Frontiers in dental medicine最新文献

{"title":"Predictive analysis of root canal morphology in relation to root canal treatment failures: a retrospective study.","authors":"Mohmed Isaqali Karobari, Vishnu Priya Veeraraghavan, P J Nagarathna, Sudhir Rama Varma, Jayaraj Kodangattil Narayanan, Santosh R Patil","doi":"10.3389/fdmed.2025.1540038","DOIUrl":"https://doi.org/10.3389/fdmed.2025.1540038","url":null,"abstract":"<p><strong>Background: </strong>Failure of root canal treatment (RCT) significantly affects patient outcomes and dental practice. Understanding the association between root canal morphology and RCT outcomes can help predict treatment success. This study aimed to analyze the predictive role of root canal morphology in RCT failure.</p><p><strong>Methods: </strong>This retrospective study included 224 patients who underwent RCT. Demographic data, tooth type, and root canal morphology were also recorded. Univariate and multivariate logistic regression analyses were performed to identify predictors of RCT failure. Additionally, machine learning algorithms were employed to develop a predictive model that was evaluated using receiver operating characteristic (ROC) curves.</p><p><strong>Results: </strong>Of the 224 RCTs, 112 (50%) were classified as successful and 112 (50%) as failure. Severe canal curvature (<i>p</i> < 0.001) and presence of accessory canals (<i>p</i> = 0.002) were significant predictors of failure. The final predictive model demonstrated an area under the ROC curve (AUC) of 0.83, indicating good accuracy in distinguishing between successful and failed RCTs.</p><p><strong>Conclusion: </strong>These findings underscore the importance of root canal morphology in predicting RCT outcomes. Machine learning approaches can enhance clinical decision making, enabling better treatment planning for patients at a higher risk of RCT failure.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1540038"},"PeriodicalIF":1.5,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Saccharibacteria</i> (TM7) in saliva and subgingival microbiome as a predictor for gingivitis in individuals with type2 diabetes evaluated by qPCR.","authors":"Boy M Bachtiar, Dicky L Tahapary, Turmidzi Fath, Citra F Theodorea, Natalina Haerani, Yuniarti Soeroso, Selvi Nafisa Shahab, Ardy Wildan, Fergie Marie Joe Grizella Runtu, Fatimah Maria Tadjoedin, Dewi Ayuningtyas, Lisa Amir, Endang W Bachtiar","doi":"10.3389/fdmed.2025.1550936","DOIUrl":"https://doi.org/10.3389/fdmed.2025.1550936","url":null,"abstract":"<p><p>Oral samples are widely used for studying oral microbiome in health and diseases. In this study, saliva and subgingival biofilm (SGB) samples obtained from patients with type2 diabetes (T2DM), without periodontitis (G1 group), with gingivitis (G2 group), and periodontitis (G3 group), were used to compare the abundance of <i>Saccharibacteria</i> (TM7), its host's bacteria (<i>Schaalia odontolytica</i>), periodontopathogen (Represented by <i>Fusobacterium nucleatum</i>), and nitrate-reducing bacteria (represented by <i>Rothia mucilaginosa</i>). The gingival crevicular fluid were also used to analyze the transcription levels of interleukin-6 (IL-6) and C-reactive protein (CRP). Healthy individuals' oral samples served as a control, and the targeted bacteria and inflammatory indicators were detected and measured using real-time PCR. The results showed that in either sample, the abundance of TM7 and other targeted bacteria showed a similar profile. Notably, within participants with T2DM, the abundance of TM7 was similar in G1 and G2 groups, but significantly decreased in G3 group. With the exception of the SGB of the G3 group, the relationship between TM7 and its bacterial host was strongly positive across all evaluated samples. Furthermore, CRP had higher transcription levels than IL-6 across the entire group. Despite the fact that the G3 group showed an adverse relationship between TM7 and CRP, patients with T2DM generally showed a positive correlation between TM7 and IL-6/CRP, which was verified by a receiver operating curve.