Dementia and neurocognitive disorders最新文献

{"title":"Demographic, Social, and Clinical Profiles of Patients Initiating Lecanemab in Clinical Practice: A Single-Center Experience in Korea.","authors":"Jeongha Lee, Hyeongjin Kim, Hee Kyung Park, Suah Kim, Kyung Bok Lee, Heekyoung Kang, Daeun Shin, Jun Pyo Kim, Byung Hwa Lee","doi":"10.12779/dnd.2026.25.2.134","DOIUrl":"10.12779/dnd.2026.25.2.134","url":null,"abstract":"","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"25 2","pages":"134-136"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13136623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-Based Dementia Prediction From Low-Dose Brain CT in Mild Cognitive Impairments.","authors":"Seongbeom Park, Jehyun Ahn, Duk L Na, Kichang Kwak, Jun Pyo Kim","doi":"10.12779/dnd.2026.25.2.91","DOIUrl":"10.12779/dnd.2026.25.2.91","url":null,"abstract":"<p><strong>Background and purpose: </strong>Magnetic resonance imaging (MRI) is often limited by safety concerns and long acquisition times in elderly patients. We evaluated the potential clinical utility of an artificial intelligence (AI) model, Morph Computed Tomography (CT) Plus, to predict three-year dementia conversion in mild cognitive impairment (MCI) using rapid low-dose CT scans, prioritizing its role as a safe and efficient triage tool.</p><p><strong>Methods: </strong>We analyzed 896 MCI (Clinical Dementia Rating [CDR]=0.5) patients from the Korea-Registries to Overcome Dementia and Accelerate Dementia Research cohort. A deep learning model quantified regional brain atrophy. We implemented a dual-cutoff risk-stratification strategy to optimize clinical workflow, comparing 90% and 95% sensitivity/specificity operating targets.</p><p><strong>Results: </strong>The model achieved an area under the curve of 0.870. The 90% strategy was superior for clinical triage, limiting the intermediate-risk group to 27.3% (n=99) compared to 49.6% (n=180) in the 95% strategy. For the combined high- and low-risk groups, the 90% strategy yielded an overall accuracy of 87.5%, with a positive predictive value of 83.3% and a negative predictive value of 90.4%. High-risk patients demonstrated a 14.13-fold higher hazard of conversion (<i>p</i><0.001).</p><p><strong>Conclusions: </strong>AI-driven CT analysis provides a high-precision, inclusive triage tool. The 90% strategy offers a scalable solution for early dementia management, especially for patients with MRI contraindications, demonstrating significant potential clinical utility.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"25 2","pages":"91-102"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13136622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concordance Between Subtest-Based and Domain Score-Based Determinations of Cognitive Impairment on the SNSB-II.","authors":"Yeje Ban, Hyun Ho Lee, Jae-Sung Lim, Yeonwook Kang","doi":"10.12779/dnd.2026.25.1.69","DOIUrl":"10.12779/dnd.2026.25.1.69","url":null,"abstract":"<p><strong>Background and purpose: </strong>Clinicians typically use 2 methods to determine impairment in a specific cognitive domain based on the Seoul Neuropsychological Screening Battery, 2nd Edition: (1) identifying impairment when one or more subtests fall below the normal range (< mean -1.5 standard deviation), and (2) using the cognitive domain score. Because agreement between these methods may differ by the severity of cognitive impairment, this study examined their concordance in the overall sample and across Clinical Dementia Rating (CDR) levels.</p><p><strong>Methods: </strong>A total of 1,086 patients (age 74.27±9.62 years; education 9.07±4.77 years) were included. Concordance between subtest-based and domain score-based classifications was assessed for each cognitive domain using cross-tabulation analyses and Cohen's kappa statistics. To assess the influence of the severity of cognitive impairment, analyses were conducted across CDR levels.</p><p><strong>Results: </strong>When impairment was defined as having at least one abnormal subtest, concordance rates were 90.8% for Attention, 88.8% for Language, 84.6% for Visuospatial Function, 74.3% for Memory, and 73.6% for Frontal/Executive Function. In the Frontal/Executive Function domain, requiring 2 or more abnormal subtests increased concordance to 90.9%. CDR subgroup analyses showed that Memory concordance was particularly low in the CDR 0.5 group (65.8%) compared with the CDR 1 (85.5%) and CDR 2 (98.5%) groups.</p><p><strong>Conclusions: </strong>Concordance between the 2 classification methods was moderately high for Attention, Language, and Visuospatial Function but substantially lower for Memory and Frontal/Executive Function, especially in individuals with mild cognitive impairment. These findings highlight the need to consider both subtest-level performance and domain scores when determining impairment in memory or frontal/executive function.