Biomedical materials (Bristol, England)最新文献

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Sequential drug release of self-ordered titania nanotubes with antibacterial function and anticancer ability for bone cancer treatments. 具有抗菌和抗癌功能的自有序二氧化钛纳米管序贯药物释放用于骨癌治疗。
Biomedical materials (Bristol, England) Pub Date : 2025-04-16 DOI: 10.1088/1748-605X/adc9ed
Chien-Chun Chang, Yuan-Shun Lo, Yu-Ping Chen, Yen-Liang Liu, Chih-Liang Wang
{"title":"Sequential drug release of self-ordered titania nanotubes with antibacterial function and anticancer ability for bone cancer treatments.","authors":"Chien-Chun Chang, Yuan-Shun Lo, Yu-Ping Chen, Yen-Liang Liu, Chih-Liang Wang","doi":"10.1088/1748-605X/adc9ed","DOIUrl":"10.1088/1748-605X/adc9ed","url":null,"abstract":"<p><p>The success of tumor prosthesis relies on the preclusion of deep infection and local recurrence in limb sparing surgery. The orthopedic implants enabling to simultaneously possess the antibacterial function and anticancer ability have become a desirable local therapy in the treatment of bone cancer. In this regard, we proposed a promising concept of the sequential release in a dual-drug system by combing titania nanotubes and chitosan as drug nanoreservoirs and sustained release films, respectively. An electrochemical anodization technique, controlled by anodization voltage, electrolyte composition, and processing time, was used to fabricate self-ordered titania nanotubes on the titanium surface, with their lengths simply tuned by the processing time, for drug loading. Two drugs of cisplatin and vancomycin as model anticancer and antibiotic, respectively, were sequentially loaded in nanotubes to investigate the release kinetics. The release profiles of cisplatin and vancomycin were found to be related to the spatial positioning of each drug on the nanotubes. Such a release sequence can be attributed to the anisotropic diffusion of drugs from the nanotubes, which can be further sustained for over 4 weeks through chitosan coverage. The drug release behavior was first evaluated in water using ultraviolet-visible spectroscopy for the quantitative analysis of release kinetics over time. The influence of dual-drug-loaded nanotubes on the growth of<i>Staphylococcus aureus</i>and osteogenic sarcoma<i>in vitro</i>was systematically evaluated for the therapeutic efficacy of bone cancer treatment. A high correlation between the viabilities of bacteria and cells and dual-drug release profiles was observed, indicating the feasibility of our nanotube-based concept utilizing a sequential release pattern to combat initial bacterial infection and prevent local recurrence.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Medical adhesives for soft tissue wound repair with good biocompatibility, flexibility, and high adhesive strength. 医用胶粘剂用于软组织创面修复,具有良好的生物相容性、柔韧性和较高的粘接强度。
Biomedical materials (Bristol, England) Pub Date : 2025-04-14 DOI: 10.1088/1748-605X/adc529
Jinju Ding, Xuehua Zhao, Chengkai Xuan, Jiayi Lin, Cuiping Zhang, Xuetao Shi
{"title":"Medical adhesives for soft tissue wound repair with good biocompatibility, flexibility, and high adhesive strength.","authors":"Jinju Ding, Xuehua Zhao, Chengkai Xuan, Jiayi Lin, Cuiping Zhang, Xuetao Shi","doi":"10.1088/1748-605X/adc529","DOIUrl":"10.1088/1748-605X/adc529","url":null,"abstract":"<p><p>Compared with traditional soft tissue wound closure methods such as sutures and staplers, bioadhesives have significant advantages in terms of tissue compatibility, ease of use, and wound adaptability, making them a hot topic among current wound repair materials. This study aimed to select polyurethane materials with good biocompatibility and high mechanical strength, optimize the prepolymer formula, develop new curing agents, and obtain a new dual-component polyurethane bioadhesive. Furthermore, key research will be conducted on its mechanical properties and tissue adhesion performance. The results show that through the optimization of prepolymer formulations and the development of novel curing agents, a dual-component polyurethane bioadhesive with good biocompatibility, flexibility, and high adhesive strength was obtained. This adhesive can quickly and effectively bond common soft tissue (skin, muscle) traumatic wounds, with an adhesive strength of up to 72 kPa. This adhesive matches well with the mechanical properties of soft tissues and safely and tightly adheres to the surface of soft tissues. Additionally, this dual-component polyurethane adhesive holds promise for repairing other soft tissues, such as the lungs and intestines, with broad application prospects.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of the solvent on the green synthesis of NIR active polymeric nanoparticles and theirin vitrophotothermal therapeutic validation. 溶剂对绿色合成近红外活性高分子纳米粒子的影响及其体外光热治疗验证。
