Frontiers in dental medicine最新文献

{"title":"Effect of the implantoplasty techniques on the fracture resistance of dental implants. Systematic review and meta-analysis.","authors":"Giovanni Pissu, Javier Flores-Fraile, Álvaro Zubizarreta-Macho, José María Montiel-Company, Ana Belén Lobo-Galindo","doi":"10.3389/fdmed.2025.1568465","DOIUrl":"https://doi.org/10.3389/fdmed.2025.1568465","url":null,"abstract":"<p><p>The aim of this systematic review and meta-analysis was to analyze and compare the effect of diamond drill, tungsten carbide drill and ultrasound tips for implantoplasty procedures on the fracture resistance of dental implants affected by periimplant disease.</p><p><strong>Materials and methods: </strong>This systematic review of the scientific literature and meta-analysis was carried out based on the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), analyzing all studies that evaluated the fracture resistance of dental implants submitted to implantoplasty through diamond drill, tungsten carbide drill and ultrasound tips for implantoplasty procedures, comparing with the fracture resistance values of non-treated dental implants. A total of 4 databases were searched in the literature: Pubmed, Scopus, Cochrane and Web of Science. After eliminating duplicate articles and applying certain inclusion criteria, a total of 9 articles were selected and compared using the random effects model and inverse variance method. The significance of the effect size was measured with the <i>z</i> test, the heterogeneity using the <i>Q</i> test and the <i>I</i> ² and publication bias was analyzed using the trim-and-fill method.</p><p><strong>Results: </strong>The difference in means between the treatment and control groups was estimated as the effect size, obtaining a statistically significant difference of -232.01 MPa., with a 95% confidence interval of the difference between -417.3 and -44.71 (<i>z</i> test = -2.43; <i>p</i>-value = 0.015). The meta-analysis has presented high heterogeneity with an <i>I</i> ² = 99.3% and a <i>Q</i> test = 2,195.7; <i>p</i>-value < 0.001. No significant differences were found between the three subgroups with the <i>Q</i> test = 0.20: <i>p</i>-value = 0.903.</p><p><strong>Conclusions: </strong>the tungsten carbide drills resulted in less fracture resistance loss than the diamond and tungsten carbide drills for the dental implants submitted to implantoplasty procedures. <b>Systematic Review Registration</b>: [http://www.prisma-statement.org], identifier [INPLASY202460018].</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1568465"},"PeriodicalIF":1.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: Evaluation of sleep position shifts in patients with obstructive sleep apnea syndrome with the use of a mandibular advancement device.","authors":"Domenico Ciavarella, Donatella Ferrara, Carlotta Fanelli, Graziano Montaruli, Giuseppe Burlon, Michele Laurenziello, Lucio Lo Russo, Fariba Esperouz, Michele Tepedino, Mauro Lorusso","doi":"10.3389/fdmed.2025.1593050","DOIUrl":"10.3389/fdmed.2025.1593050","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fdmed.2025.1524334.].</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1593050"},"PeriodicalIF":1.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of bestatin as a treatment for periodontitis.","authors":"Sudhir Rama Varma, Bader Mohamed Moustafa Elagha, Jayaraj K Narayanan, Asok Mathew","doi":"10.3389/fdmed.2025.1571989","DOIUrl":"10.3389/fdmed.2025.1571989","url":null,"abstract":"<p><p>Periodontitis is a chronic inflammatory disease impacting the supporting structures of teeth, with significant global pervasiveness and systemic health implications. Current treatments, such as scaling and root planning (SRP) and adjunctive antibiotics, face challenges including antibiotic resistance, infection recurrence, and incomplete tissue regeneration. Bestatin, a dipeptide aminopeptidase inhibitor, has shown potential as a novel therapeutic agent due to its targeted antimicrobial effects against <i>Porphyromonas gingivalis (P. gingivalis),</i> biofilm modulation, and anti-inflammatory properties. <i>in vitro</i> studies revealed bestatin's selective bacteriostatic effects against P. gingivalis, inhibiting bacterial growth and biofilm development without affecting commensal bacteria. <i>in vivo</i> studies demonstrated that bestatin modulated inflammatory responses and prevented necrotic abscess formation in guinea pig models, suggesting its potential to suppress <i>P. gingivalis</i> growth through alternative pathways. However, no clinical trials were identified, highlighting a significant gap in the translation of preclinical findings into human periodontal therapy. The current review highlights Bestatin as a promising therapeutic representative for periodontitis, where it is involved in inhibiting modulating biofilms, reducing tissue destruction, and <i>P. gingivalis</i>, in preclinical studies. Compared to traditional therapies, bestatin provides unique advantages, non-cytotoxicity, including specificity, and dual action against microbial dysbiosis along with biofilm-associated resistance.