Frontiers in dental medicine最新文献_第9页

Anesthetic-, irrigation- and pain-free dentistry? The case for a femtosecond laser enabled intraoral robotic device 麻醉、冲洗和无痛牙科？飞秒激光口腔内机器人装置的案例

Frontiers in dental medicine Pub Date : 2022-08-23 DOI: 10.3389/fdmed.2022.976097

L. Rapp, S. Madden, A. Rode, L. Walsh, H. Spallek, Q. Nguyen, V. Dau, P. Woodfield, D. Dao, Omar Zuaiter, Alaa Habeb, T. Hirst

{"title":"Anesthetic-, irrigation- and pain-free dentistry? The case for a femtosecond laser enabled intraoral robotic device","authors":"L. Rapp, S. Madden, A. Rode, L. Walsh, H. Spallek, Q. Nguyen, V. Dau, P. Woodfield, D. Dao, Omar Zuaiter, Alaa Habeb, T. Hirst","doi":"10.3389/fdmed.2022.976097","DOIUrl":"https://doi.org/10.3389/fdmed.2022.976097","url":null,"abstract":"By leveraging ultrashort pulse laser and micro-electromechanical systems (MEMS) technologies, we are developing a miniaturized intraoral dental robotic device that clamps onto teeth, is remotely controlled, and equipped with a focusing and scanning system to perform efficient, fast, and ultra-precise laser treatments of teeth and dental restorative materials. The device will be supported by a real-time monitoring system for visualization and diagnostic analysis with appropriate digital controls. It will liberate dentists from repetitive manual operations, physical strain and proximity to the patient's oro-pharyngal area that potentially contains infectious agents. The technology will provide patients with high-accuracy, minimally invasive and pain-free treatment. Unlike conventional lasers, femtosecond lasers can ablate all materials without generating heat, thus negating the need for water irrigation, allowing for a clear field of view, and lowering cross-infection hazards. Additionally, dentists can check, analyze, and perform precise cutting of tooth structure with automatic correction, reducing human error. Performing early-stage diagnosis and intervention remotely will be possible through units installed at schools, rural health centers and aged care facilities. Not only can the combination of femtosecond lasers, robotics and MEMS provide practical solutions to dentistry's enduring issues by allowing more precise, efficient, and predictable treatment, but it will also lead to improving the overall access to oral healthcare for communities at large.","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45556581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Hallermann–Streiff syndrome: Case report with abnormal pulp calcifications Hallermann–Streiff综合征：牙髓钙化异常病例报告

Frontiers in dental medicine Pub Date : 2022-08-12 DOI: 10.3389/fdmed.2022.965560

Nour Ammar, Magda M. El-Tekeya

引用次数: 1

Case Report: Applicability of sedation with nitrous oxide in the management of molar incisor hypomineralization in pediatric patients 病例报告:一氧化二氮镇静治疗小儿磨牙切牙低矿化的适用性

Frontiers in dental medicine Pub Date : 2022-08-04 DOI: 10.3389/fdmed.2022.962113

