Frontiers in dental medicine最新文献

{"title":"The presence of ACE2 and regulatory miRNAs (miR-200c-3p and miR-421-5p) in the saliva of periodontitis patients post-COVID-19 vaccination.","authors":"Boy M Bachtiar, Natalina Haerani, Yuniarti Soeroso, Nada Ismah, Endang W Bachtiar","doi":"10.3389/fdmed.2024.1438139","DOIUrl":"10.3389/fdmed.2024.1438139","url":null,"abstract":"<p><p>The effectiveness of COVID-19 mRNA vaccines in individuals with periodontitis is crucial. This study evaluated the efficacy of the BNT162b2 vaccine in individuals with periodontitis who had been vaccinated at least 6 months earlier. Using real-time PCR, the association between the SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) and miRNA-200c-3p and miRNA-421-5p as well as interleukin-6 (IL-6) was examined in the saliva of moderate (G1, <i>n</i> = 10) and severe (G2, <i>n</i> = 10) periodontitis subjects. Participants without periodontitis were included as a control group. The transcription levels of soluble ACE2 and IL-6 were higher in periodontitis participants than in control participants, but within periodontitis groups, only IL-6 expression was higher in G2 than in G1. A positive strong correlation between ACE2 and IL-6 was only observed in the G2 group (<i>p </i>= 0.008). The expression of miR-200c-3p but not miR-421-5p was higher in periodontitis individuals. Their relationship was positive but a strong correlation was only observed in the G2 group. In all periodontitis groups, a strong inverse correlation was observed between the two microRNAs and ACE2. However, receiver operating characteristic (ROC) analysis showed that only the relationship between ACE2 and miR-4215p had potential as a biomarker for the efficacy of the mRNA vaccine, with areas under the ROC curve of 0.92 and 0.80 in the G1 and G2 groups, respectively. Our study revealed that active and non-active periodontitis conditions do not interfere with the efficacy of the BNT162b2 vaccine for at least 6 months post-vaccination. This suggests that in individuals with periodontitis, soluble ACE2 in the saliva may serve as a preliminary indicator of vaccine response.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1438139"},"PeriodicalIF":1.5,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In vitro</i> and <i>ex vivo</i> comparison of reactive oxygen-releasing granules for internal tooth bleaching.","authors":"Romy M Mayer, Andrea Gubler, Thomas Attin, Matthias Zehnder","doi":"10.3389/fdmed.2024.1447459","DOIUrl":"10.3389/fdmed.2024.1447459","url":null,"abstract":"<p><strong>Introduction: </strong>Traditionally, internal tooth bleaching was performed using sodium perborate slurries. These are banned in some areas for potential carcinogenic effects. More recently, highly concentrated hydrogen peroxide gels have been used, which may cause dentin degradation. Consequently, the search for ideal internal tooth bleaching agents is still on. This study compared pure ROS-releasing granules regarding their liberation of oxidizing species, pH induction, bleaching of blood-stained dentin, and effects on mechanical dentin properties.</p><p><strong>Materials and methods: </strong>The ROS-releasing granules under investigation were sodium perborate, carbamide peroxide, and sodium percarbonate in aqueous suspension (4:3, wt/wt). The bleaching efficacy of these suspensions was compared in blood-stained human dentin (<i>n</i> = 6) <i>ex vivo</i>. In addition, effects on mechanical dentin integrity were tested using bovine dentin beams (<i>n</i> = 9) exposed to a 3-point bending test (ISO 4049) after immersion in test suspensions or control solutions (35% H₂O₂ and physiological saline) for 1 week.</p><p><strong>Results: </strong>Granules release between 21.5% and 35.2% (wt/wt) of H₂O₂ equivalent. The sodium-containing granules (perborate and percarbonate) caused an alkaline pH of 10.3 and 10.6, respectively. The carbamide peroxide suspension was acidic (pH 3.9), as was the 35% H₂O₂ solution used as a control (pH 2.2). All the suspensions bleached the blood-stained dentin, albeit with a lesser overall effect by sodium percarbonate (one-way ANOVA and Tukey's HSD, <i>p</i> < 0.05). The acidic preparations caused a severe (over 50%) reduction in flexural strength of the dentin (<i>p</i> < 0.05 compared to physiological saline solution), while the alkaline counterparts did not.