Gut microbiome (Cambridge, England)最新文献_第2页

The prairie vole gut-brain-microbiota-axis: a narrative review. 草原田鼠肠道-大脑-微生物群轴：叙述性回顾。

Gut microbiome (Cambridge, England) Pub Date : 2026-03-24 eCollection Date: 2026-01-01 DOI: 10.1017/gmb.2026.10021

Daniel A Nuccio, Angela Grippo, Pallavi Singh

{"title":"The prairie vole gut-brain-microbiota-axis: a narrative review.","authors":"Daniel A Nuccio, Angela Grippo, Pallavi Singh","doi":"10.1017/gmb.2026.10021","DOIUrl":"10.1017/gmb.2026.10021","url":null,"abstract":"The microbiota-gut-brain axis (MGBA) has garnered considerable attention for its role in health, disease, and higher psychological processes. One area of particular importance is the relationship between the MGBA and stress. Although numerous animal models are suitable for research on stress, the number suitable for research on the impact of social stressors with translatability to humans is limited. The prairie vole is regarded as an ideal organism for probing the impact of social stress, as these animals not only exhibit social behaviours rare in mammals but also lack many drawbacks that come with using non-human primates. Moreover, the neurophysiological basis of their social behaviours is well characterized, and numerous studies have examined the impact of social stress, particularly social isolation, on these animals. However, only a limited number of studies have examined the prairie vole gastrointestinal system, intestinal microbiome, or MGBA. Consequently, this leaves ample opportunity for future research. In this review article, we summarize basic aspects of prairie vole ecology, behaviour, and neurophysiology, then review the limited but valuable body of research examining the gastrointestinal system and microbiome of prairie voles. Additionally, we note potential challenges and opportunities for future MGBA research utilizing prairie voles.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":"7 ","pages":"e4"},"PeriodicalIF":0.0,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13107076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioactive ceramic-processed water modulates the gut microbiota and hepatic AMPK activation in SMP30 knockout mice. 生物活性陶瓷处理水调节SMP30基因敲除小鼠的肠道微生物群和肝脏AMPK激活。

Gut microbiome (Cambridge, England) Pub Date : 2026-01-22 eCollection Date: 2026-01-01 DOI: 10.1017/gmb.2026.10018

Dong-Hun Kim, Soo-Nyun Choi, Kyongman An, Ji-Hoon Kwak, Kyung-Seok Ko, Kyu-Shik Jeong

{"title":"Bioactive ceramic-processed water modulates the gut microbiota and hepatic AMPK activation in SMP30 knockout mice.","authors":"Dong-Hun Kim, Soo-Nyun Choi, Kyongman An, Ji-Hoon Kwak, Kyung-Seok Ko, Kyu-Shik Jeong","doi":"10.1017/gmb.2026.10018","DOIUrl":"10.1017/gmb.2026.10018","url":null,"abstract":"Effective strategies are needed to increase the healthy lifespan and prevent age-related diseases in aging populations. Using senescence marker protein 30 knockout (SMP30 KO) mice-models that mimic human vitamin C (vitC) deficiency and exhibit accelerated aging-we investigated the effects of bioactive ceramic processed water (BCP) compared to natural mineral water (MW) and MW supplemented with vitamin C (MW-vitC) on gut microbial communities and hepatic metabolism. Due to pooled fecal sampling (n=1 composite library per group), microbiome results represent descriptive trends in diversity and composition. BCP was associated with discernible shifts in gut microbiota, including increased abundances of beneficial genera, such as Akkermansia, Lactobacillus, and Allobaculum, and the Muribaculaceae family. PICRUSt2 functional analysis suggested an enrichment in secondary metabolite biosynthesis, vitamin (e.g., retinol) metabolism, and xenobiotic biodegradation pathways. Furthermore, BCP was associated with significantly higher levels of activated hepatic AMP-activated protein kinase (AMPK), a key energy metabolism regulator, compared to control groups. Although microbiome findings are descriptive due to the study design, these results suggest BCP as a potential dietary intervention to help mitigate age-related metabolic decline and promote healthy ageing.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":"7 ","pages":"e3"},"PeriodicalIF":0.0,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12892148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146183795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alterations in gut microbial metabolic pathways following bariatric surgery assessed by 16S rRNA gene sequencing. 通过16S rRNA基因测序评估减肥手术后肠道微生物代谢途径的改变