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1550936"},"PeriodicalIF":1.5,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the 4D printing linked bio-smart materials in dentistry: a concise overview.","authors":"Maajida Aafreen M, Priyanka K Cholan, Paavai Ilango, Harinath Parthasarathy, Anupama Tadepalli, Lakshmi Ramachandran","doi":"10.3389/fdmed.2025.1558382","DOIUrl":"https://doi.org/10.3389/fdmed.2025.1558382","url":null,"abstract":"<p><p>4D printing advances traditional 3D printing by incorporating the dimension of time, enabling stimuli-responsive shape or behavior changes. Bio-smart materials, crucial to this technology, enable programmable transformations with significant potential in biomechanics and dentistry. This review explores the use of smart materials and stimuli in 4D printing, emphasizing dental applications.A comprehensive search across EMBASE, Web of Science, MEDLINE, Cochrane Library and clinical trial registries identified 154 articles on 4D printing technologies, biomaterials, and stimuli relevant to dental applications. Of these, 84 were pertinent to the review's objective, with 25 specifically focused on 4D printing and various smart materials. The review highlights biomaterials engineered for programmable responses, such as shape memory polymers, shape memory elastomers, responsive inks, and hydrogels. These materials enable the creation of structures that can adapt, self-assemble, or respond to stimuli like temperature, moisture, or pH levels. In dentistry, these capabilities show potential for applications in orthodontics, implants, and tissue engineering.The integration of 4D printing and bio-smart materials has the potential to transform dentistry by creating adaptive, time-responsive structures. This technology enables personalized, precise, and minimally invasive treatments, addressing complex biomechanical challenges in dental care.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1558382"},"PeriodicalIF":1.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of artificial neural network model for predicting the rapid maxillary expansion technique in children with cleft lip and palate.","authors":"Mohamed Zahoor Ul Huqh, Johari Yap Abdullah, Adam Husein, Matheel Al-Rawas, Wan Muhamad Amir W Ahmad, Nafij Bin Jamayet, Mohammad Khursheed Alam, Mohd Rosli Bin Yahya, Siddharthan Selvaraj, Abedelmalek Kalefh Tabnjh","doi":"10.3389/fdmed.2025.1530372","DOIUrl":"https://doi.org/10.3389/fdmed.2025.1530372","url":null,"abstract":"<p><strong>Aim: </strong>The study aimed to determine the mid-palatal suture (MPS) maturation stages and to develop a binary logistic regression model to predict the possibility of surgical or non-surgical rapid maxillary expansion (RME) in children with unilateral cleft lip and palate (UCLP).</p><p><strong>Methods: </strong>A retrospective case control study was conducted. A total of 100 subjects were included. Data was gathered from the databases of Hospital Universiti Sains Malaysia and Hospital Raja Perempuan Zainab II, respectively. Cone beam computed tomography scans of both cleft and non-cleft individuals were utilized to determine the MPS maturation stages. Romexis software version 3.8.2 was used to analyze the images.</p><p><strong>Results: </strong>The results of the binary logistic regression model were utilized to establish the relationship between the probability (P) of a specific event of interest (P(Y = 1)) and a linear combination of independent variables (Xs) using the logit link function. Potential factors such as age, gender, cleft, category of malocclusion, and MPS were chosen which could play a role in predicting the technique of RME in children with UCLP and non-UCLP. A subset of these variables was validated via multilayer feed forward neural network (MLFFNN).</p><p><strong>Conclusions: </strong>The effectiveness of the hybrid biometric model created in this work, which combines bootstrap and BLR with R-syntax was evaluated in terms of how accurately it predicted a binary response variable. A validation method based on an MLFFNN was used to evaluate the precision of the generated model. This leads to a good outcome.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1530372"},"PeriodicalIF":1.