</p><p><strong>Conclusions: </strong>Sodium perborate granules in aqueous suspension combined good de-staining properties with limited untoward effects on dentin integrity. Further studies are required to identify alternative compounds with a lesser general health concern.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1447459"},"PeriodicalIF":1.5,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and eruption of human teeth in the Chinese population: a comprehensive dental atlas.","authors":"Jayakumar Jayaraman","doi":"10.3389/fdmed.2024.1434417","DOIUrl":"10.3389/fdmed.2024.1434417","url":null,"abstract":"<p><strong>Aim: </strong>The first comprehensive chart on dental development was published 75 years ago based on Caucasian children and this has been used as a standard dental chart to date. Few population specific charts have been developed recently and updated dental charts on modern subjects can provide more information on dental development patterns. This study aims to construct a comprehensive dental atlas for modern Chinese children and young adults to assist in clinical, forensic, and public health applications.</p><p><strong>Methods: </strong>The study sample comprised of 2,306 subjects, age ranging from 2 to 24 years belonging to Chinese ethnicity. Dental formation and eruption of permanent teeth and resorption of primary teeth were analyzed separately for females and males. For each age range, the number of teeth (n), and the stage of development was calculated for first (Q1), second (Q2) and third quartiles (Q3). Similar analysis was performed for the position of permanent teeth and the resorption of primary teeth. To determine the variations between the sex, Mann-Whitney <i>U</i>-test was conducted by comparing the median (Q2) stages.</p><p><strong>Results: </strong>Variations in dental formation and eruption of permanent teeth and resorption of primary teeth were observed between maxillary and mandibular dentitions and between the sex, however the difference was not statistically significant (<i>p</i> = 0.535 to <i>p</i> = 1.000). The dental atlas was presented separately for Chinese females and males.</p><p><strong>Conclusion: </strong>This atlas on modern Chinese population serves as a practical tool to assist in clinical diagnosis and treatment planning, in forensic investigations as well as indicators of developments in public health.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1434417"},"PeriodicalIF":1.5,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical parameters in patients with halitosis: a cross-sectional study.","authors":"Ahoud Jazzar, Hebah AlDehlawi, Arwa Farag, Sana Alhamed, Sara Akeel, Yasmin Mair, Kenana Flemban, Hidaya Alqassab, Khalid Aljohani","doi":"10.3389/fdmed.2024.1427280","DOIUrl":"10.3389/fdmed.2024.1427280","url":null,"abstract":"<p><strong>Background: </strong>Halitosis, a socially and psychologically impactful condition often resulting from oral or systemic issues, is exacerbated by factors like aging, poor oral hygiene, and dietary choices. This study aimed to investigate the association between halitosis and stress by measuring salivary cortisol levels and the Cohen's Perceived Stress Scale (CPSS).</p><p><strong>Methods: </strong>A cross-sectional study of 40 participants was conducted using questionnaires and clinical measurements to assess halitosis and stress levels. Saliva samples were collected and analyzed for cortisol using ELISA. Participants' stress was assessed with the Cohen's Perceived Stress Scale Questionnaire (CPSS-10) questionnaire, and halitosis was measured with a Halimeter and self-assessment questionnaire. Clinical measurements included Plaque Index (PI) and the Decayed, Missing, and Filled Teeth (DMFT) score.</p><p><strong>Results: </strong>Forty subjects were split into a halitosis group (mean age 30.75 ± 10.15) and group with no halitosis (mean age 26 ± 5.3). Objective measures confirmed higher halitosis scores (3.70 ± 0.73) in the halitosis group vs. the second group (2.60 ± 1.67). Compared with the group with no halitosis, the halitosis group exhibited significantly (<i>p</i> < 0.05) more plaque (27.92% ± 17.16% vs. 47.50 ± 33.57%; <i>p</i> < 0.05) and higher DMFT scores (10.10 ± 2.51 vs. 26 ± 5.30), respectively. Salivary cortisol levels were similar across groups (1.721 ng/ml halitosis, 1.781 ng/ml without halitosis). Correlations showed a moderate positive relationship between DMFT and halimeter scores (<i>r</i> = 0.377, <i>p</i> = 0.018) and a moderate negative correlation between stress and plaque index (<i>r</i> = -0.403, <i>p</i> = 0.011), with no correlation between halimeter score and cortisol or CPSS score.