Frontiers in dental medicine最新文献

{"title":"Unveiling sex-disparities and the impact of gender-affirming hormone therapy on periodontal health.","authors":"Cristina Cunha Villar, Mariane Cristina Sloniak, Josiane Betim de Assis, Renata Cassiano Porto, Giuseppe Alexandre Romito","doi":"10.3389/fdmed.2024.1430193","DOIUrl":"10.3389/fdmed.2024.1430193","url":null,"abstract":"<p><strong>Introduction: </strong>As personalized medicine advances, the need to explore periodontal health across different sexes and gender identities becomes crucial. This narrative review addresses the gap in understanding how biological sex and gender-affirming hormone therapy (GAHT) influence periodontitis risk.</p><p><strong>Results: </strong>Research has uncovered significant sex-based immunological disparities driven by X and Y chromosome gene expression and sex-hormones, which may influence susceptibility to periodontitis. Additionally, preliminary findings suggest that GAHT, particularly testosterone therapy in transgender men, could exacerbate pro-inflammatory cytokine production and alter immune cell responses, which may exacerbate inflammatory pathways crucial in the progression of periodontitis. Conversely, the effects of estrogen therapy in transgender women, although less extensively studied, suggest modifications in B cell functionality. These observations highlight the complex role of GAHT in modulating immune responses that are central to the development and exacerbation of periodontal disease.</p><p><strong>Discussion: </strong>The review highlights a complex interaction between sex hormones, gene expression patterns, immune responses, and periodontitis risk. While cisgender males show increased susceptibility to periodontitis that could be linked to specific immune pathways, GAHT appears to modify these pathways in transgender individuals, potentially altering their risk and disease progression patterns.</p><p><strong>Conclusion: </strong>There is a critical need for more focused research on the direct impacts of GAHT on periodontal health. Understanding the nuances of immune modulation by GAHT will aid in crafting personalized periodontal care for transgender individuals, aligning with the broader goals of inclusive and effective healthcare.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1430193"},"PeriodicalIF":1.5,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finite element analysis of dental structures: the role of mandibular kinematics and model complexity.","authors":"Canan Özcan, Philippe Lestriez, Mutlu Özcan, Yannick Josset","doi":"10.3389/fdmed.2024.1461909","DOIUrl":"10.3389/fdmed.2024.1461909","url":null,"abstract":"<p><strong>Introduction: </strong>This study observed the consequences of integrating mandibular kinematics in maxillary and mandibular teeth contact in a finite element analysis (FEA), and investigate the level of simplification of the dental models in FEA. The purpose of this study was to compare the results of finite element analysis obtained from simple to more complex dental models incorporating mandibular motion during loading phase.</p><p><strong>Methods: </strong>Six models were generated for this study. The simplest models consisted of only the crown of the tooth and an antagonist tooth with either the same properties or rigid body properties while the subsequent models incorporated the root of the study tooth and the surrounding bone. The most complex model involved the hyperelastic ligament and the other anatomical elements of the tooth and surrounding bone. Mandibular movement data recorded with the Modjaw® system (Modjaw-Technologie) were used to bring the teeth into contact and generate the loading in all models where the stresses exerted on tooth structures during the chewing process were evaluated.</p><p><strong>Results: </strong>von Mises stress and the shear stress obtained in all models, exceeded the ultimate compression strength of the materials, except for the model with the hyperelastic periodontal ligament. The forces applied to the tooth were extremely different depending on the addition or removal of anatomical elements despite the systematic study of the same teeth.</p><p><strong>Discussion: </strong>The inclusion of mandibular kinematics in the finite element analysis requires the modelling of a complex dental model as simplification generated an overestimation of the forces and stresses on the structures. Finite element dental models allow for the observation and prevention of restorative failures by numerical methods but misinterpretations caused by poorly designed models have clinical implications on estimating performance of dental restorations.