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12037576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating possible shared single nucleotide polymorphisms in isolated oral cleft and non-cleft facial morphology.","authors":"Erika Calvano Küchler, Michelle Nascimento Meger, Bruna Correia Rauta Pires, Svenja Beisel-Memmert, Daniel Hemming, Ricardo D Coletta, Rafaela Scariot, Mírian Aiko Nakane Matsumoto, Maria Angelica Hueb de Menezes Oliveira, Christian Kirschneck, Bianca Cavalcante-Leão","doi":"10.3389/fdmed.2025.1546295","DOIUrl":"https://doi.org/10.3389/fdmed.2025.1546295","url":null,"abstract":"<p><strong>Introduction: </strong>Facial morphogenesis is regulated by several cellular interactions that are mediated by numerous morphogenetic signals. Based on the existing evidence, we hypothesize that oral cleft-associated single nucleotide polymorphisms (SNPs) are involved in the normal range of human face development. Therefore, this study aimed to investigate the association between SNPs in oral cleft-related genes and variations in the normal range of facial morphology.</p><p><strong>Method: </strong>A sample of healthy Brazilian teenagers (aged between 11 and 18 years old) were screened and collected. Frontal facial digitized photographs from orthodontic records were used to determine phenotypes, while the DNA extracted from saliva samples was used to investigate the candidate SNPs. Five oral cleft-associated SNPs in <i>BMP2</i> (<i>rs235768</i>), <i>BMP4</i> (<i>rs17563</i>), <i>WNT3A</i> (<i>rs708111</i>), <i>WNT11</i> (<i>rs1533767</i>), and <i>RUNX2</i> (<i>rs1200425</i>) were selected, and allelic discrimination analysis was performed using real-time PCR.</p><p><strong>Results: </strong>A total of 58 individuals (27 boys and 31 girls) were included. The facial landmarks used for the facial measurements were the trichion (Tr), glabella (G), nassion (N), subnasale (Sn), labrale superior (Ls), labrale inferior (Li), gnathion (Gn), cheilon (Ch), and zygoma (Zg). <i>rs17563</i> in <i>BMP4</i> was associated with lip proportion, in which individuals with the homozygous GG genotype had a higher Ch-Ch:Ls-Li proportion than the heterozygous AG genotype (<i>p</i> = 0.034). rs1533767 in <i>WNT11</i> was associated with G-Sn:Sn-Gn (<i>p</i> = 0.028), N-Gn:Sn-Gn (<i>p</i> = 0.035), and Sn-Gn:Tr-Gn (<i>p</i> = 0.039).</p><p><strong>Conclusion: </strong>Our study supported the hypothesis that oral cleft-associated SNPs are involved in the normal range of human facial morphology.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1546295"},"PeriodicalIF":1.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12037601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of intracanal cryotherapy on postoperative pain in necrotic teeth with symptomatic apical periodontitis: a randomized controlled clinical trial.","authors":"Muhammad Zubair Ahmad","doi":"10.3389/fdmed.2025.1543383","DOIUrl":"https://doi.org/10.3389/fdmed.2025.1543383","url":null,"abstract":"<p><strong>Objectives: </strong>The present study aimed to assess the effects of intracanal cryotherapy on pain following single-visit non-surgical root canal treatment (NSRCT) of molar teeth with pulpal necrosis and symptomatic apical periodontitis (SAP).</p><p><strong>Methods: </strong>This parallel-two arm, single-blind, randomized superiority clinical trial was registered at www.clincaltrials.gov (NCT05611736). Patients referred for NSRCT meeting the inclusion criteria were included. Preoperative radiographs, pulp sensibility tests, and pain scores on the visual analog scale (VAS) were recorded. Following shaping and cleaning, 302 patients were randomly allocated to the two groups (<i>n</i> = 151). In the experimental group, final irrigation was done using 0.9% physiologic saline solution at 2.5 °C, whereas in the control group, final irrigation was done using the same solution at room temperature. All treatments were performed in a single visit. Analgesics intake and presence, duration, and intensity of pain using the VAS at 6, 24, 72 h, and 1 week were recorded. Any adverse events were recorded. Data was analyzed using the Mann-Whitney <i>U</i> test and the Student's <i>t</i> test (<i>P</i> < 5%).