panthi, Harsh Mathur, Eoin G Murphy, Tom Beresford, Paul D Cotter, Alice Lucey, Emma L Feeney","doi":"10.1017/gmb.2026.10031","DOIUrl":"10.1017/gmb.2026.10031","url":null,"abstract":"Fermented dairy foods offer potential to improve gastrointestinal symptoms due to their functional characteristics (e.g., presence of potentially health-promoting microorganisms, and/or bioactives), which may improve quality of life (QoL). This study examined the effect of a Lactobacillus delbrueckii subsp. bulgaricus fermented skimmed milk powder (FSMP) on gastrointestinal health in healthy individuals with mild-to-moderate gastrointestinal symptoms. Subjects received 20 g/day of either the FSMP, skimmed milk powder (SMP), or maltodextrin for 8 weeks. QoL, faecal calprotectin, gut transit time, gas evacuations, stool consistency, dietary intake, and anthropometry were all assessed. Eighty-four participants (62% female, 34.9 ± 5.9 years) completed the trial. SMP improved anxiety (P = 0.015), discomfort (P = 0.002), and global (P = 0.010) domain scores vs. maltodextrin. Similarly, SMP improved discomfort (P = 0.007) and global (P = 0.023) domain score relative to FSMP. No other differences between groups post-intervention were observed (P > 0.05). Sub-analyses indicated those with more severe symptoms at baseline had more normal stool consistency (P = 0.016) and fewer gas evacuations (P = 0.008) in response to FSMP relative to maltodextrin. Overall, this exploratory analysis found an L. delbrueckii subsp. bulgaricus FSMP had limited effects on gastrointestinal health in this cohort.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":"7 ","pages":"e14"},"PeriodicalIF":0.0,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13433340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148674899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the prebiotic potential of commercial cellobiose: a randomized, controlled trial. 探索商业纤维二糖的益生元潜力：一项随机对照试验。

Gut microbiome (Cambridge, England) Pub Date : 2026-07-27 eCollection Date: 2026-01-01 DOI: 10.1017/gmb.2026.10032

Manxi Huang, Peter Philip James Jackson, Afroditi Chatzifragkou, Robert Adrian Rastall

{"title":"Exploring the prebiotic potential of commercial cellobiose: a randomized, controlled trial.","authors":"Manxi Huang, Peter Philip James Jackson, Afroditi Chatzifragkou, Robert Adrian Rastall","doi":"10.1017/gmb.2026.10032","DOIUrl":"10.1017/gmb.2026.10032","url":null,"abstract":"Cellobiose, a β-(1 → 4)-linked disaccharide indigestible by humans, is a novel candidate prebiotic. Evidence from controlled human trials on its effects on the gut microbiota and metabolites remains limited. We conducted an exploratory randomised, double-blind, placebo-controlled trial in 37 healthy adults. Participants were allocated to three arms for 4 weeks, received 5 g/day and 10 g/day for cellobiose, oligofructose P95, or maltodextrin placebo. The primary endpoint was change in absolute abundance of Bifidobacterium and Lactobacillus (measured by 16S rRNA gene sequencing). Secondary endpoints included other taxa, diversity, faecal short-chain fatty acids (SCFAs) measured by gas chromatography-mass spectrometry and gastrointestinal (GI) tolerability. Cellobiose did not significantly change Bifidobacterium or Lactobacillus versus baseline or placebo (P > 0.05). Oligofructose P95 induced a borderline increase in Bifidobacterium (P = 0.049). Overall community composition remained unchanged. However, network analyses under cellobiose revealed tighter positive correlations among key genera. Faecal SCFA levels were not altered. GI symptom rates were low and similar across all arms. Cellobiose, at doses up to 10 g/day, is safe and well tolerated but did not enrich classic beneficial taxa. The findings suggest cellobiose drives subtle community shifts towards butyrate-producing bacteria.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":"7 ","pages":"e13"},"PeriodicalIF":0.0,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13433336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148674831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum: Partially hydrolyzed guar gum attenuates symptoms and modulates the gut microbiota in a model of SARS-CoV-2 infection - CORRIGENDUM. 在SARS-CoV-2感染模型中，部分水解瓜尔胶可减轻症状并调节肠道微生物群-更正

Gut microbiome (Cambridge, England) Pub Date : 2026-06-16 eCollection Date: 2026-01-01 DOI: 10.1017/gmb.2026.10030

Jiayue Yang, Isaiah Song, Misa Saito, Tenagy Hartanto, Takeshi Ichinohe, Shinji Fukuda

