Dementia and neurocognitive disorders最新文献

{"title":"Impact of the Ventricle Size on Alzheimer's Disease Progression: A Retrospective Longitudinal Study.","authors":"Ji-Seon Lee, Do-Yun Heo, Kyung-Hae Choi, Hee-Jin Kim","doi":"10.12779/dnd.2024.23.2.95","DOIUrl":"10.12779/dnd.2024.23.2.95","url":null,"abstract":"<p><strong>Background and purpose: </strong>Ventricle enlargement has been implicated in the pathophysiology of Alzheimer's disease (AD). We studied the relationship between ventricular size and cognitive function in patients with AD. We focused on the effect of the initial ventricle size on the rate of cognitive decline in patients with AD.</p><p><strong>Methods: </strong>A retrospective analysis of probable clinical AD participants with more than 2 magnetic resonance imaging images was performed. To measure ventricle size, we used visual rating scales of (1) Cardiovascular Health Study (CHS) score and (2) conventional linear measurement method.</p><p><strong>Results: </strong>Increased clinical dementia rating (CDR) was correlated with a decreased Mini-Mental Status Examination (MMSE) score, and increased medial temporal lobe atrophy (MTLA) and global ventricle size (<i>p</i><0.001, <i>p</i><0.001, <i>p</i>=0.021, respectively). There was a significant correlation between the change in cognitive function in the group (70%-100%ile) with a large initial ventricle size (<i>p</i>=0.021 for ΔCDR, <i>p</i>=0.01 for ΔMMSE), while the median ventricle size (30%-70%ile) showed correlation with other brain structural changes (MTLA, frontal atrophy [FA], and white matter) (<i>p</i>=0.036 for initial MTLA, <i>p</i>=0.034 for FA).</p><p><strong>Conclusions: </strong>In this study, the initial ventricle size may be a potential new imaging biomarker for initial cognitive function and clinical progression in AD. We found a relationship between the initial ventricle size and initial AD-related brain structural biomarkers.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"23 2","pages":"95-106"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11073924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140892696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Executive Summary of 2023 International Conference of the Korean Dementia Association (IC-KDA 2023): A Report From the Academic Committee of the Korean Dementia Association.","authors":"Geon Ha Kim, Jaeho Kim, Won-Seok Choi, Yun Kyung Kim, Kun Ho Lee, Jae-Won Jang, Jae Gwan Kim, Hui Jin Ryu, Soh-Jeong Yang, Hyemin Jang, Na-Yeon Jung, Ko Woon Kim, Yong Jeong, So Young Moon","doi":"10.12779/dnd.2024.23.2.75","DOIUrl":"10.12779/dnd.2024.23.2.75","url":null,"abstract":"<p><p>The Korean Dementia Association (KDA) has been organizing biennial international academic conferences since 2019, with the International Conference of the KDA (IC-KDA) 2023 held in Busan under the theme 'Beyond Boundaries: Advancing Global Dementia Solutions.' The conference comprised 6 scientific sessions, 3 plenary lectures, and 4 luncheon symposiums, drawing 804 participants from 35 countries. Notably, a Korea-Taiwan Joint Symposium addressed insights into Alzheimer's disease (AD). Plenary lectures by renowned scholars explored topics such as microbiome-related AD pathogenesis, social cognition in neurodegenerative diseases, and genetic frontotemporal dementia (FTD). On the first day, specific presentations covered subjects like the gut-brain axis and neuroinflammation in dementia, blood-based biomarkers in AD, and updates in AD therapeutics. The second day's presentations addressed recent issues in clinical neuropsychology, FTD cohort studies, and the pathogenesis of non-AD dementia. The Academic Committee of the KDA compiles lecture summaries to provide comprehensive understanding of the advanced dementia knowledge presented at IC-KDA 2023.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"23 2","pages":"75-88"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11073927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140892591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SoUth Korean study to PrEvent cognitive impaiRment and protect BRAIN health through Multidomain interventions via facE-to-facE and video communication plaTforms in mild cognitive impairment (SUPERBRAIN-MEET): Protocol for a Multicenter Randomized Controlled Trial.","authors":"Soo Hyun Cho, Hae Jin Kang, Yoo Kyoung Park, So Young Moon, Chang Hyung Hong, Hae Ri Na, Hong-Sun Song, Muncheong Choi, Sooin Jeong, Kyung Won Park, Hyun Sook Kim, Buong-O Chun, Jiwoo Jung, Jee Hyang Jeong, Seong Hye Choi","doi":"10.12779/dnd.2024.23.1.30","DOIUrl":"10.12779/dnd.2024.23.1.30","url":null,"abstract":"<p><strong>Background and purpose: </strong>The SoUth Korea study to PrEvent cognitive impaiRment and protect BRAIN health through lifestyle intervention (SUPERBRAIN) proved the feasibility of multidomain intervention for elderly people. One-quarter of the Korean population over 65 years of age has mild cognitive impairment (MCI). Digital health interventions may be cost-effective and have fewer spatial constraints. We aim to examine the efficacy of a multidomain intervention through both face-to-face interactions and video communication platforms using a tablet personal computer (PC) application in MCI.