</p><p><strong>Results: </strong>Patients in the cryotherapy group had significantly less postoperative pain at 6, 24, and 72 h (<i>P</i> < 0.05). There was no difference in postoperative pain at 1 week (<i>P</i> > 0.05). No adverse event was recorded in either group during or immediately after root canal treatment.</p><p><strong>Conclusion: </strong>Cryotherapy significantly reduces postoperative pain in single-visit root canal treatment of molars with pulp necrosis and SAP. It can be considered a biocompatible, economical, and straightforward method for managing postoperative pain.</p><p><strong>Clinical trial registration: </strong>www.clincaltrials.gov, identifier (NCT05611736).</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1543383"},"PeriodicalIF":1.5,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12034532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"India's oral health outlook: challenges, economic impact and need for preventative strategies.","authors":"Prashant Narang, Ashok Dhoble, Manu Mathur, Salaj Rana, Steve Mason, Asif Ali","doi":"10.3389/fdmed.2025.1544899","DOIUrl":"https://doi.org/10.3389/fdmed.2025.1544899","url":null,"abstract":"<p><strong>Objective: </strong>This review explores the economic and behavioral dimensions of oral health in India, emphasizing the economic burden, treatment-seeking behaviors, and policy-level interventions needed to improve oral health outcomes.</p><p><strong>Methods: </strong>A mixed-method approach was employed, integrating primary data from the Oral Health Observatory (OHO) project (2016-2020) and a systematic review of secondary literature. The OHO project surveyed dental clinic patients using mobile app questionnaires, focusing on oral health behaviors, barriers, and outcomes. Secondary data were analyzed from PubMed, MEDLINE, and Embase databases to assess the economic implications of oral health care in India.</p><p><strong>Results: </strong>The OHO data revealed a steady decline in routine dental visits after the age of 35-44 years, while emergency visits persisted across age groups. Gender disparities were observed, with men reporting higher dissatisfaction, greater oral pain, and work disruptions compared to women. Only 44.7% of participants brushed twice daily, and 36.7% brushed before bed. Secondary findings reveal that untreated oral diseases have a higher economic impact than preventive measures. This highlights the need for consumer awareness, strategic policies, and sustainable healthcare frameworks.</p><p><strong>Conclusion: </strong>India faces significant challenges in oral health due to low awareness, insufficient infrastructure, and economic barriers. Strengthening preventive strategies, increasing public-private partnerships, and integrating oral health education into primary care can dramatically reduce costs and improve population outcomes. A shift from reactive to preventive care is essential for ensuring equitable and sustainable oral health solutions.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1544899"},"PeriodicalIF":1.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12016223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiofilm potential of plant extracts: inhibiting oral microorganisms and <i>Streptococcus mutans</i>.","authors":"Nomi Bartels, Aikaterini Argyropoulou, Ali Al-Ahmad, Elmar Hellwig, Alexios Leandros Skaltsounis, Annette Wittmer, Kirstin Vach, Lamprini Karygianni","doi":"10.3389/fdmed.2025.1535753","DOIUrl":"https://doi.org/10.3389/fdmed.2025.1535753","url":null,"abstract":"<p><strong>Introduction: </strong>A range of disinfectant mouthwashes are available for oral hygiene. The gold standard is Chlorhexidine digluconate (CHX), which, like other available products, cannot be used without side effects in the long term. However, in recent years, therapy with herbal products, often considered antiquated, has regained considerable interest. Therefore, the search for plant compounds as an alternative to existing oral disinfectants is meaningful.