Frontiers in dental medicine最新文献

{"title":"Implant-supported prosthesis under progressive loading protocol stimulates alveolar bone growth in patients with severe alveolar bone atrophy. Retrospective case series.","authors":"Eduardo Anitua, Laura Piñas, Mohammad H Alkhraisat","doi":"10.3389/fdmed.2024.1465137","DOIUrl":"10.3389/fdmed.2024.1465137","url":null,"abstract":"<p><strong>Introduction: </strong>The jaw with severe bone atrophy is a difficult challenge when rehabilitating with dental implants. To be able to place dental implants in the most severe cases and to achieve an increase in bone volume by means of the tension transmitted by the load is a novelty. This work provides data on the alveolar bone changes in a severely atrophic mandible that has been treated with implant supported prosthesis under progressive loading protocol.</p><p><strong>Material and methods: </strong>This study reported on 3 patients with completely edentulous mandible. In all cases, implants were inserted in the anterior region of the mandible and progressive loading was carried out with an increase in the distal cantilever. The length of the cantilever extension was adapted to growth of the residual alveolar bone at the mandible body. The increase in bone height was controlled in the area of implant placement as well as in the area distal to the implants (1 cm behind the last implant).</p><p><strong>Results: </strong>This case series described 3 patients where 13 implants were placed. The patients were followed for 17, 19 and 20 years after implants insertion. The mean mandibular residual height of the alveolar bone was 7.8 ± 2.7 mm at the implant site. The mean mandibular body height at 1.0 cm distal to the last implant was 7.0 ± 3.9 mm in the third quadrant and 8.1 ± 4.4 mm in the fourth quadrant. The mean height at the last follow-up was 11.0 ± 3.2 mm (±3.2) in the third quadrant and 11.20 ± 4.4 mm in the fourth quadrant.</p><p><strong>Conclusions: </strong>Implant-supported prosthesis and progressive loading have resulted in vertical bone growth in a series of patients with extreme atrophy of the mandible. The long-term follow-up indicated that bone growth is confined to the dental implants but has been extended to distant regions resulting in the thickening of the mandibular body and the creation of the absent mandibular canal.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1465137"},"PeriodicalIF":1.5,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development status of mouthguard.","authors":"Wang Biqi, Wang Xinyu","doi":"10.3389/fdmed.2024.1513223","DOIUrl":"10.3389/fdmed.2024.1513223","url":null,"abstract":"<p><p>The mouthguard plays a crucial role in preventing damage to the oral and jaw system. However, the popularity of sports mouthguards remains relatively low, and research on sports mouthguards is rather scattered. This paper primarily summarizes the characteristics of materials, production methods, protection principles, and influencing factors of mouthguards, with the aim of providing a theoretical reference for the popularization and application of mouthguards.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1513223"},"PeriodicalIF":1.5,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphology and thickness of the buccal bone wall of the maxillary central incisors in population: a CBCT study.","authors":"Yaping Song, Song Yang, Chao Wang","doi":"10.3389/fdmed.2024.1472028","DOIUrl":"10.3389/fdmed.2024.1472028","url":null,"abstract":"<p><p>The objective of this study was to measure and analyze the anatomical morphology and thickness of the buccal bone wall (BBW) of the maxillary central incisors, providing a theoretical basis for immediate implant surgery. A total of 372 maxillary central incisors were collected and classified into B and P types based on the root position and the degree of coverage of the BBW. The cases were divided into male and female groups, with 180 males and 192 females. The thickness of the BBW was measured at three measurement locations: 4 mm apical to the cementoenamel junction (CEJ), the mid-root, and the root apex. The number and proportion of various types of BBW are as follows: B1 (54, 14.52%), B2 (72, 19.35%), B3 (61, 16.40%), P1 (76, 20.43%), P2 (66, 17.74%), and P3 (43, 11.56%). In the B type group, the thickest BBW at 4 mm apical to the CEJ and the mid-root was observed in B3 (0.89 mm ± 0.09 mm, 0.56 mm ± 0.07 mm). The thickest BBW at the root apex was observed in B2 (0.46 mm ± 0.05 mm). In the P-type group, the thickest BBW at all three measurement locations was observed in P3 (1.10 mm ± 0.08 mm, 1.04 mm ± 0.11 mm, 3.59 mm ± 0.12 mm). The BBW of the maxillary central incisors in males was thicker than that in females. The conclusion drawn was that most BBW of the maxillary central incisors are thin, with a portion of the maxillary central incisors having only a thin BBW coverage at 4 mm apical to the CEJ and no significant bone wall coverage elsewhere. This Type of maxillary central incisor presents a higher risk of buccal soft and hard tissue recession and even bone fenestration after implant surgery. It is, therefore, crucial to assess the three-dimensional position of the root and measure the thickness of the BBW using Cone-beam computed tomography (CBCT).