Biomedical materials (Bristol, England)最新文献_第10页

Prospects of black phosphorus nanosheets in the treatment of peri-implantitis. 黑磷纳米片在种植体周围炎治疗中的应用前景。

Biomedical materials (Bristol, England) Pub Date : 2025-02-26 DOI: 10.1088/1748-605X/adb66e

Ailin Wu, Jun Su, Yongzhi Zhang, Dongjiao Zhang, Yanhua Chen

引用次数: 0

A coaxial electrospun PLLA/PPDO/NAR mesh for abdominal wall hernia repair. 同轴电纺丝PLLA/PPDO/NAR补片用于腹壁疝修补。

Biomedical materials (Bristol, England) Pub Date : 2025-02-24 DOI: 10.1088/1748-605X/adb554

Yifan Xv, Li Xu, Dandan Wei, Yinghua Tao, Tianzhu Zhang, Zhenling Ji

{"title":"A coaxial electrospun PLLA/PPDO/NAR mesh for abdominal wall hernia repair.","authors":"Yifan Xv, Li Xu, Dandan Wei, Yinghua Tao, Tianzhu Zhang, Zhenling Ji","doi":"10.1088/1748-605X/adb554","DOIUrl":"10.1088/1748-605X/adb554","url":null,"abstract":"This study aims to employ poly-L-lactic acid (PLLA) and poly(p-dioxanone) (PPDO), loaded with naringin (NAR) to fabricate a functionalized degradable mesh which can promote abdominal wall hernia (AWH) repair. Three meshes named PPDO, PLLA/PPDO, and PLLA/PPDO/NAR were fabricated by electrospinning. The physical and chemical properties of the meshes were evaluated from the aspects of morphology, wettability, chemical composition, mechanical properties, andin vitrodegradation. Then, the meshes were implanted into rats to evaluate their repair effects on abdominal wall defect models. The mechanical properties of PLLA/PPDO/NAR mesh were superior to the other two meshes, with a fixed tensile strength of 36.47 ± 2.40 N cm-1and an elongation at break of 287.98% ± 51.67%, which adequately met the mechanical strength required for the human abdominal wall. The core-shell structure effectively delayed the degradation of PLLA/PPDO as well as PLLA/PPDO/NAR mesh, and drug release of PLLA/PPDO/NAR mesh. On the 7th, 14th, and 28th day after implantation, more neovascularization and tissue formation were observed in the PLLA/PPDO/NAR group and the newborn collagen was arranged in a regular and neat manner compared to the other two groups. The immunohistochemical results showed that the PLLA/PPDO/NAR mesh promoted abdominal wall repair by inhibiting the expression of matrix metalloproteinase2 as well as interleukin-6, and increasing the expression of vascular endothelial growth factor. The PLLA/PPDO/NAR mesh is promising for application in AWH repair.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A tannic acid coated silk fibroin sponge loaded with bioglass for noncompressible hemostasis. 单宁酸涂层丝素海绵载生物玻璃用于不可压缩止血。

Biomedical materials (Bristol, England) Pub Date : 2025-02-24 DOI: 10.1088/1748-605X/adb553

Shanshan Chu, Xu Fang, Junfeng Xu, Wenwen Yuan

引用次数: 0

Analgesic effect of microneedle with 3-acetylaconitine for neuropathic pain. 含有 3-乙酰乌头碱的微针对神经病理性疼痛的镇痛效果。

Biomedical materials (Bristol, England) Pub Date : 2025-02-24 DOI: 10.1088/1748-605X/adb671

Juan Huang, Yanhui Li, Mengru Zhu, Jigang Luo, Zhuoyue Song, Shijie Li, Tao Liu, Chunzhi Tang, Nenggui Xu, Shihui Liu

{"title":"Analgesic effect of microneedle with 3-acetylaconitine for neuropathic pain.","authors":"Juan Huang, Yanhui Li, Mengru Zhu, Jigang Luo, Zhuoyue Song, Shijie Li, Tao Liu, Chunzhi Tang, Nenggui Xu, Shihui Liu","doi":"10.1088/1748-605X/adb671","DOIUrl":"10.1088/1748-605X/adb671","url":null,"abstract":"Neuropathic pain is a worldwide problem that causes physical and psychological pain to many patients. 3-acetylaconitine (AAC) is a kind of non-narcotic analgesic with long-lasting action, non-tolerant and non-addiction. However, it has some cardiac toxicity and can easily cause toxic organ damage. To solve these problems, dissolvable microneedle (MN) patches were prepared and delivered subcutaneously through the skin barrier. The results showed that the solid dispersion made with AAC and polyvinyl pyrrolidone (PVP) effectively changed the solubility of AAC and improved its bioavailability. The MN shape was conical and the bending forces of AAC/PVP-MN were all approximately 1.2 N/needle, which was enough to penetrate the stratum corneum of the skin. Through the use of the neuropathic pain model (spared nerve injury) test, it was found that the soluble MN mediated AAC hypodermic delivery provided effective analgesic activity. Compared with the model group, AAC/PVP-MN could increase mechanical pain threshold and hind legs load-bearing capacity, reduce the inflammation in the body, and have certain protective effect to spinal cord neurons. This study provided an idea for the clinical treatment of neuropathic pain and also a new approach for the safe use of toxic drugs with a narrow range.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thiolated gellan gum/polyethylene glycol diacrylate hydrogels containing timolol maleate-loaded chitosan nanoparticles for ophthalmic delivery. 含马来酸噻莫洛尔壳聚糖纳米颗粒的硫代结冷胶/聚乙二醇二丙烯酸酯水凝胶。

