Min Young Chun, Jihye Hwang, Ji Young Yun, Geum Yun Sim, Gyoung Sil Choi, Geon Ha Kim, Jee Hyang Jeong
{"title":"The Effect of Seoul Dementia Healing Design Project on Cognition and Social Engagement.","authors":"Min Young Chun, Jihye Hwang, Ji Young Yun, Geum Yun Sim, Gyoung Sil Choi, Geon Ha Kim, Jee Hyang Jeong","doi":"10.12779/dnd.2020.19.4.140","DOIUrl":"https://doi.org/10.12779/dnd.2020.19.4.140","url":null,"abstract":"<p><strong>Background and purpose: </strong>Rapid population aging and an increase in the demented elderly became major social concerns in South Korea. Environmental design is increasingly recognized as an important aid for long-term care of patients with dementia as well as pharmacotherapy. We did a pilot study to investigate the effect of the Seoul Dementia Healing Design Project In-House Design (S-DHDP-IHD) in improving the quality of life of the cognitively impaired patients and of the S-DHDP Environmental Design (S-DHDP-ED) in increasing daily outdoor activities for cognitively impaired individuals and not cognitively impaired (NCI) elderly residents.</p><p><strong>Methods: </strong>We applied the S-DHDP-IHD to 2 households of patients with mild cognitive impairment (MCI) and early-stage vascular dementia (VD). We assessed the effectiveness of intervention by surveys and video recordings of daily tasks. Additionally, we applied the S-DHDP-ED to 5 community facilities and randomly selected 287 residents over 65 years old (32 dementia caregivers and 255 NCI elderly) to participate in surveys.</p><p><strong>Results: </strong>S-DHDP-IHD intervention showed improved instrumental activities in MCI patient and early-stage VD patient. Also, the satisfaction with an intervened home environment was increased. Following S-DHDP-ED intervention, non-demented residents engaged in more outdoor and social activities. They were also satisfied with the function and design of the installed facilities.</p><p><strong>Conclusions: </strong>S-DHDP encompassing both home and environmental improvements was effective in readapting cognitively impaired individuals and could achieve a customized, holistic approach to dementia caregiving by means of the improved design.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"19 4","pages":"140-151"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/56/38/dnd-19-140.PMC7781737.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38763276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jeongyeon Kim, Sung Wook Hyung, Junghee Seo, Heejin Lee, Hyun Jeong Yu, Mun Kyung Sunwoo
{"title":"Delayed Post-Hypoxic Leukoencephalopathy Caused by Fentanyl Intoxication in a Healthy Woman.","authors":"Jeongyeon Kim, Sung Wook Hyung, Junghee Seo, Heejin Lee, Hyun Jeong Yu, Mun Kyung Sunwoo","doi":"10.12779/dnd.2020.19.4.170","DOIUrl":"https://doi.org/10.12779/dnd.2020.19.4.170","url":null,"abstract":"Delayed post-hypoxic leukoencephalopathy (DPHL) is a rare disease caused by an anoxic event, such as carbon monoxide (CO) or asphyxial gas poisoning, cardiac arrest, and opiate or benzodiazepine overuse.1-4 At the time of prolonged cerebral hypo-oxygenation, the first manifestation is altered mental status, which is followed by a dramatic recovery. After a few days to weeks, cognitive impairment, gait disorders, parkinsonism, akinetic mutism, and psychosis can appear. We report a patient with DPHL following fentanyl patch intoxication who recovered fully, as confirmed by neuropsychiatric testing.","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"19 4","pages":"170-172"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/43/52/dnd-19-170.PMC7781733.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38763281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minji Song, Seungmin Jahng, SangYun Kim, Yeonwook Kang
{"title":"A Normative Study of the Full Version of Story Memory in the Korean-Mini Mental State Examination, 2nd Edition: Expanded Version (K-MMSE-2: EV).","authors":"Minji Song, Seungmin Jahng, SangYun Kim, Yeonwook Kang","doi":"10.12779/dnd.2020.19.4.161","DOIUrl":"10.12779/dnd.2020.19.4.161","url":null,"abstract":"<p><strong>Background and purpose: </strong>The Mini Mental State Examination, 2nd edition: Expanded version (MMSE-2: EV) involves an immediate recall (IR) of story memory (SM). A full version of SM has been developed and standardized; it includes delayed recall (DR) and recognition tests in addition to IR to increase its clinical utility as an independent story recall test. This study was conducted to provide norms for the full version of SM in the Korean version of MMSE-2: EV for clinical use.</p><p><strong>Methods: </strong>A total of 1,168 participants (496 males and 672 females) were included in the study. The ages ranged from 19 to 90 years, and the education level ranged from illiterate to post-graduate. Regression analysis was used to evaluate the relative contributions of demographic variables (age, education, and sex) on the SM measures.</p><p><strong>Results: </strong>We stratified age into 11 groups, and categorized the education level into 6 groups. It was found that the IR, DR, and recognition scores of SM were affected by age, education level, and sex. We provided corrected means and standard deviations of the IR, DR, and recognition scores of the SM for the demographic variables.</p><p><strong>Conclusions: </strong>The results indicate the importance of considering demographic variables in interpreting the full version of SM measures. The normative data we have provided in this study should be useful in clinical and research settings for detecting the impairment in verbal memory.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"19 4","pages":"161-169"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/66/f7/dnd-19-161.PMC7781735.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38763278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Young Hee Jung, Soyoung Lee, Woo Jung Kim, Jee Hee Lee, Myung Jong Kim, Hyun Jeong Han