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1571989"},"PeriodicalIF":1.5,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of nitrate-containing arugula juice on nitrate-reducing oral bacteria and periodontopathogens in smokers' biofilm.","authors":"Boy M Bachtiar, Irene E Rieuwpassa, Heni Susilowati, Retno Indrawati, Citra F Theodorea, Turmidzi Fath, Endang W Bachtiar","doi":"10.3389/fdmed.2025.1545479","DOIUrl":"10.3389/fdmed.2025.1545479","url":null,"abstract":"<p><p>Green leafy vegetables such as arugula are rich in nitrates that support oral health, yet their effects on oral microbial balance, especially in smokers, remain unclear. This study evaluated the survival and activity of nitrate-reducing bacteria (NRB; <i>Veillonella</i> spp. and <i>Rothia</i> spp.) in biofilm exposed to nitrate-containing arugula juice (3.25 or 6.25 μM). The proportions of NRB were compared with periodontopathogens (<i>Porphyromonas gingivalis</i> and <i>Fusobacterium nucleatum</i>). Using quantitative real-time PCR (qPCR), we assessed bacterial survival and transcription of nitrate reductase genes (<i>narG</i> and <i>napA</i>) in biofilm from smokers and non-smokers. The results revealed that nitrate-containing arugula juice increased NRB bacteria abundance while reducing periodontopathogen growth. A higher level of nitrate (6.25 μM) increased nitrate reductase expression. Prolonged exposure (9 h) sustained the growth-promoting effect on <i>Rothia</i> spp. These results suggest that non-smokers have more nitrate-reducing bacteria in their biofilm, which promotes oral microbial balance. Thus, smokers might be advised to consume nitrate-containing arugula juice to promote NRB, which may have health benefits.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1545479"},"PeriodicalIF":1.5,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12098498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinically relevant aspects of professional follow-up care for implant patients.","authors":"Philipp Sahrmann, Catherine Giannopoulou","doi":"10.3389/fdmed.2025.1565151","DOIUrl":"10.3389/fdmed.2025.1565151","url":null,"abstract":"<p><p>The detailed 2023 guidelines for the prevention and treatment of peri-implantitis describe evidence-based measures for the professional care and prevention in patients with dental implants. However, there remains a lack of reliable data from randomized clinical trials on many critical points, particularly regarding specific diagnostic steps and treatment decisions, to provide definitive guidance and protocols for implementation during recall sessions in daily practice. This narrative review seeks to address this gap by highlighting the critical aspects of follow-up care that should be monitored during periodontal maintenance to ensure the health of peri-implant tissues and enable timely intervention when peri-implant health is compromised.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1565151"},"PeriodicalIF":1.5,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Updates in pediatric dentistry.","authors":"Jayakumar Jayaraman, Sreekanth Kumar Mallineni","doi":"10.3389/fdmed.2025.1603591","DOIUrl":"https://doi.org/10.3389/fdmed.2025.1603591","url":null,"abstract":"","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1603591"},"PeriodicalIF":1.5,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal evolution of fibroblast responses following salivary gland ductal ligation injury.","authors":"Joey R Tavarez, James Kenney, Sergo Gabunia, Deirdre A Nelson, Melinda Larsen","doi":"10.3389/fdmed.2025.1581376","DOIUrl":"https://doi.org/10.3389/fdmed.2025.1581376","url":null,"abstract":"<p><p>Extracellular matrix remodeling is a natural response to injury but, excessive extracellular matrix accumulation, or fibrosis, is a causative factor in hundreds of diseases that limit organ function, regenerative responses, and can interfere with regenerative