Frontiers in neuroimaging最新文献

{"title":"Initial insights into post-contrast enhancement in ultra-low-field MRI: Case Report.","authors":"Ahmed Altaf, Muhammad Sami Alam, Sibgha Khan, Ali Azan, Fatima Mubarak, Edmond Knopp, Khan Siddiqui, Syed Ather Enam","doi":"10.3389/fnimg.2025.1507522","DOIUrl":"10.3389/fnimg.2025.1507522","url":null,"abstract":"<p><p>Brain tumors represent a significant burden, particularly in low- and middle-income countries (LMICs) where access to neuroimaging techniques is often limited. Conventional MRI machines are expensive and bulky, posing a significant challenge in the diagnosis and treatment of brain tumors in LMICs. However, an emerging technology, ultra-low field magnetic resonance imaging (pULF-MRI), has the potential to address this limitation. This study aimed to evaluate the feasibility and effectiveness of post-contrast enhancement in a pULF-MRI scanner for brain tumor imaging in LMICs. A single case study was conducted, and post-contrast enhancement was successfully achieved, revealing the presence of a tumor which was subsequently confirmed on biopsy. To our knowledge, this is the first study to demonstrate the feasibility of post-contrast enhancement in a pULF-MRI scanner for brain tumor imaging. This technology has the potential to significantly improve access to neuroimaging in LMICs, leading to earlier diagnosis and more effective treatment of brain tumors. These promising results suggest that further studies are warranted to explore the potential of pULF-MRI for large-scale screening and diagnosis of brain tumors in LMICs. This can provide a future roadmap for neuroimaging in LMICs, providing a cost-effective and accessible way to diagnose and treat brain tumors, leading to improved healthcare outcomes with a further prospective clinical trial.</p>","PeriodicalId":73094,"journal":{"name":"Frontiers in neuroimaging","volume":"4 ","pages":"1507522"},"PeriodicalIF":0.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case report: Re-evaluating reversibility of cytotoxic lesions of the corpus callosum.","authors":"Victoria Vold, Stein-Helge Hansen Tingvoll, Mona K Beyer, Kaja Nordengen","doi":"10.3389/fnimg.2025.1436931","DOIUrl":"10.3389/fnimg.2025.1436931","url":null,"abstract":"<p><p>Cytotoxic lesions of the corpus callosum (CLOCC) are a clinicoradiological diagnosis, characterized by transient neurological symptoms and magnetic resonance imaging (MRI) changes in the splenium of the corpus callosum (SCC), which in most cases is completely reversible. However, the long-term pathophysiological trajectory and ultimate neurological outcomes of CLOCC remain largely unknown due to limited long-term follow-up data. We report an 11-year follow-up of a postpartum female with CLOCC, initially presenting with transient focal neurological symptoms and extensive diffusion-restricted white matter involvement including the SCC and surrounding area with diffusion restriction and low apparent diffusion coefficient values, indicative of cytotoxic edema. The edema regressed in days; over the years, she remained asymptomatic despite persistent white matter changes on MRI in the centrum semiovale. This case challenges the view of CLOCC as completely reversible and raises questions regarding the significance of lasting white matter changes. The enduring absence of neurological symptoms and stable radiological profile throughout the decade underscores the singular nature of CLOCC and the lasting, though isolated, impact on white matter. This report contributes a crucial perspective, suggesting that CLOCC may involve just an isolated episode without recurrent events or progressive neurological decline. By offering the first longitudinal analysis of a CLOCC episode with an extended follow-up of over a decade, our case enhances current knowledge about the long-term neurological and radiological landscape of this condition. It suggests a reevaluation of the conceptual understanding of CLOCC as an entirely reversible, non-relapsing disorder, highlighting the need for further research into its long-term impacts on cerebral white matter integrity.</p>","PeriodicalId":73094,"journal":{"name":"Frontiers in neuroimaging","volume":"4 ","pages":"1436931"},"PeriodicalIF":0.