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1461909"},"PeriodicalIF":1.5,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Impact of uncontrolled diabetes on oral disease progression and healing.","authors":"Ryan Moseley, Rachel Jane Waddington","doi":"10.3389/fdmed.2024.1487051","DOIUrl":"10.3389/fdmed.2024.1487051","url":null,"abstract":"","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1487051"},"PeriodicalIF":1.5,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating tooth morbidity risks, prevalence, and interventions in tribal setting: a study protocol focused on the Irula community in Tamil Nadu.","authors":"Margret Beaula Alocious Sukumar, Roshni Mary Peter, Alex Joseph","doi":"10.3389/fdmed.2024.1427597","DOIUrl":"10.3389/fdmed.2024.1427597","url":null,"abstract":"<p><strong>Aim: </strong>Dentistry is uniquely positioned as a healthcare profession, distinguished from allied health or paramedical fields. It operates within a university-based structure, maintaining primary care responsibilities. Oral diseases impose a substantial worldwide health and economic burden, profoundly affecting the well-being of those affected. This cross-sectional study is centered on the Irula tribes in Tamil Nadu, India. Investigating the extent of tooth morbidity and loss, identifying possible risk factors, looking at oral hygiene habits, and evaluating the oral health-associated quality of life (OHRQoL) in this population are the main goals. As this population is at high risk for dental issues, promoting good oral hygiene becomes crucial. Indigenous populations, including the Irula tribes, have been underrepresented in research studies. The vulnerability of the Irula tribes is exacerbated by their remote locations, resulting in limited access to fundamental healthcare facilities.</p><p><strong>Materials and methods: </strong>This study employs a cluster sampling approach, aiming to include 880 individuals aged 60 and above from Kancheepuram and Chengalpattu districts. The methodology encompasses a community-based questionnaire, clinical assessments utilizing standardized indices, and the assessment of the Oral Health-Related Quality of Life (OHRQoL). The Statistical Package for Social Services, version 20, will be used to analyze all of the data that has been gathered (SPSS).Categorical variables will undergo analysis, with descriptive statistics and frequency percentages computed.</p><p><strong>Conclusion: </strong>This study evaluates tooth morbidity and dentistry's role in screening chronic diseases like diabetes among the Irula tribes. It explores risk factors, oral hygiene practices, treatment seeking behavior, and oral health-related quality of life to gain a comprehensive understanding.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1427597"},"PeriodicalIF":1.5,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel temporary endodontic medication based on calcium silicate strategy: a biological and physicochemical study.","authors":"Claire El Hachem, Salvatore Sauro, Ammar Eid, Burçin Arıcan, Raya Alrayesse, Camille Fabro, Varvara Gribova, Louis Hardan, Youssef Haikel, Naji Kharouf","doi":"10.3389/fdmed.2024.1451275","DOIUrl":"10.3389/fdmed.2024.1451275","url":null,"abstract":"<p><strong>Introduction: </strong>The purpose of this <i>in vitro</i> study was to compare the physicochemical and biological properties of a traditional calcium hydroxide-based cement (Cal) to a novel endodontic material based on calcium silicate strategy in premixed formulation (Bio-C).</p><p><strong>Methods: </strong>Crystalline structure evaluation and pH analysis were performed at different time periods (3-168 h). Contact angle, surface roughness, solubility and flowability of both materials were also investigated. The antibacterial activity of each material was assessed using a direct contact test against <i>Enterococcus faecalis (E.faecalis)</i>, and the cytotoxicity was performed by using periodontal ligament cells. Statistical analysis was accomplished using one-way analysis of variance and Kruskal-Wallis tests.</p><p><strong>Results: </strong>An alkaline pH was observed in both the tested materials. Higher pH values were attained in Cal compared to Bio-C (<i>p</i> < 0.05). Higher flowability, solubility and wettability were attained for Bio-C compared to Cal (<i>p</i> < 0.05). Crystalline structures were observed on the surface of Bio-C after immersion in PBS (168 h). Cal presented higher antibacterial activity compared to Bio-C against <i>E.faecalis</i>. Only undiluted Bio-C extracts demonstrated slight cytotoxicity, while all the other tested specimens had no cytotoxicity.</p><p><strong>Discussion: </strong>In conclusion, the novel bioceramic medication might be used as a suitable alternative agent to the traditional calcium hydroxide cements due to its biological and physicochemical properties. However, further studies on the ability of removing Bio-C from root canal are required to determine whether such a temporary bioceramic can ameliorate root canal treatments.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1451275"},"PeriodicalIF":1.5,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The presence of ACE2 and regulatory miRNAs (miR-200c-3p and miR-421-5p) in the saliva of periodontitis patients post-COVID-19 vaccination.","authors":"Boy M Bachtiar, Natalina Haerani, Yuniarti Soeroso, Nada Ismah, Endang W Bachtiar","doi":"10.3389/fdmed.2024.1438139","DOIUrl":"10.3389/fdmed.2024.1438139","url":null,"abstract":"<p><p>The effectiveness of COVID-19 mRNA vaccines in individuals with periodontitis is crucial. This study evaluated the efficacy of the BNT162b2 vaccine in individuals with periodontitis who had been vaccinated at least 6 months earlier. Using real-time PCR, the association between the SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) and miRNA-200c-3p and miRNA-421-5p as well as interleukin-6 (IL-6) was examined in the saliva of moderate (G1, <i>n</i> = 10) and severe (G2, <i>n</i> = 10) periodontitis subjects. Participants without periodontitis were included as a control group. The transcription levels of