Jessica A Davis, Fiona Collier, Mohammadreza Mohebbi, Julie A Pasco, Nitin Shivappa, James R Hébert, Felice N Jacka, Amy Loughman
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There was no evidence of associations between alpha or beta diversity and muscle health measures. A healthier ARFS score was positively associated with the relative abundance of butyrate-producing bacteria (<i>β</i> 0.09, 95%CI 0.03, 0.15) and a higher (pro-inflammatory) DII score was associated with lower relative abundance of butyrate-producing bacteria (<i>β</i> -0.60, 95%CI -1.06, -0.15). The relative abundance of butyrate-producing bacteria was positively associated with healthier muscle mass, strength and function; however, these relationships were attenuated in multivariable models. These findings support the role of diet quality in achieving a healthier gut microbiome, however, further evidence is required for a gut-muscle axis in humans.</p>","PeriodicalId":73187,"journal":{"name":"Gut microbiome (Cambridge, England)","volume":" ","pages":"e2"},"PeriodicalIF":0.0000,"publicationDate":"2021-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11406371/pdf/","citationCount":"0","resultStr":"{\"title\":\"The associations of butyrate-producing bacteria of the gut microbiome with diet quality and muscle health.\",\"authors\":\"Jessica A Davis, Fiona Collier, Mohammadreza Mohebbi, Julie A Pasco, Nitin Shivappa, James R Hébert, Felice N Jacka, Amy Loughman\",\"doi\":\"10.1017/gmb.2021.2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>This study aimed to investigate the relationships between diet quality, the relative abundance of butyrate-producing bacteria of the gut microbiome and muscle mass, strength and function. 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The relative abundance of butyrate-producing bacteria was positively associated with healthier muscle mass, strength and function; however, these relationships were attenuated in multivariable models. These findings support the role of diet quality in achieving a healthier gut microbiome, however, further evidence is required for a gut-muscle axis in humans.</p>\",\"PeriodicalId\":73187,\"journal\":{\"name\":\"Gut microbiome (Cambridge, England)\",\"volume\":\" \",\"pages\":\"e2\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-08-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11406371/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Gut microbiome (Cambridge, England)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1017/gmb.2021.2\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2021/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gut microbiome (Cambridge, England)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1017/gmb.2021.2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
摘要本研究旨在研究饮食质量、肠道微生物组中丁酸产生菌的相对丰度与肌肉质量、力量和功能之间的关系。在这项横断面研究中,来自吉隆骨质疏松症研究的n=490名男性(64.4±13.5岁)提供了食物频率问卷数据,根据这些数据计算了澳大利亚推荐食物评分(ARFS)和饮食炎症指数(DII)评分。测量肌肉质量(DXA衍生的瘦质量的骨骼肌指数)、肌肉力量(握力)和肌肉功能(Timed Up and Go测试)。参与者提供粪便样本进行16S rRNA基因测序。没有证据表明α或β多样性与肌肉健康指标之间存在关联。更健康的ARFS评分与产丁酸细菌的相对丰度呈正相关(β0.09,95%CI 0.03,0.15),更高的(促炎性)DII评分与较低的产丁酸细菌相对丰度(β-0.60,95%CI−1.06,−0.15)呈正相关。产丁酸菌的相对丰度与更健康的肌肉质量呈正相关,强度和功能;然而,这些关系在多变量模型中被削弱了。这些发现支持了饮食质量在实现更健康的肠道微生物组中的作用,然而,还需要进一步的证据来证明人类的肠道肌肉轴。
The associations of butyrate-producing bacteria of the gut microbiome with diet quality and muscle health.
This study aimed to investigate the relationships between diet quality, the relative abundance of butyrate-producing bacteria of the gut microbiome and muscle mass, strength and function. In this cross-sectional study, n = 490 men (64.4 ± 13.5 years) from the Geelong Osteoporosis Study provided food frequency questionnaire data, from which the Australian Recommended Food Score (ARFS) and Dietary Inflammatory Index (DII) score were calculated. Muscle mass (skeletal muscle index from DXA-derived lean mass), muscle strength (handgrip strength) and muscle function (Timed Up-and-Go test) were measured. Participants provided stool samples for 16S rRNA gene sequencing. There was no evidence of associations between alpha or beta diversity and muscle health measures. A healthier ARFS score was positively associated with the relative abundance of butyrate-producing bacteria (β 0.09, 95%CI 0.03, 0.15) and a higher (pro-inflammatory) DII score was associated with lower relative abundance of butyrate-producing bacteria (β -0.60, 95%CI -1.06, -0.15). The relative abundance of butyrate-producing bacteria was positively associated with healthier muscle mass, strength and function; however, these relationships were attenuated in multivariable models. These findings support the role of diet quality in achieving a healthier gut microbiome, however, further evidence is required for a gut-muscle axis in humans.