</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1472028"},"PeriodicalIF":1.5,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automated machine learning for image-based detection of dental plaque on permanent teeth.","authors":"Teerachate Nantakeeratipat, Natchapon Apisaksirikul, Boonyaon Boonrojsaree, Sirapob Boonkijkullatat, Arida Simaphichet","doi":"10.3389/fdmed.2024.1507705","DOIUrl":"10.3389/fdmed.2024.1507705","url":null,"abstract":"<p><strong>Introduction: </strong>To detect dental plaque, manual assessment and plaque-disclosing dyes are commonly used. However, they are time-consuming and prone to human error. This study aims to investigate the feasibility of using Google Cloud's Vertex artificial intelligence (AI) automated machine learning (AutoML) to develop a model for detecting dental plaque levels on permanent teeth using undyed photographic images.</p><p><strong>Methods: </strong>Photographic images of both undyed and corresponding erythrosine solution-dyed upper anterior permanent teeth from 100 dental students were captured using a smartphone camera. All photos were cropped to individual tooth images. Dyed images were analyzed to classify plaque levels based on the percentage of dyed surface area: mild (<30%), moderate (30%-60%), and heavy (>60%) categories. These true labels were used as the ground truth for undyed images. Two AutoML models, a three-class model (mild, moderate, heavy plaque) and a two-class model (acceptable vs. unacceptable plaque), were developed using undyed images in Vertex AI environment. Both models were evaluated based on precision, recall, and F1-score.</p><p><strong>Results: </strong>The three-class model achieved an average precision of 0.907, with the highest precision (0.983) in the heavy plaque category. Misclassifications were more common in the mild and moderate categories. The two-class acceptable-unacceptable model demonstrated improved performance with an average precision of 0.964 and an F1-score of 0.931.</p><p><strong>Conclusion: </strong>This study demonstrated the potential of Vertex AI AutoML for non-invasive detection of dental plaque. While the two-class model showed promise for clinical use, further studies with larger datasets are recommended to enhance model generalization and real-world applicability.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1507705"},"PeriodicalIF":1.5,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scale dependent nanomechanical properties of dentin adhesive and adhesive-collagen composite.","authors":"Viraj Singh, Ranganathan Parthasarathy, Qiang Ye, Paulette Spencer, Anil Misra","doi":"10.3389/fdmed.2024.1423461","DOIUrl":"10.3389/fdmed.2024.1423461","url":null,"abstract":"<p><p>The complex micrometer construct at the interface that joins the composite material to the tooth surface in restorative dentistry is composed of the composite formed by infiltrating adhesive into demineralized dentin (collagen matrix). The overall performance of composite restorations is therefore directly linked to the properties of the polymerized adhesive and adhesive-collagen composite. Nanoindentation and nanoDMA tests are performed on model methacrylate based adhesive and collagen-adhesive composite to study their mechanical properties. The adhesive collagen composite is prepared by the infiltration of dentin adhesive into a completely demineralized bovine dentin. The obtained experimental results show that both the neat adhesive and the collagen-adhesive composite are heterogeneous materials at the spatial scales of property interrogation. It is also found that the reduced elastic modulus generally decreases with increasing indentation contact depth reaching an asymptote for both neat adhesive and collagen-adhesive composite. This reduced modulus behavior can be attributed to the increase in the indentation interaction volume. In addition, the measured frequency dependent storage and loss moduli indicate that both the neat adhesive and collagen adhesive composites are viscoelastic materials which are likely to exhibit creep deformation and rate-dependent behavior in physiological function.