</p><p><strong>Conclusions: </strong>Our findings showed that while halitosis severity correlated with higher DMFT scores and plaque accumulation, there was no significant association with salivary cortisol levels, suggesting that stress, as measured by salivary cortisol, may not be a direct contributor to halitosis. Furthermore, the data suggest that poor oral hygiene is a more significant factor in the development of halitosis than stress levels, as assessed by the CPSS-10.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1427280"},"PeriodicalIF":1.5,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of precision medicine into the dental care setting.","authors":"Larissa Steigmann, Željka Perić Kačarević, Jessica Khoury, Katalin Nagy, Magda Feres","doi":"10.3389/fdmed.2024.1398897","DOIUrl":"10.3389/fdmed.2024.1398897","url":null,"abstract":"<p><p>This narrative review aims to discuss the incorporation of novel medical concepts and tools into dental practice, with the goal of improving early diagnosis and exploring new personalized treatment options for oral pathologies, such as caries and periodontitis. Preventative dental approaches concentrate on the timely detection of oral infections and the integration of biomarker analysis to recognize pathogenic changes at early stage of disease. Likewise, periodic monitoring after the treatment is relevant to ensure the balance in the oral biofilms and prevent relapse. Additionally, more attention has shifted towards the contributing factors to disease development, such as essential nutrients. Sufficient levels of vitamin C, vitamin D and zinc pre- and post-operatively are employed to boost immune function and reduce the risk of postoperative infections. Omega-3 fatty acids, melatonin, and antioxidants like vitamin E, which have anti-inflammatory properties, are utilized to help minimize excessive inflammation and promote faster recovery. The data presented in this manuscript emphasize the crucial integration of innovative healthcare concepts and tools into dental practices. By adopting a more holistic view of the patient, clinicians can tailor treatments to each individual's predispositions, lifestyle, and oral health conditions. This review also highlights the potential of salivary biomarkers and point-of-care technologies in enhancing early diagnostic accuracy and personalizing treatment. Bridging the gap between oral and systemic health is the most effective approach to improving patient quality of life. These findings underscore the importance of continued interdisciplinary collaboration in dentistry.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1398897"},"PeriodicalIF":1.5,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective root canal retreatment of a maxillary first molar: a case report with a 9-year follow up.","authors":"Olavo Guerreiro Viegas, João Miguel Marques Santos","doi":"10.3389/fdmed.2024.1422390","DOIUrl":"10.3389/fdmed.2024.1422390","url":null,"abstract":"<p><p>Traditional endodontic retreatments usually target the entire root canal system. In contrast, selective root canal retreatment presents a new, targeted alternative that offers a less invasive solution. However, its promising approach faces potential obstacles due to a lack of long-term data, which might affect its widespread acceptance. This case report adds to the existing body of literature by offering an in-depth analysis of a long-term outcome following selective non-surgical retreatment, thereby bridging an important gap in knowledge. A 59-year-old male presented with post-treatment apical periodontitis (PTAP) in a maxillary first molar. Initial clinical examination revealed the patient was symptomatic, and the tooth responded negative to thermal tests and positive to vertical percussion. Radiographic assessment identified a radiolucency confined to the mesiobuccal root. No radiolucencies or signs of