Frontiers in dental medicine最新文献

{"title":"Nanocomposite 3D printed resins containing titanium dioxide (TiO₂) nanoparticles: an <i>in vitro</i> analysis of color, hardness, and surface roughness properties.","authors":"Maram A AlGhamdi, Shaimaa M Fouda, Yousif A Al-Dulaijan, Soban Q Khan, Mai El Zayat, Raghad Al Munif, Zainab Albazroun, Fatma Hamza Amer, Ahmed Tharwat Al Ammary, Amr A Mahrous, Mohammed M Gad","doi":"10.3389/fdmed.2025.1581461","DOIUrl":"10.3389/fdmed.2025.1581461","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the effect of different titanium dioxide nanoparticle (TN) concentrations on the color stability and surface properties of additively fabricated (AF) denture base resins after thermal cycling.</p><p><strong>Methods: </strong>Two types of AF denture base resins, NextDent and ASIGA, were used to fabricate a total of 120 disc-shaped (10 × 2 mm) specimens (<i>n</i> = 10). The specimens of each resin were divided into 2 groups according to the concentration of titanium dioxide nanoparticles (1 wt.%, 2 wt.% TN) in addition to a control group of pure resin for each material. The specimens' color change, hardness, and surface roughness (Ra) were tested after thermal cycling (5,000 cycles). Collected data was analyzed using ANOVA and <i>post hoc</i> Tukey's test (α = 0.05). The color change was referred to the National Bureau of Standards (NBS).</p><p><strong>Results: </strong>The addition of TN resulted in significant color changes in NextDent, with unacceptable changes according to the NBS (8.84 for 1 wt.% TN and 8.28 for 2 wt.% TN). In contrast, ASIGA showed significantly less color change than NextDent, and the changes remained within clinically acceptable limits. For hardness, in comparison to the pure group, TN addition didn't show any significant change in terms of TN concentrations and material type (<i>P</i> > 0.05), and the highest hardness value was recorded with NextDent/2 wt.%TN (16.6 ± 9.0 VHN). TN addition significantly increased Ra in NextDent, which was concentration-dependent (<i>p</i> = 0.001), while AISGA showed no change in Ra with TN addition (<i>p</i> = 0.693).</p><p><strong>Conclusion: </strong>Nanocomposite denture base resins containing TN increased the color change and surface roughness with no change in hardness. The effect of TN was material-dependent; therefore, resin material selection for nanocomposite preparation should be considered.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1581461"},"PeriodicalIF":1.5,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting alveolar nerve injury and the difficulty level of extraction impacted third molars: a systematic review of deep learning approaches.","authors":"Hamza Al Salieti, Hanan M Qasem, Sakhr Alshwayyat, Noor Almasri, Mustafa Alshwayyat, Amira A Aboali, Farah Alsarayrah, Lina Khasawneh, Mohammed Al-Mahdi Al-Kurdi","doi":"10.3389/fdmed.2025.1534406","DOIUrl":"10.3389/fdmed.2025.1534406","url":null,"abstract":"<p><strong>Background: </strong>Third molar extraction, a common dental procedure, often involves complications, such as alveolar nerve injury. Accurate preoperative assessment of the extraction difficulty and nerve injury risk is crucial for better surgical planning and patient outcomes. Recent advancements in deep learning (DL) have shown the potential to enhance the predictive accuracy using panoramic radiographic (PR) images. This systematic review evaluated the accuracy and reliability of DL models for predicting third molar extraction difficulty and inferior alveolar nerve (IAN) injury risk.</p><p><strong>Methods: </strong>A systematic search was conducted across PubMed, Scopus, Web of Science, and Embase until September 2024, focusing on studies assessing DL models for predicting extraction complexity and IAN injury using PR images. The inclusion criteria required studies to report predictive performance metrics. Study selection, data extraction, and quality assessment were independently performed by two authors using the PRISMA and QUADAS-2 guidelines.</p><p><strong>Results: </strong>Six studies involving 12,419 PR images met the inclusion criteria. DL models demonstrated high accuracy in predicting extraction difficulty (up to 96%) and IAN injury (up to 92.9%), with notable sensitivity (up to 97.5%) for specific classifications, such as horizontal impactions. Geographically, three studies originated in South Korea and one each from Turkey and Thailand, limiting generalizability. Despite high accuracy, demographic data were sparsely reported, with only two studies providing patient sex distribution.</p><p><strong>Conclusion: </strong>DL models show promise in improving the preoperative assessment of third molar extraction. However, further validation in diverse populations and integration with clinical workflows are necessary to establish its real-world utility, as limitations such as limited generalizability, potential selection bias and lack of long-term follow up remain challenges.