Gut microbiome (Cambridge, England)最新文献_第5页

Dietary habits and the gut microbiota in military Veterans: results from the United States-Veteran Microbiome Project (US-VMP). 退伍军人的饮食习惯和肠道微生物群:来自美国退伍军人微生物组计划(US-VMP)的结果

Gut microbiome (Cambridge, England) Pub Date : 2021-04-28 eCollection Date: 2021-01-01 DOI: 10.1017/gmb.2021.1

Diana P Brostow, Christopher E Stamper, Maggie A Stanislawski, Kelly A Stearns-Yoder, Alexandra Schneider, Teodor T Postolache, Jeri E Forster, Andrew J Hoisington, Christopher A Lowry, Lisa A Brenner

{"title":"Dietary habits and the gut microbiota in military Veterans: results from the United States-Veteran Microbiome Project (US-VMP).","authors":"Diana P Brostow, Christopher E Stamper, Maggie A Stanislawski, Kelly A Stearns-Yoder, Alexandra Schneider, Teodor T Postolache, Jeri E Forster, Andrew J Hoisington, Christopher A Lowry, Lisa A Brenner","doi":"10.1017/gmb.2021.1","DOIUrl":"10.1017/gmb.2021.1","url":null,"abstract":"Dietary patterns influence gut microbiota composition. To date, there has not been an assessment of diet and gut microbiota in Veterans, who have a history of unique environmental exposures, including military deployment, that may influence associations between diet and gut microbiota. Our aim was to characterise Veteran habitual dietary intake and quality, and to evaluate correlations between diet and gut microbiota. We administered Food Frequency Questionnaires (FFQs) and collected stool samples from 330 Veterans. FFQ data were used to generate Healthy Eating Indices (HEI) of dietary quality. Exploratory factor analysis was used to identify two dietary patterns we defined as \"Western\" and \"Prudent.\" Stool samples underwent 16S rRNA gene sequencing, and the resulting data were used to evaluate associations with dietary variables/indices. Analyses included linear regression of α-diversity, constrained analysis of principal coordinates of β-diversity, and multivariate association with linear models and Analysis of Composition of Microbiomes analyses of dietary factors and phylum- and genus-level taxa. There were no significant associations between dietary patterns or factors and α- or β-diversity. At the phylum level, increasing HEI scores were inversely associated with relative abundance of Actinobacteria, and added sugar was inversely associated with abundance of Verrucomicrobia. Veterans largely consumed a Western-style diet, characterised by poor adherence to nutritional guidelines.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":" ","pages":"e1"},"PeriodicalIF":0.0,"publicationDate":"2021-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11406408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45869631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Lumen and mucosa-associated Lactobacillus rhamnosus from the intestinal tract of organ donors. 内脏和粘膜相关的鼠李糖乳杆菌来自器官供体肠道

Gut microbiome (Cambridge, England) Pub Date : 2020-11-10 eCollection Date: 2020-01-01 DOI: 10.1017/gmb.2020.4

Alan J Marsh, Al-Mounawara A Yaya, Sandy Ng, Kshipra Chandrashekhar, Jeff Roach, Scott T Magness, M Andrea Azcarate-Peril

{"title":"Lumen and mucosa-associated Lactobacillus rhamnosus from the intestinal tract of organ donors.","authors":"Alan J Marsh, Al-Mounawara A Yaya, Sandy Ng, Kshipra Chandrashekhar, Jeff Roach, Scott T Magness, M Andrea Azcarate-Peril","doi":"10.1017/gmb.2020.4","DOIUrl":"10.1017/gmb.2020.4","url":null,"abstract":"Knowledge of the intra-individual spatial and regional distribution of intestinal microbial populations is essential to understand gut host-microbial interactions. In this study, we performed a compositional analysis of luminal and mucosal samples from the small and large intestine of four organ donors by 16S rRNA amplicon sequencing and high-throughput quantitative polymerase chain reaction. Since the human microbiota is subject to selection pressure at lower taxonomic levels, we isolated over 400 bacterial strains and investigated strain-level variation of 11 Lactobacillus rhamnosus from different intestinal regions. Results substantiate reported inter-individual variability as well as intra-individual differences along the gastrointestinal tract. Although the luminal and mucosal-associated communities were similar within individuals, relative abundance reflected the donors' demographic and potential pathologies. The total bacterial load of all donors increased from small intestine to colon, while Bifidobacterium was in greater abundance in the small intestine. Comparative genomic analysis of L. rhamnosus showed the strains segregated into two distinct clusters and identified no features specific to location. Analysis revealed genetic differences for exopolysaccharide production, carbohydrate utilization, pilus formation and vitamin K biosynthesis between clusters. This study contributes to the understanding of niche-specific microbial communities, encouraging subsequent studies to better understand microbial signatures at lower taxonomic levels.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":" ","pages":"e4"},"PeriodicalIF":0.0,"publicationDate":"2020-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11406413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45575209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Editorial. 编辑

