肠道微生物群-神经免疫串扰和神经性疼痛:范围综述

Gut microbiome (Cambridge, England) Pub Date : 2023-06-19 eCollection Date: 2023-01-01 DOI:10.1017/gmb.2023.7
Gayani Nawarathna, Kausar S Fakhruddin, Ali I S A Shorbagi, Lakshman P Samaranayake
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引用次数: 0

摘要

摘要环境压力源会破坏肠脑关系并改变肠道微生物组成,可能导致慢性疼痛,包括神经性疼痛(NP)。为了理解这种复杂的关系,我们进行了一项系统的范围界定审查,以检查肠道微生物神经免疫与NP的联系以及潜在的治疗靶点。该综述包括2000年1月至2022年4月期间MEDLINE、Cochrane和DOAJ等数据库中的英文手稿。在审查的48篇全文中,只有15篇符合纳入标准。其中包括一项涉及327名个体的随机对照试验、一项体外试验和13项动物模型研究。研究结果表明,肠道菌群在与NP相关的免疫、神经和代谢信号通路中发挥作用。动物研究一直是这一领域的主要焦点,表明肠道微生物组失衡以及随后生物化学和神经免疫通路的激活可能会影响NP的发展。这篇综述对肠道微生物组免疫NP轴进行了全面总结,并确定了潜在的治疗靶点。然而,由于大多数证据来自动物研究,未来的研究应包括临床试验,以更好地了解肠道微生物群在NP中的作用,并发现新的治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The gut microbiota-neuroimmune crosstalk and neuropathic pain: a scoping review.

Environmental stressors can disrupt the gut-brain relationship and alter the gut microbial composition, potentially leading to chronic pain, including neuropathic pain (NP). To understand this complex relationship, we conducted a systematic scoping review to examine the gut microbial-neuroimmune connection to NP and the potential therapeutic targets. The review includes English-language manuscripts in databases such as MEDLINE, Cochrane, and DOAJ between January 2000 and April 2022. Out of the 48 full texts examined, only 15 articles met the inclusion criteria. These included a randomised controlled trial involving 327 individuals, an in vitro, and 13 animal model studies. The findings suggest that the gut flora plays a role in the immunological, neurological, and metabolic signalling pathways associated with NP. Animal studies have been the primary focus in this area, indicating that an imbalanced-gut microbiome and subsequent activation of biochemical and neuro-immunologic pathways may influence the development of NP. This review provides a comprehensive summary of the gut microbiome-immune-NP axis and identifies potential therapeutic targets. However, since most of the evidence comes from animal studies, future research should include clinical trials to gain a better understanding of the role of gut microbiota in NP and discover new therapeutic strategies.

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