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"T1-relaxation times along the corticospinal tract as a diagnostic marker in patients with amyotrophic lateral sclerosis.","authors":"Fiona Dierksen, Johanna S Geibel, Janika Albrecht, Sabine Hofer, Peter Dechent, Amelie C Hesse, Jens Frahm, Mathias Bähr, Jan C Koch, Jan Liman, Ilko L Maier","doi":"10.3389/fnimg.2025.1549727","DOIUrl":"10.3389/fnimg.2025.1549727","url":null,"abstract":"<p><strong>Background and purpose: </strong>In the differential diagnostic workup of amyotrophic lateral sclerosis (ALS), magnetic resonance imaging (MRI) is primarily used to rule out significant differential diagnoses. So far, whole-brain T1-mapping has not been assessed as a diagnostic tool in this patient population.</p><p><strong>Methods: </strong>We investigated the diagnostic potential of a novel T1-mapping method based on real-time MRI with 0.5 mm in-plane resolution and 4s acquisition time per slice. The study included patients aged 18 to 90 years who met the revised El Escorial criteria for at least possible ALS. T1-relaxation times were measured along the corticospinal tract in predefined regions of interest.</p><p><strong>Results: </strong>Twenty-nine ALS-patients and 43 control group patients (CG) were included in the study. Median ALS Functional Rating Scale revised (ALSFRS-R) was 37 (IQR, 35-44) points and the mean duration from symptom onset to MRI was 21 ± 17 (SD) months. ALS patients showed significantly higher T1-relaxation times in all ROIs compared to CG with mean differences in the hand knob of 50 ms (<i>p</i> < 0.001), corona radiata 24 ms (<i>p</i> = 0.034), internal capsule 27 ms (<i>p</i> = 0.002) and midbrain peduncles 48 ms (<i>p</i> < 0.001). There was a consistent negative correlation between the ALSFRS-R and T1-relaxation times in all ROIs.</p><p><strong>Conclusions: </strong>T1-relaxation times along the corticospinal tract are significantly elevated in ALS patients compared to CG and associated with lower ALSFRS-R. These results imply the analysis of T1-relaxation times as a promising diagnostic tool that can distinguish ALS patients from the control group. Ongoing longitudinal studies may provide deeper insights into disease progression and the effects of therapeutic interventions.</p>","PeriodicalId":73094,"journal":{"name":"Frontiers in neuroimaging","volume":"4 ","pages":"1549727"},"PeriodicalIF":0.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Role of neuroimaging in the diagnosis and treatment of rare diseases.","authors":"Mohammed Salman Shazeeb, Maria T Acosta, Cynthia J Tifft","doi":"10.3389/fnimg.2025.1566484","DOIUrl":"10.3389/fnimg.2025.1566484","url":null,"abstract":"","PeriodicalId":73094,"journal":{"name":"Frontiers in neuroimaging","volume":"4 ","pages":"1566484"},"PeriodicalIF":0.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awake brain MRSI reveals anesthetic sensitivity and regional aging effects on [¹³C]bicarbonate metabolism in mice.","authors":"Maiko Ono, Rena Kono, Kosei Hirata, Keita Saito, Motonao Nakao, Yoichi Takakusagi, Rikita Araki, Akira Sumiyoshi, Yuhei Takado","doi":"10.3389/fnimg.2025.1506126","DOIUrl":"10.3389/fnimg.2025.1506126","url":null,"abstract":"<p><p>Abnormalities and alterations in the glycolytic pathway in the pathology of neurodegenerative diseases and brain aging have received much attention, as clinical applications of proton-based magnetic resonance spectroscopy (MRS) have recently illuminated the elevation of lactate concentrations in the brains of patients with neurodegenerative diseases, including Alzheimer's disease. Hyperpolarized [1-¹³C]pyruvate MRS has shown promise for neurological applications because it enables the real-time <i>in vivo</i> detection of glycolysis and oxidative phosphorylation flux. In studies of the mouse brain using hyperpolarized [1-¹³C]pyruvate, there are few reports that the signal of [¹³C]bicarbonate, a product of oxidative phosphorylation metabolized from [1-¹³C]pyruvate, was detected using MR spectroscopic imaging (MRSI) that allows spatial mapping of metabolism, although there have been reports of [¹³C]bicarbonate signals being detected by pulse-acquire sequences in the entire brain. In the present study, we compared hyperpolarized [1-¹³C]pyruvate metabolism between the brains of awake and isoflurane-anesthetized mice using a custom-made awake mouse restraint device with MRSI. Although the signal for [1-¹³C]lactate, a product of glycolysis metabolized from [1-¹³C]pyruvate, was