Biomedical materials (Bristol, England)最新文献_第10页

Personalized assessment and monitoring of bone health from sweat: unveiling TEGO doped wearable, non-invasive hydrogel nanocomposite biosensor empowered by IL-6 detection. 汗液中骨骼健康的个性化评估和监测：揭示了由IL-6检测授权的TEGO掺杂可穿戴、非侵入性水凝胶纳米复合生物传感器。

Biomedical materials (Bristol, England) Pub Date : 2025-03-31 DOI: 10.1088/1748-605X/adc05a

Seema Rani, Sanchita Bandyopadhyay-Ghosh, Subrata Bandhu Ghosh

{"title":"Personalized assessment and monitoring of bone health from sweat: unveiling TEGO doped wearable, non-invasive hydrogel nanocomposite biosensor empowered by IL-6 detection.","authors":"Seema Rani, Sanchita Bandyopadhyay-Ghosh, Subrata Bandhu Ghosh","doi":"10.1088/1748-605X/adc05a","DOIUrl":"10.1088/1748-605X/adc05a","url":null,"abstract":"Portable biosensing is crucial for rapid detection and continuous monitoring of bone diseases such as osteoporosis and bone cancer. It is well established that such bone disorders or diseases trigger release of inflammatory cytokines including interleukin-6 (IL6), detectable in sweat by electrochemical immunosensors. To this end, this study presents a novel hydrogel nanocomposite based immunosensor with highly conductive dual-layer of thermally exfoliated graphene oxide, toward precise detection and determination of loading level of IL-6 biomarker, and in turn, developing a label-free flexible bone biosensing platform. The immunosensor employed antibody immobilization process, which was further facilitated by the modification of the dual-layer by using 1-pyrenebutyric acid N-hydroxy succinimide ester. A thorough analysis of the effects of surface modification was conducted utilizing spectroscopic, electrochemical, and morphological methods. The biosensor's response was assessed through the utilization of the cyclic voltammetry measurement, which exhibited remarkable selectivity, achieving a low limit of detection of 15.4 pg ml-1across a wide linear range. Additionally, field emission scanning electron microscopy, Fourier transform infrared spectroscopy and Raman spectroscopy were successfully used to validate the sensing substrate in bio-fluidic samples and to understand the structure-property correlation. This innovative portable and flexible biosensor thus offers a practical and effective tool for potential application in continuous monitoring of bone health.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143627007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Osteogenic function of BMP2-modified PEEK scaffolds for orbital fracture repair. bmp2修饰PEEK支架眶骨折修复的成骨功能。

Biomedical materials (Bristol, England) Pub Date : 2025-03-27 DOI: 10.1088/1748-605X/adc220

Yujie Wu, Cuihong Liu, Jinhua Liu, Wenwen Wang, Bixuan Qin, Honglei Liu

{"title":"Osteogenic function of BMP2-modified PEEK scaffolds for orbital fracture repair.","authors":"Yujie Wu, Cuihong Liu, Jinhua Liu, Wenwen Wang, Bixuan Qin, Honglei Liu","doi":"10.1088/1748-605X/adc220","DOIUrl":"10.1088/1748-605X/adc220","url":null,"abstract":"This study aimed to investigate the osteogenic function of polyetheretherketone (PEEK) scaffolds modified with bone morphogenetic protein 2 (BMP2) and its possibility for orbital fracture repair. The 3D-printed PEEK sheets were combined with BMP2-loaded hyaluronic acid hydrogel (HAH) to fabricate PEEK-BMP2-HAH composite scaffolds. Bone marrow mesenchymal stem cells (BMSCs) were seeded onto PEEK or PEEK-BMP2-HAH scaffolds. Cell adhesion and cell proliferation were measured by transmission electron microscopy and CCK-8 assay. Alkaline phosphatase (ALP) chromogenic, alizarine red S staining, and PCR analysis of Runt-related transcription factor 2 (Runx2), collagen-I (Col-I), Osterix, and osteopontin (OPN) were performed to assess osteogenic activity. The rat orbital fracture defect model is proposed for evaluating the biocompatibility, osteogenic integration, and functional recovery of PEEK orbital implants. Compared with PEEK, cell adhesion and cell proliferation were increased in PEEK-BMP2-HAH scaffolds. ALP activity and mineralized nodule formation were increased in PEEK-BMP2-HAH scaffolds than that in PEEK the mRNA expression of Runx2, Osterix, Col-I and OPN was increased on PEEK-BMP2-HAH scaffolds than that on PEEK at 14 d of osteogenic induction. Besides, a bone defect animal model revealed that BMP2-HAH-modified PEEK scaffolds could effectively facilitate the repair of the orbital bone defect, with increased expression of OPN and Runx2. BMP2-loaded HAH effectively increased adhesion, proliferation, and osteogenic differentiation of BMSCs on PEEK. PEEK-BMP2-HAH scaffolds are expected to become new materials for orbital fracture repair.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biocompatible nanozyme with dual catalytic activities for high-performance multimodality therapy against glioblastoma. 具有双重催化活性的生物相容性纳米酶，用于针对胶质母细胞瘤的高效多模式疗法。

