Frontiers in dental medicine最新文献

{"title":"Editorial: Uncovering a multidisciplinary approach in pediatric dentistry.","authors":"Amal Al-Khotani, Nikolaos Christidis, Essam Ahmed Al-Moraissi","doi":"10.3389/fdmed.2025.1639267","DOIUrl":"10.3389/fdmed.2025.1639267","url":null,"abstract":"","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1639267"},"PeriodicalIF":1.5,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12213857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socioeconomic factors and feeding in the first two years of life associated with molar incisor hypomineralisation.","authors":"Sara Ortega-Luengo, María Nieves Ábalos-Sanfrutos, María Isabel Calama-Fraile, Verónica Carballo-Tejeda, María Trinidad García-Vázquez, Antonia M Caleya-Zambrano","doi":"10.3389/fdmed.2025.1573208","DOIUrl":"10.3389/fdmed.2025.1573208","url":null,"abstract":"<p><strong>Purpose: </strong>The main objective of this study was to evaluate the relationship between Molar Incisor Hypomineralisation (MIH) and socioeconomic factors in a sample of children in the Community of Madrid.</p><p><strong>Methods: </strong>An observational, descriptive, cross-sectional, and multicentre study was designed. After a previous calibration of all the examiners and following the diagnostic criteria of the European Academy of Paediatric Dentistry (EAPD), children between 8 and 16 years old were included from among the users of the dental services of eight primary care oral health units of the Madrid Health Service. The children underwent a dental examination, and the parents were asked to complete a questionnaire on possible socioeconomic factors related to the appearance of MIH. Factors such as sex, race, parental education, area of residence, exposure to tobacco and diet in the first two years of life were analysed. With MIH (yes/no) as the dependent variable, the <i>χ</i>2 test was used to compare categorical variables between MIH and non-MIH children. A logistic regression model was made with MIH (yes/no) as the dependent variable and the independent variables being those that were clinically relevant or significant in the bivariate analysis. Their associations are expressed as odds ratios (ORs).</p><p><strong>Results: </strong>Females were significantly more likely to have MIH. The prevalence of MIH decreased with age. Residents in Parla had MIH more often than residents of other municipalities of the Community of Madrid. No other socioeconomic factor studied was associated with MIH.</p><p><strong>Conclusions: </strong>Residents in the municipality of Parla had a higher frequency of MIH, which was a municipality with a low per capita income. When comparing the presence of MIH in breastfed children, statistically significant differences were observed. Logistic regression, however, did not suggest that breastfeeding could influence the presence of MIH. Further study is warranted on possible socioeconomic risk factors for MIH, such as household income, to lower the incidence of this pathology.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1573208"},"PeriodicalIF":1.5,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12213567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of knowledge of the 2017 classification for periodontal and peri-implant diseases on diagnostic accuracy among dental students.","authors":"Shatha Bamashmous, Abdullaziz Farahat, Waleed Alharbi, Arwa Banjar, Amal Jamjoom, Arwa Badahdah","doi":"10.3389/fdmed.2025.1558380","DOIUrl":"10.3389/fdmed.2025.1558380","url":null,"abstract":"<p><strong>Background: </strong>Periodontal diseases are a significant global health problem and have been associated with various systemic diseases. The American Academy of Periodontology (AAP) and the European Federation of Periodontology (EFP) introduced a new classification system for periodontal and peri-implant diseases in 2017. However, the complexity of this new classification has presented some challenges in its implementation compared to the 1999 classification system. This study evaluates the impact of dental students' knowledge of the 2017 classification on their ability to diagnose periodontal diseases accurately.</p><p><strong>Materials and methods: </strong>This cross-sectional study enrolled 146 fifth- and sixth-year dental students from King Abdulaziz University in Jeddah, Saudi Arabia. A self-reported questionnaire was employed to assess students' knowledge of the 2017 periodontal classification system and their diagnostic abilities across five clinical cases. Students were classified into low, moderate, and high knowledge groups based on their knowledge questionnaire scores. Statistical analyses assessed the relationship between classification knowledge and diagnostic accuracy and compared these measures across different groups.</p><p><strong>Results: </strong>In the study, 41.10% of participants achieved high knowledge scores (14-16 correct answers), while 32.88% and 26.03% were categorized into moderate and low knowledge groups, respectively. There was no significant association between knowledge levels and diagnostic accuracy, except for one specific clinical case. While sixth-year students scored significantly higher in the knowledge assessment than fifth-year students (<i>p</i> = 0.005), their diagnostic accuracy did not significantly differ. The main challenge, as reported by students, was the discrepancy between case complexity and their clinical experience (28.1%).