Biomedical materials (Bristol, England)最新文献

{"title":"Osteogenesis promotion on MC3T3 by micro-area potential difference (MAPD) on titanium alloy.","authors":"Yanchun Xie, Junfan Chen, Shan Fu, Hailong Yu, Anwu Xuan, Yongcun Wei, Yi Lian, Lei Yang, Erlin Zhang","doi":"10.1088/1748-605X/ad98d7","DOIUrl":"10.1088/1748-605X/ad98d7","url":null,"abstract":"<p><p>The ability of osseointegration of implants is an important factor in ensuring the long-term stability of bone implants in their recipient sites. In this paper, Ti-M titanium alloys with different surface micro-area potential difference (MAPD) were prepared and the adhesion, proliferation, spreading, and differentiation behavior of osteoblasts (MC3T3) on the surface of Ti-M alloy were investigated in detail to reveal the effect of MAPD on cell compatibility and osteogenic differentiation. The results showed that the alloy with high MAPD facilitated bone differentiation, demonstrating that MAPD significantly enhanced the alkaline phosphatase activity and mineralization ability of osteoblasts, and upregulated the expression of osteogenic differentiation-related factors. It is suggested that it might be a strategy to promote the surface bioactivity of titanium alloy by adjusting the surface MAPD.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An aligned pattern sponge based on gelatin for rapid hemostasis.","authors":"Dayong Cao, Yimin Chen, Yulin Man, Zhaohong Chen","doi":"10.1088/1748-605X/ad9720","DOIUrl":"10.1088/1748-605X/ad9720","url":null,"abstract":"<p><p>Post-traumatic hemorrhage is a leading cause of morbidity and mortality. However, most current hemostatic materials focus on incorporating nutritional components, with limited research addressing the impact of the material's structure on hemostasis. In this study, we developed cytocompatible and hemocompatible three-dimensional gelatin sponges with a patterned and aligned structure, designed for rapid hemostasis. The sponges were characterized by light microscope photography and scanning electron microscopy (SEM). Pattern sponges with gelatin (P-Gelatin) exhibited aligned structures on their surfaces and the inner structure. In terms of biocompatibility, MTT assay, and hemolysis experiment showed that P-Gelatin had good cytocompatibility and hemocompatibility.<i>In vivo</i>blood coagulation and<i>in vivo</i>hemostasis, P-Gelatin sponges, with their aligned structure, exhibit rapid adsorption of red blood cells and platelets compared to non-patterned gelatin counterparts. This work introduces a safe and convenient patterned sponge for rapid hemostasis, especially highlighting a concept where a patterned structure can enhance the effectiveness of blood clotting, which is particularly relevant for tissue engineering.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D printed<i>β</i>-TCP scaffolds loaded with SVVYGLR peptide for promoting revascularization and osteoinduction.","authors":"Lin Gan, Chaoqian Zhao, Haojie Chen, Yucai Li, Zhen Pan, Yan Li, Xiao Wang, Jielin Wang, Jiangming Yu, Xiaojian Ye","doi":"10.1088/1748-605X/ad8d9a","DOIUrl":"https://doi.org/10.1088/1748-605X/ad8d9a","url":null,"abstract":"<p><p>It is crucial for the successful transplantation of large segmental bone defects to achieve rapid vascularization within bone scaffolds. However, there are certain limitations including uncontrolled angiogenesis and inadequate vascular function. Therefore, there is an urgent need to develop bone scaffolds with functional vascular networks. In our study, porous<i>β</i>-tricalcium phosphate (<i>β</i>-TCP) scaffolds with varying pore sizes were prepared by 3D printing technology, loaded with osteopontin derived peptide Ser-Val-Val-Tyr-Gly-Leu-Arg (SVVYGLR) to induce osteoinduction and angiogenesis.<i>In vitro</i>, the proliferation and migration behaviors of human umbilical vein endothelial cell on scaffolds were assessed by Cell Counting Kit-8, confocal laser scanning microscopy and scanning electron microscopy. And the osteogenic ability of bone marrow mesenchymal stem cells was assessed using alkaline phosphatase staining and Alizarin Red S staining. The messenger ribonucleic acid (mRNA) expression levels of cell adhesion molecule (CD31), vascular endothelial growth factor and hypoxia inducible factor-1<i>α</i>in each group were detected by quantitative real-time fluorescence polymerase chain reaction (PCR) analysis.