Frontiers in dental medicine最新文献

{"title":"Effect of double adhesive layer application on micro-tensile dentin bond strength of a universal adhesive.","authors":"Afnan O Al-Zain, Asrar Albuqayli, Abdulaziz Albogami, Abdulghani Alkudsi, Meshari Alwabiri, Abdullah T Koshak, Hattan Alsefri, Eliseu A Munchow","doi":"10.3389/fdmed.2024.1484498","DOIUrl":"10.3389/fdmed.2024.1484498","url":null,"abstract":"<p><strong>Introduction: </strong>Achieving optimal dentin bond strength is crucial for the long-term success of adhesive restorations. This study aims to evaluate the impact of double adhesive layer application, with and without light curing between applications, on the micro-tensile dentin bond strength (µ-TBS) of a universal adhesive, in comparison to the conventional single-layer application.</p><p><strong>Methods: </strong>Intact human molars were divided into three groups (<i>n</i> = 15) according to the adhesive application technique using a universal self-etch adhesive (Tetric N-Bond Universal, Ivoclar) as follows: (1) according to the manufacturer's instructions, (2) double-layer application without light curing between layers, and (3) double-layer application with light curing between layers. Samples were immediately tested for µ-TBS, with failure types recorded as adhesive, cohesive, or mixed. Representative samples were observed by scanning electron microscopy. Data were analyzed using multiple-way ANOVA (<i>α</i> = 0.05).</p><p><strong>Results: </strong>The double adhesive layer with and without light curing between layers showed similar μ-TBS to that of the control group (<i>p</i> > 0.05).</p><p><strong>Discussion: </strong>From a clinical perspective, these findings suggest that the accurate application of a single layer of a universal adhesive can be as effective as more complex techniques. Additionally, the use of universal bonding agents may have contributed to the outcomes observed in this study. In conclusion, double adhesive layer application and light curing between adhesive layers did not increase the µ-TBS with the universal adhesive agent explored.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1484498"},"PeriodicalIF":1.5,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automating bone loss measurement on periapical radiographs for predicting the periodontitis stage and grade.","authors":"Nazila Ameli, Monica Prasad Gibson, Ida Kornerup, Manuel Lagravere, Mark Gierl, Hollis Lai","doi":"10.3389/fdmed.2024.1479380","DOIUrl":"10.3389/fdmed.2024.1479380","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to develop and evaluate an automated approach for segmenting bone loss (BL) on periapical (PA) radiographs and predicting the stage and grade of periodontitis.</p><p><strong>Methods: </strong>One thousand PA radiographs obtained from 572 patients were utilized for training while a separate set of 1,582 images from 210 patients were used for testing. BL was segmented using a U-Net model, which was trained with augmented datasets to enhance generalizability. Apex detection was performed using YOLO-v9, focusing on identifying apexes of teeth to measure root length. Root length was calculated as the distance between the coordinates of detected apexes and center of cemento-enamel junction (CEJ), which was segmented utilizing a U-Net algorithm. BL percentage (ratio of BL to the root length) was used to predict the stage and grade of periodontitis. Evaluation metrics including accuracy, precision, recall, F1-score, Intersection over Union (IoU), mean absolute error (MAE), intraclass correlation coefficients (ICC), and root mean square error (RMSE) were used to evaluate the models' performance.</p><p><strong>Results: </strong>The U-Net model achieved high accuracy in segmenting BL with 94.9%, 92.9%, and 95.62% on training, validation, and test datasets, respectively. The YOLO-v9 model exhibited a mean Average Precision (mAP) of 66.7% for apex detection, with a precision of 79.6% and recall of 62.4%. The BL percentage calculated from the segmented images and detected apexes demonstrated excellent agreement with clinical assessments, with ICC exceeding 0.94. Stage and grade prediction for periodontitis showed robust performance specifically for advanced stages (III/IV) and grades (C) with an F1-score of 0.945 and 0.83, respectively.</p><p><strong>Conclusion: </strong>The integration of U-Net and YOLO-v9 models for BL segmentation and apex detection on PA radiographs proved effective in enhancing the accuracy and reliability of periodontitis diagnosis and grading.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1479380"},"PeriodicalIF":1.5,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-year clinical performance of direct restorations using low-shrinkage Giomer vs. nano-hybrid resin composite.","authors":"Tugba Toz-Akalin, Funda Öztürk-Bozkurt, Mahmut Kusdemir, Alev Özsoy, Emir Yüzbaşıoğlu, Mutlu Özcan","doi":"10.3389/fdmed.2024.1459473","DOIUrl":"10.3389/fdmed.2024.1459473","url":null,"abstract":"<p><strong>Objectives: </strong>The objective of this investigation was to compare the clinical performance of a nano-hybrid resin composite and a low-shrinkage Giomer resin composite.