</p><p><strong>Conclusion: </strong>This study found no significant impact of dental students' knowledge of the 2017 periodontal classification system on diagnostic accuracy. Challenges such as discrepancies between case complexity and clinical experience and teaching inconsistencies underscore the need for enhanced clinical simulations, case-based learning, and targeted educational training to improve diagnostic accuracy and clinical competence.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1558380"},"PeriodicalIF":1.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retention of skull anatomy knowledge in dental education: a comparative study.","authors":"Noora Helene Thune, Anna Tostrup Kristensen, Qalbi Khan, Tor Paaske Utheim, Hugo Lewi Hammer, Amer Sehic","doi":"10.3389/fdmed.2025.1596610","DOIUrl":"10.3389/fdmed.2025.1596610","url":null,"abstract":"<p><p>There is limited evidence regarding the retention of essential basic science knowledge among dental students and professionals. Understanding the anatomy of the skull, osteology, is crucial as it provides the structural framework essential for comprehending head anatomy, where various soft tissue components are organized. This study aims to evaluate and compare the retention of osteological knowledge across different stages of dental education and professional practice. Specific anatomical structures on selected skull bones and the complete cranium, taught at the pre-clinical level and including clinically and radiographically significant landmarks, were marked for assessment. The study evaluated the ability of second year and fifth year undergraduate dental students, as well as postgraduate students at various stages of specialist training in different dental fields, to independently identify these marked anatomical structures. The study demonstrated significantly higher identification accuracy among second year students compared to fifth year and postgraduate students (<i>p</i> < 0.05). Second year students achieved over 90% accuracy for individual skull bones, with slightly lower accuracy for the entire cranium (85.9%). Fifth year students showed markedly lower retention, with accuracy below 50%, ranging from 20.8% (cranium) to 48.3% (mandible). Postgraduate students performed similarly to fifth year students, notably with only 11.8% accuracy for the sphenoid bone. Significant differences in accuracy were observed among postgraduate specialties (<i>p</i> < 0.05), with oral surgery and oral medicine specialists achieving the highest accuracy (81.2% for the mandible). However, no significant correlation between years of experience and accuracy was observed among the postgraduate groups (<i>p</i> = 0.45). Our results indicate that clinically and radiologically relevant anatomical knowledge is better retained over time, while overall osteological knowledge significantly declines. This highlights the need for strategies beyond initial learning to enhance long-term retention. Integrating clinical, radiological, and surface anatomy into continuing dental education could substantially improve knowledge retention. Furthermore, our findings suggest potential benefits from increased vertical integration and encourage broader discussion regarding the traditional separation between pre-clinical and clinical training phases.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1596610"},"PeriodicalIF":1.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Dental autotransplantation for the resolution of odontogenic sinusitis using 3D replication.","authors":"Henry Paul Valverde Haro, Adriana Denisse Erazo Conde","doi":"10.3389/fdmed.2025.1607035","DOIUrl":"10.3389/fdmed.2025.1607035","url":null,"abstract":"<p><p>This case report presents the use of dental autotransplantation, a procedure in which a donor tooth is transferred to a recipient site in the same patient, improving functional and esthetic characteristics. The advantages of this technique compared to conventional prostheses and surgical treatments, such as dental implants, are discussed. A 27-year-old patient with no relevant medical history was evaluated for pain and discomfort in fractured teeth with previous endodontic treatments and odontogenic sinusitis. A non-restorable maxillary first molar was diagnosed and extracted and replaced with a previously endodontically treated maxillary third molar, for which a 3D-printed replica was used to reshape the alveolar site. The intervention was successful, after which an adequate clinical and radiographic follow-up was carried out for 3 years, showing good bone formation and continuity of the periodontal ligament, with no signs of pathological resorption. This case demonstrates that, when properly planned and executed, dental autotransplantation can be an effective and biological alternative for dental rehabilitation, especially with the use of advanced technologies, such as cone beam computed tomography and 3D-printed replicas of donor teeth.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1607035"},"PeriodicalIF":1.