<i>In vivo</i>, cube scaffolds were subcutaneously implanted on the right hips of Sprague-Dawley (SD) rats for 6 weeks. Hematoxylin and Eosin staining, Masson's trichrome staining, and immunohistochemical analysis of osteocalcin and CD31 were performed on slices for every sample with three sections to explore the effect of SVVYGLR-loaded scaffolds on angiogenesis and osteogenic induction for bone reconstruction. The results indicate that 3D printed<i>β</i>-TCP scaffolds loaded with the SVVYGLR peptide offer superior revascularization and osteoinduction to the scaffolds without the SVVYGLR<i>in situ</i>. Moreover, scaffolds with a pore size of 400 µm demonstrate higher effectiveness compared to those with a 150 µm pore size. The distinct hollow channel scaffolds and the specific SVVYGLR peptide substantially improve cell adhesion, spreading, and proliferation, as well as promote angiogenesis and bone formation. Furthermore, scaffolds with a pore size of 400 µm may exhibit greater efficacy compared to those with a pore size of 150 µm. The results of this study provide an idea for the development of practical applications for tissue-engineered bone scaffolds.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomaterials for bone tissue engineering: achievements to date and future directions.","authors":"Adithya Garimella, Subrata Bandhu Ghosh, Sanchita Bandyopadhyay-Ghosh","doi":"10.1088/1748-605X/ad967c","DOIUrl":"10.1088/1748-605X/ad967c","url":null,"abstract":"<p><p>Advancement in medicine and technology has resulted into prevention of countless deaths and increased life span. However, it is important to note that, the modern lifestyle has altered the food habits, witnessed increased life-style stresses and road accidents leading to several health complications and one of the primary victims is the bone health. More often than ever, healthcare professionals encounter cases of massive bone fracture, bone loss and generation of critical sized bone defects. Surgical interventions, through the use of bone grafting techniques are necessary in such cases. Natural bone grafts (allografts, autografts and xenografts) however, have major drawbacks in terms of delayed rehabilitation, lack of appropriate donors, infection and morbidity that shifted the focus of several investigators to the direction of synthetic bone grafts. By employing biomaterials that are based on bone tissue engineering (BTE), synthetic bone grafts provide a more biologically acceptable approach to establishing the phases of bone healing. In BTE, various materials are utilized to support and enhance bone regeneration. Biodegradable polymers like poly-(lactic acid), poly-(glycolic acid), and poly-(<i>ϵ</i>-caprolactone) are commonly used for their customizable mechanical properties and ability to degrade over time, allowing for natural bone growth. PEG is employed in hydrogels to promote cell adhesion and growth. Ceramics, such as hydroxyapatite and beta-tricalcium phosphate (<i>β</i>-TCP) mimic natural bone mineral and support bone cell attachment, with<i>β</i>-TCP gradually resorbing as new bone forms. Composite materials, including polymer-ceramic and polymer-glasses, combine the benefits of both polymers and ceramics/glasses to offer enhanced mechanical and biological properties. Natural biomaterials like collagen, gelatin, and chitosan provide a natural matrix for cell attachment and tissue formation, with chitosan also offering antimicrobial properties. Hybrid materials such as decellularized bone matrix retain natural bone structure and biological factors, while functionalized scaffolds incorporate growth factors or bioactive molecules to further stimulate bone healing and integration. The current review article provides the critical insights on several biomaterials that could yield to revolutionary improvements in orthopedic medical fields. The introduction section of this article focuses on the statistical information on the requirements of various bone scaffolds globally and its impact on economy. In the later section, anatomy of the human bone, defects and diseases pertaining to human bone, and limitations of natural bone scaffolds and synthetic bone scaffolds were detailed. Biopolymers, bioceramics, and biometals-based biomaterials were discussed in further depth in the sections that followed. The article then concludes with a summary addressing the current trends and the future prospects of potential bone transplants.