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1534406"},"PeriodicalIF":1.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12129997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Next-generation dental materials engineered for mineralized tissue reconstruction: advances, challenges and opportunities.","authors":"Paulette Spencer, Conrado Aparicio, Candan Tamerler","doi":"10.3389/fdmed.2025.1618199","DOIUrl":"10.3389/fdmed.2025.1618199","url":null,"abstract":"","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1618199"},"PeriodicalIF":1.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Periodontitis and cardiovascular disease: shared clinical challenges in patient care.","authors":"Gaetano Isola, Alessandro Polizzi","doi":"10.3389/fdmed.2025.1613091","DOIUrl":"10.3389/fdmed.2025.1613091","url":null,"abstract":"","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1613091"},"PeriodicalIF":1.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of the implantoplasty techniques on the fracture resistance of dental implants. Systematic review and meta-analysis.","authors":"Giovanni Pissu, Javier Flores-Fraile, Álvaro Zubizarreta-Macho, José María Montiel-Company, Ana Belén Lobo-Galindo","doi":"10.3389/fdmed.2025.1568465","DOIUrl":"10.3389/fdmed.2025.1568465","url":null,"abstract":"<p><p>The aim of this systematic review and meta-analysis was to analyze and compare the effect of diamond drill, tungsten carbide drill and ultrasound tips for implantoplasty procedures on the fracture resistance of dental implants affected by periimplant disease.</p><p><strong>Materials and methods: </strong>This systematic review of the scientific literature and meta-analysis was carried out based on the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), analyzing all studies that evaluated the fracture resistance of dental implants submitted to implantoplasty through diamond drill, tungsten carbide drill and ultrasound tips for implantoplasty procedures, comparing with the fracture resistance values of non-treated dental implants. A total of 4 databases were searched in the literature: Pubmed, Scopus, Cochrane and Web of Science. After eliminating duplicate articles and applying certain inclusion criteria, a total of 9 articles were selected and compared using the random effects model and inverse variance method. The significance of the effect size was measured with the <i>z</i> test, the heterogeneity using the <i>Q</i> test and the <i>I</i> ² and publication bias was analyzed using the trim-and-fill method.</p><p><strong>Results: </strong>The difference in means between the treatment and control groups was estimated as the effect size, obtaining a statistically significant difference of -232.01 MPa., with a 95% confidence interval of the difference between -417.3 and -44.71 (<i>z</i> test = -2.43; <i>p</i>-value = 0.015). The meta-analysis has presented high heterogeneity with an <i>I</i> ² = 99.3% and a <i>Q</i> test = 2,195.7; <i>p</i>-value < 0.001. No significant differences were found between the three subgroups with the <i>Q</i> test = 0.20: <i>p</i>-value = 0.903.</p><p><strong>Conclusions: </strong>the tungsten carbide drills resulted in less fracture resistance loss than the diamond and tungsten carbide drills for the dental implants submitted to implantoplasty procedures. <b>Systematic Review Registration</b>: [http://www.prisma-statement.org], identifier [INPLASY202460018].</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1568465"},"PeriodicalIF":1.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: Evaluation of sleep position shifts in patients with obstructive sleep apnea syndrome with the use of a mandibular advancement device.","authors":"Domenico Ciavarella, Donatella Ferrara, Carlotta Fanelli, Graziano Montaruli, Giuseppe Burlon, Michele Laurenziello, Lucio Lo Russo, Fariba Esperouz, Michele Tepedino, Mauro Lorusso","doi":"10.3389/fdmed.2025.1593050","DOIUrl":"10.3389/fdmed.2025.1593050","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fdmed.2025.1524334.].</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1593050"},"PeriodicalIF":1.