K. Molena, R. Lima, Taíssa Cássia de Souza Fortunato, A. M. Queiroz, F. Carvalho, M. M. Arnez, F. Paula-Silva

{"title":"Case Report: Applicability of sedation with nitrous oxide in the management of molar incisor hypomineralization in pediatric patients","authors":"K. Molena, R. Lima, Taíssa Cássia de Souza Fortunato, A. M. Queiroz, F. Carvalho, M. M. Arnez, F. Paula-Silva","doi":"10.3389/fdmed.2022.962113","DOIUrl":"https://doi.org/10.3389/fdmed.2022.962113","url":null,"abstract":"Patients with molar-incisor hypomineralization (MIH) may manifest tooth hfypersensitivity and difficulties in undergoing dental treatment, including fear, anxiety, and behavior problems in the dental office. Then, the objective of this study was to report a clinical case series using inhalation sedation with nitrous oxide and oxygen as a clinical strategy in the management of MIH pediatric patients during dental treatment. Pediatric patients and their legal guardians were properly informed and data were extracted from clinical charts. Six clinical cases were included, whose patients were between 8 and 12 years old. Of these, 4 were female. The indication of moderate sedation took into account the clinical difficulties related to patients with MIH, such as obtaining anesthesia and cooperation, in addition to odontophobia and dental anxiety. All patients were carefully examined to undergo the sedation technique, including medical history and previous experiences with nitrous oxide inhalation sedation, as well as the vital signs were properly evaluated before, during and after the procedures. The nitrous oxide concentration ranged between 30% and 60%. The procedures were restorative, endodontic or surgical (extractions). In general, the use of sedation contributed to the performance of dental procedures. The use of inhaled sedation helped in behavioral management and during the treatment, increasing the effectiveness of local anesthesia. Patients were cooperative for treatment, while no adverse effects or complications related to sedation were observed. Thus, for the patients in this case series, the use of inhalation sedation with nitrous oxide and oxygen contributed to the clinical management of patients with MIH.","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43314618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effects of inflammation in dental pulp cell differentiation and reparative response 炎症对牙髓细胞分化和修复反应的影响

Frontiers in dental medicine Pub Date : 2022-08-02 DOI: 10.3389/fdmed.2022.942714

Francine Lorencetti-Silva, L. Sales, Giuliana Campos Chaves Lamarque, Giovana Amorim Caixeta, M. M. Arnez, L. Faccioli, F. W. G. Paula-Silva

{"title":"Effects of inflammation in dental pulp cell differentiation and reparative response","authors":"Francine Lorencetti-Silva, L. Sales, Giuliana Campos Chaves Lamarque, Giovana Amorim Caixeta, M. M. Arnez, L. Faccioli, F. W. G. Paula-Silva","doi":"10.3389/fdmed.2022.942714","DOIUrl":"https://doi.org/10.3389/fdmed.2022.942714","url":null,"abstract":"The responsiveness of the dentin-pulp complex is possible due to the stimulation of dental pulp cells, which begin to synthesize and secrete dentin matrix. The inflammatory process generated by harmful stimuli should be understood as a natural event of the immune response, resulting in the recruitment of hematopoietic cells, which cross the endothelial barrier and reach the site affected by the injury in order to eliminate the damage and provide an appropriate environment for the restoration of homeostasis. The repair process occurs in the presence of adequate blood supply, absence of infection, and with the participation of pro-inflammatory cytokines, growth factors, extracellular matrix components, and other biologically active molecules. Prostaglandins and leukotrienes are bioactive molecules derived from the metabolism of arachidonic acid, as a result of a variable range of cellular stimuli. The aim of this review is to describe the process of formation and biomineralization of the dentin-pulp complex and how pro-inflammatory events can modify this response, with emphasis on the lipid mediators prostaglandins and leukotrienes derived from arachidonic acid metabolism.","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48250506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Does the RGD region of certain proteins affect metabolic activity? 某些蛋白质的RGD区是否影响代谢活性?

Frontiers in dental medicine Pub Date : 2022-07-27 DOI: 10.3389/fdmed.2022.974862

K. Nagasaki, O. Gavrilova, G. Hajishengallis, M. Somerman

{"title":"Does the RGD region of certain proteins affect metabolic activity?","authors":"K. Nagasaki, O. Gavrilova, G. Hajishengallis, M. Somerman","doi":"10.3389/fdmed.2022.974862","DOIUrl":"https://doi.org/10.3389/fdmed.2022.974862","url":null,"abstract":"A better understanding of the role of mineralized tissues and their associated factors in governing whole-body metabolism should be of value toward informing clinical strategies to treat mineralized tissue and metabolic disorders, such as diabetes and obesity. This perspective provides evidence suggesting a role for the arginine-glycine-aspartic acid (RGD) region, a sequence identified in several proteins secreted by bone cells, as well as other cells, in modulating systemic metabolic activity. We focus on (a) two of the SIBLING (small integrin-binding ligand, N-linked glycoprotein) family genes/proteins, bone sialoprotein (BSP) and osteopontin (OPN), (b) insulin-like growth factor-binding protein-1 & 2 (IGFBP-1, IGFBP-2) and (c) developmental endothelial locus 1 (DEL1) and milk fat globule–EGF factor-8 (MFG-E8). In addition, for our readers to appreciate the mounting evidence that a multitude of bone secreted factors affect the activity of other tissues, we provide a brief overview of other proteins, to include fibroblast growth factor 23 (FGF23), phosphatase orphan 1 (PHOSPHO1), osteocalcin (OCN/BGLAP), tissue non-specific alkaline phosphatase (TNAP) and acidic serine aspartic-rich MEPE-associated motif (ASARM), along with known/suggested functions of these factors in influencing energy metabolism.","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48919834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effect of switching from cigarette smoking to the use of the tobacco heating system on periodontitis treatment outcome: Periodontal parameter results from a multicenter Japanese study 从吸烟转向使用烟草加热系统对牙周炎治疗结果的影响:来自日本多中心研究的牙周参数结果

