Frontiers in neuroimaging最新文献

{"title":"Inferring neurocognition using artificial intelligence on brain MRIs.","authors":"Mohammad Arafat Hussain, Patricia Ellen Grant, Yangming Ou","doi":"10.3389/fnimg.2024.1455436","DOIUrl":"10.3389/fnimg.2024.1455436","url":null,"abstract":"<p><p>Brain magnetic resonance imaging (MRI) offers a unique lens to study neuroanatomic support of human neurocognition. A core mystery is the MRI explanation of individual differences in neurocognition and its manifestation in intelligence. The past four decades have seen great advancement in studying this century-long mystery, but the sample size and population-level studies limit the explanation at the individual level. The recent rise of big data and artificial intelligence offers novel opportunities. Yet, data sources, harmonization, study design, and interpretation must be carefully considered. This review aims to summarize past work, discuss rising opportunities and challenges, and facilitate further investigations on artificial intelligence inferring human neurocognition.</p>","PeriodicalId":73094,"journal":{"name":"Frontiers in neuroimaging","volume":"3 ","pages":"1455436"},"PeriodicalIF":0.0,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11631947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adolescent brain maturation associated with environmental factors: a multivariate analysis.","authors":"Bhaskar Ray, Dawn Jensen, Pranav Suresh, Bishal Thapaliya, Ram Sapkota, Britny Farahdel, Zening Fu, Jiayu Chen, Vince D Calhoun, Jingyu Liu","doi":"10.3389/fnimg.2024.1390409","DOIUrl":"10.3389/fnimg.2024.1390409","url":null,"abstract":"<p><p>Human adolescence marks a crucial phase of extensive brain development, highly susceptible to environmental influences. Employing brain age estimation to assess individual brain aging, we categorized individuals (<i>N</i> = 7,435, aged 9-10 years old) from the Adolescent Brain and Cognitive Development (ABCD) cohort into groups exhibiting either accelerated or delayed brain maturation, where the accelerated group also displayed increased cognitive performance compared to their delayed counterparts. A 4-way multi-set canonical correlation analysis integrating three modalities of brain metrics (gray matter density, brain morphological measures, and functional network connectivity) with nine environmental factors unveiled a significant 4-way canonical correlation between linked patterns of neural features, air pollution, area crime, and population density. Correlations among the three brain modalities were notably strong (ranging from 0.65 to 0.77), linking reduced gray matter density in the middle temporal gyrus and precuneus to decreased volumes in the left medial orbitofrontal cortex paired with increased cortical thickness in the right supramarginal and bilateral occipital regions, as well as increased functional connectivity in occipital sub-regions. These specific brain characteristics were significantly more pronounced in the accelerated brain aging group compared to the delayed group. Additionally, these brain regions exhibited significant associations with air pollution, area crime, and population density, where lower air pollution and higher area crime and population density were correlated to brain variations more prominently in the accelerated brain aging group.</p>","PeriodicalId":73094,"journal":{"name":"Frontiers in neuroimaging","volume":"3 ","pages":"1390409"},"PeriodicalIF":0.0,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11613425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain-based correlates of depression and traumatic brain injury: a systematic review of structural and functional magnetic resonance imaging studies.","authors":"Vanessa A Baltazar, Ilya Demchenko, Vanessa K Tassone, Rachel L Sousa-Ho, Tom A Schweizer, Venkat Bhat","doi":"10.3389/fnimg.2024.1465612","DOIUrl":"10.3389/fnimg.2024.1465612","url":null,"abstract":"<p><strong>Introduction: </strong>Depression is prevalent after traumatic brain injury (TBI). However, there is a lack of understanding of the brain-based correlates of depression post-TBI. This systematic review aimed to synthesize findings of structural and functional magnetic resonance imaging (MRI) studies to identify consistently reported neural correlates of depression post-TBI.</p><p><strong>Methods: </strong>A search for relevant published studies was conducted through OVID (MEDLINE, APA PsycINFO, and Embase), with an end date of August 3rd, 2023. Fourteen published studies were included in this review.