inflammation were observed in the distobuccal and palatal roots. These findings led to the decision to selectively retreat the mesiobuccal root non-surgically. This targeted approach aimed at addressing the inflammation while preserving the integrity of unaffected areas. The patient received selective non-surgical retreatment on the mesiobuccal root. During a nine-year follow-up, the patient remained asymptomatic, as confirmed by clinical observation. Periapical radiograph and Cone Beam Computed Tomography (CBCT) scan demonstrated complete healing of the treated root. Importantly, the untreated roots showed no signs or symptoms of apical periodontitis. This underscores the efficacy of the targeted treatment and its successful resolution of the inflammation. This case report aimed to show the long-term effectiveness and minimally invasive nature of selective root canal retreatment to address PTAP. It focused on the method's capacity to preserve tooth structure with minimum intervention. The positive outcomes highlight the urgent need for more controlled studies. Such research would confirm the advantages of selective retreatment, with the goal of improving endodontic protocols and patient care.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1422390"},"PeriodicalIF":1.5,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of a novel alloplast carbonate apatite granules.","authors":"Martha E Nunn, Courtney Rudick, Masahiko Nikaido, Takanari Miyamoto","doi":"10.3389/fdmed.2024.1418039","DOIUrl":"10.3389/fdmed.2024.1418039","url":null,"abstract":"<p><p>The objectives of this study are to provide a systematic review of a novel alloplastic hard-tissue grafting material, carbonate apatite granules (CO3Ap-granules), to provide a clinical case presentation of CO3Ap-granules in periodontal surgery. The following three electronic databases were searched independently by two of the authors (MN) and (CR): National Library of Medicine [MEDLINE (PubMed) and ClinicalTrials.gov], EMBASE (OVID) and the Cochrane Central Register of Controlled Trials (CENTRAL). After searching electronic databases, select journals in periodontics and implantology were also manually searched. Of the 43 studies identified from the systematic review, the following classifications were determined: (1) <i>in vitro</i> studies - 5 studies, (2) animal studies - 28 studies, (3) clinical studies - 7 studies, (4) reviews - 3 studies. Results from selected animal studies and all human studies were summarized. These results demonstrate that the novel alloplast CO3Ap-granules has the potential ability to stimulate new bone formation while CO3Ap-granules simultaneously resorb over time. Replacement of CO3Ap-granules with new bone formation has been shown to be comparable to autogenous bone grafting with one study showing superior results to a bovine-derived xenograft.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1418039"},"PeriodicalIF":1.5,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovations in oral hygiene tools: a mini review on recent developments.","authors":"Sucharitha Palanisamy","doi":"10.3389/fdmed.2024.1442887","DOIUrl":"10.3389/fdmed.2024.1442887","url":null,"abstract":"<p><strong>Background: </strong>This review examines advancements in oral hygiene aids and their impact on gingival and periodontal health. As periodontal diseases are widespread, effective hygiene is vital. Enhancements in traditional tools and innovations have improved oral hygiene status. Clinical evidence confirms these innovations improve gingival and periodontal health, though proper use and patient adherence are crucial.</p><p><strong>Methodology: </strong>A comprehensive literature search was conducted using MeSH terms like \"Gingivitis/prevention & control*\", \"Dental Plaque/prevention & control*\", \"Dentifrices\", \"Electrical Equipment and Supplies*\", \"Toothbrushing\", \"Equipment Design\", \"Anti-Infective Agents/therapeutic use\", \"Oils, Volatile/therapeutic use\", \"Dental Devices, Home Care\", \"Dentifrices*/therapeutic use\", \"Vibration\", \"Gingivitis*/drug therapy\", \"Gingivitis*/prevention & control\", \"Gingival Hemorrhage/prevention & control\", \"Anti-Inflammatory Agents/pharmacology\", \"Chlorhexidine/pharmacology\", \"Mouthwashes/pharmacology\", \"Anti-Bacterial Agents/pharmacology\", \"Mouthwashes/therapeutic