</p><p><strong>Material and methods: </strong>In total, 35 pairs of restorations were performed using either low-shrinkage Giomer (Beautifil II LS, Shofu Inc.) or nano-hybrid (Clearfil Majesty Posterior) resin composite in 35 patients by two operators using the relevant adhesives, i.e., FL-Bond II (Shofu Inc.) and Clearfil SE Bond (Kuraray), with the self-etching technique according to each manufacturer's instructions. Two clinicians assessed the restorations 2 weeks (baseline); 6 months; and 1, 2, and 3 years after the restorative procedures using FDI (World Dental Federation) criteria (Scores 1-5). Data were analyzed using the marginal homogeneity and McNemar tests. The survival rate was calculated using Kaplan-Meier survival analysis and the survival of the two groups was compared with the log-rank test (<i>p</i> = 0.05).</p><p><strong>Results: </strong>The mean observation period was 37.7 ± 6.8 months. All restorations completed their 3-year follow-up. The criteria were mainly rated with high (1 or 2) scores for quality in both groups. Only one restoration in the low-shrinkage Giomer resin composite group was accepted as a failure at the 2-year recall due to retention loss.</p><p><strong>Conclusion: </strong>At the 3-year follow-up, the performance of the restorations using the Giomer and the nano-hybrid resin composite were similar and clinically acceptable.</p><p><strong>Clinical relevance: </strong>The low-shrinkage Giomer resin composite exhibited a similar clinical performance to the nano-hybrid resin composite after 3 years in service with both materials displaying minor surface deteriorations at the 3-year recall.</p><p><strong>Clinical trial registration: </strong>https://clinicaltrials.gov, identifier: NCT02823769.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1459473"},"PeriodicalIF":1.5,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Access to dental services and use of toothpaste with optimal fluoride content in Peruvian children.","authors":"Natalie Hadad-Arrascue, María Claudia Garcés-Elías","doi":"10.3389/fdmed.2024.1467501","DOIUrl":"10.3389/fdmed.2024.1467501","url":null,"abstract":"<p><strong>Background: </strong>Leading international health organizations advise using toothpaste that contains at least 1,000 parts per million of fluoride, emphasizing that this practice should begin with the eruption of the first primary tooth.</p><p><strong>Aim: </strong>To determine the association between access to dental services and the use of toothpaste with 1,000 ppm fluoride or more in Peruvian children under twelve years of age.</p><p><strong>Materials and methods: </strong>A cross-sectional analysis was conducted using data from the 2021 Demographic and Family Health Survey. The main variable studied was the use of toothpaste containing a fluoride concentration of 1,000 ppm or more. Additionally, the access to dental care, the time elapsed since the last dental visit, and the type of healthcare facility were analyzed. Multilevel regression was applied to examine the relationship between variables and the dependent variable, with Peru's 24 regions serving as the analytical level.</p><p><strong>Results: </strong>According to the bivariate analysis, the natural region, area of residence, place of residence, wealth index, and age were associated with the use of fluoride toothpaste with 1,000 ppm or more. In the multilevel analysis, the access to dental services was not associated with the use of fluoride toothpaste with 1,000 ppm or more (<i>p</i> = 0.454); similarly, the time elapsed since the last dental visit also showed no association (<i>p</i> = 0.676), as did the type of healthcare facility (<i>p</i> = 0.752, <i>p</i> = 0.896, <i>p</i> = 0.983).</p><p><strong>Conclusion: </strong>Accessing dental services, the time elapsed since the last dentist visit, and the location where that care was received were not associated with the use of toothpaste containing 1,000 ppm or more of fluoride among Peruvian children during the year 2021.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1467501"},"PeriodicalIF":1.5,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single nucleotide polymorphism rs854560 in paraoxonase-1 regulates the cytodifferentiation of human periodontal ligament cells.","authors":"Risa Masumoto, Chiharu Fujihara, Masahiro Matsumoto, Jirouta Kitagaki, Shinya Murakami","doi":"10.3389/fdmed.2024.1449482","DOIUrl":"10.3389/fdmed.2024.1449482","url":null,"abstract":"<p><p>Aggressive periodontitis (AgP), classified as Stages III or IV and grade C periodontitis, is characterized by the rapid destruction of periodontal tissue. Genetic factors contribute to the pathogenesis of this disease, and familial aggregation of periodontitis is often observed. However, the mechanisms underlying the onset or progression of AgP have not been elucidated. Previously, we performed exome sequencing and identified AgP risk factors in Japanese AgP-patients. However, the small sample size limited our scope for detecting some of the true AgP genetic risk factors. To overcome this limitation, we searched for AgP-related genes more comprehensively from the whole exome sequencing data of the Japanese AgP-patients by extending the filtering criteria range. We identified seven AgP-associated suggestive genes, including the single nucleotide polymorphism (SNP) rs854560 in paraoxonase-1 (<i>PON-1</i>), which is correlated with AgP. However, the mechanism(s) underlying the induction of AgP pathogenesis by the SNP rs854560 <i>PON-1</i> has not been elucidated. Thus, we further analyzed the functions of the SNP rs854560 <i>PON-1</i> in human periodontal ligament (HPDL) cells through transfection of the wild-type <i>PON-1</i> (WT) or SNP rs854560 <i>PON-1</i> (mut) into HPDL cells. Real-time PCR indicated that mut had higher mRNA expression of osteogenic related-genes and showed a higher tendency of ALP activity and proliferation. The result suggested that WT <i>PON-1</i> contributes to periodontal tissue homeostasis through appropriate proliferation and cytodifferentiation of HPDL cells, while SNP rs854560 <i>PON-1</i> may mediate excessive calcification of periodontal tissue due to hyper proliferation of HPDL cells, thereby increasing the risk of AgP.