</p><p><strong>Methods: </strong>In this study, eleven Mediterranean plant extracts were tested for their antimicrobial effect <i>in vitro</i>. Methanol extracts of the following plants were produced by the pharmaceutical faculty of the University of Athens: <i>Mentha aquatica</i>, <i>Mentha longifolia</i>, <i>Sideritis euboea</i>, <i>Sideritis syriaca</i>, <i>Stachys spinosa</i>, <i>Satureja parnassica</i>, <i>Satureja thymbra</i>, <i>Lavandula stoechas</i>, <i>Achillea taygetea</i>, <i>Phlomis cretica</i>, and <i>Vaccinium myrtillus</i>. The extracts were dissolved for microdilution experiments at concentrations ranging from 10 to 0.019 mg/ml. The oral pathogens tested were <i>Streptococcus mutans</i>, <i>Streptococcus oralis</i>, <i>Streptococcus sobrinus</i>, <i>Prevotella intermedia</i>, <i>Fusobacterium nucleatum</i>, <i>Parvimonas micra</i>, <i>Porphyromonas gingivalis</i>, and <i>Candida albicans</i>. <i>Enterococcus faecalis</i>, <i>Staphylococcus aureus</i>, and <i>Escherichia coli</i> were used as references.</p><p><strong>Results: </strong>All extracts, except the methanol extract of <i>V. myrtillus</i>, showed an antibacterial effect at concentrations ranging from 10 to 0.15 mg/ml. None of the extracts exhibited a significant antifungal effect. In general, the anaerobic pathogens could be inhibited and killed at lower concentrations compared to the aerobic pathogens. <i>S. oralis</i> also showed good susceptibility to the extracts. Additionally, the extracts' ability to inhibit biofilm formation by <i>S. mutans</i> was tested. <i>L. stoechas</i> at a concentration of 0.3 mg/ml showed a moderate inhibitory effect. The extracts of <i>L. stoechas</i>, <i>S. thymbra</i>, <i>S. parnassica</i>, and the methanol extract of <i>V. myrtillus</i> were effective at concentrations up to 1.25 mg/ml. <i>P. cretica</i> was able to inhibit and kill <i>S. mutans</i> at a concentration of 0.6 mg/ml, but its effectiveness in biofilm inhibition significantly decreased at 2.5 mg/ml.</p><p><strong>Discussion: </strong>The study's hypothesis that all extracts would exhibit an antimicrobial effect was thus confirmed.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1535753"},"PeriodicalIF":1.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12006170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing disparities in oral health access and outcomes for aging adults in the United States.","authors":"Adam Lowenstein, Mabi L Singh, Athena S Papas","doi":"10.3389/fdmed.2025.1522892","DOIUrl":"https://doi.org/10.3389/fdmed.2025.1522892","url":null,"abstract":"<p><p>Oral health is essential for the overall well-being of aging adults, yet significant disparities persist in the United States, contributing to malnutrition, reduced quality of life, and social isolation. Despite advancements in preventive dentistry, older adults continue to face substantial oral health challenges. This study reviewed the current state of oral health among aging adults in the United States, analyzing national health surveys and existing preventive dentistry protocols to assess their effectiveness. National data indicated that a high percentage of older adults experience tooth loss, periodontal disease, and root caries. Results indicated that almost 40% of adults aged 65 and older have lost a significant number of teeth, and a large proportion of the aging adult population has suffered from high rates of caries and periodontal disease. Socioeconomic factors were found to significantly influence access to dental care. Key barriers included low income, inadequate insurance, and low oral health literacy exacerbating disparities. The study proposes a multifaceted approach to improve oral health equity, including policy changes, community-based preventive programs, enhanced geriatric dentistry education, and the integration of oral health into primary care. Addressing these disparities is needed to improve both oral and overall health outcomes for the growing elderly population in the United States.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1522892"},"PeriodicalIF":1.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: The etiology and pathogenesis of craniomaxillofacial birth defects.","authors":"Huaxiang Zhao, Wenbin Huang, Huan Liu, Yongchu Pan","doi":"10.3389/fdmed.2025.1592762","DOIUrl":"https://doi.org/10.3389/fdmed.2025.1592762","url":null,"abstract":"","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1592762"},"PeriodicalIF":1.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}