{"title":"Effect of Integrated Cognitive Intervention Therapy in Patients with Mild to Moderate Alzheimer's Disease.","authors":"Young Hee Jung, Soyoung Lee, Woo Jung Kim, Jee Hee Lee, Myung Jong Kim, Hyun Jeong Han","doi":"10.12779/dnd.2020.19.3.86","DOIUrl":"https://doi.org/10.12779/dnd.2020.19.3.86","url":null,"abstract":"<p><strong>Background and purpose: </strong>The effect of the integrated program comprising cognitive training, art therapy, and music therapy has not been extensively studied in patients with Alzheimer's disease (AD). The present study investigated the effect of integrated cognitive intervention therapy on cognition, and activity of daily life (ADL), and mood in patients with mild to moderate AD.</p><p><strong>Methods: </strong>In this study, the data of 59 patients who met the National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer disease and Related Disorders Association (NINCDS-ADRDS) criteria of probable AD among those who registered at the Centenarian's Good Memory Program in Goyang from September 2014 to August 2019 were collected. We statistically analyzed the scores of Korean version of a Mini-Mental Status Examination (K-MMSE), Korean Dementia Screening Questionnaire-Cognition (KDSQ-C), Geriatric Depression Scale (GDS), Beck Anxiety Inventory (BAI), and Seoul-Instrumental Activities of Daily Living (S-IADL) of the same patients before and after the use of integrated cognitive intervention therapy.</p><p><strong>Results: </strong>K-MMSE slightly increased from 18.7±4.5 to 19.7±5.0 (<i>p</i><0.001) and KDSQ-C improved from 14.5±7.6 before therapy to 12.6±7.2 after therapy (<i>p</i>=0.001). Mean S-IADL score improved from 17.6±7.6 before therapy to 15.7±9.5 after therapy (<i>p</i><0.001). Additionally, mean GDS score before the therapy was 5.6±3.5 that improved to 4.2±3.0 after the therapy (<i>p</i><0.001). Mean BAI score decreased from 8.4±10.3 before therapy to 5.9±8.4 after therapy (<i>p</i>=0.001).</p><p><strong>Conclusions: </strong>In conclusion, this study demonstrated the possibility that the use of an integrated cognitive therapy improved cognition, ADL, and mood (depression and anxiety) in patients with mild to moderate ADs.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"19 3","pages":"86-95"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ca/df/dnd-19-86.PMC7521951.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38428202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"History of Coffee Consumption and Risk of Alzheimer's Disease: a Meta-epidemiological Study of Population-based Cohort Studies.","authors":"Jong Myon Bae","doi":"10.12779/dnd.2020.19.3.108","DOIUrl":"https://doi.org/10.12779/dnd.2020.19.3.108","url":null,"abstract":"<p><strong>Background and purpose: </strong>Four published quantitative systematic reviews showed conflicting results involving coffee consumption and the risk of Alzheimer's disease (AD). The aim of this meta-epidemiological meta-analysis (MEMA) was to evaluate the factors underlying the conflicting results and estimate the effect size and direction of the AD risk associated with coffee consumption in population-based cohort studies.</p><p><strong>Methods: </strong>The primary subjects of MEMA were derived from 3 cohort studies selected by the related systematic reviews. Additional studies involving the primary subjects were searched using citation discovery tools. Prospective cohort studies evaluating the association between coffee consumption and AD risk were selected. A fixed effects model was applied to estimate the summary relative risk (sRR) and its 95% confidence intervals (CIs). Subgroup analysis was conducted according to the level of coffee consumption. Egger's test was used to evaluate publication bias.</p><p><strong>Results: </strong>Four cohort studies were finally selected. A total of 36,300 participants from Finland, Sweden, Germany, and the United States of America were selected. The sRR (and its 95% CI) (I-squared value) by highest-versus-lowest method was 0.98 (0.92-1.05) (0.0%). In addition, none of the results of subgroup analyses by the level of coffee consumption showed any statistical significance.</p><p><strong>Conclusions: </strong>This MEMA found that there was no association between coffee consumption and AD risk. Based on recent evidence suggesting that gene-environment interactions contribute to AD pathogenesis, it is necessary to conduct population-based cohort studies involving non-Caucasians.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"19 3","pages":"108-113"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/da/81/dnd-19-108.PMC7521955.