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibition of hepatocellular carcinoma progression by methotrexate-modified pH-sensitive sorafenib and Schisandrin B micelles.","authors":"Yuhui Yan, Liang Kong, Ying-Bo Lu, Si-Yang Li, Ai-Wen Yan, Yue-Wen Song, Zi-Han Huang, Hao-Nan Zhu","doi":"10.1088/1748-605X/ad9aef","DOIUrl":"https://doi.org/10.1088/1748-605X/ad9aef","url":null,"abstract":"<p><strong>Introduction: </strong>&#xD;Due to the lack of specific symptoms, hepatocellular carcinoma is often detected in advanced stages. However, pharmacological systemic therapy, a common clinical treatment for advanced hepatocellular carcinoma, is prone to serious toxic side effects. To address these issues, we designed a pH-sensitive sorafenib and Schisandrin B micelle modified by methotrexate (MTX-SOR/SchB micelles), a nanosystem that combines the advantages of targeted delivery and pH sensitivity, and is capable of improving drug bioavailability and mitigating drug toxic side effects.&#xD;Methods:&#xD;Firstly, we characterized the physical and chemical properties of micelles, including particle size, Zeta potential, encapsulation efficiency, pH sensitivity and stability. Hepa1-6 cells and fluorescence imaging were used to investigate the targeting ability of MTX-SOR/SchB micelles. Anti-hepa1-6 cell proliferation, invasion, migration, and pro-apoptotic effects were evaluated in vitro. In addition, HCC tumor-bearing mouse and lung metastasis mouse models were established to investigate the anti-HCC ability of MTX-SOR/SchB micelles, and finally their biological safety was evaluated.&#xD;Results:&#xD;We found that the particle size of MTX-SOR/SchB micelles was uniformly distributed, could effectively encapsulation of the drug, had low leakage rate, sensitive pH response, and perfect stability. And MTX-SOR/SchB micelles could target hepatocellular carcinoma cells with high expression of folate receptor in vitro and in vivo. Moreover, MTX-SOR/SchB micelles could inhibit the proliferation, invasion and metastasis of HCC in vitro and in vivo and promote apoptosis. MTX-SOR/SchB micelles also show good biosafety.&#xD;Conclusion:&#xD;In conclusion, MTX-SOR/SchB micelles can effectively enhance the therapeutic effect of hepatocellular carcinoma, reduce systemic toxicity of drugs, which is expected to be used in clinical treatment.&#xD.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Injectable, cryopreservable, preconditioned mesenchymal stromal cell-loaded microbeads for pro-angiogenic therapy: in vitro proof-of-concept.","authors":"Francesco K Touani, Inès Hamouda, Nicolas Noiseux, Corinne Hoesli, Shant Der Sarkissian, Sophie Lerouge","doi":"10.1088/1748-605X/ad9af1","DOIUrl":"https://doi.org/10.1088/1748-605X/ad9af1","url":null,"abstract":"<p><p>Despite their recognized potential for ischemic tissue repair, the clinical use of human mesenchymal stromal cells (hMSC) is limited by the poor viability of cells after injection and the variability of their paracrine function. In this study, we show how the choice of biomaterial scaffolds and the addition of cell preconditioning treatment can address these limitations and establish a proof-of-concept for cryopreservable hMSC-loaded microbeads. Injectable microbeads in chitosan, chitosan-gelatin, and alginate were produced using stirred emulsification to obtain a similar volume moment mean diameter (D[4,3]500 µm). Cell viability was determined through live/dead assays, and vascular endothelial growth factor (VEGF) release was measured by ELISA. Proangiogenic function was studied by measuring the wound closure velocity of endothelial cells (HUVEC) co-cultured with MSC-loaded microbeads. The effect of freeze-thawing on microbeads morphology, porosity, injectability and encapsulated MSC was also studied. hMSC-loaded chitosan-based microbeads were found to release 11-fold more VEGF than alginate microbeads (p˂0.0001) and chitosan-gelatin was chosen for further studies because it presented the best cell viability. Preconditioning with celastrol significantly enhanced the viability (1.12-fold) and VEGF release (1.40-fold) of MSC-loaded in chitosan-gelatin microbeads, as well as their proangiogenic paracrine function (1.2-fold; p˂0.05). In addition, preconditioning significantly enhanced the viability of hMSC after 1 and 3 days in low-serum medium after cryopreservation (p˂0.05). Cryopreserved hMSC-loaded microbeads maintained their mechanical properties, were easily injectable through a 23G needle, and maintained their paracrine function, enhancing the proliferation and migration of scratched HUVEC. This study shows the advantage of chitosan as a scaffold material and concludes that chitosan-gelatin microbeads with celastrol-preconditioned cells form a promising off-the-shelf, cryopreservable allogenic MSC product. In vivo testing is required to confirm their potential in treating ischemic diseases or other clinical applications.