Gut microbiome (Cambridge, England) Pub Date : 2026-01-19 eCollection Date: 2026-01-01 DOI: 10.1017/gmb.2026.10017

Nisreen Rashad Tashkandy

{"title":"Alterations in gut microbial metabolic pathways following bariatric surgery assessed by 16S rRNA gene sequencing.","authors":"Nisreen Rashad Tashkandy","doi":"10.1017/gmb.2026.10017","DOIUrl":"10.1017/gmb.2026.10017","url":null,"abstract":"Researchers have studied gut microbiota changes following bariatric surgery (BS), but not gut diversity and function in patients who fail to reduce weight. Stool samples were collected from three groups of women: 15 women who did not lose weight after BS (\"Yes\" group), 9 overweight women without surgery, and 8 slim women (\"No\" group). 16S ribosomal RNA gene sequencing and PICRUSt2 were used for the analysis. The surgery and control groups had equal alpha and beta diversity, perhaps due to the high proportion of overweight participants (n = 24). All groupings were dominated by Bacteroidota and Bacillota. Barnesiellaceae decreased with BS, although Streptococcaceae remained frequent in overweight people. The iron supplementation group had High abundance of Atopobiaceae and Prevotellaceae. Barnesiellaceae abundance was considerably lower in both surgical groups (with and without iron supplementation) than in the no-iron and no-surgery groups. The ornithine degradation and haem biosynthesis routes use different metabolites than the glycine super system. Finally, the \"Yes\" group significantly upregulated PWY0-1241, PWY-5177, and PWY-5855 signaling pathways. In conclusion, gut bacteria and metabolic functions may predict weight loss after surgery better than diversity markers. The requirement for orthogonal validation assays is suggested by pathway analysis outperforming diversity metrics.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":"7 ","pages":"e2"},"PeriodicalIF":0.0,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12877912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of omega-3 polyunsaturated fatty acids on short-chain fatty acid production and the gut microbiome in an in vitro colonic fermentation model. 在体外结肠发酵模型中，omega-3多不饱和脂肪酸对短链脂肪酸生成和肠道微生物组的影响。

Gut microbiome (Cambridge, England) Pub Date : 2026-01-06 eCollection Date: 2026-01-01 DOI: 10.1017/gmb.2025.10016

Joanna Aldoori, Suparna Mitra, Alexander Davie, Giles J Toogood, Christine Edwards, Mark A Hull

{"title":"The effect of omega-3 polyunsaturated fatty acids on short-chain fatty acid production and the gut microbiome in an in vitro colonic fermentation model.","authors":"Joanna Aldoori, Suparna Mitra, Alexander Davie, Giles J Toogood, Christine Edwards, Mark A Hull","doi":"10.1017/gmb.2025.10016","DOIUrl":"https://doi.org/10.1017/gmb.2025.10016","url":null,"abstract":"Oral administration of omega-3 polyunsaturated fatty acids (PUFAs) to rodents and humans is associated with an increase in gut bacteria that are predicted to synthesise short-chain fatty acids (SCFAs). We tested the hypothesis that physiological levels of omega-3 PUFAs in the distal intestinal lumen (1-50 μg/mL) are associated with increased SCFA synthesis in an in vitro fermentation model using faecal slurry from 10 healthy participants (mean age 30 years), with and without exogenous dietary fibres. SCFAs were measured by gas chromatography-flame ionisation detection (n = 10), and changes in bacterial composition were analysed by shotgun metagenomic sequencing (n = 6). In the presence of omega-3 PUFAs, there was a mean 9.3% (no inulin; P = 0.03) and 19.3% (+ 0.01 mg/mL inulin; P = 0.01) increase in total SCFA concentration at 24 h compared with paired control fermentations. Omega-3 PUFAs had a limited effect on the fermentation model microbiome in the absence of inulin. However, omega-3 PUFAs (50 μg/mL) were associated with increased abundance of Bifidobacteriaceae compared with paired control fermentations, if inulin (0.01 mg/mL) was present. Prebiotic activity of omega-3 PUFAs drives SCFA synthesis in an in vitro colonic fermentation model and is augmented by the soluble fibre inulin.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":"7 ","pages":"e1"},"PeriodicalIF":0.0,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12835959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146094445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The therapeutic effects of Lacticaseibacillus rhamnosus on stress-induced anxiety: a systematic review of evidence from animal studies. 鼠李糖乳杆菌对应激性焦虑的治疗作用：动物研究证据的系统回顾。