Biomedical materials (Bristol, England) Pub Date : 2025-03-26 DOI: 10.1088/1748-605X/adc05b

Guihong Lu, Xiaoyan Li, Wenfei Xu, Fan Zhang, Xiang Chen, Huibin Wu, Haibing Dai, Feng Li, Weidong Nie

{"title":"Biocompatible nanozyme with dual catalytic activities for high-performance multimodality therapy against glioblastoma.","authors":"Guihong Lu, Xiaoyan Li, Wenfei Xu, Fan Zhang, Xiang Chen, Huibin Wu, Haibing Dai, Feng Li, Weidong Nie","doi":"10.1088/1748-605X/adc05b","DOIUrl":"10.1088/1748-605X/adc05b","url":null,"abstract":"Nanozymes based on metals have been regarded as a promising candidate in the metabolic reprogramming of low-survival, refractory glioblastoma multiforme (GBM). However, due to size limitations, nanozymes struggle to balance catalytic activity with the ability to cross the blood-brain barrier (BBB), limiting their efficiency in GBM therapy. Herein, we establish a hybrid nanocluster, AuMn NCs, by cross-linking ultrasmall nano-gold (Au) and manganese oxide (MnO2), which overcomes the size requirement conflict for integrating catalytic activities, long-period circulation, photothermal effect, glucose consumption, and chemodynamic effect for multimodality treatment against GBM. After administered intravenously, the overall large-size AuMn NCs can escape kidney filtration and cross the BBB for GBM accumulation. Then the individual ultrasmall nano-MnO2components effectively catalyze H2O2degradation as catalase to produce oxygen, which is utilized by individual ultrasmall nano-Au components to consume glucose as glucose oxidase for starvation therapy. The H2O2generated during Au-catalyzed glucose consumption further facilitates MnO2catalytic activity. Such positive feedback overwhelmingly intervenes in the glucose metabolism of GBM. Concurrently, clustered Au-induced photothermal effect and released Mn2+-induced chemodynamic effect further contribute to eliminating GBM cells. The versatile clustered nanozyme offers a feasible strategy for the multimodality intervention of GBM.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing visible light-induced 3D bioprinting: alternating extruded support materials for bioink gelation. 增强可见光诱导的三维生物打印：交替挤压支撑材料促进生物墨水凝胶化。

Biomedical materials (Bristol, England) Pub Date : 2025-03-26 DOI: 10.1088/1748-605X/adc0d6

Takashi Kotani, Takehito Hananouchi, Shinji Sakai

{"title":"Enhancing visible light-induced 3D bioprinting: alternating extruded support materials for bioink gelation.","authors":"Takashi Kotani, Takehito Hananouchi, Shinji Sakai","doi":"10.1088/1748-605X/adc0d6","DOIUrl":"10.1088/1748-605X/adc0d6","url":null,"abstract":"In 3D bioprinting, two promising approaches have gained significant attention: the use of support materials during printing and the utilization of bioinks gelled through ruthenium(II) tris-bipyridyl dication ([Ru(bpy)3]2+)-catalyzed photocrosslinking consuming sodium persulfate (SPS). Integrating these approaches while ensuring simplicity and printability remains a challenge. To address this challenge, we propose a technique in which the support material containing SPS is alternately extruded with the bioink containing polymer having phenolic hydroxyl moieties (polymer-Ph) and [Ru(bpy)3]2+under visible light irradiation. This method eliminates the problems of light shading and deformation caused by the support material, as the contact between the alternately extruded ink and the support material initiates the gelation of the ink via photocrosslinking. Using an ink containing 0.5 w/v% hyaluronic acid with phenolic hydroxyl moieties (HA-Ph) and 2.0 mM [Ru(bpy)3]2+alongside a support material containing 10 mM SPS, various constructs were successfully printed under 450 nm visible light. The human hepatoblastoma cells embedded in the printed construct showed approximately 95% viability after printing and proliferation over 14 d of culture. These results highlight the potential of this method to advance 3D bioprinting for tissue engineering applications.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143631096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Compression and bending performance of selective laser melted Ti6Al4V porous structures with cylindrical thin walls for dental implants. 用于牙科植入物的选择性激光熔化 Ti6Al4V 圆柱薄壁多孔结构的压缩和弯曲性能。