引用次数: 0

Erratum: The prairie vole gut-brain-microbiota-axis: a narrative review - CORRIGENDUM. 勘误：草原田鼠肠道-大脑-微生物群轴：叙述回顾-勘误。

Gut microbiome (Cambridge, England) Pub Date : 2026-06-15 eCollection Date: 2026-01-01 DOI: 10.1017/gmb.2026.10029

Daniel A Nuccio, Angela Grippo, Pallavi Singh

引用次数: 0

Ig-microbiota binding patterns in mothers and infants: a scoping review. 母亲和婴儿中igg -微生物群结合模式：范围综述。

Gut microbiome (Cambridge, England) Pub Date : 2026-06-01 eCollection Date: 2026-01-01 DOI: 10.1017/gmb.2026.10028

Alicia Tan Yi Jia, Christopher S Peacock, Danielle E Dye, Claus T Christophersen

{"title":"Ig-microbiota binding patterns in mothers and infants: a scoping review.","authors":"Alicia Tan Yi Jia, Christopher S Peacock, Danielle E Dye, Claus T Christophersen","doi":"10.1017/gmb.2026.10028","DOIUrl":"10.1017/gmb.2026.10028","url":null,"abstract":"Studies characterising the immunoglobulin (Ig)-bound microbiota apply varying methodologies, making comparisons difficult. This scoping review synthesised evidence on Ig-microbiota binding patterns in maternal and infant contexts, identified recurrent Ig-bound and -unbound bacteria across studies, and highlighted knowledge gaps for further study. Nine articles investigating Ig-microbiota binding patterns in stool or breastmilk samples in mothers or infants were included. Ig-microbiota associations were influenced by sample type, Ig-subclass, genetics, and diet. The most important antibody was IgA, with partial functional redundancy with IgM, while IgG appeared more selective for pathobionts. Ig-bound taxa in early life included important commensals and pathobionts, with high levels of individuality. Ig-microbiota associations shifted with microbiome maturation, environmental and host factors, resembling adults at around 2 years of age. Transfer of Ig-bound Bifidobacterium through breastmilk may contribute to vertical transmission from mother to infant. Ig-microbiota associations also differed between health and disease states, beyond the overall microbiota. Results were limited by study numbers and a lack of methodological consistency. We propose the standardised term \"Ig-Seq\" in referring to the technique to study Ig-microbiota binding patterns, and suggest standardisation of laboratory protocols, bioinformatic pipelines, and statistical analyses to improve consistency in Ig-Seq.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":"7 ","pages":"e12"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13279975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148297538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between gut microbiome and 24-hour blood pressure variability: a cross-sectional study highlighting sex differences and potential therapeutic targets. 肠道微生物组与24小时血压变异性之间的关系：一项强调性别差异和潜在治疗靶点的横断面研究

Gut microbiome (Cambridge, England) Pub Date : 2026-05-18 eCollection Date: 2026-01-01 DOI: 10.1017/gmb.2026.10026

Preeti Dinesh Virwani, Gordon Qian, Carman Nga-Man Cheung, Tommy K K T S Pijarnvanit, Matthew S S Hsu, Yick Hin Chow, Lok Kan Tang, Yiu-Hei Tse, Jia-Wen Xian, Shirley Sau-Wing Lam, Crystal P I Lee, Chelsea C W Lo, Roxanna K C Liu, Tsi Lok Ho, Bak Yue Chow, Kin Sum Leung, Emily K K Lo, Man-Fung Yuen, Suet Yi Leung, Ivan Fan-Ngai Hung, Jimmy Chun Yu Louie, Kay-Cheong Teo, Hani El-Nezami, Joshua Wing Kei Ho, Kui Kai Lau

