Biomedical materials (Bristol, England)最新文献_第8页

Multifunctional nanocomposite hydrogels: an effective approach to promote diabetic wound healing. 多功能纳米复合水凝胶：促进糖尿病伤口愈合的有效途径。

Biomedical materials (Bristol, England) Pub Date : 2025-05-06 DOI: 10.1088/1748-605X/add06f

Yuchen Hu, Junchao Zhou, Yuhang Gao, Ying Fan, Ban Chen, Jiangtao Su, Hong Li

{"title":"Multifunctional nanocomposite hydrogels: an effective approach to promote diabetic wound healing.","authors":"Yuchen Hu, Junchao Zhou, Yuhang Gao, Ying Fan, Ban Chen, Jiangtao Su, Hong Li","doi":"10.1088/1748-605X/add06f","DOIUrl":"https://doi.org/10.1088/1748-605X/add06f","url":null,"abstract":"Diabetes, a metabolic disease that is becoming increasingly severe globally, presents a significant challenge in the medical field. Diabetic wounds are characterized by their chronicity, difficulty healing, and complex microenvironment that harbors multiple adverse factors, including elevated hyperglycemia, persistent inflammation, susceptibility to infections, and oxidative stress, all of which contribute to the impaired healing process. Nanocomposite hydrogels, as materials with unique physicochemical properties and biocompatibility, have gained growing attention in recent years for their potential applications in diabetic wound healing. These hydrogels provide a moist healing environment for wounds and regulate cellular behavior and signaling pathways, promoting wound repair and healing. By introducing specific functional groups and nanoparticles, nanocomposite hydrogels can respond to pathological features of wounds, enabling adaptive drug release. Owing to their diverse bioactive functions, nanocomposite hydrogels are powerful tools for the treatment of diabetic wounds. Thus, this article provides an overview of recent progress in the use of nanocomposite hydrogels for diabetic wound healing.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":"20 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improved apoptosis and mitochondrial dysfunction: the potential of carmofur-platinum nanoparticles. 改善细胞凋亡和线粒体功能障碍：卡摩福-铂纳米颗粒的潜力。

Biomedical materials (Bristol, England) Pub Date : 2025-04-23 DOI: 10.1088/1748-605X/adcbfa

Gökçe Erdemir-Cilasun, Dilşad Özerkan, İshak Afşin Kariper, Esra Sert, Işık Neslişah Korkut, Ferdane Danışman-Kalındemirtaş

{"title":"Improved apoptosis and mitochondrial dysfunction: the potential of carmofur-platinum nanoparticles.","authors":"Gökçe Erdemir-Cilasun, Dilşad Özerkan, İshak Afşin Kariper, Esra Sert, Işık Neslişah Korkut, Ferdane Danışman-Kalındemirtaş","doi":"10.1088/1748-605X/adcbfa","DOIUrl":"https://doi.org/10.1088/1748-605X/adcbfa","url":null,"abstract":"Despite their impact on cancer therapy, limitations such as systemic toxicity and drug resistance are encountered with platinum-based drugs. This study explores the potential of combining PtIV-based NP with carmofur (Car) to address these issues. In this study, platinum nanoparticles (PtNPs) and Car-loaded PtNP (Car@PtNP) were synthesized and their cytotoxic and apoptotic effects on colorectal and breast cancer cells were evaluated. Following characterization of the synthesized NPs by dynamic light scattering, UV-VIS spectroscopy, FTIR, and STEM, it was found that the average size of PtNPs was 55.42 nm and the size increased to approximately 186.06 nm upon synthesis of Car@PtNP. MTT assays demonstrated that Car@PtNP exhibited higher levels of cellular toxicity than carmofur alone. While it significantly decreased cell viability in both colon and breast cancer cells, its toxicity to HUVEC cells was minimal. Treatment of MCF-7 and HCT116 cells with 50 µg ml-1of free Car resulted in cell viabilities of 65.2% and 76.93%, respectively, whereas the viability of cells treated with Car@PtNP decreased to 49.60% and 55.47%. Flow cytometric analysis confirmed that apoptosis was increased in healthy HCT116 cells treated with Car@PtNP, with a marked increase in both early and late apoptotic cell populations. Furthermore, these results were confirmed by Hoescht and Rhodamin123 immunofluorescence staining, and significant mitochondrial dysfunction and apoptotic morphological changes were observed in treated cells. The findings underscore the promise of Car@PtNP as a novel chemotherapeutic approach, integrating the benefits of PtIVcomplexes and Car to enhance antitumor efficacy while mitigating the drawbacks of conventional platinum-based therapies.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":"20 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in manufacturing technologies in the small-diameter artificial blood vessels field. 小直径人工血管制造技术进展。