</p><p><strong>Methods: </strong>Three hundred participants aged 60-85 years, with MCI and at least one modifiable dementia risk factor, will be recruited from 17 centers and randomly assigned in a 1:1 ratio to the multidomain intervention and the waiting-list control groups. Participants will receive the 24-week intervention through the tablet PC SUPERBRAIN application, which encompasses the following five elements: managing metabolic and vascular risk factors, cognitive training, physical exercise, nutritional guidance, and boosting motivation. Participants will attend the interventions at a facility every 1-2 weeks. They will also engage in one or two self-administered cognitive training sessions utilizing the tablet PC application at home each week. They will participate in twice or thrice weekly online exercise sessions at home via the ZOOM platform. The primary outcome will be the change in the total scale index score of the Repeatable Battery for the Assessment of Neuropsychological Status from baseline to study end.</p><p><strong>Conclusions: </strong>This study will inform the effectiveness of a comprehensive multidomain intervention utilizing digital technologies in MCI.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT05023057.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"23 1","pages":"30-43"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10864697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Amyloid Positivity and Sleep Characteristics in the Elderly With Subjective Cognitive Decline.","authors":"Kyung Joon Jo, SeongHee Ho, Yun Jeong Hong, Jee Hyang Jeong, SangYun Kim, Min Jeong Wang, Seong Hye Choi, SeungHyun Han, Dong Won Yang, Kee Hyung Park","doi":"10.12779/dnd.2024.23.1.22","DOIUrl":"10.12779/dnd.2024.23.1.22","url":null,"abstract":"<p><strong>Background and purpose: </strong>Alzheimer's disease (AD) is a neurodegenerative disease characterized by a progressive decline in cognition and performance of daily activities. Recent studies have attempted to establish the relationship between AD and sleep. It is believed that patients with AD pathology show altered sleep characteristics years before clinical symptoms appear. This study evaluated the differences in sleep characteristics between cognitively asymptomatic patients with and without some amyloid burden.</p><p><strong>Methods: </strong>Sleep characteristics of 76 subjects aged 60 years or older who were diagnosed with subjective cognitive decline (SCD) but not mild cognitive impairment (MCI) or AD were measured using Fitbit^® Alta HR, a wristwatch-shaped wearable device. Amyloid deposition was evaluated using brain amyloid plaque load (BAPL) and global standardized uptake value ratio (SUVR) from fluorine-18 florbetaben positron emission tomography. Each component of measured sleep characteristics was analyzed for statistically significant differences between the amyloid-positive group and the amyloid-negative group.</p><p><strong>Results: </strong>Of the 76 subjects included in this study, 49 (64.5%) were female. The average age of the subjects was 70.72±6.09 years when the study started. 15 subjects were classified as amyloid-positive based on BAPL. The average global SUVR was 1.598±0.263 in the amyloid-positive group and 1.187±0.100 in the amyloid-negative group. Time spent in slow-wave sleep (SWS) was significantly lower in the amyloid-positive group (39.4±13.1 minutes) than in the amyloid-negative group (49.5±13.1 minutes) (p=0.009).</p><p><strong>Conclusions: </strong>This study showed that SWS is different between the elderly SCD population with and without amyloid positivity. How SWS affects AD pathology requires further research.