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"25 1","pages":"69-78"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12876448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Protocol of Korean JOint RegistrY for ALZheimer's Treatment and Diagnostics (JOY-ALZ).","authors":"Geon Ha Kim, Jung-Min Pyun, Danbee Kang, Sung Hoon Kang, Seong-Ho Koh, Jae Seung Kim, So Young Moon, Won-Jin Moon, Young Ho Park, YongSoo Shim, Dong Won Yang, Young Chul Youn, Young Hee Jung, Hanna Cho, Hojin Choi, Jae-Sung Lim, Kee Hyung Park, Seong Hye Choi","doi":"10.12779/dnd.2026.25.1.25","DOIUrl":"10.12779/dnd.2026.25.1.25","url":null,"abstract":"<p><strong>Background and purpose: </strong>To assess the long-term effectiveness, safety, and economic viability of recently approved Alzheimer's disease (AD) therapies, as well as to evaluate the real-world application of novel diagnostics among AD patients with diverse comorbidities, comprehensive real-world data (RWD) analysis is essential. The Korean JOint RegistrY for ALZheimer's Treatment and Diagnostics (JOY-ALZ) endeavors to create a registry of RWD derived from clinical practice on new diagnostic methods and therapeutic agents for AD introduced in Korea since 2021.</p><p><strong>Methods: </strong>Participants must fulfill all the following: 1) be at least 19 years old; 2) be actively receiving, scheduled to initiate, or undergoing evaluation for any AD disease-modifying treatment; 3) have completed amyloid positron emission tomography or cerebrospinal fluid AD immunoassay (a positive result is not essential for participation); 4) have a clinical classification of cognitively unimpaired, mild cognitive impairment, or probable AD dementia. Data generated during routine care is segmented into a minimum dataset, extended dataset, and research-only dataset requiring extra consent. Assessments encompass clinical, cognitive, functional, neurobehavioral, neuroimaging, and biomarker evaluations, in addition to systematic monitoring of new AD treatments and their safety. Data are collected and monitored at baseline, at semiannual intervals during the initial 2 years, and then annually up to 2034. To date, 46 medical centers will participate in JOY-ALZ.</p><p><strong>Conclusions: </strong>JOY-ALZ is expected to promote understanding of the long-term clinical outcomes, safety, and cost-effectiveness of recently introduced diagnostics and treatments for AD, thereby supporting the progress of precision medicine in AD care and diagnosis.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT06889818.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"25 1","pages":"25-41"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12876444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Prior Exercise Habits and Adherence on Cognitive Function, Physical Fitness, and Vascular Health in Older Adults: An Exploratory Exercise-Based Intervention Trial.","authors":"Da Ae Kim, Muncheong Choi, Buongo Chun, Kyunghwa Sun, So Young Moon, Hong-Sun Song, Sun Min Lee","doi":"10.12779/dnd.2026.25.1.54","DOIUrl":"10.12779/dnd.2026.25.1.54","url":null,"abstract":"<p><strong>Background and purpose: </strong>Given the irreversible nature of dementia, this study examined the effects of a 20-week exercise-based dementia prevention program in community-dwelling older adults, focusing on prior exercise experience and program adherence.</p><p><strong>Methods: </strong>In this exploratory, non-randomized trial, 55 older adults (65-79 years) were allocated to an intervention (n=26) or control (n=29) group, and blinding was not feasible. The intervention comprised supervised rhythmic aerobic exercise with cognitive-motor components performed three times per week. Cognition was the primary outcome, and secondary outcomes included physical fitness, blood pressure, and blood biomarkers. Subgroup analyses classified participants by prior exercise experience and intervention exposure: G1 and G2 comprised control subgroups with no intervention exposure, whereas G3 and G4 comprised intervention-exposed subgroups stratified by adherence.</p><p><strong>Results: </strong>No significant group-by-time interactions were observed for cognitive outcomes. Participants with prior exercise experience and low adherence (G2) showed significant improvement on the Korean Mini-Mental State Examination (β=1.66, <i>p</i>=0.024) despite declines in physical fitness, whereas higher adherence in G3-G4 was associated with stable or favorable physical performance, with G4 showing a positive trend in the 30-second sit-to-stand test. Systolic blood pressure decreased significantly in G2-G4.</p><p><strong>Conclusions: </strong>Although overall cognitive gains were modest and not group specific, prior exercise experience and sustained adherence were associated with favorable changes in physical fitness and vascular outcomes, suggesting that tailored multicomponent exercise programs and long-term engagement may help promote cognitive health in older adults.