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38428204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Relationship between Lower Urinary Tract Dysfunction and Dementia.","authors":"Hae Ri Na, Sung Tae Cho","doi":"10.12779/dnd.2020.19.3.77","DOIUrl":"https://doi.org/10.12779/dnd.2020.19.3.77","url":null,"abstract":"<p><p>Lower urinary tract dysfunction (LUTD) is a common health challenge in dementia patients with significant morbidity and socioeconomic burden. It often causes lower urinary tract (LUT) symptoms, restricts activities of daily life, and impairs quality of life. Among several LUT symptoms, urinary incontinence (UI) is the most prominent storage symptom in the later stages of dementia. UI in patients with dementia results not only from cognitive impairment, but also from urological defects such as detrusor overactivity. Management of LUTD in patients with dementia is based on multiple factors, including cognitive state, functional impairment, concurrent comorbidities, polypharmacy and urologic condition. Behavioral therapy under caregiver support represents appropriate treatment strategy for UI in these patients. Pharmacological treatment can be considered in patients refractory to behavioral therapy, but it is more effective when combined with behavioral therapy. Antimuscarinics and mirabegron, a beta-3 receptor agonist, are effective for managing storage symptoms involving the LUT. However, anticholinergic side effects in elderly subjects are a concern, particularly when there is a risk of exacerbating cognitive impairment with prolonged use of antimuscarinics. Proper recognition and treatment of LUTD in dementia can improve quality of life in these patients.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"19 3","pages":"77-85"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7f/fc/dnd-19-77.PMC7521953.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38428200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Artificial Intelligence Approaches to Social Determinants of Cognitive Impairment and Its Associated Conditions.","authors":"Kwang Sig Lee, Kun Woo Park","doi":"10.12779/dnd.2020.19.3.114","DOIUrl":"https://doi.org/10.12779/dnd.2020.19.3.114","url":null,"abstract":"<p><strong>Background and purpose: </strong>This study uses an artificial-intelligence model (recurrent neural network) for evaluating the following hypothesis: social determinants of disease association in a middle-aged or old population are different across gender and age groups. Here, the disease association indicates an association among cerebrovascular disease, hearing loss and cognitive impairment.</p><p><strong>Methods: </strong>Data came from the Korean Longitudinal Study of Ageing (2014-2016), with 6,060 participants aged 53 years or more, that is, 2,556 men, 3,504 women, 3,640 aged 70 years or less (70-), 2,420 aged 71 years or more (71+). The disease association was divided into 8 categories: 1 category for having no disease, 3 categories for having 1, 3 categories for having 2, and 1 category for having 3. Variable importance, the effect of a variable on model performance, was used for finding important social determinants of the disease association in a particular gender/age group, and evaluating the hypothesis above.</p><p><strong>Results: </strong>Based on variable importance from the recurrent neural network, important social determinants of the disease association were different across gender and age groups: 1) leisure activity for men; 2) parents alive, income and economic activity for women; 3) children alive, education and family activity for 70-; and 4) brothers/sisters cohabiting, religious activity and leisure activity for 70+.</p><p><strong>Conclusions: </strong>The findings of this study support the hypothesis, suggesting the development of new guidelines reflecting different social determinants of the disease association across gender and age groups.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"19 3","pages":"114-123"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/11/40/dnd-19-114.PMC7521952.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38428205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eun Hye Lee, Bori R Kim, Hyungho Kim, Soo Hyun Kim, Min Young Chun, Hee Kyung Park, Kee Duk Park, Jee Hyang Jeong, Geon Ha Kim
{"title":"Four-Week, Home-Based, Robot Cognitive Intervention for Patients with Mild Cognitive Impairment: a Pilot Randomized Controlled Trial.","authors":"Eun Hye Lee, Bori R Kim, Hyungho Kim, Soo Hyun Kim, Min Young Chun, Hee Kyung Park, Kee Duk Park, Jee Hyang Jeong, Geon Ha Kim","doi":"10.12779/dnd.2020.19.3.96","DOIUrl":"https://doi.org/10.12779/dnd.2020.19.3.96","url":null,"abstract":"<p><strong>Background and purpose: </strong>Previous studies suggest that cognitive intervention can mitigate the development of dementia in patients with mild cognitive impairment (MCI). However, the previous cognitive intervention was mostly provided as a group session, in which MCI patients sometimes had difficulty in regularly attending sessions or were reluctant to participate in group-based classes. Additionally, experienced instructors for traditional cognitive intervention may be unavailable in some chronic-care facilities or community centers. Considering these reasons, we have developed 5 programs for home-based cognitive intervention using a personal robot for MCI patients. In this preliminary study, we aimed to demonstrate the effects of our newly developed home-based cognitive intervention with robots on cognitive function in MCI patients.