{"title":"Associations between gut microbiome and 24-hour blood pressure variability: a cross-sectional study highlighting sex differences and potential therapeutic targets.","authors":"Preeti Dinesh Virwani, Gordon Qian, Carman Nga-Man Cheung, Tommy K K T S Pijarnvanit, Matthew S S Hsu, Yick Hin Chow, Lok Kan Tang, Yiu-Hei Tse, Jia-Wen Xian, Shirley Sau-Wing Lam, Crystal P I Lee, Chelsea C W Lo, Roxanna K C Liu, Tsi Lok Ho, Bak Yue Chow, Kin Sum Leung, Emily K K Lo, Man-Fung Yuen, Suet Yi Leung, Ivan Fan-Ngai Hung, Jimmy Chun Yu Louie, Kay-Cheong Teo, Hani El-Nezami, Joshua Wing Kei Ho, Kui Kai Lau","doi":"10.1017/gmb.2026.10026","DOIUrl":"10.1017/gmb.2026.10026","url":null,"abstract":"Blood pressure (BP) variability is an independent risk factor for cardiovascular disease. Gut microbiome (GM) regulates BP, but its association with BP variability remains unclear. We examined the association of GM, determined by stool shotgun metagenomic sequencing, with 24-hour BP average real variability (ARV) assessed by ambulatory BP monitoring in 235 community-dwelling adults from Hong Kong (111 men and 124 women, mean age 54 ± 6 years) using covariate-adjusted statistical models. The GM alpha diversity was negatively associated with systolic BP (SBP) ARV in the full cohort, driven by women. In men, beta diversity of both GM species and function was associated with SBP ARV, while Bacteroides nordii and the steroid hormone biosynthesis pathway had a positive association with SBP ARV. Bacteroides nordii emerged as the key species driving the significant positive association of steroid hormone biosynthesis and other pro-pathogenic pathways with SBP ARV, including lipopolysaccharide biosynthesis, phenylalanine, and sulfur metabolism in men, warranting further investigation for its causal role. We demonstrated distinct signatures of GM dysbiosis, composition, and function with minimal overlap between men and women with increased 24-hour SBP variability. Our work suggests that sex differences should be an important consideration in mechanistic and therapeutic investigations of GM-mediated BP variability.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":"7 ","pages":"e9"},"PeriodicalIF":0.0,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13279954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148297483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine learning identifies differences between breast milk and formula in the gut microbiome. 机器学习可以识别母乳和配方奶粉在肠道微生物组中的差异。

Gut microbiome (Cambridge, England) Pub Date : 2026-05-08 eCollection Date: 2026-01-01 DOI: 10.1017/gmb.2026.10020

Ting Chia Liu, David Rojas-Velazquez, Sarah Kidwai, Astrid Hogenkamp, Johan Garssen, Aletta D Kraneveld, Alejandro Lopez-Rincon

{"title":"Machine learning identifies differences between breast milk and formula in the gut microbiome.","authors":"Ting Chia Liu, David Rojas-Velazquez, Sarah Kidwai, Astrid Hogenkamp, Johan Garssen, Aletta D Kraneveld, Alejandro Lopez-Rincon","doi":"10.1017/gmb.2026.10020","DOIUrl":"10.1017/gmb.2026.10020","url":null,"abstract":"In this study, we analysed differences in the infant gut microbiome between breastfed and formula-fed infants using novel machine learning techniques. Breast milk, rich in bioactive agents, supports microbiota composition and immune development, while formulas aim to replicate its nutritional profile. We applied a methodology combining the DADA2 pipeline for 16S rRNA sequencing with the Recursive Ensemble Feature Selection (REFS) algorithm for biomarker discovery. We analysed three publicly available 16S rRNA datasets: PRJNA633365 (70 stool samples from China), PRJDB7295 (40 stool samples from the Philippines), and PRJNA562650 (40 stool samples from China). The discovery dataset (PRJNA633365) revealed 16 significant taxa out of 1,227, validated across the other two datasets. Next, we compared REFS performance with another feature selection algorithm, SelectKBest. Finally, we conducted a literature review to explore links between identified taxa and medical conditions. Additionally, we used MicrobiomeAnalyst to examine associations with diseases, diet, and lifestyle. Our results show differences in the bacterial composition between breastfed and formula-fed infants, and these findings were validated in two independent datasets. Future research should explore the functional roles of these taxa and consider regional and dietary variability to enhance understanding of microbiome dynamics and long-term health outcomes.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":"7 ","pages":"e7"},"PeriodicalIF":0.0,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13161719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147935923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum: Intestinal microbiome changes in response to amino acid and micronutrient supplementation: secondary analysis of the AMAZE trial - CORRIGENDUM. 肠道微生物组对氨基酸和微量营养素补充的反应变化：AMAZE试验的二次分析-勘误。

Gut microbiome (Cambridge, England) Pub Date : 2026-05-07 eCollection Date: 2026-01-01 DOI: 10.1017/gmb.2026.10025

Monica N Mweetwa, Kazi Ahsan, John Louis-Auguste, Ellen Besa, Joram M Posma, Nathan P McNulty, Michael J Barratt, Jeffrey I Gordon, Paul Kelly

引用次数: 0

Evaluating the gut microbiome, dietary patterns, and cognition: a sub-study protocol from the brain health and the gut microbiome study in cognitive decline (bMicrobiome study). 评估肠道微生物组、饮食模式和认知：认知衰退中大脑健康和肠道微生物组研究的一个子研究方案（bMicrobiome研究）。

