Dementia and neurocognitive disorders最新文献_第10页

A Case of a Patient Who Presented with Rapidly Progressive Dementia and Capricious RT-QuIC Results. 1例患者表现为快速进展性痴呆和反复无常的RT-QuIC结果。

Dementia and neurocognitive disorders Pub Date : 2020-03-01 Epub Date: 2020-03-16 DOI: 10.12779/dnd.2020.19.1.36

Eunjoo Rhee, Sung Eun Chung, Hyung Ji Kim, Jae Hong Lee

引用次数: 1

Alzheimer's Disease Diagnosis Using Misfolding Proteins in Blood. 利用血液中错误折叠蛋白诊断阿尔茨海默病。

Dementia and neurocognitive disorders Pub Date : 2020-03-01 Epub Date: 2020-03-06 DOI: 10.12779/dnd.2020.19.1.1

HeeYang Lee, Daniella Ugay, Seungpyo Hong, YoungSoo Kim

{"title":"Alzheimer's Disease Diagnosis Using Misfolding Proteins in Blood.","authors":"HeeYang Lee, Daniella Ugay, Seungpyo Hong, YoungSoo Kim","doi":"10.12779/dnd.2020.19.1.1","DOIUrl":"https://doi.org/10.12779/dnd.2020.19.1.1","url":null,"abstract":"Alzheimer's disease (AD) is pathologically characterized by a long progressive phase of neuronal changes, including accumulation of extracellular amyloid-β (Aβ) and intracellular neurofibrillary tangles, before the onset of observable symptoms. Many efforts have been made to develop a blood-based diagnostic method for AD by incorporating Aβ and tau as plasma biomarkers. As blood tests have the advantages of being highly accessible and low cost, clinical implementation of AD blood tests would provide preventative screening to presymptomatic individuals, facilitating early identification of AD patients and, thus, treatment development in clinical research. However, the low concentration of AD biomarkers in the plasma has posed difficulties for accurate detection, hindering the development of a reliable blood test. In this review, we introduce three AD blood test technologies emerging in South Korea, which have distinctive methods of heightening detection sensitivity of specific plasma biomarkers. We discuss in detail the multimer detection system, the self-standard analysis of Aβ biomarkers quantified by interdigitated microelectrodes, and a biomarker ratio analysis comprising Aβ and tau.","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4b/7b/dnd-19-1.PMC7105719.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37740477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Determining the Neurocognitive Status and the Functional Ability of Patients to Screen for HIV-Associated Neurocognitive Disorder (HAND). 确定患者筛查hiv相关神经认知障碍(HAND)的神经认知状态和功能能力。

Dementia and neurocognitive disorders Pub Date : 2020-03-01 Epub Date: 2019-12-24 DOI: 10.12779/dnd.2020.19.1.19

Ritika Agarwal, Ravinder Singh Aujla, Amit Gupta, Mukesh Kumar

{"title":"Determining the Neurocognitive Status and the Functional Ability of Patients to Screen for HIV-Associated Neurocognitive Disorder (HAND).","authors":"Ritika Agarwal, Ravinder Singh Aujla, Amit Gupta, Mukesh Kumar","doi":"10.12779/dnd.2020.19.1.19","DOIUrl":"https://doi.org/10.12779/dnd.2020.19.1.19","url":null,"abstract":"Background and purpose: To adequately evaluate the extent of neurocognitive impairment in patient living with human immunodeficiency virus (PLHIV), a battery of neuropsychological tests is typically administered which are neither cost effective nor time efficient in the outpatient clinical setting. The aim of the study was to assess neurocognitive status and functional ability of people living with HIV and find a brief screening tool to identify those who would benefit from a full diagnostic evaluation.Methods: The study enrolled 160 PLHIV (80 pre-antiretroviral therapy [ART] and 80 on ART) fulfilling the inclusion and exclusion criteria. Neurocognitive assessment and an assessment of Functional ability was done by using the Montreal Cognitive Assessment (MoCA) and Lawton and Brody Instrumental Activities of Daily Living Scale scale, respectively.Results: The study population consisted of 75.6% males and 24.4% females with mean age of 44±10 years. The overall prevalence of HIV associated neurocognitive disorder (HAND) in the study subjects was 52.5%. Of these, 47.5% had asymptomatic neurocognitive impairment and 5% had minor neurocognitive disorder. In MoCA, the most frequently affected domains were Language (97.6%), visuospatial ability (92.9%) and memory (71.4%).Conclusions: The prevalence of HAND in both groups were similar suggesting that neurocognitive impairment starts early in HIV infection. Memory and Visuospatial function impairment had the most predictive potential for detecting the presence of HAND. HAND screening is recommended in all PLHIV at enrolment into care. Simple tools like MoCA can be used in busy outpatient settings by healthcare workers to screen for HAND.","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/81/6d/dnd-19-19.PMC7105717.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37740473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