Frontiers in dental medicine Pub Date : 2022-07-22 DOI: 10.3389/fdmed.2022.915079

S. Pouly, Weeteck Ng, N. Blanc, P. Hession, Filippo Zanetti, J. Battey, G. de La Bourdonnaye, A. Heremans, C. Haziza

{"title":"Effect of switching from cigarette smoking to the use of the tobacco heating system on periodontitis treatment outcome: Periodontal parameter results from a multicenter Japanese study","authors":"S. Pouly, Weeteck Ng, N. Blanc, P. Hession, Filippo Zanetti, J. Battey, G. de La Bourdonnaye, A. Heremans, C. Haziza","doi":"10.3389/fdmed.2022.915079","DOIUrl":"https://doi.org/10.3389/fdmed.2022.915079","url":null,"abstract":"Objectives We conducted a 6-month randomized clinical study to evaluate the impact of exposure to the aerosol of the Tobacco Heating System (THS), a smoke-free alternative to cigarettes, on changes in periodontal parameters after scaling and root planing (SRP) for periodontitis in subjects who were either continuing to smoke cigarettes or had switched to THS. Material and methods Smokers with generalized periodontitis were randomized to continue smoking cigarettes or switch to THS use. They underwent SRP for up to 8 weeks, with dental assessments conducted at baseline and at 3 and 6 months after the first treatment. Results After SRP treatment, all groups showed improvements in the mean full-mouth probing depth (PD), full-mouth clinical attachment level (CAL), gingival inflammation score, plaque control record (PCR), and bleeding on probing (BoP). There were no statistically significant intergroup differences. However, as compared to smokers, THS users showed a trend toward more favorable outcomes in BoP, PCR, and PD improvement at sites with higher initial PD (≥7 mm). Conclusions Our results indicate that SRP improves the course of periodontitis similarly in cigarette smokers and THS users. The beneficial effects of this treatment might mask the favorable changes that may occur upon modifying one of the several periodontitis risk factors, such as cigarette smoking. Clinical trial registration ClinicalTrials.gov, identifer: NCT03364751.","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45120089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Editorial: Insights in systems integration: 2021 社论：系统集成的见解：2021

Frontiers in dental medicine Pub Date : 2022-07-18 DOI: 10.3389/fdmed.2022.972134

F. Nociti

引用次数: 0

Editorial: Omics Research for Pediatric Dentistry in Health and Disease 社论：奥密克戎对儿童牙科健康与疾病的研究

Frontiers in dental medicine Pub Date : 2022-07-15 DOI: 10.3389/fdmed.2022.959479

A. Ribeiro, Adriana Modesto Vieira, M. Portela, Robert S. Jones

引用次数: 0

A pioneer surgical technique for isolated periodontal defects by “closed” retraction of the papilla; A feasibility study 通过乳头“闭合”回缩治疗孤立性牙周缺损的先驱手术技术；可行性研究

Frontiers in dental medicine Pub Date : 2022-07-15 DOI: 10.3389/fdmed.2022.956601