Gut microbiome (Cambridge, England) Pub Date : 2025-12-17 eCollection Date: 2025-01-01 DOI: 10.1017/gmb.2025.10015

Iman Imtiyaz Ahmed Juvale, Alina Arulsamy

{"title":"The therapeutic effects of Lacticaseibacillus rhamnosus on stress-induced anxiety: a systematic review of evidence from animal studies.","authors":"Iman Imtiyaz Ahmed Juvale, Alina Arulsamy","doi":"10.1017/gmb.2025.10015","DOIUrl":"10.1017/gmb.2025.10015","url":null,"abstract":"Lacticaseibacillus rhamnosus may modulate stress-induced anxiety, yet animal evidence has not been systematically evaluated. Following PRISMA guidelines, PubMed, Embase, and Scopus were searched (2011-2024) for animal studies evaluating the role of L. rhamnosus in stress-induced anxiety. Primary outcomes were behavioural anxiety measures; secondary outcomes included neuroendocrine, immune, epithelial, and microbiota changes. Fifteen studies met the inclusion criteria. Species included mice (n=7), rats (n=5), and hens (n=3). Stress models comprised chronic unpredictable mild stress (n=8), social defeat (n=2), maternal separation (n=1), restraint stress (n=1), and severe feather-pecking (n=3). Common strains were JB-1 (n=8), HN001 (n=2), LGG (n=2), LR-32 (n=1), 4B15 (n=1), and LR3201 (n=1). Of the 15 studies, 12 reported significant anxiolytic effects, most frequently in the elevated plus maze (7/10) and open-field test (6/9). JB-1 showed the most consistent behavioural improvement (7/8 studies). Mechanistic findings were reported in subsets of studies: HPA axis modulation in 4/15, monoamine changes in 4/15, GABAergic effects in 4/15, immune/anti-inflammatory changes in 4/15, tight junction restoration in 2/15, and gut microbiota or SCFA-related changes in 7/15. L. rhamnosus, particularly strain JB-1, shows consistent anxiolytic effects and multiple putative mechanistic pathways, though more rigorous and standardised preclinical designs are needed.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":"6 ","pages":"e20"},"PeriodicalIF":0.0,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12766537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145914095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overcoming barriers to gut microbiome development through nutritional factors in the first 1,000 days of life: strategies and implications for preventing non-communicable diseases. 生命最初1 000天内通过营养因素克服肠道微生物群发育障碍：预防非传染性疾病的战略和影响。

Gut microbiome (Cambridge, England) Pub Date : 2025-09-10 eCollection Date: 2025-01-01 DOI: 10.1017/gmb.2025.10014

Zoe Teh, Cristina Garcia-Maurino Alcazar, Komal Bhatia

{"title":"Overcoming barriers to gut microbiome development through nutritional factors in the first 1,000 days of life: strategies and implications for preventing non-communicable diseases.","authors":"Zoe Teh, Cristina Garcia-Maurino Alcazar, Komal Bhatia","doi":"10.1017/gmb.2025.10014","DOIUrl":"10.1017/gmb.2025.10014","url":null,"abstract":"Current efforts to reduce the incidence of non-communicable disease (NCD) are slow, but increasing evidence highlights the microbiome as a potential target for prevention. The majority of microbial development occurs in the first 1,000 days of life, presenting opportunities for strategic intervention to reduce the prevalence of future NCDs. In this review, we explore the social, structural, and political barriers that may hinder physiological gut microbial development in the first 1,000 days in the context of current scientific knowledge, focusing on nutritional factors in pregnancy, and during the exclusive breastfeeding and complementary feeding periods. We summarise emerging evidence and explore obstacles to nutritional choices affecting microbial development, and unpack the rhetoric that healthy eating to develop a microbiome that supports optimum health is an individual choice. As evidence on the role of the microbiome in health and disease grows, specific attention must be applied to existing social, structural, and political barriers that may hinder optimal microbial development. Addressing the role of corporate actors and social determinants influencing dietary choices and barriers surrounding breastfeeding must be prioritised, alongside efforts to advance basic scientific research. Until a wider public health perspective is taken, the success of interventions and recommendations will be limited.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":"6 ","pages":"e18"},"PeriodicalIF":0.0,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12509159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum: The effects of inorganic nitrate and inulin co-ingestion on circulating metabolites and blood pressure in young adults: a pilot double-blind randomised crossover trial - CORRIGENDUM. 勘误：无机硝酸盐和菊粉共同摄入对年轻人循环代谢物和血压的影响：一项先导双盲随机交叉试验-勘误。

