Frontiers in dental medicine最新文献

{"title":"Therapeutic potential of curcumin in regenerative dentistry.","authors":"Anahid A Birjandi, Paul Sharpe","doi":"10.3389/fdmed.2025.1537478","DOIUrl":"10.3389/fdmed.2025.1537478","url":null,"abstract":"<p><strong>Introduction: </strong>Natural compounds have emerged as promising candidates in drug development due to their potent immunomodulatory anti-inflammatory, antibacterial, analgesic, and healing properties. They have shown significant therapeutic potential in clinical applications, such as mouth rinses, toothpastes, and localized delivery systems. The use of natural alternatives can contribute to tackling antimicrobial resistance. Among natural compounds, curcumin has gained particular attention, demonstrating robust anti-cancer, antibiotic, and anti-inflammatory activities in numerous <i>in vivo</i> studies, while exhibiting a favorable safety profile for the treatment of various diseases. In this study, the remedial effects of curcumin and its metabolite, tetrahydrocurcumin, on dental pulp were explored. In addition, these results were compared with our previous findings on the effects of these natural compounds on periodontal ligament and gingival epithelial cells, further broadening our understanding of their therapeutic potential in oral disease such as caries and periodontitis.</p><p><strong>Methods: </strong>RNA sequencing was used to investigate the differentially expressed genes in dental pulp cells following treatments with curcumin and tetrahydrocurcumin.</p><p><strong>Results: </strong>We show that treatment of dental pulp cells with 1 μM of curcumin or tetrahydrocurcumin is sufficient to promote Wnt signaling pathway in dental pulp cells. Curcumin treatment promotes the upregulation of cellular metabolism and enhances cellular response to stress. Our enrichment analysis shows that treatment with tetrahydrocurcumin modulates the extracellular matrix and angiogenesis.</p><p><strong>Conclusions: </strong>The findings of this study highlight the cytoprotective and regenerative properties of curcumin and tetrahydrocurcumin. These properties could be leveraged as a therapeutic approach to promote tissue regeneration in oral diseases.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1537478"},"PeriodicalIF":1.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salivary periostin levels as a non-invasive biomarker and their clinical correlates among healthy and periodontitis patients-a cross-sectional analytical study.","authors":"Priyanka Padalkar, Sunaina Shetty Yadadi, Gopinath Vivekanandan, Shishir Ram Shetty, Mangesh Andhare, Aditi Pashine, Vineet Vinay, Vijay Desai, Raghavendra M Shetty","doi":"10.3389/fdmed.2025.1512252","DOIUrl":"10.3389/fdmed.2025.1512252","url":null,"abstract":"<p><strong>Background: </strong>The diagnosis of periodontitis is primarily through clinical and radiographic assessments. However, it is difficult for clinicians to detect incipient periodontitis during the routine clinical assessment. Identifying people at risk for periodontitis and tracking disease development need a dependable biomarker. Currently, no biomarkers meet all the criteria required for an ideal diagnostic test. Therefore, the clinical utility of salivary periostin as a potential screening tool for periodontitis warrants further investigation, particularly through large samples across diverse populations. The present study aimed to investigate salivary periostin levels as a biomarker in individuals with periodontitis and healthy controls.</p><p><strong>Methods: </strong>Forty-five patients with generalized periodontitis stage III grade A/B and an equivalent number of periodontally healthy controls were evaluated for plaque index (PI), gingival index (GI), pocket probing depth (PPD), and clinical attachment level (CAL). Unstimulated salivary samples from all subjects were taken, and periostin levels were quantified using an ELISA kit.</p><p><strong>Results: </strong>The average salivary periostin levels were 4.63 in the healthy group and 1.24 in the periodontitis group (<i>P</i> < 0.05). The Spearman coefficient indicated a negative correlation between periostin levels and the gingival index (<i>r</i> = -0.761), plaque index (<i>r</i> = -0.780; <i>P</i> < 0.05), probing pocket depth (PPD) (<i>r</i> = -0.713; <i>P</i> < 0.05) and clinical attachment level (CAL) (<i>r</i> = -0.713; <i>P</i> < 0.05). Linear regression analysis validated the indirect correlation between salivary periostin levels and clinical indicators (Adjusted R square = 0.947).</p><p><strong>Conclusions: </strong>Salivary periostin levels are associated with periodontal disease. Salivary periostin levels indirectly influence as a non-invasive biomarker of periodontitis. The biomarker periostin is effective for evaluating both healthy and diseased periodontium.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1512252"},"PeriodicalIF":1.5,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: Innovations in oral hygiene tools: a mini review on recent developments.","authors":"Sucharitha Palanisamy","doi":"10.3389/fdmed.2025.1577857","DOIUrl":"https://doi.org/10.3389/fdmed.2025.1577857","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fdmed.2024.1442887.].