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1423461"},"PeriodicalIF":1.5,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of air-particle abrasion and methacryloyloxydecyl phosphate primer on fracture load of thin zirconia crowns: an <i>in vitro</i> study.","authors":"Ruwaida Z Alshali, Mohammed A Alqahtani, Basem N Alturki, Loay I Algizani, Abdullah O Batarfi, Zuhair K Alshamrani, Razan M Faden, Dalea M Bukhary, Mosa M Altassan","doi":"10.3389/fdmed.2024.1501909","DOIUrl":"10.3389/fdmed.2024.1501909","url":null,"abstract":"<p><p>The study aimed to investigate the effects of airborne-particle abrasion (APA) and 10-methacryloxydecyl dihydrogen phosphate (10-MDP primer) surface treatments on the fracture load of thin zirconia crowns made from 3Y-TZP and 5Y-PSZ zirconia. Eighty full-contour zirconia crowns of 0.5 mm thickness were fabricated from 3Y-TZP and 5Y-PSZ zirconia. Crowns of each material were divided into four groups based on the surface treatment applied to the fitting surface (<i>n</i> = 10): Group 1 (control), Group 2 (10-MDP Primer Only), Group 3 (APA Only), and Group 4 (10-MDP Primer + APA). Crowns were cemented using self-adhesive resin cement and subjected to thermocycling. Fracture load tests were performed using a universal testing machine with a hemispherical indenter. Statistical analysis was performed using one-way ANOVA, Tukey's <i>post hoc</i> test, and independent samples <i>T</i>-test (<i>α</i> = 0.05). The fracture load of 3Y-TZP was significantly higher than 5Y-PSZ crowns across all groups (<i>P</i> ≤ 0.001). Group 1 had the lowest fracture load, while Group 4 had the highest for both materials. In 3Y-TZP, the fracture load of Group 2 increased by 40% (<i>P</i> = 0.002) and Group 3 by 50% (<i>P</i> < 0.001) compared to Group 1. Group 4 showed a 90% increase over Group 1 (<i>P</i> < 0.001). For 5Y-PSZ, fracture load of Group 4 increased by 70% compared to Group 1 (<i>P</i> < 0.001). It was concluded that applying a 10-MDP primer or APA significantly increases the fracture load of thin 3Y-TZP zirconia crowns, with the combination of both treatments yielding the highest values. For 5Y-PSZ, a significant increase in fracture load is observed only when both APA and the 10-MDP primer are used together.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1501909"},"PeriodicalIF":1.5,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: Development and eruption of human teeth in the Chinese population: a comprehensive dental atlas.","authors":"Jayakumar Jayaraman","doi":"10.3389/fdmed.2024.1504277","DOIUrl":"https://doi.org/10.3389/fdmed.2024.1504277","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fdmed.2024.1434417.].</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1504277"},"PeriodicalIF":1.5,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating knowledge and awareness of 3D design and printing among dental students in Saudi Arabia: a cross-sectional study.","authors":"Hamdan Alamri, Falah R Alshammari, Abdullah Bin Rahmah, Mohammed I Alsaif, Farah Almutairi, Hissah Alolaywi, Aroub Altariqi, Sarah Alotaibi, Rahaf Almutairi, Hossam Almadhoon, Hani S AlMoharib","doi":"10.3389/fdmed.2024.1466393","DOIUrl":"10.3389/fdmed.2024.1466393","url":null,"abstract":"<p><strong>Introduction: </strong>As 3D design and printing technology gains popularity, there remains limited evidence on dental students' perceptions in Saudi Arabia regarding its use. This study aims to assess the knowledge and awareness of dental students in Saudi Arabia about 3D design and printing technology.</p><p><strong>Methods: </strong>A cross-sectional questionnaire-based study was conducted among dental students in their third, fourth, and fifth years at multiple universities in Saudi Arabia between February and October 2023. A validated self-administered questionnaire with 15 close-ended items, including demographic and knowledge-related questions about 3D design and printing, was used. Statistical analysis was performed using Chi-square and Fisher exact tests to identify factors associated with knowledge and awareness levels.</p><p><strong>Results: </strong>A total of 374 dental students participated in the study, with 63.1% being female students. Of the participants, 40.4% identified the cost of equipment as the primary barrier to 3D printing usage in dentistry in Saudi Arabia. The majority (94.4%) recognized the advantages of 3D models for implant placement. Awareness of 3D printing utilization in the field was reported by 69.3% of participants, and 74.3% acknowledged its increasing popularity. Furthermore, 73.8% of participants expressed confidence in the biocompatibility and safety of 3D printed materials. A significant percentage (64.0%) were aware of 3D printing's role in creating Invisalign aligners, and 42.4% believed in the value of 3D printed drill guides for root canal treatment. The study found statistically significant regional differences (<i>p</i> < 0.05) across all questions. Participants primarily relied on colleges (64.8%) as their source of information, and a high proportion (82.4%) expressed interest in further exploring the usage of 3D printing in dentistry.