Gut microbiome (Cambridge, England) Pub Date : 2025-09-08 eCollection Date: 2025-01-01 DOI: 10.1017/gmb.2025.10010

Jessica Virgili, Gwenaelle Le Gall, Anni Vanhatalo, Bert Bond, David Vauzour, Luciana Torquati

引用次数: 0

Intestinal microbiome changes in response to amino acid and micronutrient supplementation: secondary analysis of the AMAZE trial. 肠道微生物组对氨基酸和微量营养素补充的反应变化：AMAZE试验的二次分析。

Gut microbiome (Cambridge, England) Pub Date : 2025-09-08 eCollection Date: 2025-01-01 DOI: 10.1017/gmb.2025.10011

Monica N Mweetwa, Kazi Ahsan, John Louis-Auguste, Ellen Besa, Joram M Posma, Nathan McNulty, Micheal J Barrat, Jeff Gordon, Paul Kelly

{"title":"Intestinal microbiome changes in response to amino acid and micronutrient supplementation: secondary analysis of the AMAZE trial.","authors":"Monica N Mweetwa, Kazi Ahsan, John Louis-Auguste, Ellen Besa, Joram M Posma, Nathan McNulty, Micheal J Barrat, Jeff Gordon, Paul Kelly","doi":"10.1017/gmb.2025.10011","DOIUrl":"10.1017/gmb.2025.10011","url":null,"abstract":"Microbial dysbiosis has been linked to environmental enteropathy (EE) and alterations in nutrient absorption; however, compositional modifications following exposure to supplementary nutrients are poorly understood. Here, we report the effect of amino acid and micronutrient supplementation on the gut microbiome of adults with EE. In the AMAZE trial, adults with EE were randomized to amino acids (AA) and/or micronutrients (MM) for 16 weeks in a 2 × 2 factorial design against placebo. Endoscopy was performed before and after intervention, during which duodenal aspirates were collected as well as fecal samples. 16S rRNA amplicon sequencing was performed on both these samples, and differences in bacterial community composition before and after interventions were investigated using differential abundance analysis, corrected using false discovery rate, plus alpha and beta diversity measurements. HIV seropositive participants exhibited lower alpha and beta diversity at baseline. AA and/or MM supplementation did not show significant changes in abundance or diversity of genera post-intervention compared to placebo. Micronutrient supplementation resulted in an increase in the pyruvate fermentation to acetone MetaCyc pathways compared to the placebo arm. This study provides insights into the responsiveness of the gut microbiome to micronutrient and amino acid supplementation in adults with EE.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":"6 ","pages":"e16"},"PeriodicalIF":0.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12509164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145282018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of non-nutritive sweeteners on bacterial quorum sensing and phenotypic expression: implications for gut microbiome dynamics. 非营养性甜味剂对细菌群体感应和表型表达的影响：对肠道微生物组动力学的影响。

Gut microbiome (Cambridge, England) Pub Date : 2025-09-03 eCollection Date: 2025-01-01 DOI: 10.1017/gmb.2025.10006

Mindani Watawana, Emilia Maria Franca Lima, Beatriz Ximena Valencia Quecan, Max Sherry, Daniel Granato, Achim Schmalenberger, Christian Hoffmann, Uelinton M Pinto, Fabiana Andrea Hoffmann Sarda