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing precision dentistry: the integration of multi-omics and cutting-edge imaging technologies-a systematic review.","authors":"Neelam Das","doi":"10.3389/fdmed.2025.1581738","DOIUrl":"10.3389/fdmed.2025.1581738","url":null,"abstract":"<p><strong>Background: </strong>The convergence of multi-omics, advanced imaging technologies, and artificial intelligence (AI) is reshaping diagnostic strategies in precision dentistry. This systematic review critically assesses how the integration of multi-omics (genomics, proteomics, metabolomics), advanced imaging modalities (CBCT, MRI), and AI-based techniques synergistically enhances diagnostic accuracy, clinical decision-making, and personalized care in dentistry.</p><p><strong>Methods: </strong>The review follows PRISMA 2020 guidelines. A total of 50 studies published between 2015 and 2024 were selected using a PICOS framework. Analytical tools included meta-analysis (Forest and Funnel plots), risk of bias assessment, VOS viewer-based bibliometric mapping, and GRADE evidence grading.</p><p><strong>Results: </strong>Multi-omics approaches revealed key biomarkers such as TP53, IL-1, and MMPs in early diagnosis. CBCT reduced diagnostic error by 35% (CI: 30%-40%), while MRI improved soft-tissue evaluation by 25% (CI: 18%-32%). AI tools, including convolutional neural networks and radiomics, led to a 40% reduction in diagnostic time (CI: 33%-45%) and improved lesion classification.</p><p><strong>Conclusion: </strong>Integrating AI with omics and imaging technologies enhances diagnostic precision in dentistry. Future efforts must address data standardization, ethical implementation, and validation through multicenter trials for clinical adoption.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1581738"},"PeriodicalIF":1.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective evaluation of subgingival irrigation with i-PRF following non-surgical treatment of peri-implantitis.","authors":"Laurie Deterville, Jérôme Frédéric Lasserre, Selena Toma","doi":"10.3389/fdmed.2025.1568889","DOIUrl":"10.3389/fdmed.2025.1568889","url":null,"abstract":"<p><strong>Introduction: </strong>Peri-implantitis, an inflammatory condition around dental implants, is challenging to manage with conventional non-surgical treatments alone. Emerging adjunctive therapies like glycine air-polishing and injectable platelet-rich fibrin (i-PRF) show potential to enhance decontamination.</p><p><strong>Aim: </strong>To clinically and radiographically evaluate the efficacy of glycine air-polishing and the adjunctive use of injectable platelet rich fibrin (i-PRF) for the non-surgical treatment of slight peri-implantitis.</p><p><strong>Methods: </strong>For this prospective case series, nine patients (<i>n</i> = 14 implants), with at least one implant with a slight peri-implantitis (radiographic bone loss visible and up to 4 mm) were enrolled. All treated implants received the same treatment: non-surgical mechanical debridement with an air abrasive device (PERIOFLOW®) followed by a subgingival irrigation with an injectable platelet rich fibrin (i-PRF). The following clinical parameters were measured: Plaque Index (PI), Bleeding on Probing (BoP), Suppuration on Probing (SoP), Probing Pocket Depth (PPD), Relative Attachment Level (RAL) and Recession (REC). They were assessed at baseline (M0), 3 and 6 months (M3 and M6). To compare bone level (BL), radiographs were taken at M0 and M6 (<i>p</i> > 0.05, ANOVA, Bonferroni).</p><p><strong>Results: </strong>Results indicated that PI significantly decreased over 6 months to a mean value of <0.05. Both BoP (<i>p</i> < 0.05) and SoP (<i>p</i> < 0.05) were substantially reduced at 3 months, although a slight increase was noted at 6 months. Mean PPD was 3.61 ± 0.25 mm (<i>p</i> < 0.05) at M6, and RAL gain was significantly improved at 6 months (7.76 ± 0.34 mm, <i>p</i> < 0.05). BL showed a significant grain at 6 months (<i>p</i> < 0.05). Most mucosal recession occurred within the first 3 months, with no significant change at 6 months.</p><p><strong>Conclusion: </strong>The application of i-PRF after a subgingival debridement using glycine air-polishing shows significant improvement of clinical parameters and a bone level stability for at least six months. However, if we consider that no bleeding on probing is needed to control the disease, none of the implants were considered successfully treated. Further randomized clinical trials are needed to evaluate the benefits of i-PRF as an adjuvant to the treatment of peri-implantitis.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1568889"},"PeriodicalIF":1.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiparameter flow cytometry enables immune profiling and IFN pathway analysis in human minor salivary glands.","authors":"Eiko Yamada, Kalie Dominick, Rachel J Kulchar, Joseph Twohig, Zohreh Khavandgar, Margaret Beach, Eileen Pelayo, Alan Baer, Paola Perez, Blake M Warner","doi":"10.3389/fdmed.2025.1590516","DOIUrl":"10.3389/fdmed.2025.1590516","url":null,"abstract":"<p><strong>Aim/introduction: </strong>We aimed to achieve direct quantitative measurement of activated and therapeutically actionable pathways (e.g., Type-I interferon) in target organs of autoimmune disease using flow cytometry of human salivary glands. Sjögren's Disease (SjD) is a systemic autoimmune disorder characterized by lymphocytic inflammation and dysfunction of the lacrimal and salivary glands. Minor salivary glands are routinely biopsied and are used for the histopathological diagnosis of SjD. In this study, we optimized the dissociation, permeabilization, antibody panel, and analytical parameters to characterize both the immune and epithelial cells in the glands, and the activation status of a specified pathway by measuring intracellular phosphorylated proteins.