Dementia and neurocognitive disorders最新文献

{"title":"Development of the Diagnostic Matrix of the Seoul Cognitive Status Test, Compared to Traditional Paper-and-Pencil Neuropsychological Tests.","authors":"Seunghee Na, Young Ju Kim, Si Eun Kim, Na-Yeon Jung, Seung Joo Kim, Hee Jin Kim, Joon Soo Shin, Duk L Na, Sang Won Seo, Yeshin Kim, Eek-Sung Lee","doi":"10.12779/dnd.2024.23.4.224","DOIUrl":"https://doi.org/10.12779/dnd.2024.23.4.224","url":null,"abstract":"<p><strong>Background and purpose: </strong>We aimed to develop the diagnostic matrix of the Seoul Cognitive Status Test (SCST) and compare its performance with traditional paper-and-pencil neuropsychological tests, including the Seoul Neuropsychological Screening Battery-II (SNSB-II) and the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD-K).</p><p><strong>Methods: </strong>We recruited 197 participants from the head-to-head SCST-SNSB cohort, and 204 participants from the head-to-head SCST-CERAD cohort. They underwent either SNSB-II or CERAD-K, in addition to SCST. The diagnostic matrix was developed by combining cognitive function, determined by neuropsychological tests, and activities of daily living (ADL), determined by Instrumental-ADL scales.</p><p><strong>Results: </strong>The diagnostic agreement between the SCST and the SNSB-II was 83.9% (weighted kappa=0.87). The agreement between the SCST and the CERAD-K was 84.3% (weighted kappa=0.88). In the SCST-SNSB cohort, all differences in SCST scores between the cognitively unimpaired (CU), mild cognitive impairment (MCI), and dementia diagnosed with the SNSB-II were significant in all cognitive domains (all <i>p</i><0.01), except for the executive domain between CU and MCI (<i>p</i>=0.145). In the SCST-CERAD cohort, all differences in SCST scores between the 3 groups diagnosed with the CERAD-K were significant in all cognitive domains (all <i>p</i><0.01), except for the language and visuospatial domains between MCI and dementia (<i>p</i>=0.169 and <i>p</i>=0.778, respectively).</p><p><strong>Conclusions: </strong>Our findings suggest that the tablet-based SCST may be another option to traditional paper-and-pencil neuropsychological tests, especially in situations where time and space are relatively limited, and neuropsychological testing specialists are not available.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"23 4","pages":"224-235"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11538856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Choline Alfoscerate on the Progression From Mild Cognitive Impairment to Dementia: Distributed Network Analysis of a Multicenter Korean Database Using a Common Data Model.","authors":"Jung-Min Pyun, Inho Lee, Kyungbok Lee, Min-Ho Kim, ChulHyoung Park, Hyeon-Jong Yang","doi":"10.12779/dnd.2024.23.4.202","DOIUrl":"https://doi.org/10.12779/dnd.2024.23.4.202","url":null,"abstract":"<p><strong>Background and purpose: </strong>Choline alfoscerate (CA) is an acetylcholine precursor known for its beneficial effect on cognition in patient with Alzheimer's disease dementia (ADD). However, there is little evidence of its effects in patients with mild cognitive impairment (MCI). We assessed the influence of CA on the progression from MCI to all-cause dementia or ADD in three observational Korean databases using a Common Data Model (CDM).</p><p><strong>Methods: </strong>Patients who were diagnosed with MCI and were aged over 60 years were included. After propensity score matching, 3,062 matched pairs patients using CA use and those not using CA were included. The Cox regression model was used to analyze the hazard ratio (HR) of CA use for conversion from MCI to all-cause dementia or ADD. Subgroup analyses were performed based on sex, acetylcholine esterase inhibitor (AchEI) use, and donepezil use.</p><p><strong>Results: </strong>A meta-analysis across three hospitals revealed that CA use was not associated with the progression from MCI to all-cause dementia (hazard ratio [HR], 0.93; 95% confidence interval [CI], 0.59-1.26) or ADD (HR, 1.05; 95% CI, 0.51-1.59). Subgroup analyses revealed that CA use was not related to progression to all-cause dementia or ADD when stratified by sex, AchEI use, and donepezil use.</p><p><strong>Conclusions: </strong>In this multicenter cohort study based on the Observational Medical Outcomes Partnership CDM real-world data, no association was noted between CA use and disease progression from MCI to all-cause dementia or ADD.