The R278I Mutation of PSEN1 in the Familial Alzheimer Disease. 家族性阿尔茨海默病PSEN1基因R278I突变

Dementia and neurocognitive disorders Pub Date : 2020-03-01 Epub Date: 2020-02-25 DOI: 10.12779/dnd.2020.19.1.33

Jong Hun Kim, Seong Hye Choi, Jun Hong Lee

引用次数: 0

A Case of Anti-NMDA Receptor Encephalitis with Normal Findings on Initial Diagnostic Tests. 抗nmda受体脑炎1例，初步诊断结果正常。

Dementia and neurocognitive disorders Pub Date : 2020-03-01 Epub Date: 2020-02-27 DOI: 10.12779/dnd.2020.19.1.28

Hyuk Sung Kwon, Sung Ho Jo, Yangmi Park, Hojin Choi, Young Joo Lee, Seong Ho Koh, Kyu Yong Lee

{"title":"A Case of Anti-NMDA Receptor Encephalitis with Normal Findings on Initial Diagnostic Tests.","authors":"Hyuk Sung Kwon, Sung Ho Jo, Yangmi Park, Hojin Choi, Young Joo Lee, Seong Ho Koh, Kyu Yong Lee","doi":"10.12779/dnd.2020.19.1.28","DOIUrl":"https://doi.org/10.12779/dnd.2020.19.1.28","url":null,"abstract":"Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is an immune-mediated disease, more common in females. It is often related to ovarian tumor.1 Clinically, it is characterized by rapid onset (<3 months) of diverse symptoms including abnormal behavioral change, decreased level of consciousness, speech dysfunction, epileptic seizure, autonomic dysfunction, psychosis, rigidity, and dyskinesia.1 The diagnostic criteria for definite antiNMDAR encephalitis includes the presence of immunoglobulin G (IgG) antibodies against the GluN1 subunit of NMDAR.2 However, test for antibodies is not readily accessible in many institutions and can take weeks to obtain results.2 So diagnostic tests such as cerebrospinal fluid (CSF) analysis, electroencephalogram (EEG), and magnetic resonance imaging (MRI), are used as integral supportive findings, in addition to suggestive clinical symptoms and excluding other disorders. Here, we report a patient who presented with acute onset of psychosis with normal EEG, and normal brain MRI, and non-inflammatory CSF initially.","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/54/22/dnd-19-28.PMC7105718.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37740475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Impact of Comorbid Alzheimer's Disease in a Patient with Normal Pressure Hydrocephalus? 合并症阿尔茨海默病对常压脑积水患者的影响?

Dementia and neurocognitive disorders Pub Date : 2020-03-01 Epub Date: 2020-02-28 DOI: 10.12779/dnd.2020.19.1.31

Halil Onder

引用次数: 0

Air Pollution and Dementia. 空气污染与痴呆症。

Dementia and neurocognitive disorders Pub Date : 2019-12-01 Epub Date: 2020-01-06 DOI: 10.12779/dnd.2019.18.4.109