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing the porosity of biphasic calcium phosphate using polyethylene glycol as the porogen for bone regeneration applications.","authors":"Anh Phuong Nguyen Hong, Ngoc Hoi Nguyen, Quoc Vinh Ho, Luan Minh Nguyen, Ngoc Thuy Trang Le, Phuong Le Thi, Pham Nguyen Dong Yen, Thanh Son Cu, Thi Thanh Thuy Nguyen, Dai Hai Nguyen","doi":"10.1088/1748-605X/ad971f","DOIUrl":"10.1088/1748-605X/ad971f","url":null,"abstract":"<p><p>Biphasic calcium phosphate (BCP) has been used as a material to support bone grafting, repair, recovery, and regeneration over the past decades. However, the inherent weakness of BCP is its low porosity, which limits the infiltration, differentiation, and proliferation of bone cells. To address this issue, porous BCP was synthesized using polyethylene glycol (PEG) 1000 with weight ratio ranging from 20%-60% in BCP as the porogen through the powder-forming method. Analytical methods such as Fourier transform infrared spectroscopy, x-ray diffraction, scanning electron microscopy were used to demonstrate the purity, morphology and functional groups on the material surface of the obtained BCP samples. Structurally, the BCP sample with 60% PEG, named B60, possessed the highest porosity of 71% and its pore diameters ranging from 5 to 75 µm. Besides, the<i>in vitro</i>biocompatibility of B60 material have been demonstrated on the L929 cell line (90% cell viability) and simulated body fluid (apatite formation after 1 d). These results suggested that B60 should be further studied as a promising artificial material for bone regenerating applications.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A positionally stable anatomic smooth breast implant.","authors":"Hector F Salazar, Tim Y Li, Sophia Salingaros, Carlos Y Urrea de la Puerta, George S Corpuz, Gillian M O'Connell, Celia C Aboaf, Xue Dong, Luke P Poveromo, Lawrence J Bonassar, Jason Spector","doi":"10.1088/1748-605X/ad9721","DOIUrl":"10.1088/1748-605X/ad9721","url":null,"abstract":"<p><p>The voluntary recall of textured breast implants due to their association with breast implant-associated anaplastic large cell lymphoma has resulted in the loss of the primary advantage of the textured surface: positional stability. We have engineered a novel soft gel-filled smooth implant with a surface that promotes positional stability without texture, known as the positionally stable smooth implant (PSSI). Miniature anatomically shaped breast implant shells were fabricated from polydimethylsiloxane using 3D-printed molds. The implant shell design incorporates cylindrical wells 1-4 mm in diameter. Implants were filled with commercial breast implant-derived silicone gel. Smooth and textured implants were also fabricated, serving as controls. Six implants per group were implanted subcutaneously into the bilateral rat dorsum. Rotation was measured every 2 weeks for a total of 12 weeks to assess stability. Animals were sacrificed at 4 and 12 weeks, and implant-capsule units were explanted for histological and Micro-computed tomography (MicroCT) analyzes. Four weeks after implantation, PSSI conditions showed tissue ingrowth and conformation to well dimensions, as assessed by histological staining and MicroCT imaging. Twelve weeks post implantation, textured implants and PSSI conditions with larger widths, depths, and well number demonstrated statistically significant increased stability compared to smooth implants (<i>p</i>< 0.05). Tissue ingrowth into shell features occurred by 4 weeks and remained throughout longer time points. No significant differences were found in capsule thickness or collagen content between groups. These results suggest a promising alternative to textured surfaces for inducing implant positional stability.