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"25 1","pages":"54-68"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12876443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Nationwide Survey on the Awareness of Mild Cognitive Impairment.","authors":"Hyuk Sung Kwon, Kee Hyung Park, Jin San Lee, Hojin Choi, Chan-Nyoung Lee, Jae-Sung Lim, Jae-Won Jang, YongSoo Shim, Seong Hye Choi, Dong Won Yang","doi":"10.12779/dnd.2026.25.1.90","DOIUrl":"https://doi.org/10.12779/dnd.2026.25.1.90","url":null,"abstract":"<p><p>[This corrects the article on p. 198 in vol. 24, PMID: 40746342.].</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"25 1","pages":"90"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12876439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Clinical Utility of the Cognitive Impairment Screening Test (CIST).","authors":"Hyeseon Han, Soyeon Lim, Suah Kim, Byung Hwa Lee, Hee Jin Kim, Juhee Chin","doi":"10.12779/dnd.2026.25.1.42","DOIUrl":"10.12779/dnd.2026.25.1.42","url":null,"abstract":"<p><strong>Background and purpose: </strong>The Cognitive Impairment Screening Test (CIST) was developed for use at the Community Dementia Reassurance Center in South Korea. This study evaluated convergent and discriminant validity of CIST, as well as its clinical utility in identifying cognitive impairment and differentiating amyloid deposition.</p><p><strong>Methods: </strong>We enrolled 252 participants from a hospital memory clinic (47 cognitively unimpaired [CU], 116 amnestic mild cognitive impairment, and 89 dementia). Participants completed CIST, K-MMSE-2, the Seoul Neuropsychological Screening Battery, 2nd edition (SNSB-II), and underwent amyloid positron emission tomography. To evaluate the convergent and discriminant validity of CIST, we conducted correlation analyses with SNSB-II. Receiver operating characteristic analyses were used to evaluate the ability to discriminate cognitive impairment and to distinguish amyloid positivity. Areas under the curve (AUCs) for CIST and K-MMSE-2 were compared using DeLong's test.</p><p><strong>Results: </strong>The total score of CIST correlated significantly with all SNSB-II subtests, and the domain scores of CIST showed stronger associations with corresponding SNSB-II subtests than with unrelated ones. Both CIST and K-MMSE-2 effectively distinguished cognitively impaired individuals from CU, with CIST demonstrating superior discrimination (AUC=0.926 vs. 0.887, <i>p</i>=0.042). In the non-demented group, both CIST and K-MMSE-2 showed acceptable discrimination for amyloid positivity (AUC≈0.73), with high specificity but low sensitivity; however, there were no significant differences between the two tests.</p><p><strong>Conclusions: </strong>The CIST demonstrated strong validity and discriminatory ability for detecting cognitive impairment. It also showed acceptable discrimination for amyloid positivity in non-demented participants, supporting its utility as a screening tool in both clinical and community settings.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"25 1","pages":"42-53"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12876441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Association Between Physical Fitness Components and Cognitive Function in Older Korean Adults: The SUPERBRAIN Exploratory Sub-study.","authors":"Da Ae Kim, Buongo Chun, Muncheong Choi, Kyunghwa Sun, Jee Hyang Jeong, Yoo Kyoung Park, Chang Hyung Hong, Hae Ri Na, Seong Hye Choi, So Young Moon, Hong-Sun Song, Sun Min Lee","doi":"10.12779/dnd.2026.25.1.13","DOIUrl":"10.12779/dnd.2026.25.1.13","url":null,"abstract":"<p><strong>Background and purpose: </strong>Tailored physical exercise interventions have the potential to promote cognitive health in older adults and offer significant advantages for those more vulnerable to decline. The specific relationship between physical fitness and cognition among the elderly has not been clearly established. The purpose of this investigation was to assess the relationship between physical fitness and cognitive function in older Korean adults.</p><p><strong>Methods: </strong>Eighty-four community-dwelling older adults (mean age: 70.7±5.3 years; 81.0% female) completed a standardized physical fitness battery assessing handgrip strength, sit-and-reach, 30-second sit-to-stand, 2-minute stationary march, 3-m sit-walk-and-return, figure-8-walk, and T-wall response time. Cognitive function was evaluated using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Descriptive statistics, partial correlation analyses, and stepwise multiple linear regression were conducted.</p><p><strong>Results: </strong>Slower T-wall response time was significantly correlated with lower RBANS total index, immediate memory, and delayed memory scores. In regression models, slower T-wall response time was independently associated with lower RBANS total index (β=-0.234, <i>p</i>=0.026) and delayed memory scores (β=-0.295, <i>p</i>=0.029). The regression model for immediate memory was not statistically significant overall; therefore, no predictive conclusion was drawn for this domain. Higher education showed a significant positive association with cognitive performance.