</p><p><strong>Results: </strong>TBI patients with depression exhibited distinct changes in diffusion- based white matter fractional anisotropy, with the direction of change depending on the acuteness or chronicity of TBI. Decreased functional connectivity (FC) of the salience and default mode networks was prominent alongside the decreased volume of gray matter within the insular, dorsomedial prefrontal, and ventromedial prefrontal cortices. Seven studies reported the correlation between observed neuroimaging and depression outcomes. Of these studies, 42% indicated that FC of the bilateral medial temporal lobe subregions was correlated with depression outcomes in TBI.</p><p><strong>Discussion: </strong>This systematic review summarizes existing neuroimaging evidence and reports brain regions that can be leveraged as potential treatment targets in future studies examining depression post-TBI.</p>","PeriodicalId":73094,"journal":{"name":"Frontiers in neuroimaging","volume":"3 ","pages":"1465612"},"PeriodicalIF":0.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11573519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<ArticleTitle xmlns:ns0=\"http://www.w3.org/1998/Math/MathML\">Iron load in the normal aging brain measured with QSM and <ns0:math> <ns0:msubsup><ns0:mrow><ns0:mi>R</ns0:mi></ns0:mrow> <ns0:mrow><ns0:mn>2</ns0:mn></ns0:mrow> <ns0:mrow><ns0:mo>*</ns0:mo></ns0:mrow> </ns0:msubsup> </ns0:math> at 7T: findings of the SENIOR cohort.","authors":"Miguel Guevara, Stéphane Roche, Vincent Brochard, Davy Cam, Jacques Badagbon, Yann Leprince, Michel Bottlaender, Yann Cointepas, Jean-François Mangin, Ludovic de Rochefort, Alexandre Vignaud","doi":"10.3389/fnimg.2024.1359630","DOIUrl":"10.3389/fnimg.2024.1359630","url":null,"abstract":"<p><strong>Background: </strong>Iron accumulates in the brain during aging and is the focus of intensive research as an abnormal load, particularly in Deep Gray Matter (DGM), is related to neurodegeneration. Magnetic Resonance Imaging (MRI) metrics such as Quantitative Susceptibility Mapping (QSM) and apparent transverse relaxation rate <math> <msubsup><mrow><mi>R</mi></mrow> <mrow><mn>2</mn></mrow> <mrow><mo>*</mo></mrow> </msubsup> </math> can be used to follow up iron <i>in vivo</i>. While the influence of age and sex on iron levels has already been reported, a careful consideration of neuronal risk factors, as well as for an enhanced sensitivity, is needed to define the normal evolution.</p><p><strong>Methods: </strong>QSM and <math> <msubsup><mrow><mi>R</mi></mrow> <mrow><mn>2</mn></mrow> <mrow><mo>*</mo></mrow> </msubsup> </math> at ultra-high field MRI are used to study iron in DGM using a carefully-characterized cohort of the healthy aging brain (SENIOR). Seventy-seven cognitively healthy elders (from 54 to 78 y/o) with clinical, biology, genetics, and cardiovascular risk factors careful evaluation. Differences linked with age, sex, cardiovascular risk factors and weight are studied.</p><p><strong>Results: </strong>Age and sex have an influence on the brain iron deposition measured by QSM and <math> <msubsup><mrow><mi>R</mi></mrow> <mrow><mn>2</mn></mrow> <mrow><mo>*</mo></mrow> </msubsup> </math> in a context of normal aging, without appearance of a pathological neurodegenerative process. Iron deposition shows higher values in the caudate and the putamen in older participants. Female participants present a higher level of iron in the amygdala, and males in the thalamus. Female participants also present differences in the accumbens, caudate and hippocampus when evaluating the joint age and sex effect. Participants with higher cardiovascular risk factors showed higher values of the iron, even without any impairment in their cognitive capability. An overweight is related with a higher iron load in the putamen for QSM and <math> <msubsup><mrow><mi>R</mi></mrow> <mrow><mn>2</mn></mrow> <mrow><mo>*</mo></mrow> </msubsup> </math> in female participants. We controlled that these modifications of iron deposition are not related to a specific profile in the genotype of ApoE loci.</p><p><strong>Conclusions: </strong>Establishing baseline values of QSM and <math> <msubsup><mrow><mi>R</mi></mrow> <mrow><mn>2</mn></mrow> <mrow><mo>*</mo></mrow> </msubsup> </math> as iron probes in the context of aging is essential to determine differences in the process of neurodegeneration. Age and sex of participants are important factors that affect brain iron normal values. On the other hand, the presence of cardiovascular risk factors, which can be associated with age related diseases, can also potentially be linked with the iron deposition in the brain.</p>","PeriodicalId":73094,"journal":{"name":"Frontiers in neuroimaging","volume":"3 ","pages":"1359630"},"PeriodicalIF":0.