Biomedical materials (Bristol, England) Pub Date : 2025-02-21 DOI: 10.1088/1748-605X/adb555

Golnaz Shajari, Hamid Erfan-Niya, Marziyeh Fathi, Nazanin Amiryaghoubi

{"title":"Thiolated gellan gum/polyethylene glycol diacrylate hydrogels containing timolol maleate-loaded chitosan nanoparticles for ophthalmic delivery.","authors":"Golnaz Shajari, Hamid Erfan-Niya, Marziyeh Fathi, Nazanin Amiryaghoubi","doi":"10.1088/1748-605X/adb555","DOIUrl":"10.1088/1748-605X/adb555","url":null,"abstract":"The combination of hydrogels with nanoformulations can significantly enhance the delivery and effectiveness of drugs in ophthalmic drug delivery systems. In the current study, the polyethylene glycol diacrylate (PEGDA)/thiolated gellan gum (GGSH) hydrogels based on GGSH and PEGDA were prepared via thiol-ene reaction using Irgacure 2959 as a photoinitiator. To this end, the modification of GG was achieved by esterification of the hydroxyl groups of GG with the carboxyl group of mercaptopropionic acid with a free thiol amount of 95.5 μmol g-1. To provide sustained release, chitosan nanoparticles (CSNPs) containing timolol maleate (TM) with 56.4% entrapment efficiency were synthesized by the desolvation method and encapsulated in the developed hydrogel. The values of zeta potential and particle size of CSNPs were +26.0 mV and 182.4 nm, respectively. The physico/chemical properties of the hydrogels were investigated via texture analyzer, FT-IR, XRD, and SEM. Thein vitrodegradation, swelling behavior, rheological assessments, cell viability testing, and porosity determination were evaluated. With the increase in PEGDA concentration, the mechanical properties were increased. While the rate of swelling, degradation, and drug release were decreased. Thein vitrobiocompatibility of hydrogels was confirmed using the MTT test. According to anex vivostudy, ocular drug delivery using the obtained transparent hydrogels is promising due to improved drug permeation and sustained release of TM via CSNPs.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on the development of nanoparticles based on levan for oral insulin delivery. 用于口服胰岛素给药的levan纳米颗粒的研制。

Biomedical materials (Bristol, England) Pub Date : 2025-02-20 DOI: 10.1088/1748-605X/adb22d

Desy Kurniawati, Neng Fisheri Kurniati, Enny Ratnaningsih, Rukman Hertadi

{"title":"Study on the development of nanoparticles based on levan for oral insulin delivery.","authors":"Desy Kurniawati, Neng Fisheri Kurniati, Enny Ratnaningsih, Rukman Hertadi","doi":"10.1088/1748-605X/adb22d","DOIUrl":"10.1088/1748-605X/adb22d","url":null,"abstract":"Oral insulin administration has gained attention as a promising alternative to injections. However, its effectiveness is hindered by the major challenge of degradation by gastric acid. Biopolymer-based nanocarriers have been explored as a solution to address this challenge. This study examines levan, a biopolymer derived fromBacillus licheniformisBK1, for its viability as a nanocarrier for insulin. Levan was modified through acetylation, and both levan (I-Lv) and its acetylated (I-ALv) form were utilized as carriers for insulin in a nanoparticles (NPs) delivery system. The resulting NPs were spherical, with diameters ranging from 250 to 500 nm and encapsulation efficiencies of 78.64% and 88.30%, respectively. The insulin release from I-Lv NPs in simulated gastric fluid exhibited a burst release pattern that was more rapid than that of I-ALv. To further evaluate, the conformational stability of insulin in NPs was analyzed by measuring the transition enthalpy of secondary and tertiary structures. The stability of the secondary structure was determined through alpha-helix content using circular dichroism, while the tertiary structure stability was evaluated via the fluorescence intensity of tryptophan residues. The result revealed that insulin in I-ALv NPs exhibited enhanced conformational stability compared to free-state (FS) insulin and I-Lv NP, with transition enthalpies of 0.91 ± 0.62 and 4.42 ± 0.46 kcal mol-1for secondary and tertiary structures, respectively. Moreover, preliminaryin vivostudies revealed that I-ALv had a significant impact compared to FS insulin and I-Lv, demonstrating reduction in blood glucose levels. These findings highlight the potential of I-ALv as a promising candidate for antidiabetic therapy and an efficient oral delivery system.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":"20 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ficus caricaleaves extract-loaded PLGA nanoparticles: preparation, characterization, andin vitroanticancer activity on TFK-1 cell line. 载PLGA纳米颗粒的无花果叶提取物：制备、表征及其对TFK-1细胞系的体外抗癌活性