</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1577857"},"PeriodicalIF":1.5,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11939011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interleukin-6/soluble IL-6 receptor-induced secretion of cathepsin B and L from human gingival fibroblasts is regulated by caveolin-1 and ERK1/2 pathways.","authors":"Ayaka Goto, Kazuhiro Omori, Tomoko Yamaguchi-Tomikawa, Hiroya Kobayashi, Yuki Shinoda-Ito, Kimito Hirai, Atsushi Ikeda, Shogo Takashiba","doi":"10.3389/fdmed.2025.1547222","DOIUrl":"10.3389/fdmed.2025.1547222","url":null,"abstract":"<p><strong>Aims: </strong>Cathepsins are essential lysosomal enzymes that maintain organismal homeostasis by degrading extracellular substrates. The inflammatory cytokine interleukin-6 (IL-6) increases the production of cathepsins through the caveolin-1 (Cav-1) and c-Jun N-terminal kinase (JNK) signaling pathways, which have been implicated in the destruction of periodontal tissue. This study investigated the effect of the IL-6/soluble IL-6 receptor (sIL-6R) complex on the extracellular secretion of cathepsins in human gingival fibroblasts (HGFs) and examined the function of extracellularly secreted cathepsins B and L under acidic culture conditions <i>in vitro</i>.</p><p><strong>Methods: </strong>HGFs were isolated from healthy volunteer donors. The expression of Cav-1 was suppressed via transfection with small interfering RNA (siRNA) targeting Cav-1. The expression levels of cathepsins B and L induced by extracellular IL-6/sIL-6R were measured using western blotting and enzyme-linked immunosorbent assay. Extracellular cathepsin activity following IL-6/sIL-6R stimulation was assessed using a methylcoumarylamide substrate in a fluorescence-based assay. IL-6/sIL-6R-induced expression of cathepsins B and L in HGFs was quantified under inhibitory conditions for extracellular signal-regulated kinase (ERK) 1/2 and/or JNK signaling, both of which are transduction pathways activated by IL-6/sIL-6R. This quantification was also performed in HGFs with suppressed Cav-1 expression using western blotting.</p><p><strong>Results: </strong>Cathepsins B and L were secreted in their precursor forms from HGFs, with significantly elevated protein levels observed at 24, 48, and 72 h post-IL-6/sIL-6R stimulation. Under acidic culture conditions, cathepsin B activity increased at 48 and 72 h. Cav-1 suppression inhibited the secretion of cathepsin B regardless of IL-6/sIL-6R stimulation, whereas the secretion of cathepsin L was reduced only after 48 h of IL-6/sIL-6R stimulation. Inhibition of ERK1/2 and JNK pathways decreased the secretion of cathepsin B after 48 h of IL-6/sIL-6R stimulation, and JNK inhibition reduced the secretion of cathepsin L under similar conditions.</p><p><strong>Conclusion: </strong>IL-6/sIL-6R stimulation increased the extracellular secretion of cathepsin B and L precursors in HGFs, and these precursors became activated under acidic conditions. Cav-1 and ERK1/2 are involved in regulating the secretion of cathepsin B precursors.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1547222"},"PeriodicalIF":1.5,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11933118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The aesthetic perception of orthodontic specialists, general dentists and laypeople regarding different smile displays for a patient missing one upper lateral incisor and the other one peg-shaped.","authors":"Federica Montinaro, Ludovica Nucci, Maria Chiara Chiarenza, Fabrizia d'Apuzzo, Letizia Perillo, Vincenzo Grassia","doi":"10.3389/fdmed.2025.1532220","DOIUrl":"10.3389/fdmed.2025.1532220","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of maxillary lateral incisor agenesis ranges from 1% to 3%, with slight global variability. The unilateral agenesis of the maxillary lateral incisor is often associated with a contralateral tooth with microdontia or a peg shape and can have esthetic, functional, and psychosocial implications for patients. The aim of the present survey was to assess the perceptions of smile aesthetics among orthodontists, general dentists and laypeople on different treatment choices, modifying the initial condition of the right maxillary lateral incisor agenesis and the contralateral peg-shaped tooth.</p><p><strong>Methods: </strong>A series of 6 photographs of different smile simulations were presented to 109 orthodontic specialists, 109 general dentists and 141 laypeople through an online survey. Each photograph was duplicated and judged from 1 to 10 for 2 different bipolar adjectives.</p><p><strong>Results: </strong>Statistically significant results were found for all the groups investigated. All three groups preferred the photo that maintained the typical symmetrical 'high-low-high gingival contour. Moreover, both orthodontic specialists and general dentists preferred unilateral mesialization of the canine and conservative rehabilitation of the peg-shaped incisor. In contrast, the laypeople preferred bilateral mesialization of the canines with peg-shaped incisor avulsion.</p><p><strong>Conclusion: </strong>The normal symmetrical array of the central incisor, lateral incisor and canine had the best aesthetic results for all subjects. Laypeople were more attracted to a symmetrical smile than were the groups of orthodontic specialists and general dentists.