对牙周病的见解:动物模型的比较分析。

IF 1.8 Q3 DENTISTRY, ORAL SURGERY & MEDICINE
Frontiers in dental medicine Pub Date : 2025-04-25 eCollection Date: 2025-01-01 DOI:10.3389/fdmed.2025.1560101
Binapani Barik, Saurabh Chawla, Bhabani Sankar Satapathy, Swadesh Kumar Pattanik, J Aravind Kumar, Saleh Al-Farraj, Gurudutta Pattnaik, Mika Sillanpää
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引用次数: 0

摘要

牙周病是一种以牙龈组织、牙周韧带和牙槽骨退化为特征的进行性疾病,如果不及时治疗,通常会导致牙齿脱落。其发病机制受细菌感染、宿主免疫反应和环境因素的影响。虽然人类细胞培养提供了对细胞机制的见解,但动物模型在理解复杂的宿主-病原体相互作用和开发治疗干预措施方面发挥着至关重要的作用。由于与人类在解剖学和免疫学上的相似性,包括啮齿动物、狗、非人类灵长类动物和迷你猪在内的各种物种已被用于牙周研究。这些模型允许在受控环境下研究疾病进展、全身效应和潜在治疗方法。然而,诸如解剖学差异、伦理问题和准确复制人类牙周病的困难等挑战仍然存在。尽管存在这些局限性,但动物模型对于推进牙周研究是不可或缺的,它提供了对疾病机制的见解,并有助于开发新的治疗方法。本综述评估了用于牙周病研究的几种动物模型的优势和局限性,强调需要进一步完善以增强其与人类状况的相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Insights into periodontal disease: comparative analysis of animal models.

Periodontal disease is a progressive condition characterized by the degradation of gingival tissues, periodontal ligaments, and alveolar bone, often resulting in tooth loss if untreated. Its pathogenesis is influenced by bacterial infections, host immune responses, and environmental factors. While human cell cultures provide insights into cellular mechanisms, animal models play a crucial role in understanding the complex host-pathogen interactions and developing therapeutic interventions. Various species, including rodents, dogs, non-human primates, and mini-pigs, have been employed in periodontal research due to their anatomical and immunological similarities to humans. These models allow the study of disease progression, systemic effects, and potential treatments in a controlled environment. However, challenges such as anatomical differences, ethical concerns, and the difficulty of accurately replicating human periodontal disease remain. Despite these limitations, animal models are indispensable for advancing periodontal research, offering insights into disease mechanisms and contributing to the development of novel therapies. This review evaluates the strengths and limitations of several animal models used in periodontal disease studies, emphasizing the need for further refinement to enhance their relevance to human conditions.

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CiteScore
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