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"23 4","pages":"202-211"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11538851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparison of Item Characteristics and Test Information Between the K-MMSE~2:SV and K-MMSE.","authors":"Jihyang Kim, Seungmin Jahng, SangYun Kim, Yeonwook Kang","doi":"10.12779/dnd.2024.23.3.117","DOIUrl":"10.12779/dnd.2024.23.3.117","url":null,"abstract":"<p><strong>Background and purpose: </strong>The Korean-Mini Mental State Examination, 2nd edition (K-MMSE~2) was recently released. This study aimed to determine whether the K-MMSE~2: Standard Version (K-MMSE~2:SV) had the same test characteristics as the K-MMSE.</p><p><strong>Methods: </strong>A total of 1,514 healthy community-based participants aged 19 to 90 years were administered the K-MMSE~2:SV Blue Form along with the language items from the K-MMSE. The item and test characteristics and test information for the K-MMSE~2:SV and K-MMSE were compared using Item Response Theory analysis.</p><p><strong>Results: </strong>Item discriminations for the K-MMSE~2:SV and K-MMSE were above the moderate range for all items except Recall. Most of the items on the K-MMSE~2:SV and K-MMSE had item category difficulty in the very easy or easy range. The test information curve (TIC) showed that the K-MMSE~2:SV and K-MMSE provide almost the same amount of information (27.86 vs. 28.44), with both tests providing the most information at an ability level of -1.57. The generalizability (G) coefficient for the K-MMSE~2:SV and K-MMSE was 0.99.</p><p><strong>Conclusions: </strong>These results indicate that the K-MMSE~2:SV and K-MMSE are equally optimal tests for screening for mild cognitive impairment and early dementia. Given that the amount of test information provided by the two tests was almost identical, the shapes of the TICs were very similar, and the G coefficient was close to 1, we can conclude that the K-MMSE and K-MMSE~2:SV are equivalent tests.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"23 3","pages":"117-126"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11300688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141903765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Impact of Defacing Algorithms on Brain Volumetry Accuracy in MRI Analyses.","authors":"Dong-Woo Ryu, ChungHwee Lee, Hyuk-Je Lee, Yong S Shim, Yun Jeong Hong, Jung Hee Cho, Seonggyu Kim, Jong-Min Lee, Dong Won Yang","doi":"10.12779/dnd.2024.23.3.127","DOIUrl":"10.12779/dnd.2024.23.3.127","url":null,"abstract":"<p><strong>Background and purpose: </strong>To ensure data privacy, the development of defacing processes, which anonymize brain images by obscuring facial features, is crucial. However, the impact of these defacing methods on brain imaging analysis poses significant concern. This study aimed to evaluate the reliability of three different defacing methods in automated brain volumetry.</p><p><strong>Methods: </strong>Magnetic resonance imaging with three-dimensional T1 sequences was performed on ten patients diagnosed with subjective cognitive decline. Defacing was executed using mri_deface, BioImage Suite Web-based defacing, and Defacer. Brain volumes were measured employing the QBraVo program and FreeSurfer, assessing intraclass correlation coefficient (ICC) and the mean differences in brain volume measurements between the original and defaced images.</p><p><strong>Results: </strong>The mean age of the patients was 71.10±6.17 years, with 4 (40.0%) being male. The total intracranial volume, total brain volume, and ventricle volume exhibited high ICCs across the three defacing methods and 2 volumetry analyses. All regional brain volumes showed high ICCs with all three defacing methods. Despite variations among some brain regions, no significant mean differences in regional brain volume were observed between the original and defaced images across all regions.</p><p><strong>Conclusions: </strong>The three defacing algorithms evaluated did not significantly affect the results of image analysis for the entire brain or specific cerebral regions. These findings suggest that these algorithms can serve as robust methods for defacing in neuroimaging analysis, thereby supporting data anonymization without compromising the integrity of brain volume measurements.