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11533018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre- and post-therapy functional MRI connectivity in severe acute brain injury with suppression of consciousness: a comparative analysis to epilepsy features.","authors":"Emilio G Cediel, Erika A Duran, Jeffrey Laux, William Reuther, Olivia Leggio, Belfin Robinson, Varina L Boerwinkle","doi":"10.3389/fnimg.2024.1445952","DOIUrl":"https://doi.org/10.3389/fnimg.2024.1445952","url":null,"abstract":"<p><p>Severe acute brain injury (SABI) with suppressed consciousness is a major societal burden, with early prognosis being crucial for life-and-death treatment decisions. Resting-state functional MRI (rs-fMRI) is promising for prognosis and identifying epileptogenic activity in SABI. While established for SABI prognosis and seizure networks (SzNET) identification in epilepsy, the rs-fMRI use for SzNET detection in SABI is limited. This study compared evolution of SzNET and resting-state networks (RSN) pre-to-post treatment in SABI and epilepsy, hypothesizing that changes would align with clinical evolution. Therapies included epilepsy surgery for the epilepsy group and antiseizure medication for the SABI group. Independent component analysis (ICA) was used to identify SzNET and RSNs in all rs-fMRI. High-frequency BOLD (HF-BOLD), an ICA power spectrum-based index, quantified RSN and SzNET changes by the patient. Confidence intervals measured HF-BOLD changes pre-to-post-therapy. Baseline HF-BOLD and HF-BOLD changes were compared using linear-mixed models and interaction tests. Five SABI and ten epilepsy patients were included. SzNET were identified in all SABI's pre-therapy rs-fMRI. The clinical changes in SABI and epilepsy were consistent with rs-fMRI findings across groups. HF-BOLD reduced in the epilepsy group RSN post-therapy (-0.78, 95% CI -3.42 to -0.33), but the evidence was insufficient to determine an HF-BOLD reduction in SABI patients or SzNET. The HF-BOLD change trend in pre-to-post epilepsy surgery scans paralleled the clinical improvement, suggesting that the power spectrum may quantify the degree of abnormality on ICA-derived networks. Despite limitations such as small sample sizes, this exploratory study provides valuable insights into network dysfunction in SABI and epilepsy.</p>","PeriodicalId":73094,"journal":{"name":"Frontiers in neuroimaging","volume":"3 ","pages":"1445952"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11473429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal functional imaging and clinical correlates of pain regions in chronic low-back pain patients treated with spinal cord stimulation: a pilot study.","authors":"Yazan Shamli Oghli, Arjun Ashok, Steven Glener, Isaiah Ailes, Mashaal Syed, Ki Chang Kang, Sara Naghizadehkashani, Islam Fayed, Feroze B Mohamed, Kiran Talekar, Laura Krisa, Chengyuan Wu, Caio Matias, Mahdi Alizadeh","doi":"10.3389/fnimg.2024.1474060","DOIUrl":"https://doi.org/10.3389/fnimg.2024.1474060","url":null,"abstract":"<p><strong>Objective: </strong>Spinal cord stimulation (SCS) is an invasive treatment option for patients suffering from chronic low-back pain (cLBP). It is an effective treatment that has been shown to reduce pain and increase the quality of life in patients. However, the activation of pain processing regions of cLBP patients receiving SCS has not been assessed using objective, quantitative functional imaging techniques. The purpose of the present study was to compare quantitative resting-state (rs)-fMRI and arterial spin labeling (ASL) measures between SCS patients and healthy controls and to correlate clinical measures with quantitative multimodal imaging indices in pain regions.</p><p><strong>Methods: </strong>Multi-delay 3D GRASE pseudo-continuous ASL and rs-fMRI data were acquired from five patients post-SCS with cLBP and five healthy controls. Three ASL measures and four rs-fMRI measures were derived and normalized into MNI space and smoothed. Averaged values for each measure from a pain atlas were extracted and compared between patients and controls. Clinical pain scores assessing intensity, sensitization, and catastrophizing, as well as others assessing global pain effects (sleep quality, disability, anxiety, and depression), were obtained in patients and correlated with pain regions using linear regression analysis.</p><p><strong>Results: </strong>Arterial transit time derived from ASL and several rs-fMRI measures were significantly different in patients in regions involved with sensation (primary somatosensory cortex and ventral posterolateral thalamus [VPL]), pain input (posterior short gyrus of the insula [PS]), cognition (dorsolateral prefrontal cortex [DLPC] and posterior cingulate cortex [PCC]), and fear/stress response (hippocampus and hypothalamus). Unidimensional pain rating and sensitization scores were linearly associated with PS, VPL, DLPC, PCC, and/or amygdala activity in cLBP patients.</p><p><strong>Conclusion: </strong>The present results provide evidence that ASL and rs-fMRI can contrast functional activation in pain regions of cLBP patients receiving SCS and healthy subjects, and they can be associated with clinical pain evaluations as quantitative assessment tools.