D. Apatzidou

{"title":"A pioneer surgical technique for isolated periodontal defects by “closed” retraction of the papilla; A feasibility study","authors":"D. Apatzidou","doi":"10.3389/fdmed.2022.956601","DOIUrl":"https://doi.org/10.3389/fdmed.2022.956601","url":null,"abstract":"Aim A pioneer periodontal surgical approach employing the closed surgical technique (CST) in combination with the tissue-engineered biocomplex aimed to gain access to the osseous defect and improve soft-tissue architecture. Methods The CST was applied in four systemically healthy periodontitis patients/defects who were followed for 12-months. It avoids papilla dissection and retraction of flaps in an open manner thus, suturing is not required. It is designed for the reconstruction of residual isolated periodontal defects and is best indicated in the aesthetic region. It can be applied as a sole treatment approach to facilitate deep instrumentation of the defect, or it could be combined with subgingival application of regenerative materials. Hereby, the biocomplex was applied containing autologous alveolar Bone-Marrow Mesenchymal-Stem-Cells, seeded into collagen scaffolds, enriched with autologous fibrin/platelet lysate. Results The CST minimized post-operative discomfort and led to improved treatment outcomes with probing pocket depth reduction [average (SD)] of 24.4 (18.5) %, gain in clinical attachment levels of 25.8 (20.1) %, and evidence of remineralisation of the alveolar crest. Conclusion The CST is a tissue-friendly operation and facilitates subgingival application of biological agents via tunneling the soft-tissues. However, surgical experience is required for non-traumatic manipulation of the gingival tissues during “closed” retraction of the flaps. Clinical trial registration Registered with Clinicaltrials.gov; ClinicalTrials.gov ID: NCT02449005.","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41924067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Local Drug-Induced Modulation of gp130 Receptor Signaling Delays Disease Progression in a Pig Model of Temporo-Mandibular Joint Osteoarthritis 在猪颞下颌关节骨关节炎模型中，局部药物诱导的gp130受体信号调节延迟疾病进展

Frontiers in dental medicine Pub Date : 2022-07-11 DOI: 10.3389/fdmed.2022.937819

N. Liu, Shuo Chen, Dawei Geng, Jie Lei, Jiankang Zhang, Liangliang Li, Yu-cheng Lin, Yuxin B. Ouyang, R. Shkhyan, B. van Handel, Fangzhou Bian, Tadiwanashe Mkaratigwa, Y. Chai, D. Evseenko

{"title":"Local Drug-Induced Modulation of gp130 Receptor Signaling Delays Disease Progression in a Pig Model of Temporo-Mandibular Joint Osteoarthritis","authors":"N. Liu, Shuo Chen, Dawei Geng, Jie Lei, Jiankang Zhang, Liangliang Li, Yu-cheng Lin, Yuxin B. Ouyang, R. Shkhyan, B. van Handel, Fangzhou Bian, Tadiwanashe Mkaratigwa, Y. Chai, D. Evseenko","doi":"10.3389/fdmed.2022.937819","DOIUrl":"https://doi.org/10.3389/fdmed.2022.937819","url":null,"abstract":"Temporomandibular joint disorders (TMJs) are a multifaceted group of chronic disorders characterized by stiffness in the jaw, limited jaw mobility and pain when opening or closing the mouth. TMJs are relatively common, with incidence rates in the range of 5–12%, with nearly twice as many women as men being affected. One of the primary causes of TMJs is a degenerative disease of joints, such as osteoarthritis (OA), characterized by progressive loss of cartilage which causes stiffness, swelling, and pain. Currently, there are no disease-modifying agents on the market for OA. We have recently discovered a small molecule, R805 acting as a modulator of glycoprotein 130 (gp130) receptor for IL-6 family of cytokines. R805 enables regenerative outputs of endogenous joint stem and progenitor cells through immunomodulation in the joint microenvironment by reducing the levels of destructive cytokines and supporting chondrocyte survival and anabolism. Extensive testing has shown R805 to be safe at doses far above the therapeutic level. Here, we have conducted a pivotal efficacy study in our newly-established pig model of TMJ post-traumatic OA. IA injection of R805 has shown a highly significant reduction of articular cartilage degeneration, reduced synovitis and degenerative changes in subchondral bone in the mandibular condyle compared to the vehicle-treated group. These data will support additional pre-clinical development of R805 as a first-in-class injectable therapeutic for TMJ osteoarthritis.","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46463067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0