detectable in multiple brain regions that include the orbitofrontal cortex and hippocampus in both awake and anesthetized mice, the signal for [¹³C]bicarbonate metabolized from [1-¹³C]pyruvate was only detectable in the brains of awake mice. Moreover, a comparison of hyperpolarized [1-¹³C]pyruvate metabolism in young and aged mouse brains using awake MRSI detected age-related decreases in oxidative phosphorylation flux in brain regions that include the hippocampus with variations in the extent of these changes across different brain regions. These results demonstrate that hyperpolarized [1-¹³C]pyruvate MRSI under awake conditions is useful for the spatial detection of abnormalities and alterations in glycolysis and oxidative phosphorylation flux in the brains of mice. Thus, the use of hyperpolarized [1-¹³C]pyruvate MRSI has potential in pathological and mechanistic studies of brain diseases and brain aging.</p>","PeriodicalId":73094,"journal":{"name":"Frontiers in neuroimaging","volume":"4 ","pages":"1506126"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11861090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between cerebral blood flow and progression of white matter hyperintensities.","authors":"Siriluk Thammasart, Danielle J Harvey, Pauline Maillard, Charles DeCarli, Corinne A Donnay, Gregory J Wheeler, Audrey P Fan","doi":"10.3389/fnimg.2024.1463311","DOIUrl":"10.3389/fnimg.2024.1463311","url":null,"abstract":"<p><strong>Introduction: </strong>In an aging population, white matter hyperintensities (WMHs), observed on FLAIR MRI sequences, are indicators of cognitive decline, motor impairment, and increased vascular risk. However, the pathophysiological mechanisms underlying WMHs, including dynamic changes in cerebral blood flow (CBF) within and adjacent to lesions, remain poorly understood.</p><p><strong>Methods: </strong>Our study examined a diverse cohort of 300 elderly participants through arterial spin labeling (ASL) on 3 Tesla MRI, analyzing both cross-sectional and longitudinal data. We characterized the relationship between CBF and WMH development in different lesion locations (based on distance from ventricles) and brain tissue types (WMH lesion, penumbra, and normal white matter).</p><p><strong>Results: </strong>Our findings reveal that WMHs exhibit significantly lower relative CBF (rCBF) compared to penumbra, normal-appearing white matter, and gray matter, with juxtaventricular WMHs (JVWMH) displaying the most substantial reductions. Longitudinally, WMHs that increased in size over a two-year period had lower baseline rCBF than those that remained stagnant, particularly in juxtaventricular and periventricular regions.</p><p><strong>Discussion: </strong>This study not only highlights the predictive value of rCBF in WMH progression but also provides location-specific hemodynamic information about WMHs that can guide clinical management of WMH-related brain changes and their clinical manifestations.</p>","PeriodicalId":73094,"journal":{"name":"Frontiers in neuroimaging","volume":"3 ","pages":"1463311"},"PeriodicalIF":0.0,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11790564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Learning to build low-field MRIs for remote northern communities.","authors":"Gordon E Sarty, Logi Vidarsson, Christopher Hansen, Keifer Corrigal, Lionel Sutherland, Millie Jamieson, Micheal Hogue, Haile Kassahun, William Greyeyes, David Teixeira, Lawrence Goertzen, Jonathan McEvoy, Mark Pollard","doi":"10.3389/fnimg.2024.1521517","DOIUrl":"10.3389/fnimg.2024.1521517","url":null,"abstract":"<p><p>Low-field Magnetic Resonance Imaging (MRI) has the potential to provide autonomous accessible neuroimaging in remote communities, particularly in the Canadian north. Remoteness necessitates that these MRIs be built and maintained within the communities. This approach not only ensures that the MRIs remain operational but will also allow the youth from the communities to pursue technical careers at home. The first step in this vision is to establish that the technical resources needed for building MRIs are available in remote communities and to establish an educational program that will give students the required technical skills. Over the summer of 2024, a team of students working within an Aircraft Maintenance Engineering (AME) program built the hardware for a