Biomedical materials (Bristol, England) Pub Date : 2025-04-10 DOI: 10.1088/1748-605X/adc865
Anusha Srivastava, Vibha Choudhary, Priyanka Payal, Maxim Shevtsov, Sharad Gupta
{"title":"Effect of the solvent on the green synthesis of NIR active polymeric nanoparticles and their<i>in vitro</i>photothermal therapeutic validation.","authors":"Anusha Srivastava, Vibha Choudhary, Priyanka Payal, Maxim Shevtsov, Sharad Gupta","doi":"10.1088/1748-605X/adc865","DOIUrl":"10.1088/1748-605X/adc865","url":null,"abstract":"<p><p>Nanoparticle-mediated drug delivery has revolutionized nano-therapeutics. It ensures improved biodistribution, longer blood circulation, and improved bioavailability inside the body. The loading efficiency and stability of the drug within the carrier are the major challenges for ideal drug delivery. In this study, we have synthesized indocyanine green (ICG) loaded Poly-L-Lysine (PLL) nanoparticles by a two-step self-assembly process using a green chemistry approach, where water-based solvents were used for fabrication such as phosphate-buffered saline (PBS, pH 7.4), deionized water (DI), and Milli-Q water (MQ). The effect of these solvents on the morphology, stability and loading efficiency of ICG was investigated using UV-visible spectroscopy, fluorescence spectroscopy, scanning electron microscopy, and dynamic light scattering. The results demonstrated that nanoparticles can be fabricated using all the three solvents, however, there was a huge difference between their functional and morphological properties. These functional and morphological properties play important role in their biomedical applications. It was found that PBS-based NPs showed the maximum loading of ICG followed by DI water and MQ water respectively. The PBS suspended ICG-loaded PLL nanoparticles were highly monodispersed with the mean diameter of ∼200 nm and showed highest photothermal efficiency. The green synthesized biocompatible and biodegradable NPs were designed to treat solid tumors via local hyperthermia due to photothermal property of these NPs. The photothermal cytotoxicity assessment of PBS-based PLL-ICG NPs in both 2D and 3D<i>in vitro</i>cultures displayed notable efficacy. Therefore, we conclusively demonstrate that selection of right solvent is crucial to realize the full potential of green-synthesized polymeric nanoparticles.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Construction of naturally derived hydrogels containing anti-inflammatory melittin for sustained drug delivery to treat osteoarthritis disease. 构建含有抗炎蜂毒素的天然衍生水凝胶,用于持续给药治疗骨关节炎疾病。
Biomedical materials (Bristol, England) Pub Date : 2025-04-10 DOI: 10.1088/1748-605X/adc864
Jun Yao, Sunfang Chen, Zaihua Zhu, Jianjiang Chen, Jiajie Xia, Bin Fang, Jingjing Guo, Bing Wu, Gaoxiang Ma
{"title":"Construction of naturally derived hydrogels containing anti-inflammatory melittin for sustained drug delivery to treat osteoarthritis disease.","authors":"Jun Yao, Sunfang Chen, Zaihua Zhu, Jianjiang Chen, Jiajie Xia, Bin Fang, Jingjing Guo, Bing Wu, Gaoxiang Ma","doi":"10.1088/1748-605X/adc864","DOIUrl":"10.1088/1748-605X/adc864","url":null,"abstract":"<p><p>Osteoarthritis (OA) has become a common degenerative joint disease, lacking clinical means to alleviate this disease. Melittin, taken from natural honeybee venom, possesses outstanding anti-inflammatory properties and has great potential to treat OA. However, its high toxicity and hemolytic properties limit its application. In this work, a biocompatible hydrogel was prepared from extracellular matrix (ECM) of rib cartilage, possessing fibrous mesh structure characteristics, which was beneficial for melittin loading. It was found that the use of ECM hydrogel loaded with melittin can reduce the intrinsic toxicity of melittin and prolong the release behavior, simultaneously. The<i>in vitro</i>study demonstrated that melittin-hydrogel could effectively inhibit phosphorylation-ERK/JNK, prevent the exacerbation of TNF-<i>α</i>-induced apoptosis in ATDC5 cells, and reduce their inflammatory markers, effectively alleviating OA and preventing cartilage degradation. Subsequently,<i>in vivo</i>studies have demonstrated that injecting melittin-hydrogel into the joint cavity of OA mice can effectively reduce cartilage degeneration. These findings suggest that melittin-hydrogel plays a critical role in the development of OA and may provide a therapeutic option for the treatment of OA disease.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of induced pluripotent stem cell-derived anterior foregut endoderms on integrin-binding short peptide-based synthetic substrates. 整合素结合短肽合成底物诱导多能干细胞衍生前肠内胚层。