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of bestatin as a treatment for periodontitis.","authors":"Sudhir Rama Varma, Bader Mohamed Moustafa Elagha, Jayaraj K Narayanan, Asok Mathew","doi":"10.3389/fdmed.2025.1571989","DOIUrl":"10.3389/fdmed.2025.1571989","url":null,"abstract":"<p><p>Periodontitis is a chronic inflammatory disease impacting the supporting structures of teeth, with significant global pervasiveness and systemic health implications. Current treatments, such as scaling and root planning (SRP) and adjunctive antibiotics, face challenges including antibiotic resistance, infection recurrence, and incomplete tissue regeneration. Bestatin, a dipeptide aminopeptidase inhibitor, has shown potential as a novel therapeutic agent due to its targeted antimicrobial effects against <i>Porphyromonas gingivalis (P. gingivalis),</i> biofilm modulation, and anti-inflammatory properties. <i>in vitro</i> studies revealed bestatin's selective bacteriostatic effects against P. gingivalis, inhibiting bacterial growth and biofilm development without affecting commensal bacteria. <i>in vivo</i> studies demonstrated that bestatin modulated inflammatory responses and prevented necrotic abscess formation in guinea pig models, suggesting its potential to suppress <i>P. gingivalis</i> growth through alternative pathways. However, no clinical trials were identified, highlighting a significant gap in the translation of preclinical findings into human periodontal therapy. The current review highlights Bestatin as a promising therapeutic representative for periodontitis, where it is involved in inhibiting modulating biofilms, reducing tissue destruction, and <i>P. gingivalis</i>, in preclinical studies. Compared to traditional therapies, bestatin provides unique advantages, non-cytotoxicity, including specificity, and dual action against microbial dysbiosis along with biofilm-associated resistance.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1571989"},"PeriodicalIF":1.5,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of nitrate-containing arugula juice on nitrate-reducing oral bacteria and periodontopathogens in smokers' biofilm.","authors":"Boy M Bachtiar, Irene E Rieuwpassa, Heni Susilowati, Retno Indrawati, Citra F Theodorea, Turmidzi Fath, Endang W Bachtiar","doi":"10.3389/fdmed.2025.1545479","DOIUrl":"10.3389/fdmed.2025.1545479","url":null,"abstract":"<p><p>Green leafy vegetables such as arugula are rich in nitrates that support oral health, yet their effects on oral microbial balance, especially in smokers, remain unclear. This study evaluated the survival and activity of nitrate-reducing bacteria (NRB; <i>Veillonella</i> spp. and <i>Rothia</i> spp.) in biofilm exposed to nitrate-containing arugula juice (3.25 or 6.25 μM). The proportions of NRB were compared with periodontopathogens (<i>Porphyromonas gingivalis</i> and <i>Fusobacterium nucleatum</i>). Using quantitative real-time PCR (qPCR), we assessed bacterial survival and transcription of nitrate reductase genes (<i>narG</i> and <i>napA</i>) in biofilm from smokers and non-smokers. The results revealed that nitrate-containing arugula juice increased NRB bacteria abundance while reducing periodontopathogen growth. A higher level of nitrate (6.25 μM) increased nitrate reductase expression. Prolonged exposure (9 h) sustained the growth-promoting effect on <i>Rothia</i> spp. These results suggest that non-smokers have more nitrate-reducing bacteria in their biofilm, which promotes oral microbial balance. Thus, smokers might be advised to consume nitrate-containing arugula juice to promote NRB, which may have health benefits.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1545479"},"PeriodicalIF":1.5,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12098498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinically relevant aspects of professional follow-up care for implant patients.","authors":"Philipp Sahrmann, Catherine Giannopoulou","doi":"10.3389/fdmed.2025.1565151","DOIUrl":"10.3389/fdmed.2025.1565151","url":null,"abstract":"<p><p>The detailed 2023 guidelines for the prevention and treatment of peri-implantitis describe evidence-based measures for the professional care and prevention in patients with dental implants. However, there remains a lack of reliable data from randomized clinical trials on many critical points, particularly regarding specific diagnostic steps and treatment decisions, to provide definitive guidance and protocols for implementation during recall sessions in daily practice. This narrative review seeks to address this gap by highlighting the critical aspects of follow-up care that should be monitored during periodontal maintenance to ensure the health of peri-implant tissues and enable timely intervention when peri-implant health is compromised.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1565151"},"PeriodicalIF":1.5,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Updates in pediatric dentistry.","authors":"Jayakumar Jayaraman, Sreekanth Kumar Mallineni","doi":"10.3389/fdmed.2025.1603591","DOIUrl":"https://doi.org/10.3389/fdmed.2025.1603591","url":null,"abstract":"","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1603591"},"PeriodicalIF":1.5,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}