Biomedical materials (Bristol, England) Pub Date : 2025-02-17 DOI: 10.1088/1748-605X/adaff7

Bushra Aziz, Esmeralda Dc Bosman, Kim Mg van der Wurff-Jacobs, Cornelus F van Nostrum, Ahmat Khurshid

{"title":"Ficus caricaleaves extract-loaded PLGA nanoparticles: preparation, characterization, andin vitroanticancer activity on TFK-1 cell line.","authors":"Bushra Aziz, Esmeralda Dc Bosman, Kim Mg van der Wurff-Jacobs, Cornelus F van Nostrum, Ahmat Khurshid","doi":"10.1088/1748-605X/adaff7","DOIUrl":"10.1088/1748-605X/adaff7","url":null,"abstract":"Ficus caricaextract (FCe) is a natural herb that has received a lot of interest in cancer treatment due to its potential anticancer activities against various malignancies. However, due to FCe's low bioavailability and low solubility, its clinical use as an anti-cancer medicine is constrained. The current study aimed to prepare FCe-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) for cancer treatment. Prepared NPs were characterized by UV-v is spectroscopy, dynamic light scattering, zeta potential, and transmission electron microscopy. The results showed that the spherical FCe-loaded PLGA NPs had a particle size of 162 ± 0.7 nm, a polydispersity index of 0.08 ± 0.005, and a zeta potential of -4.7 ± 0.6 mV. The encapsulation and loading efficiency were found to be 56 ± 2.3% and 14 ± 1.5%, respectively. A drug release study indicated a diffusion-based release profile. Cytotoxicity was evaluated on the extrahepatic bile duct carcinoma (TFK-1) cell line, which showed that both free FCe and corresponding FCe concentrations in NPs were cytotoxic. Cell cycle analysis showed that the FCe arrests the cells in G0/G1 phase, and the cell arrest rate is higher in FCe-loaded NPs compared to free form. A phototoxicity study also showed that the phototoxicity of FCe-loaded PLGA NPs was time-dependent and enhanced in comparison to free FCe. The study's results demonstrated that FCe-encapsulated PLGA NPs are promising for cancer therapy as a phyto- and phototherapeutic agent-based system.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D printed polycaprolactone/poly (L-lactide-co-ϵ-caprolactone) composite ureteral stent with biodegradable and antibacterial properties. 3D打印具有生物降解和抗菌性能的聚己内酯/聚（l -乳酸-co-ε-己内酯）复合输尿管支架。

Biomedical materials (Bristol, England) Pub Date : 2025-02-14 DOI: 10.1088/1748-605X/adb2ce

Yanjiao Teng, Xinyan Wang, Lin Song, Jianing Yang, Shike Hou, Qi Lv, Li Jiang, Yong Guan, Jie Shi

{"title":"3D printed polycaprolactone/poly (L-lactide-co-ϵ-caprolactone) composite ureteral stent with biodegradable and antibacterial properties.","authors":"Yanjiao Teng, Xinyan Wang, Lin Song, Jianing Yang, Shike Hou, Qi Lv, Li Jiang, Yong Guan, Jie Shi","doi":"10.1088/1748-605X/adb2ce","DOIUrl":"10.1088/1748-605X/adb2ce","url":null,"abstract":"The clinical application of biodegradable ureteral stents holds significant potential. There is an urgent need to develop new materials for ureteral stents to address the limitations related to performance degradation and antibacterial properties observed in current designs. Here, we developed a Polycaprolactone (PCL)/Poly (L-lactide-co-ϵ-caprolactone) (PLCL) composite ureteral stent by three-dimensional (3D) printing, which exhibits biodegradable and antibacterial properties. Silver nanoparticles (AgNPs) were bonded to the surface of the stent through the polymerization of dopamine (PDA) and coating with type I collagen (Col I). The ureteral stent (PP-PDA-Ag-Col) had a densely spiraled structure and higher hydrophilicity. The release behavior of silver ions from the stent was found to be slow and continuous when coated with AgNPs, which can enable long-term antibacterial effects after being implantedin vivo. Additionally,in vitrodegradation experiments demonstrated that the different ratios of ureteral stents degraded slowly in artificial urine over 6 weeks without compromising functionality. The stent exhibits excellent hemocompatibility and cell compatibility. The subcutaneous implantation experiment in Sprague-Dawley rats showed that the PP-PDA-Ag-Col stent degraded slowlyin vivoand had good biocompatibility. The stent PCL5/PLCL5 was the most promising ureteral stent regarding antibacterial, mechanical properties, and degradation. The novel 3D-printed PP-PDA-Ag-Col stent exhibits biocompatibility for safein vivotransplantation and antibacterial properties that reduce reliance on antibiotics. Additionally, its biodegradability eliminates the need for secondary surgical removal, making it a promising option for the clinical application of ureteral stents.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improvement of cellular pattern organization and clarity through centrifugal force. 通过离心力改善细胞图案的组织和清晰度。