Gut microbiome (Cambridge, England) Pub Date : 2020-08-28 eCollection Date: 2020-01-01 DOI: 10.1017/gmb.2020.1

Kristin Verbeke

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You have the microbiome you deserve. 你有你应得的微生物群

Gut microbiome (Cambridge, England) Pub Date : 2020-08-27 eCollection Date: 2020-01-01 DOI: 10.1017/gmb.2020.3

Colin Hill

{"title":"You have the microbiome you deserve.","authors":"Colin Hill","doi":"10.1017/gmb.2020.3","DOIUrl":"10.1017/gmb.2020.3","url":null,"abstract":"The human microbiome is one of the most exciting areas of microbiology. From a starting point of tens of papers annually a couple of decades ago, there are now thousands of papers published every year on the microbiome. Huge strides have been made in terms of defining the individual members of complex human microbiomes from different body sites. The individuality and diversity of the human microbiome almost surpasses our ability to comprehend it. Advances in metagenomics and computational sciences have increased the complexity of the field, while at the same time we have moved from regarding the human microbiome as a benign passenger to a situation where it has been linked to almost every chronic disease, including obesity, cancer and infectious disease. The microbiome tantalizes us with the promise of novel therapeutic molecules and modalities for a range of intractable diseases. And yet, very few microbiome-based therapies have made it to the clinic or the pharmacy and we still cannot really define a healthy microbiome. We are entering the most exciting phase of microbiome research, as we develop effective, evidence-based interventions to preserve and restore human health. But we need rigour and numeracy if we are to realize this vision.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":"1 1","pages":"e3"},"PeriodicalIF":0.0,"publicationDate":"2020-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11406403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42707917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The role of probiotics on the roadmap to a healthy microbiota: a symposium report. 益生菌在健康微生物群路线图中的作用：一份研讨会报告

Gut microbiome (Cambridge, England) Pub Date : 2020-08-26 eCollection Date: 2020-01-01 DOI: 10.1017/gmb.2020.2

Stacey Lockyer, Marisol Aguirre, Louise Durrant, Bruno Pot, Kaori Suzuki

{"title":"The role of probiotics on the roadmap to a healthy microbiota: a symposium report.","authors":"Stacey Lockyer, Marisol Aguirre, Louise Durrant, Bruno Pot, Kaori Suzuki","doi":"10.1017/gmb.2020.2","DOIUrl":"10.1017/gmb.2020.2","url":null,"abstract":"The ninth International Yakult Symposium was held in Ghent, Belgium in April 2018. Keynote lectures were from Professor Wijmenga on using biobanks to understand the relationship between the gut microbiota and health; and Professor Hill on phage-probiotic interactions. Session one included talks from Professor Plӧsch on epigenetic programming by nutritional and environmental factors; Professor Wilmes on the use of \"omics\" methodologies in microbiome research and Professor Rescigno on the gut vascular barrier. Session two explored the evidence behind Lactobacillus casei Shirota with Dr Nanno explaining the plasticity in immunomodulation that enables the strain to balance immune functions; Dr Macnaughtan outlining its potential therapeutic use in cirrhosis and Professor Nishida detailing effects in subjects under stress. The third session saw Professor Marchesi describing that both the host genes and the gut microbiota can play a role in cancer; Professor Bergheim highlighting crosstalk between the gut and the liver and Professor Cani describing the relationship between the gut microbiota and the endocrine system. The final session explored probiotic mechanisms, with Professor Lebeer dissecting the challenges in conducting mechanistic studies; Professor Wehkamp describing the mucosal defence system and Professor Van de Wiele detailing methods for modelling the gut microbiota in vitro.","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":" ","pages":"e2"},"PeriodicalIF":0.0,"publicationDate":"2020-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11406418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47700431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0