Biomedical materials (Bristol, England) Pub Date : 2025-04-22 DOI: 10.1088/1748-605X/adca7b

Di Xiao, Xuelian Mi, Qian Wang, Shaojun Chen, Rongtao Chen, Yongjie Zhao, Yihao Liu, Dongmei Wei

引用次数: 0

I-PRF functionalized gelatin methacrylate microspheres for improving the proliferation and osteogenic differentiation of human periodontal ligament stem cells. I-PRF功能化甲基丙烯酸明胶微球促进人牙周韧带干细胞增殖和成骨分化。

Biomedical materials (Bristol, England) Pub Date : 2025-04-22 DOI: 10.1088/1748-605X/adc52a

Ke Yi, Huilin Zhu, Xiaodong Lian, Zhihui Tang, Qing Li

引用次数: 0

A review on pancreatic duct stents: materials and emerging trends. 胰管支架的研究进展：材料和发展趋势。

Biomedical materials (Bristol, England) Pub Date : 2025-04-22 DOI: 10.1088/1748-605X/adcb7d

Huijuan Fan, Nan Li, Xingguang Zhang, Wei Xu, Wencheng Zhang, Yangjuan Ding, Lingjian Li, Taotao Liu, Shihai Xia

{"title":"A review on pancreatic duct stents: materials and emerging trends.","authors":"Huijuan Fan, Nan Li, Xingguang Zhang, Wei Xu, Wencheng Zhang, Yangjuan Ding, Lingjian Li, Taotao Liu, Shihai Xia","doi":"10.1088/1748-605X/adcb7d","DOIUrl":"https://doi.org/10.1088/1748-605X/adcb7d","url":null,"abstract":"Pancreatic duct strictures, which can arise from trauma, inflammation, or malignancy, often result in complications such as duct obstruction, pancreatic parenchymal hypertension, and ischemia. Endoscopic stenting is an effective therapeutic approach for managing these strictures. However, traditional plastic pancreatic duct stents fail to conform to the physiological curvature of the pancreas, while metal pancreatic duct stents with flared ends reduce migration but are associated with complications such as de novo strictures. Additionally, plastic and metal pancreatic duct stents require surgical removal. Whereas biodegradable pancreatic duct stents present a promising alternative due to their superior biocompatibility and ability to decompose into non-toxic materials, potentially eliminating the need for additional surgeries. Despite these advantages, biodegradable pancreatic duct stents remain in the experiment stage. This review assesses current materials of pancreatic duct stents, and emphasizes recent advancements in biodegradable options and emerging trends in clinical applications.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":"20 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of the advances in implant technology: accomplishments and challenges for the design of functionalized surface structures. 植入体技术的进展综述：功能化表面结构设计的成就和挑战。

Biomedical materials (Bristol, England) Pub Date : 2025-04-17 DOI: 10.1088/1748-605X/adca7c

Ming-Feng Wang, Tao Yan, Ming-Cen Gao, Cheng-Wei Han, Zhuo-Qun Yan, Yu-Zhong Gao, Wei Zhang, Zhe Yi

{"title":"A review of the advances in implant technology: accomplishments and challenges for the design of functionalized surface structures.","authors":"Ming-Feng Wang, Tao Yan, Ming-Cen Gao, Cheng-Wei Han, Zhuo-Qun Yan, Yu-Zhong Gao, Wei Zhang, Zhe Yi","doi":"10.1088/1748-605X/adca7c","DOIUrl":"10.1088/1748-605X/adca7c","url":null,"abstract":"Biomedical implants are extensively utilized to replace hard-tissue defects owing to their biocompatibility and remarkable tissue-affinity. The materials and functional design are selected based on the resultant osseointegration level and resistance to infection, and these considerations constitute the dominant research topic in this field. However, high rates of implantation failure and peri-implantitis have been reported. Current research on biomedical-implant design encompasses enhancement of the implant surface properties, such as the roughness, nano/micro topography, and hydrophilicity, along with the realization of advanced features including antibacterial properties and cell and immunomodulation regulation. This review considers the two achievements of contemporary implant manufacturing; namely, osseointegration and the realization of antibacterial properties. Present mainstream surface modifications and coatings are discussed, along with functional design technologies and achievements. The impacts of direct surface-treatment techniques and osteogenic functional coatings on osseointegration performance and antibacterial surface structures are elucidated, considering inorganic and organic coatings with antibacterial properties as well as antibiotic-releasing coatings. Furthermore, this review highlights recent advancements in physically driven antimicrobial strategies. Expanding upon existing research, future directions for implant studies are proposed, including the realization of comprehensive functionality that integrates osseointegration and antibacterial properties, as well as patient-specific design. Our study presents a comprehensive review and offers a novel perspective on the design of biomedical implants for enhanced versatility. An in-depth exploration of future research directions will also stimulate subsequent investigations.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optomechanical evaluation of knot security in Monocryl and Maxon sutures under varying pH conditions. 不同pH条件下Monocryl和Maxon缝线打结安全性的光力学评价。