Biomedical materials (Bristol, England) Pub Date : 2025-03-26 DOI: 10.1088/1748-605X/adc0d5

Zefang Guo, Tianmin Guan, Mingli Liu, David Hui, Yun Zhai

{"title":"Compression and bending performance of selective laser melted Ti6Al4V porous structures with cylindrical thin walls for dental implants.","authors":"Zefang Guo, Tianmin Guan, Mingli Liu, David Hui, Yun Zhai","doi":"10.1088/1748-605X/adc0d5","DOIUrl":"10.1088/1748-605X/adc0d5","url":null,"abstract":"Titanium alloy dental implants play a crucial role in the field of oral rehabilitation. However, the use of solid designs can give rise to mechanical problems such as mismatched compressive elastic modulus with the host bone tissue, resulting in stress shielding and stress concentration. These problems have been a persistent bottleneck in their application effectiveness. To overcome this challenge, this study creatively designed five types of porous structures with cylindrical thin wall based on the Gibson-Ashby theoretical model. The aim is to optimize the mechanical performance of dental implants, enhance their compatibility with the host bone tissue, and utilize selective laser melting technology for precise fabrication of porous structures using Ti6Al4V material. Through a combination of simulation analysis and compression experiments, the stress and strain distributions of the five structures are systematically investigated under different bite conditions. The experimental results demonstrate that all five porous structures designed in this study effectively alleviate stress shielding phenomenon in dental implants, significantly improving the bonding performance between the implants and bone tissue. This meets the clinical implantation requirements and provides strong theoretical support for the application of dental implants in clinical settings.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143631095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances and perspectives in bioresorbable metal coronary drug-eluting stents. 生物可吸收金属冠状动脉药物洗脱支架的研究进展与展望。

Biomedical materials (Bristol, England) Pub Date : 2025-03-26 DOI: 10.1088/1748-605X/adc058

Chengyan Bai, Xiangyi Feng, Liang Lan, Chao Zhou, Haijun Zhang

引用次数: 0

Polyethylene glycol hexadecyl ether modified heparin for paclitaxel nano-delivery system. 聚乙二醇十六烷基醚修饰肝素用于紫杉醇纳米递送系统。

Biomedical materials (Bristol, England) Pub Date : 2025-03-25 DOI: 10.1088/1748-605X/adbaa1

Van Toan Nguyen, Thi Le Hang Dang, Minh-Thanh Vu, Thi Phuong Le, Thi Loan Nguyen, Thi Huong Nguyen, Ngoc Quyen Tran

{"title":"Polyethylene glycol hexadecyl ether modified heparin for paclitaxel nano-delivery system.","authors":"Van Toan Nguyen, Thi Le Hang Dang, Minh-Thanh Vu, Thi Phuong Le, Thi Loan Nguyen, Thi Huong Nguyen, Ngoc Quyen Tran","doi":"10.1088/1748-605X/adbaa1","DOIUrl":"10.1088/1748-605X/adbaa1","url":null,"abstract":"A paclitaxel (PTX) nano-delivery system using modified heparin and polyethylene glycol hexadecyl ether (Brij 58) was developed in this study. Brij 58 was conjugated to the heparin backbone via the cystamine bridge, denoted as Hep-Brij 58, to facilitate self-assembly into stable nanoparticles in an aqueous environment. The self-assembled formation of Hep-Brij nanoparticles was demonstrated through dynamic light scattering and TEM, while the iodine method identified the critical concentration for the self-assembled process. PTX was incorporated into Hep-Brij nanoparticles through physical entrapment. The PTX-loaded Hep-Brij nanoparticles were then characterized according to particle size and size distribution, drug-loading content, and efficiency. Compared to Brij 58, Hep-Brij 58 was more effective in terms of the amount of PTX loaded. Hep-Brij 58/PTX was stable over two weeks of storage in distilled water.In vitrorelease of PTX from Hep-Brij 58 exhibited a controlled drug release effect following the diffusion kinetics. Furthermore, Hep-Brij 58 was non-toxic to primary healthy cells and cancer cells. Thein vitroanticancer test with Hela cells indicated remarkable anticancer activity of PTX-loaded Hep-Brij 58 nanoparticles compared to free PTX. In summary, Hep-Brij 58 nanoparticles hold considerable potential for use as a delivery system for managing PTX therapy.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highly elastic bioactive bR-GelMA micro-particles: synthesis and precise micro-fabrication via stop-flow lithography. 高弹性生物活性 bR-GelMA 微颗粒：通过停流光刻技术合成和精确微制造。