Hojin Choi, Seung Hyun Kim

{"title":"Air Pollution and Dementia.","authors":"Hojin Choi, Seung Hyun Kim","doi":"10.12779/dnd.2019.18.4.109","DOIUrl":"https://doi.org/10.12779/dnd.2019.18.4.109","url":null,"abstract":"Air pollution is a current and growing global problem. It also has a major adverse effect on our health. Air pollution exposure, a powerful health risk factor, is more likely to cause disease than the commonly known modifiable disease risk factor, and impacts health life reduction and labor productivity degradation in addition to disease outbreaks and early deaths.1,2 The association between air pollution and cardiovascular or respiratory problems has been well documented. Conversely, there has been an insufficient number of studies on the relationship between air pollution and cognitive functions.3,4 In Korea, since the late 1990s, the impact of air pollution on health has been recognized, and epidemiological studies on public health have been actively conducted. However, the relationship between cognitive function and air pollution is insufficient. In this paper, we reviewed the relationship between particulate matter (PM), which inflicts the greatest harm to humans among air pollutants, and cognitive functions and dementia and introduced the plans of the Korean Dementia Association (KDA) for this study on the relationship between PM and dementia.","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a8/9e/dnd-18-109.PMC6946615.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37547700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Delusional Parasitosis in a Patient with an Infarction in the Territory of the Right Posterior Cerebral Artery. 右脑后动脉区梗死患者妄想性寄生虫病1例。

Dementia and neurocognitive disorders Pub Date : 2019-12-01 Epub Date: 2019-12-13 DOI: 10.12779/dnd.2019.18.4.149

Tae Hwan Yoon, Tae-Beom Ahn

引用次数: 2

A Case of Creutzfeldt-Jakob Disease Presented as Rapid Progressive Parkinsonism. 克雅氏病表现为快速进行性帕金森病1例。

Dementia and neurocognitive disorders Pub Date : 2019-12-01 Epub Date: 2019-12-30 DOI: 10.12779/dnd.2019.18.4.152

Yoonah Park, Chan-Nyeong Lee

引用次数: 1

The Effect of Clinical Characteristics and Subtypes on Amyloid Positivity in Patients with Amnestic Mild Cognitive Impairment. 临床特征及亚型对健忘轻度认知障碍患者淀粉样蛋白阳性的影响。

Dementia and neurocognitive disorders Pub Date : 2019-12-01 Epub Date: 2019-12-13 DOI: 10.12779/dnd.2019.18.4.130

Jeong Yeon Kim, Jun Ho Lim, Young Jin Jeong, Do-Young Kang, Kyung Won Park

{"title":"The Effect of Clinical Characteristics and Subtypes on Amyloid Positivity in Patients with Amnestic Mild Cognitive Impairment.","authors":"Jeong Yeon Kim, Jun Ho Lim, Young Jin Jeong, Do-Young Kang, Kyung Won Park","doi":"10.12779/dnd.2019.18.4.130","DOIUrl":"https://doi.org/10.12779/dnd.2019.18.4.130","url":null,"abstract":"Background and purpose: Mild cognitive impairment (MCI) is a prodromal stage of dementia. Amyloid deposits in positron-emission tomography (PET) imaging of MCI patients imply a higher risk for advancing to dementia, with rates of 10%-15% yearly. The purpose of this study was to investigate the clinical characteristics of subgroups of amnestic MCI (aMCI) that may have a higher impact on amyloid positivity.Methods: We recruited 136 aMCI patients. All patients underwent a 20-minute F-18 florbetaben or flutemetamol PET scan. We classified amyloid PET images as positive or negative according to a semi-quantitative method. We evaluated the amyloid positivity of subgroups of aMCI (early vs. late type, single vs. multiple amnestic type, verbal vs. verbal, and visual amnestic type), and compared baseline clinical characteristics including key risk factors, apolipoprotein E4 (apoE4) genotype, and neuropsychological assessments with amyloid positivity in aMCI.Results: The amyloid positivity in total aMCI was 41%. The positivity rate according to subgroup of aMCI were as follow: Late aMCI (49%) vs. early aMCI (33%) (p=0.13), multiple aMCI (40%) vs. single aMCI (38%) (p=0.51), and verbal and visual aMCI (59%) vs. verbal aMCI (35%) (p=0.01), respectively. The mean age and the frequency of apoE4 allele of the amyloid-positive group was higher than that of the amyloid-negative group in aMCI (p<0.01).Conclusions: We found that the amyloid positivity was related to patterns of clinical subtypes, characteristics, and risk factors in patients with aMCI.","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/61/33/dnd-18-130.PMC6946617.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37547166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6