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"23 1","pages":"22-29"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10864700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Anti-Aging Standard Forest Healing Program With Multiple Visits to a Forest Facility on Cognition in Older Age Patients.","authors":"Jinseok Park, Sheng-Min Wang, Dong Woo Kang, Beom Lee, Hojin Choi","doi":"10.12779/dnd.2024.23.1.44","DOIUrl":"10.12779/dnd.2024.23.1.44","url":null,"abstract":"<p><strong>Background and purpose: </strong>The anti-aging standard forest healing program (ASFHP), which uses forest therapy, was reported to be effective in improving psychological, physical, and cognitive functions. However, there are several challenges to directly visiting the forest. This study aimed to investigate the impact of multi-session ASFHP with forest visit on the mental and physical health of the older people with visits to forest facilities and compared them with those of the same program conducted indoors.</p><p><strong>Methods: </strong>Individuals aged over 70 years with concerns about cognitive decline were recruited at dementia relief centers and divided into control and experimental groups. A total of 33 people were administered ASFHP under the supervision of a forest therapy instructor. The control group stayed indoors, while the experimental group visited a forest healing center and repeated the program 20 weeks.</p><p><strong>Results: </strong>The multiple-session ASFHP positively affected cognitive impairment screening test (CIST) total scores (<i>p</i>=0.002), memory (<i>p</i>=0.014), Korean version of the Repeatable Battery for the Assessment of Neuropsychological Status total scores (<i>p</i><0.001), immediate recall (<i>p</i>=0.001), visuospatial/construction (<i>p</i><0.001), language (<i>p</i><0.001), forest healing standard questionnaire total scores (<i>p</i>=0.002), and cognitive function (<i>p</i>=0.019), regardless of location. The forest visits during the ASFHP showed positive effects on orientation (<i>p</i>=0.035), delayed recall (<i>p</i>=0.042), emotional stability (<i>p</i>=0.032), physical activity (<i>p</i>=0.005), and health (<i>p</i>=0.022). The CIST scores of the memory domain were the strongest indicator of the multiple-session ASFHP effects.</p><p><strong>Conclusions: </strong>The 20-week multi-session ASFHP with forest visit showed effects on cognitive improvement and physical and emotional stability compared to indoor education.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"23 1","pages":"44-53"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10864698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Usefulness of ¹⁸F-FDG PET to Differentiate Subtypes of Dementia: The Systematic Review and Meta-Analysis.","authors":"Seunghee Na, Dong Woo Kang, Geon Ha Kim, Ko Woon Kim, Yeshin Kim, Hee-Jin Kim, Kee Hyung Park, Young Ho Park, Gihwan Byeon, Jeewon Suh, Joon Hyun Shin, YongSoo Shim, YoungSoon Yang, Yoo Hyun Um, Seong-Il Oh, Sheng-Min Wang, Bora Yoon, Hai-Jeon Yoon, Sun Min Lee, Juyoun Lee, Jin San Lee, Hak Young Rhee, Jae-Sung Lim, Young Hee Jung, Juhee Chin, Yun Jeong Hong, Hyemin Jang, Hongyoon Choi, Miyoung Choi, Jae-Won Jang","doi":"10.12779/dnd.2024.23.1.54","DOIUrl":"10.12779/dnd.2024.23.1.54","url":null,"abstract":"<p><strong>Background and purpose: </strong>Dementia subtypes, including Alzheimer's dementia (AD), dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD), pose diagnostic challenges. This review examines the effectiveness of ¹⁸F-Fluorodeoxyglucose Positron Emission Tomography (¹⁸F-FDG PET) in differentiating these subtypes for precise treatment and management.</p><p><strong>Methods: </strong>A systematic review following Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines was conducted using databases like PubMed and Embase to identify studies on the diagnostic utility of ¹⁸F-FDG PET in dementia. The search included studies up to November 16, 2022, focusing on peer-reviewed journals and applying the gold-standard clinical diagnosis for dementia subtypes.</p><p><strong>Results: </strong>From 12,815 articles, 14 were selected for final analysis. For AD versus FTD, the sensitivity was 0.96 (95% confidence interval [CI], 0.88-0.98) and specificity was 0.84 (95% CI, 0.70-0.92). In the case of AD versus DLB, 18F-FDG PET showed a sensitivity of 0.93 (95% CI 0.88-0.98) and specificity of 0.92 (95% CI, 0.70-0.92). Lastly, when differentiating AD from non-AD dementias, the sensitivity was 0.86 (95% CI, 0.80-0.91) and the specificity was 0.88 (95% CI, 0.80-0.91). The studies mostly used case-control designs with visual and quantitative assessments.</p><p><strong>Conclusions: </strong>¹⁸F-FDG PET exhibits high sensitivity and specificity in differentiating dementia subtypes, particularly AD, FTD, and DLB. This method, while not a standalone diagnostic tool, significantly enhances diagnostic accuracy in uncertain cases, complementing clinical assessments and structural imaging.