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1449482"},"PeriodicalIF":1.5,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling sex-disparities and the impact of gender-affirming hormone therapy on periodontal health.","authors":"Cristina Cunha Villar, Mariane Cristina Sloniak, Josiane Betim de Assis, Renata Cassiano Porto, Giuseppe Alexandre Romito","doi":"10.3389/fdmed.2024.1430193","DOIUrl":"10.3389/fdmed.2024.1430193","url":null,"abstract":"<p><strong>Introduction: </strong>As personalized medicine advances, the need to explore periodontal health across different sexes and gender identities becomes crucial. This narrative review addresses the gap in understanding how biological sex and gender-affirming hormone therapy (GAHT) influence periodontitis risk.</p><p><strong>Results: </strong>Research has uncovered significant sex-based immunological disparities driven by X and Y chromosome gene expression and sex-hormones, which may influence susceptibility to periodontitis. Additionally, preliminary findings suggest that GAHT, particularly testosterone therapy in transgender men, could exacerbate pro-inflammatory cytokine production and alter immune cell responses, which may exacerbate inflammatory pathways crucial in the progression of periodontitis. Conversely, the effects of estrogen therapy in transgender women, although less extensively studied, suggest modifications in B cell functionality. These observations highlight the complex role of GAHT in modulating immune responses that are central to the development and exacerbation of periodontal disease.</p><p><strong>Discussion: </strong>The review highlights a complex interaction between sex hormones, gene expression patterns, immune responses, and periodontitis risk. While cisgender males show increased susceptibility to periodontitis that could be linked to specific immune pathways, GAHT appears to modify these pathways in transgender individuals, potentially altering their risk and disease progression patterns.</p><p><strong>Conclusion: </strong>There is a critical need for more focused research on the direct impacts of GAHT on periodontal health. Understanding the nuances of immune modulation by GAHT will aid in crafting personalized periodontal care for transgender individuals, aligning with the broader goals of inclusive and effective healthcare.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1430193"},"PeriodicalIF":1.5,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finite element analysis of dental structures: the role of mandibular kinematics and model complexity.","authors":"Canan Özcan, Philippe Lestriez, Mutlu Özcan, Yannick Josset","doi":"10.3389/fdmed.2024.1461909","DOIUrl":"10.3389/fdmed.2024.1461909","url":null,"abstract":"<p><strong>Introduction: </strong>This study observed the consequences of integrating mandibular kinematics in maxillary and mandibular teeth contact in a finite element analysis (FEA), and investigate the level of simplification of the dental models in FEA. The purpose of this study was to compare the results of finite element analysis obtained from simple to more complex dental models incorporating mandibular motion during loading phase.</p><p><strong>Methods: </strong>Six models were generated for this study. The simplest models consisted of only the crown of the tooth and an antagonist tooth with either the same properties or rigid body properties while the subsequent models incorporated the root of the study tooth and the surrounding bone. The most complex model involved the hyperelastic ligament and the other anatomical elements of the tooth and surrounding bone. Mandibular movement data recorded with the Modjaw® system (Modjaw-Technologie) were used to bring the teeth into contact and generate the loading in all models where the stresses exerted on tooth structures during the chewing process were evaluated.</p><p><strong>Results: </strong>von Mises stress and the shear stress obtained in all models, exceeded the ultimate compression strength of the materials, except for the model with the hyperelastic periodontal ligament. The forces applied to the tooth were extremely different depending on the addition or removal of anatomical elements despite the systematic study of the same teeth.</p><p><strong>Discussion: </strong>The inclusion of mandibular kinematics in the finite element analysis requires the modelling of a complex dental model as simplification generated an overestimation of the forces and stresses on the structures. Finite element dental models allow for the observation and prevention of restorative failures by numerical methods but misinterpretations caused by poorly designed models have clinical implications on estimating performance of dental restorations.