wrist-sized prototype MRI. The student team included a high school student, AME students, engineering students and a post doctoral fellow. The skills required to maintain aircraft, namely 3D printing, sheet metal work and electrical harness building, were sufficient to build a low-field MRI. The prototype built was a radio frequency (RF) encoding MRI, whose design was optimized for eventual use in space, but the techniques and procedures developed are applicable to other MRI designs. Furthermore the breadth of students from high school to the post doctoral fellow level facilitated an extremely rich learning environment for the students while they focused on the task of designing and building the prototype MRI. Educational programs around building low-field MRIs can be created at all levels.</p>","PeriodicalId":73094,"journal":{"name":"Frontiers in neuroimaging","volume":"3 ","pages":"1521517"},"PeriodicalIF":0.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11782269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurological complications of left atrial myxoma: a case report on stroke with left atrial myxoma and postoperative brain metastasis and cerebral aneurysm.","authors":"Xudong Ai, Qingqing Shao, Xueyan Tian, Yicheng Zhou, Tiantian Zhou","doi":"10.3389/fnimg.2024.1524901","DOIUrl":"10.3389/fnimg.2024.1524901","url":null,"abstract":"<p><p>Atrial myxoma is a rare benign tumor that can cause a variety of complications, including cerebral infarction. We present a case of a 52-year-old female patient who developed cerebral infarction caused by an atrial myxoma. The patient underwent successful surgical resection of the tumor, and the infarction was managed accordingly. However, 15-months post-surgery, the patient developed new neurological symptoms. Imaging studies revealed multiple cerebral metastases, consistent with the possibility of seeding of tumor cells. This rare complication emphasizes the importance of long-term monitoring after the resection of atrial myxomas. The occurrence of metastasis in the brain, though rare, should be considered in follow-up care, particularly in patients who have had embolic events related to atrial myxomas. Our case highlights the potential for cerebral myxoma metastasis even after initial successful surgical intervention, underscoring the need for comprehensive follow-up and vigilant monitoring of such patients.</p>","PeriodicalId":73094,"journal":{"name":"Frontiers in neuroimaging","volume":"3 ","pages":"1524901"},"PeriodicalIF":0.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting-state fMRI seizure onset localization meta-analysis: comparing rs-fMRI to other modalities including surgical outcomes.","authors":"Varina L Boerwinkle, Mary A Nowlen, Jesus E Vazquez, Martin A Arhin, William R Reuther, Emilio G Cediel, Patrick J McCarty, Iliana Manjón, Jubran H Jubran, Ashley C Guest, Kirsten D Gillette, Frances M Nowlen, Andrew R Pines, Meitra H Kazemi, Bahjat F Qaqish","doi":"10.3389/fnimg.2024.1481858","DOIUrl":"10.3389/fnimg.2024.1481858","url":null,"abstract":"<p><strong>Objective: </strong>Resting-state functional MRI (rs-fMRI) may localize the seizure onset zone (SOZ) for epilepsy surgery, when compared to intracranial EEG and surgical outcomes, per a prior meta-analysis. Our goals were to further characterize this agreement, by broadening the queried rs-fMRI analysis subtypes, comparative modalities, and same-modality comparisons, hypothesizing SOZ-signal strength may overcome this heterogeneity.</p><p><strong>Methods: </strong>PubMed, Embase, Scopus, Web of Science, and Google Scholar between April 2010 and April 2020 via PRISMA guidelines for SOZ-to-established-modalities were screened. Odd ratios measured agreement between SOZ and other modalities. Fixed- and random-effects analyses evaluated heterogeneity of odd ratios, with the former evaluating differences in agreement across modalities and same-modality studies.