Biomedical materials (Bristol, England) Pub Date : 2025-04-09 DOI: 10.1088/1748-605X/adc52b
Shujun Wu, Huan Wang, Yanbei Ren, Ying Liu, Xuejun Wen
{"title":"Generation of induced pluripotent stem cell-derived anterior foregut endoderms on integrin-binding short peptide-based synthetic substrates.","authors":"Shujun Wu, Huan Wang, Yanbei Ren, Ying Liu, Xuejun Wen","doi":"10.1088/1748-605X/adc52b","DOIUrl":"10.1088/1748-605X/adc52b","url":null,"abstract":"<p><p>Anterior foregut endoderms (AFEs) derived from induced pluripotent stem cells (iPSCs) are an important cell source in stem cell technology as they give rise to some important lineages like lung progenitors and thyroid cells. Coating substrates plays a critical role in AFE generation. Currently, conventional large molecule proteins like Matrigel are used in most differentiation protocols. However, the complex components and mechanisms of these coatings have limited both the exploration of cell-extracellular matrix (ECM) interaction and potential clinical applications. In this study, we identified eight pure synthetic integrin-binding short peptides as effective coatings for iPSC growth and AFE generation with an integrin-binding peptide array. Our results showed that integrin<i>α</i>5<i>β</i>1-,<i>α</i>V<i>β</i>8-, and<i>α</i>IIb<i>β</i>3-binding peptides supported the adhesion and expansion of iPSCs and AFE generation by guided differentiation via a definitive endoderm (DE) in a full-anchorage-dependent manner. AFE generation was also found on coatings based on integrin<i>α</i>3<i>β</i>1-,<i>α</i>6<i>β</i>1-,<i>α</i>V<i>β</i>1-,<i>α</i>V<i>β</i>6-, and<i>α</i>M<i>β</i>2-binding peptides following a process with temporal suspension growth in the DE-inducing stage, with lower AFE generation efficiency compared to the full-anchorage-dependent peptide groups and Matrigel. According to the results, the integrin<i>α</i>5<i>β</i>1-binding peptide is the most promising defined substrate for inducing AFEs because of its equivalent efficiency with traditional Matrigel coating in supporting iPSC expansion and differentiation toward AFEs. Additionally, the other seven peptide-based coatings also exhibit potential and could be further investigated for developing synthetic-coating strategies in future studies involving AFEs. Our findings provide valuable insights into the role of integrin and ECM function and hold great potential for disease modeling as well as therapeutic exploration of AFE origin organs.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential of novel antibacterial bio-adhesive for the treatment of periodontitis. 新型抗菌生物胶粘剂治疗牙周炎的潜力。
Biomedical materials (Bristol, England) Pub Date : 2025-04-07 DOI: 10.1088/1748-605X/adc6df
Yin Xu, Yixian Zhou, Shengjin Meng, Chengchao Zhou, Nannan Yang, Luhan Bao, Weizhong Lu
{"title":"Potential of novel antibacterial bio-adhesive for the treatment of periodontitis.","authors":"Yin Xu, Yixian Zhou, Shengjin Meng, Chengchao Zhou, Nannan Yang, Luhan Bao, Weizhong Lu","doi":"10.1088/1748-605X/adc6df","DOIUrl":"10.1088/1748-605X/adc6df","url":null,"abstract":"<p><p>Periodontitis seriously affects people's daily health, and the development of a non-antibiotic bio-adhesive with antimicrobial and periodontitis regeneration for periodontal pockets will effectively promote the treatment of periodontitis. In this study, we constructed a hybrid hydrogel (GelMA-BC-PL) by introducing aldehyde bacterial cellulose (BC) short nanofibers into the photosensitive hydrogel gelatin methacryloyl (GelMA), which binds to periodontal tissues to play an adhesive role through the Schiff base reaction, and further introducing ϵ-polylysine (PL), which could achieve the adhesive, antibacterial, and regenerative effect. Pigskin adhesion experiments showed that the adhesion of GelMA hydrogel to pigskin was only 0.39 N, while that of GelMA-BC-PL reached 1.42 N. The adhesion performance of the hydrogel was significantly improved by adding aldehyde BC nanofibers. Due to the introduction of PL, the antimicrobial properties of the hybrid hydrogel against two typical periodontitis bacteria (porphyromanas gingivalis and fusobacterium nucleatum), were significantly improved. Experiments with human periodontal membrane fibroblasts showed that the hybrid hydrogel had excellent cell spreading and proliferation promotion properties. The hybrid hydrogel simultaneously achieves adhesion, antimicrobial properties and promotes periodontal regeneration, which has great potential for application in the treatment of periodontitis diseases.