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"23 1","pages":"54-66"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10864694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of a Screening Questionnaire for Dementia With Lewy Bodies (DLB): the DLB Screening Questionnaire (DLBSQ).","authors":"Mincheol Park, Kyoungwon Baik, Young H Sohn, Byoung Seok Ye","doi":"10.12779/dnd.2024.23.1.11","DOIUrl":"10.12779/dnd.2024.23.1.11","url":null,"abstract":"<p><strong>Background and purpose: </strong>Although dementia with Lewy bodies (DLB) is the second most common cause of neurodegenerative dementia, its clinical prevalence is low. We developed a short and easy-to-complete DLB screening questionnaire (DLBSQ) to raise diagnostic sensitivity in routine clinical settings.</p><p><strong>Methods: </strong>A total of 501 participants were retrospectively enrolled, including 71 controls, 184 patients without DLB, and 246 patients with probable DLB. All patients underwent clinical evaluation, including core features of DLB, the DLBSQ, brain magnetic resonance imaging, and detailed neuropsychological assessments. The diagnostic performance of the DLBSQ for probable DLB was investigated using a receiver operating characteristic curve analysis.</p><p><strong>Results: </strong>Total DLBSQ score was associated with visuospatial and frontal/executive dysfunction and the diagnosis of probable DLB. The area under the receiver operating characteristic curve for total DLBSQ score was 0.727. Youden's method revealed an optimal cutoff value of 3. The sensitivity and specificity of the DLBSQ were 68.7% and 62.4%, respectively. Its discriminating performance improved when cognitive test profiles were additionally considered (area under the curve: 0.822, sensitivity: 80.6%, and specificity: 70.4%).</p><p><strong>Conclusions: </strong>The DLBSQ might be a useful screening tool for DLB in routine clinical practice with good sensitivity and specificity.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"23 1","pages":"11-21"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10864695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Multifocal Dural Arteriovenous Fistula Presumed to Present as a Progressive Cognitive Impairment.","authors":"Seunghee Na, Seung-Keun Lee, Eek-Sung Lee","doi":"10.12779/dnd.2024.23.1.67","DOIUrl":"10.12779/dnd.2024.23.1.67","url":null,"abstract":"","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"23 1","pages":"67-70"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10864701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Pathogenic Missense <i>NF1</i>-Variant Associated With Cognitive Impairment.","authors":"Faheem Arshad, Ashwin Prasad, Aparna Somaraj, Gautham Arunachal Udupi, Subasree Ramakrishnan, Suvarna Alladi","doi":"10.12779/dnd.2024.23.1.71","DOIUrl":"10.12779/dnd.2024.23.1.71","url":null,"abstract":"","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"23 1","pages":"71-73"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10864699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing the Power of Voice: A Deep Neural Network Model for Alzheimer's Disease Detection.","authors":"Chan-Young Park, Minsoo Kim, YongSoo Shim, Nayoung Ryoo, Hyunjoo Choi, Ho Tae Jeong, Gihyun Yun, Hunboc Lee, Hyungryul Kim, SangYun Kim, Young Chul Youn","doi":"10.12779/dnd.2024.23.1.1","DOIUrl":"10.12779/dnd.2024.23.1.1","url":null,"abstract":"<p><strong>Background and purpose: </strong>Voice, reflecting cerebral functions, holds potential for analyzing and understanding brain function, especially in the context of cognitive impairment (CI) and Alzheimer's disease (AD). This study used voice data to distinguish between normal cognition and CI or Alzheimer's disease dementia (ADD).</p><p><strong>Methods: </strong>This study enrolled 3 groups of subjects: 1) 52 subjects with subjective cognitive decline; 2) 110 subjects with mild CI; and 3) 59 subjects with ADD. Voice features were extracted using Mel-frequency cepstral coefficients and Chroma.</p><p><strong>Results: </strong>A deep neural network (DNN) model showed promising performance, with an accuracy of roughly 81% in 10 trials in predicting ADD, which increased to an average value of about 82.0%±1.6% when evaluated against unseen test dataset.</p><p><strong>Conclusions: </strong>Although results did not demonstrate the level of accuracy necessary for a definitive clinical tool, they provided a compelling proof-of-concept for the potential use of voice data in cognitive status assessment. DNN algorithms using voice offer a promising approach to early detection of AD. They could improve the accuracy and accessibility of diagnosis, ultimately leading to better outcomes for patients.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"23 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10864696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}