use\", \"Anti-Infective Agents, Local*/therapeutic use\", \"Mouthwashes/chemistry*\", \"Plant Extracts/therapeutic use*\", \"Sodium Dodecyl Sulfate/therapeutic use*\", \"Treatment Outcome\", \"Oral Hygiene/methods\", \"Toothpastes/therapeutic use*\", \"Hyaluronic Acid/therapeutic use\", \"Chronic Periodontitis*/therapy\", \"Periodontal Attachment Loss/therapy\", \"Probiotics*/therapeutic use\", \"Oral Hygiene*\", \"Periodontal Index\" and so on. This search utilized PubMed and Google Scholar, restricted to English-language publications from 2018 to 2024. The screening process involved reviewing titles, abstracts, and keywords, focusing on randomized clinical trials only. Inclusion criteria focused on novel innovations in conventional oral hygiene methodologies. A total of 86 randomized clinical trial articles met the inclusion criteria.</p><p><strong>Results: </strong>Recent innovations in traditional oral hygiene tools have markedly enhanced oral hygiene levels and patient compliance. These newer innovations demonstrate substantial efficacy in plaque control and gingival health. Clinical outcomes underscore their pivotal role in improving oral hygiene standards, promoting reduced gingivitis and enhanced patient adherence to oral care regimens.</p><p><strong>Conclusion: </strong>Advanced oral hygiene aids significantly improve gingival and periodontal health. However, patient adherence and correct usage are crucial for their optimal performance. Incorporating advanced oral hygiene aids into daily practices is essential for achieving optimal periodontal health, and continuous education is necessary to ensure their effective use.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1442887"},"PeriodicalIF":1.5,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of inflammatory mediators in dental pulp inflammation and the potential for their control.","authors":"Nobuyuki Kawashima, Takashi Okiji","doi":"10.3389/fdmed.2024.1426887","DOIUrl":"10.3389/fdmed.2024.1426887","url":null,"abstract":"<p><p>Dental pulp is a mesenchymal connective tissue located inside the rigid encasement of the dentin. When bacteria or bacterial products invade the dental pulp, inflammation known as pulpitis is induced in this tissue. Various mediators produced during the course of pulpitis profoundly modify the pathophysiology of the inflammation. Typical mediators include cytokines, chemokines, nitric oxide, reactive oxygen species, matrix metalloproteinases, proteases, neutrophil extracellular traps, neuropeptides, and eicosanoids. Controlling these mediators may potentially lead to the healing of pulpitis and the preservation of pulp tissue. This review discusses these mediators and further explores the possibility of controlling them.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1426887"},"PeriodicalIF":1.5,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Painful ulcerations associated with COVID-19 in an adolescent patient: a case report.","authors":"David O Danesh, Kyulim Lee, Rebecca G Wallihan, Janice A Townsend, Ira Mulo, Ashok Kumar","doi":"10.3389/fdmed.2024.1412439","DOIUrl":"10.3389/fdmed.2024.1412439","url":null,"abstract":"<p><p>Oral lesions associated with SARS-CoV-2 (COVID-19) include aphthous-like ulcers, herpetiform eruption of vesicles and erosions and other findings. Reactive infectious mucocutaneous eruption (RIME) has recently been used to describe non-<i>Mycoplasma pneumoniae</i> pathogens that can lead to rash and mucositis. RIME secondary to SARS-CoV-2 infection is consistent with reports in the literature. The patient in this case report is significant in that it involves only the oral mucosa, although there are cases reported where mucosal involvement is limited to one site. The degree of mucosal involvement in our case report was in the presence of an acute COVID-19 infection without ocular or genital involvement. Oral lesions associated with COVID-19 infection vary in presentation. This paper adds to the understanding of systemic manifestations of COVID-19 infection and provides a reference of clinical findings, management, and interdisciplinary collaboration for caring for this patient.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1412439"},"PeriodicalIF":1.5,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}