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalizing β-TCP porous scaffolds to promote osteogenesis: a study of segmental femoral defects in beagle models.","authors":"Kai Cheng, Yuanhao Peng, Jingjing Diao, Haotian Zhu, Qiji Lu, Naru Zhao, Yingjun Wang, Huanwen Ding","doi":"10.1088/1748-605X/ad98d8","DOIUrl":"https://doi.org/10.1088/1748-605X/ad98d8","url":null,"abstract":"<p><strong>Background: </strong>&#xD;Increasing clinical occurrence of segmental bone defects demands constant improvements in bone transplantation to overcome issues of limited resources, immune rejection and poor structural complement. This study aimed to develop a personalized bone defect repair modality using 3D-printed β-TCP grafts and to assess its osteogenic impacts in a femoral segmental defect model in beagles, as a basis for clinical studies and application.&#xD;Methods:&#xD;A β-TCP scaffold was designed and manufactured using CAD with a 3 cm segmental bone defect model was established in 27 one-year-old male beagles, randomly divided into three groups. A control group utilizing only intramedullary fixation, the positive control group with an added autologous bone graft and experimental group using a β-TCP scaffold. The study animals were monitored for 24 weeks postoperative and assessed for vital signs, imaging, and histological indicators at every month.&#xD;Results:&#xD;All the Beagles underwent successful modelling and experimentation, and were fully ambulatory at four weeks. Postoperative X-rays showed no evidence of loosening or displacement of the intramedullary nails. Micro-CT and histological staining indicated Osteogenesis starting from the fourth week, with the most significant growth seen using autografts (P < 0.05). New bone formation is seen adhering to the surface and proximal femur after osteotomy. The β-TCP group had significantly more evidence of Osteogenesis when compared to the control group (P < 0.05), characterized by new bone visible throughout the porous structure and distal residual femur. The control group showed bone formation impeded by fibrosis, showing poor bone growth mainly around the distal end after osteotomy, with poor overall repair outcomes.&#xD;Conclusion:&#xD;Growth factor-deficient β-TCP porous scaffolds demonstrated promising Osteoinductive properties in repairing large segment bone defects in Beagles' femurs. It effectively promoted bone growth and is structurally advantageous for weight bearing long bones.&#xD.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing orthopaedic implant efficacy: the development of Cerium-doped bioactive glass and polyvinylpyrrolidone composite coatings via MAPLE technique.","authors":"Grațiela Grădișteanu-Pircălăbioru, Irina Negut, Mihaela Dinu, Anca Constantina Parau, Bogdan Bita, Liviu Duta, Carmen Ristoscu, Bogdan Sava","doi":"10.1088/1748-605X/ad98d5","DOIUrl":"https://doi.org/10.1088/1748-605X/ad98d5","url":null,"abstract":"<p><p>This study investigates the potential of combining Cerium-doped bioactive glass (BBGi) with Polyvinylpyrrolidone (PVP) to enhance the properties of titanium (Ti) implant surfaces using the Matrix-Assisted Pulsed Laser Evaporation (MAPLE) technique. The primary focus is on improving osseointegration, corrosion resistance, and evaluating the cytotoxicity of the developed thin films towards host cells. The innovative approach involves synthesizing a composite thin film comprising BBGi and PVP, leveraging the distinct benefits of both materials: BBGi's biocompatibility and osteoinductive capabilities, and PVP's film-forming and biocompatible properties. Results demonstrate that the BBGi+PVP coatings significantly enhance hydrophilicity, indicating improved cell-material interaction potential. The electrochemical analysis reveals superior corrosion resistance of the BBGi+PVP films compared to BBGi alone, which is critical for long-term implant stability. The mechanical adherence tests confirm the robust attachment of the coatings to Ti substrates, surpassing the ISO standards for implant materials. Biocompatibility tests show promising cell viability and negligible cytotoxic effects, with a controlled inflammatory response, underscoring the potential of BBGi+PVP coatings for orthopedic applications. The study concludes that the synergistic combination of BBGi and PVP, applied through the MAPLE technique, offers a promising route to fabricate bioactive and corrosion-resistant coatings for Ti implants, potentially enhancing osseointegration and longevity in clinical settings.&#xD.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}