soluble ACE2 and IL-6 were higher in periodontitis participants than in control participants, but within periodontitis groups, only IL-6 expression was higher in G2 than in G1. A positive strong correlation between ACE2 and IL-6 was only observed in the G2 group (<i>p </i>= 0.008). The expression of miR-200c-3p but not miR-421-5p was higher in periodontitis individuals. Their relationship was positive but a strong correlation was only observed in the G2 group. In all periodontitis groups, a strong inverse correlation was observed between the two microRNAs and ACE2. However, receiver operating characteristic (ROC) analysis showed that only the relationship between ACE2 and miR-4215p had potential as a biomarker for the efficacy of the mRNA vaccine, with areas under the ROC curve of 0.92 and 0.80 in the G1 and G2 groups, respectively. Our study revealed that active and non-active periodontitis conditions do not interfere with the efficacy of the BNT162b2 vaccine for at least 6 months post-vaccination. This suggests that in individuals with periodontitis, soluble ACE2 in the saliva may serve as a preliminary indicator of vaccine response.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1438139"},"PeriodicalIF":1.5,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In vitro</i> and <i>ex vivo</i> comparison of reactive oxygen-releasing granules for internal tooth bleaching.","authors":"Romy M Mayer, Andrea Gubler, Thomas Attin, Matthias Zehnder","doi":"10.3389/fdmed.2024.1447459","DOIUrl":"10.3389/fdmed.2024.1447459","url":null,"abstract":"<p><strong>Introduction: </strong>Traditionally, internal tooth bleaching was performed using sodium perborate slurries. These are banned in some areas for potential carcinogenic effects. More recently, highly concentrated hydrogen peroxide gels have been used, which may cause dentin degradation. Consequently, the search for ideal internal tooth bleaching agents is still on. This study compared pure ROS-releasing granules regarding their liberation of oxidizing species, pH induction, bleaching of blood-stained dentin, and effects on mechanical dentin properties.</p><p><strong>Materials and methods: </strong>The ROS-releasing granules under investigation were sodium perborate, carbamide peroxide, and sodium percarbonate in aqueous suspension (4:3, wt/wt). The bleaching efficacy of these suspensions was compared in blood-stained human dentin (<i>n</i> = 6) <i>ex vivo</i>. In addition, effects on mechanical dentin integrity were tested using bovine dentin beams (<i>n</i> = 9) exposed to a 3-point bending test (ISO 4049) after immersion in test suspensions or control solutions (35% H₂O₂ and physiological saline) for 1 week.</p><p><strong>Results: </strong>Granules release between 21.5% and 35.2% (wt/wt) of H₂O₂ equivalent. The sodium-containing granules (perborate and percarbonate) caused an alkaline pH of 10.3 and 10.6, respectively. The carbamide peroxide suspension was acidic (pH 3.9), as was the 35% H₂O₂ solution used as a control (pH 2.2). All the suspensions bleached the blood-stained dentin, albeit with a lesser overall effect by sodium percarbonate (one-way ANOVA and Tukey's HSD, <i>p</i> < 0.05). The acidic preparations caused a severe (over 50%) reduction in flexural strength of the dentin (<i>p</i> < 0.05 compared to physiological saline solution), while the alkaline counterparts did not.</p><p><strong>Conclusions: </strong>Sodium perborate granules in aqueous suspension combined good de-staining properties with limited untoward effects on dentin integrity. Further studies are required to identify alternative compounds with a lesser general health concern.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1447459"},"PeriodicalIF":1.5,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and eruption of human teeth in the Chinese population: a comprehensive dental atlas.","authors":"Jayakumar Jayaraman","doi":"10.3389/fdmed.2024.1434417","DOIUrl":"10.3389/fdmed.2024.1434417","url":null,"abstract":"<p><strong>Aim: </strong>The first comprehensive chart on dental development was published 75 years ago based on Caucasian children and this has been used as a standard dental chart to date. Few population specific charts have been developed recently and updated dental charts on modern subjects can provide more information on dental development patterns. This study aims to construct a comprehensive dental atlas for modern Chinese children and young adults to assist in clinical, forensic, and public health applications.</p><p><strong>Methods: </strong>The study sample comprised of 2,306 subjects, age ranging from 2 to 24 years belonging to Chinese ethnicity. Dental formation and eruption of permanent teeth and resorption of primary teeth were analyzed separately for females and males. For each age range, the number of teeth (n), and the stage of development was calculated for first (Q1), second (Q2) and third quartiles (Q3). Similar analysis was performed for the position of permanent teeth and the resorption of primary teeth. To determine the variations between the sex, Mann-Whitney <i>U</i>-test was conducted by comparing the median (Q2) stages.</p><p><strong>Results: </strong>Variations in dental formation and eruption of permanent teeth and resorption of primary teeth were observed between maxillary and mandibular dentitions and between the sex, however the difference was not statistically significant (<i>p</i> = 0.535 to <i>p</i> = 1.000). The dental atlas was presented separately for Chinese females and males.