therapies. Fibrosis is closely related to inflammation, both of which occur in the salivary glands of patients treated with radiation for head and neck cancers and in patients suffering from autoimmune conditions, such as Sjögren's Disease. Despite the known involvement of fibrosis in disease and the inhibitory effects of fibrosis on tissue regeneration, the mechanisms through which extracellular matrix is elaborated in the salivary gland are poorly understood. Stromal fibroblasts are the primary matrix-producing cells and are known to drive both fibrosis and inflammation. To define the temporal responses of fibroblasts to injury, we induced a temporary obstructive injury though ligation of the primary submandibular and sublingual salivary gland ducts and then performed single-cell RNA sequencing and pathway analysis at timepoints immediately following the injury. Using bioinformatic approaches, we identified three unique fibroblast groups that dynamically respond to the injury. We characterized the changes in matrisomal and inflammatory gene expression over a 7-day time course and identified one group of fibroblasts to be the primary injury-responsive fibrogenic cell type. Understanding how fibroblasts respond at the early and later injury timepoints, along with defining signaling pathways regulated by fibroblasts, could lead to a better understanding of the contribution of fibroblast to acute injury responses to facilitate the development of therapeutics that minimize fibrosis and promote regenerative gland responses in chronic disease states.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1581376"},"PeriodicalIF":1.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influencing factors and survival rates in immediate vs. delayed dental implant placement: a six-year retrospective analysis.","authors":"Yanfei Cheng, Zhifen Lai, Weiguang Yu","doi":"10.3389/fdmed.2025.1563641","DOIUrl":"10.3389/fdmed.2025.1563641","url":null,"abstract":"<p><strong>Objective: </strong>This retrospective cohort study aimed to compare survival rates between immediate (≤24 h post-extraction) and delayed (3-4 months post-extraction) dental implants and to identify patient- and site-specific risk factors for implant failure, with emphasis on anatomical site, sex, and osteoporosis.</p><p><strong>Methods: </strong>We analyzed 1,500 implants (300 immediate, 1,200 delayed) from patients treated at the Guangdong Provincial Hospital of Traditional Chinese Medicine (2005-2023). Kaplan-Meier analysis evaluated cumulative survival rates over 72 months, with Cox regression modeling to assess predictors of failure. Propensity score matching (PSM) addressed baseline covariate imbalances.</p><p><strong>Results: </strong>Delayed implants exhibited significantly higher survival rates than immediate implants at 72 months (81.1% vs. 53.2%, <i>p</i> < 0.0001). Survival divergence intensified after 24 months, with delayed implants retaining 979 patients at risk vs. 202 for immediate implants. Mandibular sites consistently outperformed maxillary sites in both strategies (delayed: 88.5% vs. 72.2%; immediate: 70.5% vs. 40.7%, <i>p</i> < 0.0001). Male sex (HR: 1.64, 95% CI: 1.28-1.88; <i>p</i> < 0.001) and osteoporosis (HR: 2.50, 95% CI: 1.17-4.52; <i>p</i> = 0.024) emerged as independent risk factors, while tobacco use, diabetes, and hypertension showed no significant associations. PSM resolved most baseline imbalances, with post-matching standardized mean differences (SMD) <0.1 for key covariates.</p><p><strong>Conclusions: </strong>Delayed implantation at 3-4 months post-extraction provides superior intermediate-term survival, particularly in mandibular sites. Male patients and individuals with osteoporosis face elevated failure risks, warranting tailored clinical protocols. While both strategies remain viable, delayed placement is recommended for high-risk populations to optimize long-term outcomes.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1563641"},"PeriodicalIF":1.5,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soft-tissue modification in Class III non-growing patients treated with clear aligners: a prospective clinical trial.","authors":"R Lione, C Pavoni, F Gazzani, F C De Razza, L Lugli, P Cozza","doi":"10.3389/fdmed.2025.1584088","DOIUrl":"10.3389/fdmed.2025.1584088","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of the present prospective study was to assess the soft tissue modifications induced by camouflage treatment with clear aligners in adult patients with mild Class III malocclusion.