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1532220"},"PeriodicalIF":1.5,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11933056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of sleep position shifts in patients with obstructive sleep apnea syndrome with the use of a mandibular advancement device.","authors":"Domenico Ciavarella, Donatella Ferrara, Carlotta Fanelli, Graziano Montaruli, Giuseppe Burlon, Michele Laurenziello, Lucio Lo Russo, Fariba Esperouz, Michele Tepedino, Mauro Lorusso","doi":"10.3389/fdmed.2025.1524334","DOIUrl":"10.3389/fdmed.2025.1524334","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to evaluate position shifts during sleep of patients with obstructive sleep apnea (OSA) syndrome both with and without the use of a mandibular advancement device (MAD).</p><p><strong>Methods: </strong>In total, 73 adult Caucasian patients diagnosed with obstructive sleep apnea syndrome confirmed by polysomnography were retrospectively enrolled. Inclusion criteria were as follows: age >20 years, body mass index <34 kg/m², polysomnographic diagnosis of OSA, non-smoker, absence of comorbidities at diagnosis, and treatment with a MAD. Two polysomnographic monitoring were performed: one at the time of diagnosis (T0) and another after 3 months of treatment (T1). The parameters evaluated were the apnea-hypopnea index, oxygen desaturation index, the total number of position shifts, and position shift index (number of shifts per hour). Since the variables failed the normality test, the Wilcoxon test was performed to analyze the correlation between the mean of polysomnographic parameters at T0 and T1. The difference between the T1 and T0 values for each variable was evaluated using Spearman's rho correlation test. Statistical significance was set at <i>p</i> < 0.05.</p><p><strong>Results and conclusions: </strong>All the parameters, including respiratory and positional measures, were significantly reduced after the use of a MAD compared to the beginning. Spearman's correlation test revealed a relationship between the total number of sleep position shifts and the sleep position shift index with the oxygen desaturation index. However, no significant correlation was observed between the apnea-hypopnea index and the positional values.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1524334"},"PeriodicalIF":1.5,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital technology-enhanced reconstruction and rehabilitation following mandible fibular flap grafting with implants: a case report.","authors":"Shuang Li, Jian Liu, Jian Li, Baoheng Yin, Yuanyong Feng, Yanshan Liu, Na Bai","doi":"10.3389/fdmed.2025.1554315","DOIUrl":"10.3389/fdmed.2025.1554315","url":null,"abstract":"<p><strong>Objective: </strong>In this paper, we report a case of missing posterior teeth after mandibular fibular flap grafting and implant restoration by means of a digital restorative process, in the hope that the application of digital technology will help the patient to comfortably establish an adapted occlusal relationship.</p><p><strong>Case report: </strong>A 29-year-old male patient developed a left mandibular ameloblastoma measuring 35 mm × 35 mm × 25 mm, which did not invade the surrounding bone tissue, submandibular gland tissue, or lymph nodes. After resection of an 85 mm mandibular segment, the patient was reconstructed using a gastrocnemius flap transfer. He was then referred to our institution for postoperative dental implant restoration. The restorative process incorporated various digital technologies including a digital facebow, intraoral scanner, extraoral scanner, facial scanner, and CAD/CAM systems. Following 1 year post-implantation, the patient received second-stage implantation alongside autologous dermal allograft (ADM) transplantation; subsequently, a temporary prosthesis was fabricated while employing an electronic articulator to accurately transfer occlusal relationships before finalizing with permanent restorations. The integration of digital technology throughout this restorative process enhanced both precision and comfort.</p><p><strong>Conclusions: </strong>This case study offers an innovative and efficient clinical approach for addressing dentition defect following mandibular reconstruction via advanced digital methodologies.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1554315"},"PeriodicalIF":1.5,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking tiny titans: 360 view of the quantum dots nanotechnology for dental applications.","authors":"Tasneem Alluhaidan, Isadora Martini Garcia, Meghan Alexis, Masoumah Qaw, Fabrício Mezzomo Collares, Mary Ann Williams, Mary Anne S Melo","doi":"10.3389/fdmed.2025.1503057","DOIUrl":"10.3389/fdmed.2025.1503057","url":null,"abstract":"<p><p>Quantum dots (QDs) nanotechnology has gained significant attention in dentistry due to its unique properties, such as fluorescence, antimicrobial activity, and drug delivery potential. This review aims to identify the dental applications most actively incorporating QD technology and to examine the distinctive properties of QDs within Dentistry. Employing the Arksey and O'Malley five-stage framework, a systematic search was conducted across PubMed, EMBASE, and Scopus databases for English-language publications on QDs in dentistry. Scientific contributions were evaluated by analyzing publication volume, research trends, patents, and key areas of investigation. Of the 1,034 studies initially identified, 71 were fully screened, with 22 meeting the criteria for data extraction. Results showed that antimicrobial properties and bone regeneration are the primary focus areas for QDs in dental materials. Stock solutions and resin composites are the most common materials developed, with the studies primarily targeting ofenhancing antimicrobial capabilities and osteogenesis enhancement. Over the last decade, QDs have demonstrated potential in enhancing drug delivery, antimicrobial efficacy, and optical performance in dental materials. Despite their growing prominence, the clinical translation of QD-based technologies remains limited due to a lack of long-term studies.