</p>","PeriodicalId":73094,"journal":{"name":"Frontiers in neuroimaging","volume":"3 ","pages":"1474060"},"PeriodicalIF":0.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11470492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative reliability assessment of brain MRI volumetric measurements in type II GM1 gangliosidosis patients.","authors":"Christopher Zoppo, Josephine Kolstad, Jean Johnston, Precilla D'Souza, Anna Luisa Kühn, Zeynep Vardar, Ahmet Peker, Clifford Lindsay, Zubir S Rentiya, Robert King, Heather Gray-Edwards, Behroze Vachha, Maria T Acosta, Cynthia J Tifft, Mohammed Salman Shazeeb","doi":"10.3389/fnimg.2024.1410848","DOIUrl":"10.3389/fnimg.2024.1410848","url":null,"abstract":"<p><strong>Purpose: </strong>GM1-gangliosidosis (GM1) leads to extensive neurodegenerative changes and atrophy that precludes the use of automated MRI segmentation techniques for generating brain volumetrics. We developed a standardized segmentation protocol for brain MRIs of patients with type II GM1 and then assessed the inter- and intra-rater reliability of this methodology. The volumetric data may be used as a biomarker of disease burden and progression, and standardized methodology may support research into the natural history of the disease which is currently lacking in the literature.</p><p><strong>Approach: </strong>Twenty-five brain MRIs were included in this study from 22 type II GM1 patients of which 8 were late-infantile subtype and 14 were juvenile subtype. The following structures were segmented by two rating teams on a slice-by-slice basis: whole brain, ventricles, cerebellum, lentiform nucleus, thalamus, corpus callosum, and caudate nucleus. The inter- and intra-rater reliability of the segmentation method was assessed with an intraclass correlation coefficient as well as Sorensen-Dice and Jaccard coefficients.</p><p><strong>Results: </strong>Based on the Sorensen-Dice and Jaccard coefficients, the inter- and intra-rater reliability of the segmentation method was significantly better for the juvenile patients compared to late-infantile (<i>p</i> < 0.01). In addition, the agreement between the two rater teams and within themselves can be considered good with all <i>p</i>-values < 0.05.</p><p><strong>Conclusions: </strong>The standardized segmentation approach described here has good inter- and intra-rater reliability and may provide greater accuracy and reproducibility for neuromorphological studies in this group of patients and help to further expand our understanding of the natural history of this disease.</p>","PeriodicalId":73094,"journal":{"name":"Frontiers in neuroimaging","volume":"3 ","pages":"1410848"},"PeriodicalIF":0.0,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11440193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142333851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probing hippocampal stimulation in experimental temporal lobe epilepsy with functional MRI.","authors":"Niels Schwaderlapp, Enya Paschen, Pierre LeVan, Dominik von Elverfeldt, Carola A Haas","doi":"10.3389/fnimg.2024.1423770","DOIUrl":"https://doi.org/10.3389/fnimg.2024.1423770","url":null,"abstract":"<p><p>Electrical neurostimulation is currently used to manage epilepsy, but the most effective approach for minimizing seizure occurrence is uncertain. While functional MRI (fMRI) can reveal which brain areas are affected by stimulation, simultaneous deep brain stimulation (DBS)-fMRI examinations in patients are rare and the possibility to investigate multiple stimulation protocols is limited. In this study, we utilized the intrahippocampal kainate mouse model of mesial temporal lobe epilepsy (mTLE) to systematically examine the brain-wide responses to electrical stimulation using fMRI. We compared fMRI responses of saline-injected controls and epileptic mice during stimulation in the septal hippocampus (HC) at 10 Hz and demonstrated the effects of different stimulation amplitudes (80-230 μA) and frequencies (1-100 Hz) in epileptic mice. Motivated by recent studies exploring 1 Hz stimulation to prevent epileptic seizures, we furthermore investigated the effect of prolonged 1 Hz stimulation with fMRI. Compared to sham controls, epileptic mice showed less propagation to the contralateral HC, but significantly stronger responses in the ipsilateral HC and a wider spread to the entorhinal cortex and septal region. Varying the stimulation amplitude had little effect on the resulting activation patterns, whereas the stimulation frequency represented the key parameter and determined whether the induced activation remained local or spread from the hippocampal formation into cortical areas. Prolonged stimulation of epileptic mice at 1 Hz caused a slight reduction in local excitability. In this way, our study contributes to a better understanding of these stimulation paradigms.