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1461909"},"PeriodicalIF":1.5,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Impact of uncontrolled diabetes on oral disease progression and healing.","authors":"Ryan Moseley, Rachel Jane Waddington","doi":"10.3389/fdmed.2024.1487051","DOIUrl":"10.3389/fdmed.2024.1487051","url":null,"abstract":"","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1487051"},"PeriodicalIF":1.5,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating tooth morbidity risks, prevalence, and interventions in tribal setting: a study protocol focused on the Irula community in Tamil Nadu.","authors":"Margret Beaula Alocious Sukumar, Roshni Mary Peter, Alex Joseph","doi":"10.3389/fdmed.2024.1427597","DOIUrl":"10.3389/fdmed.2024.1427597","url":null,"abstract":"<p><strong>Aim: </strong>Dentistry is uniquely positioned as a healthcare profession, distinguished from allied health or paramedical fields. It operates within a university-based structure, maintaining primary care responsibilities. Oral diseases impose a substantial worldwide health and economic burden, profoundly affecting the well-being of those affected. This cross-sectional study is centered on the Irula tribes in Tamil Nadu, India. Investigating the extent of tooth morbidity and loss, identifying possible risk factors, looking at oral hygiene habits, and evaluating the oral health-associated quality of life (OHRQoL) in this population are the main goals. As this population is at high risk for dental issues, promoting good oral hygiene becomes crucial. Indigenous populations, including the Irula tribes, have been underrepresented in research studies. The vulnerability of the Irula tribes is exacerbated by their remote locations, resulting in limited access to fundamental healthcare facilities.</p><p><strong>Materials and methods: </strong>This study employs a cluster sampling approach, aiming to include 880 individuals aged 60 and above from Kancheepuram and Chengalpattu districts. The methodology encompasses a community-based questionnaire, clinical assessments utilizing standardized indices, and the assessment of the Oral Health-Related Quality of Life (OHRQoL). The Statistical Package for Social Services, version 20, will be used to analyze all of the data that has been gathered (SPSS).Categorical variables will undergo analysis, with descriptive statistics and frequency percentages computed.</p><p><strong>Conclusion: </strong>This study evaluates tooth morbidity and dentistry's role in screening chronic diseases like diabetes among the Irula tribes. It explores risk factors, oral hygiene practices, treatment seeking behavior, and oral health-related quality of life to gain a comprehensive understanding.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1427597"},"PeriodicalIF":1.5,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel temporary endodontic medication based on calcium silicate strategy: a biological and physicochemical study.","authors":"Claire El Hachem, Salvatore Sauro, Ammar Eid, Burçin Arıcan, Raya Alrayesse, Camille Fabro, Varvara Gribova, Louis Hardan, Youssef Haikel, Naji Kharouf","doi":"10.3389/fdmed.2024.1451275","DOIUrl":"10.3389/fdmed.2024.1451275","url":null,"abstract":"<p><strong>Introduction: </strong>The purpose of this <i>in vitro</i> study was to compare the physicochemical and biological properties of a traditional calcium hydroxide-based cement (Cal) to a novel endodontic material based on calcium silicate strategy in premixed formulation (Bio-C).</p><p><strong>Methods: </strong>Crystalline structure evaluation and pH analysis were performed at different time periods (3-168 h). Contact angle, surface roughness, solubility and flowability of both materials were also investigated. The antibacterial activity of each material was assessed using a direct contact test against <i>Enterococcus faecalis (E.faecalis)</i>, and the cytotoxicity was performed by using periodontal ligament cells. Statistical analysis was accomplished using one-way analysis of variance and Kruskal-Wallis tests.</p><p><strong>Results: </strong>An alkaline pH was observed in both the tested materials. Higher pH values were attained in Cal compared to Bio-C (<i>p</i> < 0.05). Higher flowability, solubility and wettability were attained for Bio-C compared to Cal (<i>p</i> < 0.05). Crystalline structures were observed on the surface of Bio-C after immersion in PBS (168 h). Cal presented higher antibacterial activity compared to Bio-C against <i>E.faecalis</i>. Only undiluted Bio-C extracts demonstrated slight cytotoxicity, while all the other tested specimens had no cytotoxicity.</p><p><strong>Discussion: </strong>In conclusion, the novel bioceramic medication might be used as a suitable alternative agent to the traditional calcium hydroxide cements due to its biological and physicochemical properties. However, further studies on the ability of removing Bio-C from root canal are required to determine whether such a temporary bioceramic can ameliorate root canal treatments.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1451275"},"PeriodicalIF":1.5,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}