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"23 3","pages":"127-135"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11300685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141903766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shunt-Responsive Idiopathic Normal Pressure Hydrocephalus Patient With Parkinson's Disease-Compatible Findings on Dopamine Transporter Scans.","authors":"Chaejin Lee, Sang-Youl Yoon, Sang-Woo Lee, Shin Young Jeong, Eunhee Park, Jeong-Hyun Hwang, Ki-Su Park, Kyunghun Kang","doi":"10.12779/dnd.2024.23.3.161","DOIUrl":"10.12779/dnd.2024.23.3.161","url":null,"abstract":"","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"23 3","pages":"161-163"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11300687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141903768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Speech Emotion Recognition in People at High Risk of Dementia.","authors":"Dongseon Kim, Bongwon Yi, Yugwon Won","doi":"10.12779/dnd.2024.23.3.146","DOIUrl":"10.12779/dnd.2024.23.3.146","url":null,"abstract":"<p><strong>Background and purpose: </strong>The emotions of people at various stages of dementia need to be effectively utilized for prevention, early intervention, and care planning. With technology available for understanding and addressing the emotional needs of people, this study aims to develop speech emotion recognition (SER) technology to classify emotions for people at high risk of dementia.</p><p><strong>Methods: </strong>Speech samples from people at high risk of dementia were categorized into distinct emotions via human auditory assessment, the outcomes of which were annotated for guided deep-learning method. The architecture incorporated convolutional neural network, long short-term memory, attention layers, and Wav2Vec2, a novel feature extractor to develop automated speech-emotion recognition.</p><p><strong>Results: </strong>Twenty-seven kinds of Emotions were found in the speech of the participants. These emotions were grouped into 6 detailed emotions: happiness, interest, sadness, frustration, anger, and neutrality, and further into 3 basic emotions: positive, negative, and neutral. To improve algorithmic performance, multiple learning approaches were applied using different data sources-voice and text-and varying the number of emotions. Ultimately, a 2-stage algorithm-initial text-based classification followed by voice-based analysis-achieved the highest accuracy, reaching 70%.</p><p><strong>Conclusions: </strong>The diverse emotions identified in this study were attributed to the characteristics of the participants and the method of data collection. The speech of people at high risk of dementia to companion robots also explains the relatively low performance of the SER algorithm. Accordingly, this study suggests the systematic and comprehensive construction of a dataset from people with dementia.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"23 3","pages":"146-160"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11300689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141903769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discriminative Power of Seoul Cognitive Status Test in Differentiating Subjective Cognitive Decline, Amnestic Mild Cognitive Impairment, and Dementia Based on CERAD-K Standards.","authors":"Hasom Moon, Eek-Sung Lee, Seunghee Na, Dayeong An, Joon Soo Shin, Duk L Na, Hyemin Jang","doi":"10.12779/dnd.2024.23.3.136","DOIUrl":"10.12779/dnd.2024.23.3.136","url":null,"abstract":"<p><strong>Background and purpose: </strong>We developed a new digital cognitive assessment called Seoul Cognitive Status Test (SCST), formerly called Inbrain Cognitive Screening Test. The purpose of this study was to validate the clinical utility of the SCST by comparing its scores of those with subjective cognitive decline (SCD), amnestic mild cognitive impairment (aMCI), and dementia diagnosed by the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet (CERAD-K).</p><p><strong>Methods: </strong>All participants (n=296) who completed the CERAD-K, SCST, and Instrumental Activities of Daily Living tests were included in this study. Total score, cognitive domain scores, and subtest scores of the SCST were compared among the 3 groups (SCD, aMCI, and dementia). Additionally, correlations between SCST and CERAD-K subtests were examined.</p><p><strong>Results: </strong>Cognitive domain scores and total score of the SCST showed significant differences among the three groups, with scores being the highest in the order of SCD, aMCI, and dementia (<i>p</i><0.001). Most subtests of the SCST also showed higher scores in the order of SCD, aMCI, and dementia (<i>p</i><0.001). However, SCD and aMCI groups showed no significant differences in scores of the Phonemic Word Fluency Test (<i>p</i>=0.083) or Korean Trail Making Test-Elderly version Part A (<i>p</i>=0.434). Additionally, there was no significant difference in the score of Place Recognition (<i>p</i>=0.274) of the Word-Place Association Test between aMCI and dementia groups.</p><p><strong>Conclusions: </strong>In conclusion, differences in total score, cognitive domain scores, and subtest scores of the SCST among the 3 groups of participants diagnosed using CERAD-K confirm the clinical utility of the SCST for cognitive assessment.