Biomedical materials (Bristol, England) Pub Date : 2025-04-17 DOI: 10.1088/1748-605X/adcb0d

Mohammed A El-Bakary, Aliaa A Nafad, Nayera M El-Sayed

{"title":"Optomechanical evaluation of knot security in Monocryl and Maxon sutures under varying pH conditions.","authors":"Mohammed A El-Bakary, Aliaa A Nafad, Nayera M El-Sayed","doi":"10.1088/1748-605X/adcb0d","DOIUrl":"https://doi.org/10.1088/1748-605X/adcb0d","url":null,"abstract":"Knot stability and security are crucial factors in surgical suture performance, ensuring optimal tension distribution and minimizing the risk of wound dehiscence. The mechanical behavior of surgical knots is influenced by suture material properties, knot configuration, and environmental factors such as localized pH deviations, which can accelerate material degradation. This study investigates the impact of pH-induced degradation on the mechanical and optomechanical performance of square and surgeon's knots tied with Maxon and Monocryl sutures under acidic (pH 5) and neutral (pH 7) conditions. Stress-strain analysis and Mach-Zehnder interferometry were employed to assess Young's modulus, mechanical loss percentages, tensile strength, toughness, phase maps, and 3D refractive index profiles over 20 d. Young's modulus results revealed significant reductions in acidic conditions. Maxon's surgeon knot decreased from 516 MPa to 228 MPa, while Monocryl's surgeon knot dropped from 434 MPa to 132 MPa over 20 d. Mechanical loss was notably higher in acidic conditions, with Maxon's surgeon knot exhibiting a 65.30% reduction and Monocryl's surgeon knot showing an 82.3% decrease. Toughness declined similarly, particularly in knotted configurations. Phase maps revealed substantial structural distortion, especially in Monocryl's perpendicular orientation at pH 5, indicating severe degradation. 3D refractive index profiles demonstrated that Maxon maintained greater internal uniformity, while Monocryl showed pronounced structural disruption under acidic conditions. Maxon's stability under different pH conditions makes it suitable for long-term applications, while Monocryl's rapid degradation suggests its suitability for scenarios requiring faster material breakdown. These findings provide valuable insights for suture selection in diverse wound conditions.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":"20 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sequential drug release of self-ordered titania nanotubes with antibacterial function and anticancer ability for bone cancer treatments. 具有抗菌和抗癌功能的自有序二氧化钛纳米管序贯药物释放用于骨癌治疗。

Biomedical materials (Bristol, England) Pub Date : 2025-04-16 DOI: 10.1088/1748-605X/adc9ed

Chien-Chun Chang, Yuan-Shun Lo, Yu-Ping Chen, Yen-Liang Liu, Chih-Liang Wang

{"title":"Sequential drug release of self-ordered titania nanotubes with antibacterial function and anticancer ability for bone cancer treatments.","authors":"Chien-Chun Chang, Yuan-Shun Lo, Yu-Ping Chen, Yen-Liang Liu, Chih-Liang Wang","doi":"10.1088/1748-605X/adc9ed","DOIUrl":"10.1088/1748-605X/adc9ed","url":null,"abstract":"The success of tumor prosthesis relies on the preclusion of deep infection and local recurrence in limb sparing surgery. The orthopedic implants enabling to simultaneously possess the antibacterial function and anticancer ability have become a desirable local therapy in the treatment of bone cancer. In this regard, we proposed a promising concept of the sequential release in a dual-drug system by combing titania nanotubes and chitosan as drug nanoreservoirs and sustained release films, respectively. An electrochemical anodization technique, controlled by anodization voltage, electrolyte composition, and processing time, was used to fabricate self-ordered titania nanotubes on the titanium surface, with their lengths simply tuned by the processing time, for drug loading. Two drugs of cisplatin and vancomycin as model anticancer and antibiotic, respectively, were sequentially loaded in nanotubes to investigate the release kinetics. The release profiles of cisplatin and vancomycin were found to be related to the spatial positioning of each drug on the nanotubes. Such a release sequence can be attributed to the anisotropic diffusion of drugs from the nanotubes, which can be further sustained for over 4 weeks through chitosan coverage. The drug release behavior was first evaluated in water using ultraviolet-visible spectroscopy for the quantitative analysis of release kinetics over time. The influence of dual-drug-loaded nanotubes on the growth ofStaphylococcus aureusand osteogenic sarcomain vitrowas systematically evaluated for the therapeutic efficacy of bone cancer treatment. A high correlation between the viabilities of bacteria and cells and dual-drug release profiles was observed, indicating the feasibility of our nanotube-based concept utilizing a sequential release pattern to combat initial bacterial infection and prevent local recurrence.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medical adhesives for soft tissue wound repair with good biocompatibility, flexibility, and high adhesive strength. 医用胶粘剂用于软组织创面修复，具有良好的生物相容性、柔韧性和较高的粘接强度。