</p><p><strong>Conclusion: </strong>This atlas on modern Chinese population serves as a practical tool to assist in clinical diagnosis and treatment planning, in forensic investigations as well as indicators of developments in public health.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1434417"},"PeriodicalIF":1.5,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical parameters in patients with halitosis: a cross-sectional study.","authors":"Ahoud Jazzar, Hebah AlDehlawi, Arwa Farag, Sana Alhamed, Sara Akeel, Yasmin Mair, Kenana Flemban, Hidaya Alqassab, Khalid Aljohani","doi":"10.3389/fdmed.2024.1427280","DOIUrl":"10.3389/fdmed.2024.1427280","url":null,"abstract":"<p><strong>Background: </strong>Halitosis, a socially and psychologically impactful condition often resulting from oral or systemic issues, is exacerbated by factors like aging, poor oral hygiene, and dietary choices. This study aimed to investigate the association between halitosis and stress by measuring salivary cortisol levels and the Cohen's Perceived Stress Scale (CPSS).</p><p><strong>Methods: </strong>A cross-sectional study of 40 participants was conducted using questionnaires and clinical measurements to assess halitosis and stress levels. Saliva samples were collected and analyzed for cortisol using ELISA. Participants' stress was assessed with the Cohen's Perceived Stress Scale Questionnaire (CPSS-10) questionnaire, and halitosis was measured with a Halimeter and self-assessment questionnaire. Clinical measurements included Plaque Index (PI) and the Decayed, Missing, and Filled Teeth (DMFT) score.</p><p><strong>Results: </strong>Forty subjects were split into a halitosis group (mean age 30.75 ± 10.15) and group with no halitosis (mean age 26 ± 5.3). Objective measures confirmed higher halitosis scores (3.70 ± 0.73) in the halitosis group vs. the second group (2.60 ± 1.67). Compared with the group with no halitosis, the halitosis group exhibited significantly (<i>p</i> < 0.05) more plaque (27.92% ± 17.16% vs. 47.50 ± 33.57%; <i>p</i> < 0.05) and higher DMFT scores (10.10 ± 2.51 vs. 26 ± 5.30), respectively. Salivary cortisol levels were similar across groups (1.721 ng/ml halitosis, 1.781 ng/ml without halitosis). Correlations showed a moderate positive relationship between DMFT and halimeter scores (<i>r</i> = 0.377, <i>p</i> = 0.018) and a moderate negative correlation between stress and plaque index (<i>r</i> = -0.403, <i>p</i> = 0.011), with no correlation between halimeter score and cortisol or CPSS score.</p><p><strong>Conclusions: </strong>Our findings showed that while halitosis severity correlated with higher DMFT scores and plaque accumulation, there was no significant association with salivary cortisol levels, suggesting that stress, as measured by salivary cortisol, may not be a direct contributor to halitosis. Furthermore, the data suggest that poor oral hygiene is a more significant factor in the development of halitosis than stress levels, as assessed by the CPSS-10.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1427280"},"PeriodicalIF":1.5,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of precision medicine into the dental care setting.","authors":"Larissa Steigmann, Željka Perić Kačarević, Jessica Khoury, Katalin Nagy, Magda Feres","doi":"10.3389/fdmed.2024.1398897","DOIUrl":"10.3389/fdmed.2024.1398897","url":null,"abstract":"<p><p>This narrative review aims to discuss the incorporation of novel medical concepts and tools into dental practice, with the goal of improving early diagnosis and exploring new personalized treatment options for oral pathologies, such as caries and periodontitis. Preventative dental approaches concentrate on the timely detection of oral infections and the integration of biomarker analysis to recognize pathogenic changes at early stage of disease. Likewise, periodic monitoring after the treatment is relevant to ensure the balance in the oral biofilms and prevent relapse. Additionally, more attention has shifted towards the contributing factors to disease development, such as essential nutrients. Sufficient levels of vitamin C, vitamin D and zinc pre- and post-operatively are employed to boost immune function and reduce the risk of postoperative infections. Omega-3 fatty acids, melatonin, and antioxidants like vitamin E, which have anti-inflammatory properties, are utilized to help minimize excessive inflammation and promote faster recovery. The data presented in this manuscript emphasize the crucial integration of innovative healthcare concepts and tools into dental practices. By adopting a more holistic view of the patient, clinicians can tailor treatments to each individual's predispositions, lifestyle, and oral health conditions. This review also highlights the potential of salivary biomarkers and point-of-care technologies in enhancing early diagnostic accuracy and personalizing treatment. Bridging the gap between oral and systemic health is the most effective approach to improving patient quality of life. These findings underscore the importance of continued interdisciplinary collaboration in dentistry.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"5 ","pages":"1398897"},"PeriodicalIF":1.5,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}