</p><p><strong>Methods: </strong>Patients were consecutively enrolled in the study sample according to the following inclusion criteria: adult age (≥19 years), permanent dentition including second permanent molars, skeletal Class I or slight Class III (-2° < difference between sella-nasion^ point A and sella-nasion^ point B < +2°), normal skeletal divergence pattern (SN^GoGn, 27°-37°), Class III canine and molar relationship at baseline (T0) with moderate lower arch crowding (≤+4 mm), and good compliance with aligners and elastics (≥20 h/day). All the participants underwent the lower distalization protocol, which included extraction of the lower third molars before starting treatment and a 50% sequential lower distalization, and Class III intermaxillary elastics (1/4 in., 6.5 oz) from buttons on the upper first molars to precision cuts at the level of the lower canines to reinforce the anchorage. Lateral cephalograms were taken at T0 (before treatment) and at the end of the clear aligner treatment (T1) with an average time interval of 24 ± 6 months. A customized digitization regimen and cephalometric analysis were created to assess the esthetic outcomes at T1. The significance level was set at <i>P</i> < 0.05.</p><p><strong>Results: </strong>The lower distalization supported by Class III elastics resulted in a slight improvement of the facial esthetic profile with no significant changes in the lower third of the face. A mildly better projection of the upper lip was detected at the end of treatment, mainly due to the extensive use of Class III elastics.</p><p><strong>Discussion: </strong>The lower distalization supported by Class III elastics determined slight improvement of the facial aesthetic profile with no significant changes in the lower third of the face. A mild better projection of the upper lip was detected at the end of treatment, mainly due to the extensive use of Class III elastics.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1584088"},"PeriodicalIF":1.5,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring career impact and satisfaction in a graduate program in dentistry.","authors":"Isadora Dos Santos Rotta, Fernando Valentim Bitencourt, Fabrício Mezzomo Collares, Roger Junges, Susana Maria Werner Samuel, Ramona Fernanda Ceriotti Toassi, Cassiano Kuchenbecker Rösing","doi":"10.3389/fdmed.2025.1566272","DOIUrl":"10.3389/fdmed.2025.1566272","url":null,"abstract":"<p><strong>Introduction: </strong>The assessment of student outcomes is essential for monitoring the quality of graduate programs in healthcare sciences. As such, this study focused on developing a self-employed questionnaire that allowed for the evaluation of elements focused on career impact and levels of satisfaction regarding graduate program education. Following, this instrument was utilized in a cross-sectional study design with alumni that had obtained their degree (MSc or PhD) over a 25-year span (1995-2020) from a graduate program in dentistry located in Brazil.</p><p><strong>Methods: </strong>The employed instrument comprised a total of 43 questions presenting a mix of both close and open-ended questions coupled with 5-point Likert scales. The questionnaire was hosted online and a total of 528 alumni were invited to participate through e-mail and social media outreach.</p><p><strong>Results: </strong>376 alumni answered the questionnaire (71.2% response rate). The majority were female (69.9%), and with a MSc (58.5%). Levels of satisfaction towards the program as well the impact in career and life were higher in alumni that had obtained a PhD degree compared to MSc. After obtaining the degree, an increase in involvement in teaching/research positions (3.4% vs 21.5%, <i>p</i> < 001) and a decrease in unemployment (21.9% vs 2.1%, <i>p</i> < 001) were observed. The highest levels of impact were observed regarding the achievement of the professional goals as nearly 90% of the population agreed with this statement.</p><p><strong>Conclusions: </strong>This study highlighted the creation and employment of an assessment tool that can be utilized to monitor the perceptions of student outcomes. Among the findings, a decrease in unemployment and a high degree of career impact and satisfaction were observed in the population of this study. Moving forward, it is essential that monitoring educational outcomes remains a priority worldwide.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1566272"},"PeriodicalIF":1.5,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}