</p><p><strong>Results: </strong>In total, 9,550 of 14,384 were non-duplicative articles and 25 met inclusion criteria. Comparative modalities were EEG 7, surgical outcome 6, intracranial EEG 5, anatomical MRI 4, EEG-fMRI 2, and magnetoencephalography 1. Independent component analysis 9 and seed-based analysis 8 were top rs-fMRI methods. Study-level odds ratio heterogeneity in both the fixed- and random-effects analysis was significant (<i>p</i> < 0.001). Marked cross-modality and same-modality systematic differences in agreement between rs-fMRI and the comparator were present (<i>p</i> = 0.005 and <i>p</i> = 0.002), respectively, with surgical outcomes having higher agreement than EEG (<i>p</i> = 0.002) and iEEG (<i>p</i> = 0.007). The estimated population mean sensitivity and specificity were 0.91 and 0.09, with predicted values across studies ranging from 0.44 to 0.96 and 0.02 to 0.67, respectively.</p><p><strong>Significance: </strong>We evaluated centrality and heterogeneity in SOZ agreement between rs-fMRI and comparative modalities using a wider variety of rs-fMRI analyzing subtypes and comparative modalities, compared to prior. Strong evidence for between-study differences in the agreement odds ratio was shown by both the fixed- and the random-effects analyses, attributed to rs-fMRI analysis variability. Agreement with rs-fMRI differed by modality type, with surgical outcomes having higher agreement than EEG and iEEG. Overall, sensitivity was high, but specificity was low, which may be attributed in part to differences between other modalities.</p>","PeriodicalId":73094,"journal":{"name":"Frontiers in neuroimaging","volume":"3 ","pages":"1481858"},"PeriodicalIF":0.0,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11685199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediterranean diet and brain functional connectivity in a population without dementia.","authors":"Efstratios Karavasilis, Vasileios Balomenos, Foteini Christidi, Georgios Velonakis, Georgia Angelopoulou, Mary Yannakoulia, Eirini Mamalaki, Archontoula Drouka, Dora Brikou, Angeliki Tsapanou, Yian Gu, Nikolaos Scarmeas","doi":"10.3389/fnimg.2024.1473399","DOIUrl":"10.3389/fnimg.2024.1473399","url":null,"abstract":"<p><strong>Introduction: </strong>Adjustable lifestyle factors, such as diet, are associated with cognitive functions, structural and functional brain measures, but the association between the functional connectivity (FC) and the Mediterranean Diet (Medicine) in population without dementia is yet to be explored.</p><p><strong>Methods: </strong>The association between MeDi and brain FC in 105 individuals without dementia aged 63 (SD ± 8.72) years old who underwent brain MRI including resting-state (rs) functional MRI (fMRI) was examined. Dietary intake was evaluated through four 24-h recalls using the multiple-pass method and adherence to the MeDi was estimated using the MedDietScore, with higher values indicating greater adherence to MeDi. Multivariable linear regression models were used to investigate the associations between FC (both positive and negative associations) and MedDietScore.</p><p><strong>Results: </strong>Rs-fMRI analysis revealed significant associations between FC and MedDietScore. The FC between the medial prefrontal cortex and a cluster located in left postcentral gyrus and in the left supramarginal gyrus was positively associated with MedDietScore. On the other hand, the FC between medial visual and right posterior division of both middle and superior temporal gyrus was negatively associated with MedDietScore. Of note, a temporal negative correlation was detected between above-mentioned FC networks. The FC between superior temporal gyrus and occipital regions was associated with participants' attention, executive functions, and memory scores. Furthermore, the associations for attention and executive functions were pronounced in participants with high adherence to MeDi compared to those with low adherence to MeDi.</p><p><strong>Discussion: </strong>In conclusion, our study documented an association between higher adherence to MeDi and rs-FC in fronto-parietal and temporo-occipital regions, particularly in areas that are involved in cognitive processes altered across normal and pathological aging. From a clinical point of view, our findings support a favorable role of MeDi on FC which may have significant clinical implications in the rapidly aging population. Rs-fMRI is also proposed as a useful tool in the emerging field of nutritional neuroscience and a candidate non-invasive biomarker of brain aging.</p>","PeriodicalId":73094,"journal":{"name":"Frontiers in neuroimaging","volume":"3 ","pages":"1473399"},"PeriodicalIF":0.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11659224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}