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Degradation, swelling, and drug release behavior of injectable ETTMP/PEGDA hydrogels. 注射用ETTMP/PEGDA水凝胶的降解、肿胀和药物释放行为。
Biomedical materials (Bristol, England) Pub Date : 2025-04-07 DOI: 10.1088/1748-605X/adc21e
Paige N Rockwell, Erin L Jablonski, Brandon M Vogel
{"title":"Degradation, swelling, and drug release behavior of injectable ETTMP/PEGDA hydrogels.","authors":"Paige N Rockwell, Erin L Jablonski, Brandon M Vogel","doi":"10.1088/1748-605X/adc21e","DOIUrl":"10.1088/1748-605X/adc21e","url":null,"abstract":"<p><p>The erosion and drug release behavior of an injectable hydrogel composed of ethoxylated trimethylolpropane tri-3-mercaptopropionate (ETTMP) and poly(ethylene glycol) diacrylate were determined under physiological conditions. Water and polymer mass changes were monitored over time to characterize the swelling/deswelling and erosion of the hydrogel tablets. Experimental data were collected for hydrogels with varying polymer fractions. These data were used to develop an empirical model to predict the eroding mass change and equilibrium water content across different compositions. Three easily detectable model drugs (methylene blue (MB), sulforhodamine 101, and chloroquine) were loaded into 25, 35, and 50 wt% polymer hydrogels to understand their drug release behavior. The gelation time and time for total drug release were dependent on the weight fraction of the polymer in the hydrogel and varied with the pH of the drug solutions, with more acidic drugs increasing gelation time. Complete drug release was not observed for MB because of the reaction with ETTMP thiol groups, demonstrating the importance of understanding the potential interactions between the drug and polymer. Drug-loaded hydrogels were also monitored for erosion and were found to swell more than their neat counterparts for all drugs tested, suggesting an effect of drug loading on the extent of hydrogel crosslinking.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of PLGA microspheres loaded with natural drug tannins in tumor treatment. 载入天然药物单宁酸的聚乳酸乙二醛(PLGA)微球在肿瘤治疗中的应用。
Biomedical materials (Bristol, England) Pub Date : 2025-04-04 DOI: 10.1088/1748-605X/adc6d7
Yiqiao Zhao, Yixuan Huang, Chaofan Chen, Chaoyu Cai, Xin Liu, Xiaohong Jiang, Aliaksandr Rahachou
{"title":"Application of PLGA microspheres loaded with natural drug tannins in tumor treatment.","authors":"Yiqiao Zhao, Yixuan Huang, Chaofan Chen, Chaoyu Cai, Xin Liu, Xiaohong Jiang, Aliaksandr Rahachou","doi":"10.1088/1748-605X/adc6d7","DOIUrl":"10.1088/1748-605X/adc6d7","url":null,"abstract":"<p><p>Although conventional chemotherapeutic drugs exhibit broad-spectrum antitumor efficacy, their toxic effects on normal cells cannot be ignored, and there is an urgent need to develop novel drugs to improve therapeutic efficacy and reduce side effects. In this study, we prepared PLGA/TA microspheres with TA as the target drug and PLGA as the carrier, and evaluated their physicochemical properties, including particle size, morphology, and release behavior, with the aim of exploring the potential of PLGA/TA microspheres for tumor therapy. The results of RNA sequencing showed that PLGA/TA microspheres may act on tumor cells mainly through the pathway of PI3K-Akt, and do not interfere with the synthesis of DNA directly. Overall, PLGA/TA microspheres, as a novel drug delivery system, showed good anti-tumor potential and provided new ideas and directions for cancer therapy.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of magnesium-based components for intraocular drug delivery byin vitrobiocompatibility and drug-device interaction. 通过体外生物相容性和药物装置相互作用评估眼内给药镁基组分。
Biomedical materials (Bristol, England) Pub Date : 2025-04-03 DOI: 10.1088/1748-605X/adc21f
Marco Ferroni, Francesco De Gaetano, Manuela Zonfrillo, Nina Bono, Matteo Giuseppe Cereda, Pasquale Pierimarchi, Gianluca Sferrazza, Gabriele Candiani, Federica Boschetti