Biomedical materials (Bristol, England) Pub Date : 2025-03-21 DOI: 10.1088/1748-605X/adc059

Basel A Khader, Christian Volpe, Stephen D Waldman, Dae Kun Hwang

引用次数: 0

Biodegradable Mg-1%Ca alloy inhibits the growth of cervical cancer. 可生物降解Mg-1%Ca合金抑制宫颈癌的生长。

Biomedical materials (Bristol, England) Pub Date : 2025-03-20 DOI: 10.1088/1748-605X/adb2cc

Yunshan Ouyang, Lingling Cao, Qian Zhao, Wang Yang, Chen Lin

{"title":"Biodegradable Mg-1%Ca alloy inhibits the growth of cervical cancer.","authors":"Yunshan Ouyang, Lingling Cao, Qian Zhao, Wang Yang, Chen Lin","doi":"10.1088/1748-605X/adb2cc","DOIUrl":"10.1088/1748-605X/adb2cc","url":null,"abstract":"The traditional treatment for cervical cancer involves aggressive surgery combined with radiotherapy and chemotherapy. Nevertheless, these treatments have certain limitations and side effects, thus breakthroughs and advances are required in cervical cancer therapy. Magnesium alloy is a promising antitumor biomaterial with excellent biocompatibility and biodegradability. However, the potential effects of magnesium alloy on cervical tumors have not been extensively explored. Recent studies have demonstrated that adding a small amount of calcium to the magnesium matrix can reduce grain size and corrosion rate while providing good biocompatibility. We conductedin vivoandin vitroexperiments to test the antitumor properties of Mg-1%Ca alloys. The results indicated that the Mg-1%Ca alloy released Mg2+and OH-more slowly, inhibited the proliferation of SiHa and HeLa cells, induced apoptosis in tumor cells, disrupted the cytoskeleton, and inhibited cell migration and invasion. At the molecular level, Mg-1%Ca alloy significantly activated the mitochondrial apoptosis pathway and inhibited the MAPK/ERK signaling pathway. In the future, Mg-1%Ca may be employed in the treatment of cervical cancer as a novel adjuvant therapeutic material with anticancer function to prevent the occurrence and progression of cancer proliferation and metastasis.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chitosan hydrochloride coated and nonionic surfactant modified niosomes: a better way for oral administration of semaglutide. 盐酸壳聚糖包衣和非离子表面活性剂修饰乳小体：一种较好的口服给药方式。

Biomedical materials (Bristol, England) Pub Date : 2025-03-18 DOI: 10.1088/1748-605X/adb2cf

Ben Wang, Zhengxing Su, Meiyan Kuang, Yi Luo, Minhao Xu, Meng Sun, Xingyou Liu, Yue Guo, Lu Bai, Yu Wang, Xinlei Yan, Jing Xie, Yaqin Tang

{"title":"Chitosan hydrochloride coated and nonionic surfactant modified niosomes: a better way for oral administration of semaglutide.","authors":"Ben Wang, Zhengxing Su, Meiyan Kuang, Yi Luo, Minhao Xu, Meng Sun, Xingyou Liu, Yue Guo, Lu Bai, Yu Wang, Xinlei Yan, Jing Xie, Yaqin Tang","doi":"10.1088/1748-605X/adb2cf","DOIUrl":"10.1088/1748-605X/adb2cf","url":null,"abstract":"Diabetes is now a global chronic disease, with the number of people with diabetes expected to reach 643 million by the end of 2030. Semaglutide, a human glucagon-like peptide-1 (GLP-1) analogue with 94% similarity to human GLP-1, can promote insulin secretion and repress glucagon secretion in a glucose concentration-dependent manner, resulting in substantial improvement of blood glucose levels and reducing the risk of hypoglycemia in patients with type 2 diabetes. To improve the absorption efficiency of semaglutide in oral delivery, we developed chitosan hydrochloride-coated and nonionic surfactant-modified niosomes (CS.HCL-NSPEs-NIO) as a new way to encapsulate it. The results showed that CS.HCL-NSPEs-NIO could efficiently penetrate the cell junctions in the intestinal endothelium and therefore promote drug absorbance. In addition, gastrointestinal distribution studies revealed that CS. HCL-NSPEs-NIO could stay in the intestine for more than 4 h, thus allowing for long-term glucose regulation. Effective reduction of blood glucose levels and weight loss were observed in db/db mice while no toxicity was detected in major organs. On the whole, our recommendation is that CS.HCL-NSPEs-NIO shows promise as an oral delivery tool for enhancing the hypoglycemic effects of semaglutide.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0