</p>","PeriodicalId":73094,"journal":{"name":"Frontiers in neuroimaging","volume":"3 ","pages":"1423770"},"PeriodicalIF":0.0,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11349577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142115659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The importance of brain mapping for rehabilitation in birth nonprogressive neuromuscular diseases","authors":"Aleksandra Tolmacheva, Olga Agranovich, E. Blagovechtchenski","doi":"10.3389/fnimg.2024.1359491","DOIUrl":"https://doi.org/10.3389/fnimg.2024.1359491","url":null,"abstract":"While motor mapping has been extensively studied in acquired motor conditions, a lack has been observed in terms of research on neurological disorders present since birth, with damage to the spinal cord and peripheral nerves (hence, defined in this study as nonprogressive neuromuscular diseases). Despite an injury at the level below the brain, the subsequent changes in the motor system involve cortical reorganization. In the scientific community, the need for a comprehensive approach targeting the brain is increasingly recognized for greater motor recovery in these patients. Transcranial magnetic stimulation (TMS) and functional magnetic resonance imaging (fMRI) are the most utilized techniques for motor mapping. The knowledge obtained through motor mapping may be used to develop effective individual neuromodulation therapy that helps in functional motor recovery. This brief review compares the results of the brain mapping of a few existing studies in individuals with nonprogressive motor disorders of nonbrain origin present at birth to the brain mapping of individuals with similar acquired motor conditions. The review reveals some particular features in terms of central adaptation in individuals with birth conditions compared to their acquired counterparts, such as the nonsomatotopic presentation of involved muscles in the sensorimotor cortex and nonadjacent cortical areas. This topic is undoubtedly intriguing, justifying further research in the field. This review also discusses the benefits these patients can obtain from neuromodulation therapy addressed to the central nervous system and the importance of individual neurophysiological assessment in designing rehabilitation therapy for children with birth motor disorders.","PeriodicalId":73094,"journal":{"name":"Frontiers in neuroimaging","volume":"26 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141645502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic off-resonance correction improves functional image analysis in fMRI of awake behaving non-human primates.","authors":"Mo Shahdloo, Nima Khalighinejad, Luke Priestley, Matthew Rushworth, Mark Chiew","doi":"10.3389/fnimg.2024.1336887","DOIUrl":"10.3389/fnimg.2024.1336887","url":null,"abstract":"<p><strong>Introduction: </strong>Use of functional MRI in awake non-human primate (NHPs) has recently increased. Scanning animals while awake makes data collection possible in the absence of anesthetic modulation and with an extended range of possible experimental designs. Robust awake NHP imaging however is challenging due to the strong artifacts caused by time-varying off-resonance changes introduced by the animal's body motion. In this study, we sought to thoroughly investigate the effect of a newly proposed dynamic off-resonance correction method on brain activation estimates using extended awake NHP data.</p><p><strong>Methods: </strong>We correct for dynamic B0 changes in reconstruction of highly accelerated simultaneous multi-slice EPI acquisitions by estimating and correcting for dynamic field perturbations. Functional MRI data were collected in four male rhesus monkeys performing a decision-making task in the scanner, and analyses of improvements in sensitivity and reliability were performed compared to conventional image reconstruction.</p><p><strong>Results: </strong>Applying the correction resulted in reduced bias and improved temporal stability in the reconstructed time-series data. We found increased sensitivity to functional activation at the individual and group levels, as well as improved reliability of statistical parameter estimates.</p><p><strong>Conclusions: </strong>Our results show significant improvements in image fidelity using our proposed correction strategy, as well as greatly enhanced and more reliable activation estimates in GLM analyses.</p>","PeriodicalId":73094,"journal":{"name":"Frontiers in neuroimaging","volume":"3 ","pages":"1336887"},"PeriodicalIF":0.0,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11231096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141565315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}