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1503057"},"PeriodicalIF":1.5,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into the schizophrenia and dental care: focusing on interaction between implant treatments and oxidative stress.","authors":"Ecaterina Burlui, Viorica Rarinca, Alin Ciobica, Vasile Burlui, Romeo Dobrin, Carmen Stadoleanu","doi":"10.3389/fdmed.2025.1542913","DOIUrl":"https://doi.org/10.3389/fdmed.2025.1542913","url":null,"abstract":"<p><p>Schizophrenia is a complex mental condition characterized by the deterioration of thought processes and inappropriate emotional responses. Compared to the general population, individuals diagnosed with schizophrenia have an increased risk of developing various dental diseases, including dental caries, periodontal disease, oral mucosal diseases, and conditions associated with oral resonance. In this context, we propose to establish links between schizophrenia and dental illness, emphasizing the importance of oxidative stress (OS) markers in schizophrenia, and also the role of dental treatments, particularly dental implants. This highlights the urgent need for an intervention program to improve oral health in patients with schizophrenia, including aspects such as prevention and prosthetic treatment. Dental implants can be a favorable option, offering good aesthetic and functional results for treated patients with schizophrenia. Additionally, a carefully developed surgical plan is essential, requiring collaboration between psychiatry, oral and maxillofacial surgery, anesthesiology, and prosthodontics departments.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1542913"},"PeriodicalIF":1.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11906696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flexural properties of rapidly prototyped denture base materials: the effect of nanoparticle addition and post-curing duration <i>in vitro</i>.","authors":"Shaimaa M Fouda, Mohammed M Gad, Mai El Zayat, Soban Q Khan, Sultan Akhtar, Ahmed Othman, Constantin von See","doi":"10.3389/fdmed.2025.1544474","DOIUrl":"10.3389/fdmed.2025.1544474","url":null,"abstract":"<p><strong>Objectives: </strong>The flexural strength and elastic modulus of rapidly prototyped denture base materials are affected by numerous factors including reinforcement with nanoparticles (NPs) and post-curing duration (PCD), though the effect of these two factors together has been overlooked. The present study tested the effect of nanodiamonds (NDs) or silicon dioxide nanoparticles (SNPs) with various PCDs on the flexural strength and elastic modulus of rapidly prototyped denture base materials.</p><p><strong>Methods: </strong>To measure the flexural strength and elastic modulus, bar-shaped specimens (64 × 10 × 3.3 mm) were designed and rapidly prototyped using ASIGA and NextDent denture base resins. Each resin (<i>N</i> = 150) was divided into five groups (<i>n</i> = 30) according to NP type and concentrations: pure group as a control without additives, 0.25% NDs, 0.5% NDs, 0.25% SNPs, and 0.5% SNPs. Specimens from each group were further divided into three groups (<i>n</i> = 10) and post-cured for 15, 60, or 90 min, followed by thermocycling for 5,000 cycles. After measuring the flexural strength and elastic modulus using a three-point bending test, a scanning electron microscope was used to analyze the fractured surface. The bonds between the NPs and the resin were tested by Fourier-transform infrared spectroscopy. ANOVA and <i>post hoc</i> tests were used for data analysis (<i>α</i> = 0.05).</p><p><strong>Results: </strong>The flexural strength increased with prolonged PCD and the highest values for all tested groups were reported at 90 min (<i>P</i> < 0.001). The flexural strength of both materials increased significantly with the addition of NDs and SNPs in comparison to the pure groups (<i>P</i> < 0.05). <i>K</i>-factor ANOVA analysis of the elastic modulus showed that each factor (NP type, PCD, and material type) had a significant effect on the elastic modulus (<i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>The flexural strength and elastic modulus of rapidly prototyped denture base resin were increased with the addition of NDs or SNPs and when increasing the PCD. Factors including nanoparticle type and concentration, the post-curing duration, and the material type solely or in combination could affect the flexural strength and elastic modulus of prototyped denture base materials.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1544474"},"PeriodicalIF":1.5,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}