Gut microbiome (Cambridge, England) Pub Date : 2026-04-20 eCollection Date: 2026-01-01 DOI: 10.1017/gmb.2026.10024

Karol Suchowiecki, Patrick G Corr, Aidan Schurr, Aryan Asemani, Leigh A Frame

{"title":"Evaluating the gut microbiome, dietary patterns, and cognition: a sub-study protocol from the brain health and the gut microbiome study in cognitive decline (bMicrobiome study).","authors":"Karol Suchowiecki, Patrick G Corr, Aidan Schurr, Aryan Asemani, Leigh A Frame","doi":"10.1017/gmb.2026.10024","DOIUrl":"10.1017/gmb.2026.10024","url":null,"abstract":"The aim of this study is to describe the development and implementation of a novel Readiness to Change Nutritional Habits (RCNH) survey for use along with dietary assessment and gut microbiome profiling in a proof-of-concept study in individuals with early Alzheimer's disease dementia (eAD), mild cognitive impairment (MCI), and healthy controls (HC). Overall, this methods paper contributes to emerging research examining how behavioural readiness for change can be integrated with dietary assessment and gut microbiome profiling to better understand the microbiome's influence on the nervous system. This is a sub-study embedded within a multi-prong proof-of-concept, observational study mapping the gut microbiome in 45 participants (15 HC, 15 MCI, 15 eAD) at baseline, 3 months, and 6 months. The parent study collects gut microbiome profiles, dietary patterns, and cognitive assessments. The sub-study develops and administers the 32-item RCNH survey to characterize participants' readiness to adopt nutritional change. This manuscript reports the RCNH survey, its development process, the sub-study protocol including data collection procedures, and planned exploratory analyses. This protocol presents a novel intervention to assess the gut microbiome, individual dietary patterns, and readiness to make lifestyle changes related to diet.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":"7 ","pages":"e8"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13200020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148038369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neonatal faecal abundance of Bifidobacterium longum subspecies infantis is not associated with anthropometric outcomes up to 6 months of age in Bangladeshi infants. 在孟加拉国婴儿中，新生儿粪便中长双歧杆菌亚种婴儿的丰度与6个月大的人体测量结果无关。

Gut microbiome (Cambridge, England) Pub Date : 2026-04-16 eCollection Date: 2026-01-01 DOI: 10.1017/gmb.2026.10023

Cole K Heasley, Veselina Stefanova, Celine Funk, Aline C Freitas, Grace Li, Lisa G Pell, Diego G Bassani, Karen M O'Callaghan, Prakesh S Shah, Jakaria Shawon, S M Abdul Gaffar, Rashidul Haque, Shafiqul Alam Sarker, Daniel E Roth

{"title":"Neonatal faecal abundance of Bifidobacterium longum subspecies infantis is not associated with anthropometric outcomes up to 6 months of age in Bangladeshi infants.","authors":"Cole K Heasley, Veselina Stefanova, Celine Funk, Aline C Freitas, Grace Li, Lisa G Pell, Diego G Bassani, Karen M O'Callaghan, Prakesh S Shah, Jakaria Shawon, S M Abdul Gaffar, Rashidul Haque, Shafiqul Alam Sarker, Daniel E Roth","doi":"10.1017/gmb.2026.10023","DOIUrl":"10.1017/gmb.2026.10023","url":null,"abstract":"B. infantis abundance in the infant gut may be associated with growth and health outcomes. However, these relationships have not been widely studied in settings where B. infantis is a dominant early-life commensal and growth faltering is prevalent. Here, we estimated associations between neonatal B. infantis abundance and anthropometric outcomes up to 6 months of age in generally healthy infants in Dhaka, Bangladesh; diarrhoea and hospitalizations (at 1-2 and 6 months) were secondary morbidity outcomes. B. infantis stool absolute abundance was quantified by qPCR; for each infant, the primary exposure was mean abundance (0-28 days). Length-for-age, weight-for-age, and weight-for-length z-scores were derived at birth, 2, 3, and 6 months. Neonatal B. infantis abundance had a bimodal distribution, with 63% of infants having detectable B. infantis by 28 days of age. Anthropometric z-score distributions were shifted down, with means below zero. Neonatal B. infantis abundance was not associated with any anthropometric outcome at 2, 3, or 6 months of age (n = 830), or with the risks of diarrhoea or hospitalizations. The lack of association of neonatal B. infantis abundance with growth outcomes suggests that promoting early B. infantis colonization is unlikely to improve growth in populations with postnatal faltering.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":"7 ","pages":"e5"},"PeriodicalIF":0.0,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13161717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147935926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0