Biomedical materials (Bristol, England) Pub Date : 2025-02-13 DOI: 10.1088/1748-605X/ada508

Lauren E Mehanna, James D Boyd, Shelley Remus-Williams, Nicole M Racca, Dawson P Spraggins, Martha E Grady, Brad J Berron

{"title":"Improvement of cellular pattern organization and clarity through centrifugal force.","authors":"Lauren E Mehanna, James D Boyd, Shelley Remus-Williams, Nicole M Racca, Dawson P Spraggins, Martha E Grady, Brad J Berron","doi":"10.1088/1748-605X/ada508","DOIUrl":"10.1088/1748-605X/ada508","url":null,"abstract":"Rapid and strategic cell placement is necessary for high throughput tissue fabrication. Current adhesive cell patterning systems rely on fluidic shear flow to remove cells outside of the patterned regions, but limitations in washing complexity and uniformity prevent adhesive patterns from being widely applied. Centrifugation is commonly used to study the adhesive strength of cells to various substrates; however, the approach has not been applied to selective cell adhesion systems to create highly organized cell patterns. This study shows centrifugation as a promising method to wash cellular patterns after selective binding of cells to the surface has taken place. After patterning H9C2 cells using biotin-streptavidin as a model adhesive patterning system and washing with centrifugation, there is a significant number of cells removed outside of the patterned areas of the substrate compared to the initial seeding, while there is not a significant number removed from the desired patterned areas. This method is effective in patterning multiple size and linear structures from line widths of 50-200 μm without compromising immediate cell viability below 80%. We also test this procedure on a variety of tube-forming cell lines (MPCs, HUVECs) on various tissue-like surface materials (collagen 1 and Matrigel) with no significant differences in their respective tube formation metrics when the cells were seeded directly on their unconjugated surface versus patterned and washed through centrifugation. This result demonstrates that our patterning and centrifugation system can be adapted to a variety of cell types and substrates to create patterns tailored to many biological applications.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11823422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and characterization of mesoporous core-shell bioactive glass-based cements for direct pulp capping. 直接盖髓用中孔核壳生物活性玻璃基胶合剂的制备与表征。

Biomedical materials (Bristol, England) Pub Date : 2025-02-13 DOI: 10.1088/1748-605X/adb119

Xiaoting Xu, Yehong He, Xiaochen Chen, Zhen Fan, Deping Wang

{"title":"Preparation and characterization of mesoporous core-shell bioactive glass-based cements for direct pulp capping.","authors":"Xiaoting Xu, Yehong He, Xiaochen Chen, Zhen Fan, Deping Wang","doi":"10.1088/1748-605X/adb119","DOIUrl":"10.1088/1748-605X/adb119","url":null,"abstract":"Direct pulp capping is crucial for maintaining dental pulp vitality. The materials employed for this purpose should possess properties such as easy-handling, excellent biocompatibility, infection resistance, and the ability to stimulate the formation of reparative dentin. Mineral trioxide aggregate (MTA) is commonly used for pulp capping. However, certain limitations, including its long setting time, insufficient anti-washout ability, high initial curing pH, and handling difficulties, restrict MTA from meeting a broader range of clinical demands. Bioactive glass (BG) is known for its osteo-inductive and bone restoration properties. This study aims to develop a novel BG-based cement (BG-x/SA) for pulp capping applications, using BG microspheres (BG-x) as the solid phase and sodium alginate solution (SA) as the liquid phase. The solid phase has core-shell microspheres made byin-situtransformation, with BG in the core and hydroxyapatite in the shell. The study focuses on how thein-situsynthesis reaction parameters affect the cement's properties. Ultimately, BG-6/SA cement was identified as the optimal formulation, and a comparison with MTA shows BG-6/SA cement has a short setting time, good anti-washout performance, can adjust pH to mildly alkaline, promotes dentin formation, and has antibacterial effects. Thus, BG-6/SA cement has significant research value and good prospects as a new pulp-capping material.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0