{"title":"Impact of non-nutritive sweeteners on bacterial quorum sensing and phenotypic expression: implications for gut microbiome dynamics.","authors":"Mindani Watawana, Emilia Maria Franca Lima, Beatriz Ximena Valencia Quecan, Max Sherry, Daniel Granato, Achim Schmalenberger, Christian Hoffmann, Uelinton M Pinto, Fabiana Andrea Hoffmann Sarda","doi":"10.1017/gmb.2025.10006","DOIUrl":"10.1017/gmb.2025.10006","url":null,"abstract":"Non-nutritive sweeteners (NNSs) are popular sugar substitutes, valued for their potential to reduce caloric intake and associated health risks. However, their long-term effects on the human gut microbiome remain debatable. This study investigates the impact of tagatose, allulose, Rebaudioside-A (Reb-A), and saccharin on quorum-sensing (QS)-regulated phenotypes and gene expression in QS biosensor model bacteria. It sheds light on their potential influence on the gut microbiome. Our study revealed diverse effects among the NNSs. Tagatose and allulose demonstrated QS phenotypic inhibition in Chromobacterium violaceum (≈50%) and Pseudomonas aeruginosa (20-50%) in a concentration-dependent manner. Additionally, tagatose and allulose decreased the P. aeruginosa lasI gene expression. Reb-A and saccharin presented a significant, however less prominent, phenotypic inhibition on C. violaceum (25-30%) and P. aeruginosa swarming motility (≈20%). Both NNSs decreased the expression of the lasI gene of P. aeruginosa. Molecular docking of QS regulatory proteins showed that saccharin and Reb-A have significantly higher binding affinity compared to allulose and tagatose, relative to native inducers. These results suggest the complex interactions mediated by NNSs in QS regulatory pathways. These findings provide valuable insights into the varied, species and dose-dependent effects of NNS on microbial communication, suggesting potential implications for the gut microbiome.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":"6 ","pages":"e19"},"PeriodicalIF":0.0,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12571687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The gut microbiome and child and adolescent depression and anxiety: a systematic review and meta-analysis with youth consultation. 肠道微生物组与儿童和青少年抑郁和焦虑：与青少年咨询的系统回顾和荟萃分析。

Gut microbiome (Cambridge, England) Pub Date : 2025-09-01 eCollection Date: 2025-01-01 DOI: 10.1017/gmb.2025.10013

Susan C Campisi, Flora Zhang, Minjoo Seo, Jessica Muha, Anett Schumacher, Isabella De Luca, Glyneva Bradley-Ridout, Kaitlyn Merriman, John Parkinson, Daphne J Korczak

{"title":"The gut microbiome and child and adolescent depression and anxiety: a systematic review and meta-analysis with youth consultation.","authors":"Susan C Campisi, Flora Zhang, Minjoo Seo, Jessica Muha, Anett Schumacher, Isabella De Luca, Glyneva Bradley-Ridout, Kaitlyn Merriman, John Parkinson, Daphne J Korczak","doi":"10.1017/gmb.2025.10013","DOIUrl":"10.1017/gmb.2025.10013","url":null,"abstract":"Decreased gut microbial diversity is associated with greater depression symptoms in adults. Findings on the relationship between the gut microbiome and depression or anxiety in children and adolescents are mixed, and evidence syntheses are needed. Seven databases were searched for peer-reviewed studies on the gut microbiome and internalizing symptoms, depression, or anxiety, in children and adolescents (<19 years). Random-effects meta-analyses of alpha diversity indices were performed. Youth advisors validated the research findings' relevance to their experiences and contributed to dissemination planning. Eight studies were included, representing 2,865 participants (mean age = 11.4 years, SD = 4.3). Study designs were cross-sectional (n = 5), longitudinal (n = 2), and interventional (n = 1). No association was found between alpha or beta diversity and internalizing problems, depression, or anxiety. Increased abundance of genera within phyla Bacillota (e.g., Fusicatenibacter) and Pseudomonadota (e.g., Escherichia), along with decreased abundance of other Bacillota genera (e.g., Faecalibacterium), were associated with depression and anxiety symptoms. This review identified preliminary associations between specific bacterial taxa and depression and anxiety in children and adolescents. Larger studies using comprehensive analytical approaches are needed to explore the role of the gut microbiome in the genesis and treatment of internalizing disorders.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":"6 ","pages":"e17"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12509154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0