</p><p><strong>Methods: </strong>We conducted a single-blind randomized controlled trial enrolling 46 MCI patients. Participants were randomized into 2 groups: the robot cognitive intervention (robot) (<i>n</i>=24) group and without cognitive intervention (control) (<i>n</i>=22) group. The interventions comprised 60-min sessions per day for 4 weeks. The primary outcome was the change in cognitive function measured using the Cambridge Neuropsychological Test Automated Battery.</p><p><strong>Results: </strong>There were no significant baseline demographic or clinical differences between the robot and control groups. After the 4-week cognitive intervention, the robot group showed greater improvement in working memory than did the control group.</p><p><strong>Conclusions: </strong>Our home-based cognitive intervention with a personal robot improved the working memory in MCI patients. Further studies with larger samples and longer study periods are required to demonstrate the effects of these programs in other cognitive domains in MCI patients.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"19 3","pages":"96-107"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7c/2c/dnd-19-96.PMC7521954.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38428203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Home-Visiting Cognitive Intervention for the Community-Dwelling Elderly Living Alone.","authors":"Juyoun Lee, Ae Young Lee","doi":"10.12779/dnd.2020.19.2.65","DOIUrl":"https://doi.org/10.12779/dnd.2020.19.2.65","url":null,"abstract":"<p><strong>Background and purpose: </strong>The elderly living alone feel lonelier and more isolated than do those live with others, and they are at higher risk for cognitive decline and depression. This study aimed to assess whether a home-visiting cognitive intervention (HCI) can have positive effects on cognitive improvement for the elderly who living alone.</p><p><strong>Methods: </strong>HCI was conducted from April 2016 to November 2019. Every elder who lived alone and 2 matched partners met for 8 weeks once a week. The partners visited participants' home and did the HCI which composed of cognitive training and cognitive stimulation activities. The Mini-Mental State Examination-dementia screening (MMSE), Geriatric Depression Scale (GDS), the Korean version of instrumental activities of daily living (K-IADL), and the Social Support Scale (SSS) were evaluated before and after HCI to compare the effect of HCI.</p><p><strong>Results: </strong>A total of 258 participants showed significant improvements in MMSE, GDS, K-IADL, and SSS. The MMSE and GDS scores were significantly improved after HCI in both the normal cognition (NC, <i>n</i>=210) and cognitive impairment (CI, <i>n</i>=48) groups. The cognitive effect of HCI for CI was higher than for NC. Among the NC, the magnitude of cognitive improvement was greater in the higher educated group (above 7 years) than in the other groups.</p><p><strong>Conclusions: </strong>Active cognitive interventions could provide possible benefits to improve cognition, emotion, and functional abilities. Regular cognitive-care services like HCI are necessary to reduce dementia risk for the elderly who live alone in the community.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"19 2","pages":"65-73"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1e/3e/dnd-19-65.PMC7326612.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38099268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
YoungSoon Yang, Nagaendran Kandiah, SangYun Kim, Yong Tae Kwak
{"title":"Clinical Aspects of Neurobehavioral Symptoms of Dementia.","authors":"YoungSoon Yang, Nagaendran Kandiah, SangYun Kim, Yong Tae Kwak","doi":"10.12779/dnd.2020.19.2.54","DOIUrl":"https://doi.org/10.12779/dnd.2020.19.2.54","url":null,"abstract":"<p><p>Neurobehavioral symptoms of dementia (NBSD) are very common and are significant symptoms of the illness, contributing most to caregiver burdens and often resulting in premature institutionalization of the person with dementia. The main symptoms of NBSD are anxiety, depression, delusions, and hallucinations. NBSD produce significant problems for both patients and caregivers. The pathophysiology of NBSD is determined by genetic, structural, or environmental factors. Therefore, treatment of NBSD requires continuous and organic cooperation between patients, caregivers, social environments, and doctors. Therefore, it is important for neurologists, who mainly view NBSD for dementia patients, to increase their understanding of these more comprehensive areas as well as the latest insights and treatments to help patients and caregivers.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"19 2","pages":"54-64"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f7/f1/dnd-19-54.PMC7326614.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38099267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}