{"title":"Assessment of magnesium-based components for intraocular drug delivery by<i>in vitro</i>biocompatibility and drug-device interaction.","authors":"Marco Ferroni, Francesco De Gaetano, Manuela Zonfrillo, Nina Bono, Matteo Giuseppe Cereda, Pasquale Pierimarchi, Gianluca Sferrazza, Gabriele Candiani, Federica Boschetti","doi":"10.1088/1748-605X/adc21f","DOIUrl":"10.1088/1748-605X/adc21f","url":null,"abstract":"<p><p>The development of magnesium-based intraocular drug delivery devices holds significant promise for biomedical applications, particularly in treating wet age-related macular degeneration (AMD) using vascular endothelial growth factor inhibitors such as bevacizumab. Magnesium's rapid degradation, which can be finely tuned to achieve the controlled release required for AMD treatment, along with its well-established biocompatibility and biodegradable properties, positioning it as an ideal material for these applications. The study aimed to evaluate magnesium's potential as a carrier for ocular drug delivery systems by demontrating the stability of monoclonal antibodies, specifically bevacizumab, in the presence of magnesium corrosion products and the biocompatibility of these products with various cell lines, including murine fibroblasts (3T3), rat retinal Müller cells, and human retinal pigment epithelial cells (ARPE19). The stability of bevacizumab with pure magnesium (Mg) was investigated through an indirect enzyme-linked immunosorbent assay protocol, developed and customized for this specific aim. The biocompatibility of Mg corrosion products was assessed by toxicological evaluations through MTT and Trypan Blue Viability assays, along with cell cycle analysis. Results demonstrated no significant impact of Mg corrosion products on bevacizumab stability, with changes in mean values consistently below or equal to 10%. Furthermore, Mg extracts showed minimal cytotoxicity, as metabolic activity exceeded 80% across all cell lines, classified as Grade 0/1 cytotoxicity under ISO 10993-5 standards. Cell viability, proliferation, and morphology remained unaffected for up to 72 h of exposure. This study provides the first<i>in vitro</i>evaluation of bevacizumab's stability in the presence of magnesium corrosion products and its biocompatibility with retinal cell lines, laying the foundation for future ophthalmic research and underscoring magnesium's potential as a material for intraocular drug delivery systems.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Curcumin delivery system based on a chitosan-liposome encapsulated zeolitic imidazolate framework-8: a potential treatment antioxidant and antibacterial treatment after phacoemulsification. 基于壳聚糖-脂质体包裹沸石咪唑酸框架-8的姜黄素输送系统:一种潜在的乳化术后抗氧化和抗菌治疗方法。
Biomedical materials (Bristol, England) Pub Date : 2025-04-03 DOI: 10.1088/1748-605X/adc05c
Meiting Lin, Kunyuan Tang, Wendi Zheng, Shijie Zheng, Ke Hu
{"title":"Curcumin delivery system based on a chitosan-liposome encapsulated zeolitic imidazolate framework-8: a potential treatment antioxidant and antibacterial treatment after phacoemulsification.","authors":"Meiting Lin, Kunyuan Tang, Wendi Zheng, Shijie Zheng, Ke Hu","doi":"10.1088/1748-605X/adc05c","DOIUrl":"10.1088/1748-605X/adc05c","url":null,"abstract":"<p><p>Curcumin is a natural polyphenol extracted from plants that can interact with various molecular targets, including antioxidant, antibacterial, anticancer, and anti-aging activities. Due to its variety of pharmacological activities and large margin pf safety, curcumin has been used in the prevention and treatment of various diseases, such as Alzheimer's, heart, and rheumatic immune diseases. To develop curcumin eye drops that can be used as antioxidant and antibacterial agents after phacoemulsification, we have designed a nano-based drug delivery system to improve curcumin bioavailability and duration of action. We successfully prepared zeolitic imidazolate framework-8 (ZIF-8) coated with chitosan-liposome (Cur@ZIF-8/CS-Lip) for curcumin delivery. It can release curcumin for over 20 h<i>in vitro</i>and exhibits excellent biosafety, antioxidant, and antibacterial activities. Therefore, we hypothesized that Cur@ZIF-8/CS-Lip could reduce the incidence of oxidative stress and infection after cataract surgery.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143627000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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