Biomedical materials (Bristol, England) Pub Date : 2025-04-14 DOI: 10.1088/1748-605X/adc529

Jinju Ding, Xuehua Zhao, Chengkai Xuan, Jiayi Lin, Cuiping Zhang, Xuetao Shi

{"title":"Medical adhesives for soft tissue wound repair with good biocompatibility, flexibility, and high adhesive strength.","authors":"Jinju Ding, Xuehua Zhao, Chengkai Xuan, Jiayi Lin, Cuiping Zhang, Xuetao Shi","doi":"10.1088/1748-605X/adc529","DOIUrl":"10.1088/1748-605X/adc529","url":null,"abstract":"Compared with traditional soft tissue wound closure methods such as sutures and staplers, bioadhesives have significant advantages in terms of tissue compatibility, ease of use, and wound adaptability, making them a hot topic among current wound repair materials. This study aimed to select polyurethane materials with good biocompatibility and high mechanical strength, optimize the prepolymer formula, develop new curing agents, and obtain a new dual-component polyurethane bioadhesive. Furthermore, key research will be conducted on its mechanical properties and tissue adhesion performance. The results show that through the optimization of prepolymer formulations and the development of novel curing agents, a dual-component polyurethane bioadhesive with good biocompatibility, flexibility, and high adhesive strength was obtained. This adhesive can quickly and effectively bond common soft tissue (skin, muscle) traumatic wounds, with an adhesive strength of up to 72 kPa. This adhesive matches well with the mechanical properties of soft tissues and safely and tightly adheres to the surface of soft tissues. Additionally, this dual-component polyurethane adhesive holds promise for repairing other soft tissues, such as the lungs and intestines, with broad application prospects.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of the solvent on the green synthesis of NIR active polymeric nanoparticles and theirin vitrophotothermal therapeutic validation. 溶剂对绿色合成近红外活性高分子纳米粒子的影响及其体外光热治疗验证。

Biomedical materials (Bristol, England) Pub Date : 2025-04-10 DOI: 10.1088/1748-605X/adc865

Anusha Srivastava, Vibha Choudhary, Priyanka Payal, Maxim Shevtsov, Sharad Gupta

{"title":"Effect of the solvent on the green synthesis of NIR active polymeric nanoparticles and theirin vitrophotothermal therapeutic validation.","authors":"Anusha Srivastava, Vibha Choudhary, Priyanka Payal, Maxim Shevtsov, Sharad Gupta","doi":"10.1088/1748-605X/adc865","DOIUrl":"10.1088/1748-605X/adc865","url":null,"abstract":"Nanoparticle-mediated drug delivery has revolutionized nano-therapeutics. It ensures improved biodistribution, longer blood circulation, and improved bioavailability inside the body. The loading efficiency and stability of the drug within the carrier are the major challenges for ideal drug delivery. In this study, we have synthesized indocyanine green (ICG) loaded Poly-L-Lysine (PLL) nanoparticles by a two-step self-assembly process using a green chemistry approach, where water-based solvents were used for fabrication such as phosphate-buffered saline (PBS, pH 7.4), deionized water (DI), and Milli-Q water (MQ). The effect of these solvents on the morphology, stability and loading efficiency of ICG was investigated using UV-visible spectroscopy, fluorescence spectroscopy, scanning electron microscopy, and dynamic light scattering. The results demonstrated that nanoparticles can be fabricated using all the three solvents, however, there was a huge difference between their functional and morphological properties. These functional and morphological properties play important role in their biomedical applications. It was found that PBS-based NPs showed the maximum loading of ICG followed by DI water and MQ water respectively. The PBS suspended ICG-loaded PLL nanoparticles were highly monodispersed with the mean diameter of ∼200 nm and showed highest photothermal efficiency. The green synthesized biocompatible and biodegradable NPs were designed to treat solid tumors via local hyperthermia due to photothermal property of these NPs. The photothermal cytotoxicity assessment of PBS-based PLL-ICG NPs in both 2D and 3Din vitrocultures displayed notable efficacy. Therefore, we conclusively demonstrate that selection of right solvent is crucial to realize the full potential of green-synthesized polymeric nanoparticles.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0