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"23 3","pages":"136-145"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11300686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141903767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender Differences in Items of the Instrumental Activities of Daily Living in Mild Cognitive Impairment and Alzheimer's Disease Dementia.","authors":"Hui Jin Ryu, Yeonsil Moon","doi":"10.12779/dnd.2024.23.2.107","DOIUrl":"10.12779/dnd.2024.23.2.107","url":null,"abstract":"<p><strong>Background and purpose: </strong>Each item in the instrumental activities of daily living (IADL) questionnaire has differential importance to an individual's life functioning based on gender. However, IADL has mostly been utilized for its total score alone, without gender specificity. We identify the impact of each item on the transition from amnestic mild cognitive impairment (aMCI) to Alzheimer's disease dementia (ADD), and determine if the impact of each item differs by gender.</p><p><strong>Methods: </strong>Subjects were aMCI or ADD with a global clinical dementia rating of 0.5 or 1. The sample size was 146 men and 154 women. We used logistic regression analysis to determine the effect of each item of IADL on the transition from aMCI to ADD.</p><p><strong>Results: </strong>The odds ratio (OR) for \"remembering recent events\" had similar values: 27.2 for men, and 27.7 for women. Gender difference was identified in the item with the highest OR value. For women, the \"using transportation\" item was 63.3, and for men, \"conducting financial affairs\" was overwhelmingly high at 89.1.</p><p><strong>Conclusions: </strong>Functional decline on items with relatively higher ORs may indicate higher probability of a transition from aMCI to ADD. The OR of \"conducting financial affairs\" was relatively higher for both genders. In terms of gender differences, \"conducting home repair\" for men, and \"using transportation\" for women, have relatively higher impact. This study demonstrates that during the transition from aMCI to ADD, each item of IADL shows a staggered decline in functioning, and that this decline is gender-specific.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"23 2","pages":"107-114"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11073925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140892595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ventral Anterior Cingulate Atrophy as a Predisposing Factor for Transient Global Amnesia.","authors":"Jeewon Suh, Young Ho Park, Hang-Rai Kim, Jae-Won Jang, SangHak Yi, Min Ju Kang, Yun Jung Bae, Byung Se Choi, Jae Hyoung Kim, SangYun Kim","doi":"10.12779/dnd.2024.23.2.89","DOIUrl":"10.12779/dnd.2024.23.2.89","url":null,"abstract":"<p><strong>Background and purpose: </strong>This study aimed to evaluate the brain magnetic resonance imaging (MRI) of patients with acute transient global amnesia (TGA) using volumetric analysis to verify whether the brains of TGA patients have pre-existing structural abnormalities.</p><p><strong>Methods: </strong>We evaluated the brain MRI data from 87 TGA patients and 20 age- and sex-matched control subjects. We included brain MRIs obtained from TGA patients within 72 hours of symptom onset to verify the pre-existence of structural change. For voxel-based morphometric analyses, statistical parametric mapping was employed to analyze the structural differences between patients with TGA and control subjects.</p><p><strong>Results: </strong>TGA patients exhibited significant volume reductions in the bilateral ventral anterior cingulate cortices (corrected <i>p</i><0.05).</p><p><strong>Conclusions: </strong>TGA patients might have pre-existing structural changes in bilateral ventral anterior cingulate cortices prior to TGA attacks.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"23 2","pages":"89-94"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11073926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140892677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: A Patient With Fahr's Disease Who Presented Prominent Visuospatial Dysfunction.","authors":"Dongwhane Lee, Sun Young Chae, Sung Hun Kim, Hyung-Ji Kim","doi":"10.12779/dnd.2024.23.2.115","DOIUrl":"https://doi.org/10.12779/dnd.2024.23.2.115","url":null,"abstract":"<p><p>[This corrects the article on p. 117 in vol. 22, PMID: 37545866.].</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"23 2","pages":"115"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11073923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140892579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}