</p><p><strong>Conclusions: </strong>Coordination, as measured by T-wall response time, emerged as the only physical fitness component consistently associated with cognitive performance in older adults. Coordination-related fitness may be an important correlate of cognitive function in older adults and a promising target for future exercise interventions.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"25 1","pages":"13-24"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12876446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Brain Amyloid PET Positivity Using the Amyloid Beta Composite (ABC) Index in Patients With Cognitive Impairment.","authors":"Juyoun Lee, Sukyoung Jung, Ae Young Lee","doi":"10.12779/dnd.2026.25.1.79","DOIUrl":"10.12779/dnd.2026.25.1.79","url":null,"abstract":"<p><strong>Background and purpose: </strong>Amyloid positron emission tomography (PET) is a crucial diagnostic tool for Alzheimer's disease (AD), but its application is constrained by cost and accessibility. This study aimed to create a practical composite index to predict cerebral amyloid positivity in patients with cognitive impairment.</p><p><strong>Methods: </strong>We included patients with mild cognitive impairment or early-stage AD who underwent amyloid PET. Various combinations of clinical and imaging variables were assessed through receiver operating characteristic analysis to identify the optimal model for predicting amyloid positivity. The Amyloid Beta Composite (ABC) index, a risk scoring model, was developed using logistic regression and a weighted scoring system. We evaluated the ABC index's performance based on accuracy, sensitivity, and specificity, and conducted internal validation using a chronological split-sample from the same cohort.</p><p><strong>Results: </strong>We analyzed a total of 223 patients. The best-performing model incorporated five variables: Mini-Mental State Examination (MMSE), secondary memory recall from the modified MMSE, Clinical Dementia Rating-Sum of Boxes, medial temporal lobe atrophy, and apolipoprotein E genotype. This model demonstrated excellent performance in the development group (area under the curve [AUC], 0.88; 95% confidence interval, 0.82-0.94). In the validation group, the ABC index achieved an AUC of 0.74, with an accuracy of 0.70, sensitivity of 0.63, and specificity of 0.78.</p><p><strong>Conclusions: </strong>The ABC index, utilizing commonly accessible clinical data, serves as a simple and practical screening tool for predicting cerebral amyloid deposition. It may aid in patient selection for amyloid PET, anti-amyloid therapies, and clinical trials, thereby reducing unnecessary imaging.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"25 1","pages":"79-89"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12876445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Gut-Brain Connection: The Role of Microbiota in Alzheimer's Disease Pathogenesis.","authors":"Azar Rahi, Erfaneh Jafari, Reza Azizian, Mohammad Reza Mohammadi, Atousa Razmfarsa, Sara Shakeri Hosseinabad, Masoud Hamidi","doi":"10.12779/dnd.2026.25.1.1","DOIUrl":"10.12779/dnd.2026.25.1.1","url":null,"abstract":"<p><p>Alzheimer's disease (AD), the primary cause of dementia accounting for 60% to 70% of cases globally, results in a gradual decline in cognitive abilities, affecting memory, executive function, and daily activities. Recent research highlights the essential involvement of the microbiota-gut-brain axis in AD pathogenesis, characterized by complex bidirectional signaling that modulates neuroinflammation, neurogenesis, neurotransmission, and immune functions. This manuscript extends the discussion beyond the gut alone by emphasizing the significance of the oral-gut microbiota axis as a dynamic and relatively under-investigated factor in AD progression. Microbial populations in both the oral cavity and gastrointestinal tract produce key neurotransmitters, such as gamma-aminobutyric acid, noradrenaline, and dopamine, as well as neuroactive metabolites like short-chain fatty acids, which together impact brain physiology. Disturbances in gut and oral microbial balance can compromise barrier integrity, promoting systemic inflammation and neuroinflammation, and facilitating amyloid-β plaque formation and tau-related changes typical of AD. This review introduces a novel probiotic, prebiotics, synbiotics, and postbiotics (PPSP) therapeutic model designed to modulate both oral and gut microbiota, aiming to restore homeostasis, regulate neuroimmune interactions, and counteract cognitive impairment. We comprehensively assess emerging clinical and translational findings supporting the effectiveness of microbiota-targeted therapies in the scope of this dual-axis framework, addressing both their potential to alter disease course and recognized limitations. By underscoring the importance of the integrated oral-gut microbiota axis alongside targeted PPSP interventions, this manuscript puts forth a paradigm-shifting conceptual strategy that may redefine approaches to AD management and improve cognitive outcomes.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"25 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12876440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}