</p><p><strong>Conclusion: </strong>Our study found that students' knowledge and awareness in Saudi Arabia are generally satisfactory. Integrating 3D printing into dental curricula and providing workshops is crucial to meet dental students' interest in exploring its usage and equipping them for its future implementation.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1466393"},"PeriodicalIF":1.5,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic analysis of potential markers and therapeutic targets for immunity in periodontitis.","authors":"Hui Li, Wanqing Du, Xin Ye, Xi Luo, Xuejing Duan","doi":"10.3389/fdmed.2024.1480346","DOIUrl":"10.3389/fdmed.2024.1480346","url":null,"abstract":"<p><strong>Objective: </strong>Periodontitis is a chronic inflammatory periodontal disease resulting in destroyed periodontal tissue. Many studies have found that the host's inflammatory immune responses are involved in the risk of periodontal tissue damage. In this study, we aim to identify potential biomarkers and therapeutic targets related to immunity in periodontitis.</p><p><strong>Methods: </strong>GSE16134 and GSE10334 were downloaded from the Gene Expression Omnibus (GEO) database, and the immune-related genes were obtained from the Immunology Database and Analysis Portal (ImmPort). After the differentially expressed immune-related genes (DE-IRGs) were identified, enrichment analysis was performed. Two machine learning methods, the least absolute shrinkage and selector operation (LASSO) logistic regression and the support vector machine-recursive feature elimination (SVM-RFE), were used to screen out potential markers for the diagnosis of periodontitis. The CIBERSORT algorithm and LM22 matrix were used to analyze the percentage of infiltrating immune cells in periodontitis. Finally, the potential drug targets for the selected immune-related marker genes were predicted using relevant databases.</p><p><strong>Results: </strong>A total of 7 genes (CD19, CXCR4, FABP4, FOS, IGHD, IL2RG, and PPBP) were upregulated in periodontitis samples. The area under the receiver operating characteristic curve (AUC) value of only one gene for distinguishing periodontitis from healthy samples ranged from 0.724 to 0.894. The prediction ability of the combined risk score of these 7 DE-IRGs was improved (AUC = 0.955). Naïve B cells, neutrophils, plasma cells, and activated memory CD4 T cells were significantly enriched in periodontitis samples, and 25 drugs targeting 4 DE-IRGs were predicted.</p><p><strong>Conclusion: </strong>We developed a diagnostic model based on seven IRGs for periodontitis. The possible drugs targeting IRGs may provide new ideas for periodontitis treatment.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1480346"},"PeriodicalIF":1.5,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral health-related quality of life in Northland Māori children and adolescents with Polynesian amelogenesis imperfecta.","authors":"Michelle Martin, Sunitha Gowda, Lyndie Foster Page, W Murray Thomson","doi":"10.3389/fdmed.2024.1485419","DOIUrl":"10.3389/fdmed.2024.1485419","url":null,"abstract":"<p><strong>Introduction: </strong>Amelogenesis Imperfecta (AI) is a hereditary developmental disorder of tooth enamel with few known variants with differing characteristics, depending on where in the amelogenesis process an error has occurred. Polynesian AI (or Poly AI) is prevalent among people of Polynesian descent and is prevalent among New Zealand Māori. While the impact of AI on the quality of life has been reported in some studies, however, the role of Poly AI on oral health-related quality of life (OHRQoL) is not known. This study explores OHRQoL among New Zealand Māori with and without AI.</p><p><strong>Methods: </strong>A cross-sectional study was undertaken, with ethical approval obtained from the New Zealand Health and Disability Ethics Committee. 30 Māori children and adolescents with Poly AI and 60 Māori children and adolescents with no Poly AI as the comparison group matched by age and sex, were randomly selected and recruited participated in the study. OHRQoL was measured using the 19-item COHIP-SF.</p><p><strong>Results: </strong>Statistically significant differences were observed in the OHRQoL between those with Poly AI and the comparison group. Linear regression analyses controlling for age and deprivation showed significantly poorer OHRQoL among those with Poly AI than in those with no Poly AI.</p><p><strong>Discussion: </strong>The study findings highlight poorer OHRQoL among Māori children with Poly AI, emphasizing the need for early detection and management of the condition and the importance of providing appropriate training in diagnosing Poly AI and managing hypersensitivity. Further research among Polynesian populations is needed to understand the impact OHRQoL among those with Poly AI.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1485419"},"PeriodicalIF":1.5,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}