</p><p><strong>Methods: </strong>Fresh human MSG biopsies were dissociated into single-cell suspensions and permeabilized under optimized conditions. MSG suspensions were stained for cell surface and intracellular markers then analyzed using nine-color conventional flow cytometry, including two intracellular markers.</p><p><strong>Results: </strong>Our optimized dissociation and permeabilization protocols for human MSG preserved key cell surface markers. Our flow cytometry panel identified major immune cell populations and distinguished epithelial cells via cytokeratin-18. We demonstrate the protocol's utility showing differential interferon pathway activity in SjD vs. healthy MSG leukocytes and epithelial cells. We provide guidance on panel selection, analytical capabilities, and the impact of cell yield on resolution using conventional flow cytometry.</p><p><strong>Conclusion: </strong>Our optimized protocol enables high-resolution characterization of immune and epithelial cell populations in human MSG, preserving key markers and capturing interferon pathway activity. Our protocol provides a robust framework for the direct study of immune heterogeneity and signaling dynamics in SjD at single cell resolution.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1590516"},"PeriodicalIF":1.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overdenture pickup without retaining material; a novel dental technique.","authors":"Noha Waleed Barakat, Mahmoud Mokhtar El Far, Ahmed Mustafa Hashim Kotb","doi":"10.3389/fdmed.2025.1589993","DOIUrl":"10.3389/fdmed.2025.1589993","url":null,"abstract":"<p><p>This article describes a novel technique for overdenture metal housing pickup for a digitally fabricated overdenture using an extraoral scanner and ExoCAD software. This technique could help the clinician save time and reduce the hassle of extra visits and additional laboratory steps.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1589993"},"PeriodicalIF":1.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subgingival microbiota and genetic factors (A-2570G, A896G, and C1196T TLR4 polymorphisms) as periodontal disease determinants.","authors":"Raúl Castro-Casarrubias, Natividad Castro-Alarcón, Salvador Reyes-Fernández, Elena Salazar-Hernández, Mirna Vázquez-Villamar, Norma Samanta Romero-Castro","doi":"10.3389/fdmed.2025.1576429","DOIUrl":"10.3389/fdmed.2025.1576429","url":null,"abstract":"<p><strong>Background: </strong>Subgingival microbiota play an important role in maintaining oral health. Subgingival dysbiosis leads to the aggregation of highly pathogenic bacteria, and the host's genetics modulates the innate immune response. The interaction between these two factors plays an important role in the aggravation of periodontitis. Therefore, evaluating the association between the TLR-4 polymorphisms and subgingival microbiota in patients with periodontitis is necessary.</p><p><strong>Methods: </strong>We included 58 cases with periodontitis and 53 controls without periodontitis in this study. A896G, A-2570G, and C1196T polymorphisms of the <i>TLR4</i> gene were determined by the polymerase chain reaction and restriction fragment length polymorphism technique. The DNA-DNA checkerboard hybridization technique was used for the identification and quantification of 18 bacterial species of subgingival plaque.</p><p><strong>Results: </strong><i>Cutibacterium acne</i>s occurred in greater number and frequency than other bacterial species ( <math><mover><mi>χ</mi> <mo>¯</mo></mover> </math> 1.32 E + 05) in individuals with periodontitis. Patients with <i>C. acnes</i> had a higher risk [odds ratio (OR)= 3.82 (95% confidence interval (CI): 1.37-10.3)] of developing periodontitis (<i>p</i> < 0.05), as did those with orange and red complex bacteria (<i>Treponema denticola</i>, <i>Tannerella forsythia</i>, <i>Porphyromonas gingivalis</i>, <i>Prevotella nigrescens</i>, <i>Prevotella intermedia, Fusobacterium periodonticum</i>, <i>Fusobacterium nucleatum</i>, <i>Eubacterium nodatum,</i> and <i>Campylobacter rectus</i>). The A/G genotype of SNP -2570 of the <i>TLR4</i> gene was identified as a risk factor for the development of periodontitis [OR = 2.28 (95% CI: 1.04-5.00)]. Furthermore, there was an antagonistic biological effect of the presence of bacteria such as <i>Capnocytophaga gingivalis</i> [OR = 0.44 (95% CI: 0.20-1.96)] and <i>C. rectus</i> [OR = 0.39 (95% CI: 0.18-0.87)] (<i>p</i> < 0.05). The A/G genotype of SNP-2570 was correlated with greater clinical attachment loss and periodontal pocket depth.</p><p><strong>Conclusions: </strong>The agonistic or antagonistic biological effect of each bacterial species depends on the genotype present in each individual and the destruction processes of dental support tissues.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1576429"},"PeriodicalIF":1.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}