Biomedical materials (Bristol, England)最新文献_第9页

Fast shaping, biodegradation and microenvironment modulation in bioceramic calcium phosphate cement enhances osteointegration and bone regeneration. 生物陶瓷磷酸钙水泥的快速成型、生物降解和微环境调节促进骨整合和骨再生。

Biomedical materials (Bristol, England) Pub Date : 2025-05-07 DOI: 10.1088/1748-605X/adcd1c

Yukai Yin, Xiao Lu, Yumeng Xie, Shiyong Lin, Jin He, Yuanming Ouyang

{"title":"Fast shaping, biodegradation and microenvironment modulation in bioceramic calcium phosphate cement enhances osteointegration and bone regeneration.","authors":"Yukai Yin, Xiao Lu, Yumeng Xie, Shiyong Lin, Jin He, Yuanming Ouyang","doi":"10.1088/1748-605X/adcd1c","DOIUrl":"https://doi.org/10.1088/1748-605X/adcd1c","url":null,"abstract":"Critical bone defects require repair materials for optimal treatment. The current range of available materials has limitations, including donor availability, rejection, disease transmission, and inadequate filling. Calcium phosphate bone cement (CPC) is a bone repair material, but most CPCs on the market have two drawbacks: difficulty degrading and prolonged solidification time. The purpose of this study was to develop a CPC that is rapidly moldable and biodegradable, improves the acid‒base microenvironment, and is more suitable for clinical use. This CPC was prepared fromβ-tricalcium phosphate bioceramics (TCP) and calcium phosphate monohydrate and is designated a bioceramic CPC (BCPC). TCP was used as a control to determine the biocompatibility of BCPC and its impact on osteogenesis-related protein activity. The BCPC and TCP implants were placed in the femurs of rabbits, and x-ray/micro-CT images were obtained at weeks 4, 8, and 12 postoperatively. Additionally, samples from the three time points were stained and analyzed for their osteogenic and degradation properties. BCPC submerged in phosphate buffer reached a neutral pH of 6.98 ± 0.02 on Day 3.In vitrotests revealed that BCPC increased alkaline phosphatase and osteopontin activities in MC3T3-E1 cells. The x-ray and micro-CT results revealed that BCPC degraded while the TCP volume remained stable. Micro-CT revealed that BCPC degraded by 26.93% and formed 12.89% new bone by week 12. The histological results showed that BCPC had good biocompatibility and osteointegration ability. BCPC is characterized by rapid solidification and molding and good biocompatibility, and its degradation rate matches the rate of bone regeneration. BCPC could rapidly improve the surrounding pH, providing the foundation for its clinical application.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":"20 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and characterization of bifunctional conductive and magnetic scaffold based on polyvinyl alcohol/polypyrrole/magnetite composite for neural tissue engineering. 神经组织工程用聚乙烯醇/聚吡咯/磁铁矿复合材料双功能导电磁性支架的研制与表征

Biomedical materials (Bristol, England) Pub Date : 2025-05-06 DOI: 10.1088/1748-605X/add06d

Mohammad Hossein Golbabaei, Fatemehsadat Pishbin, S A Seyyed Ebrahimi, Nooshin Haghighipour

{"title":"Development and characterization of bifunctional conductive and magnetic scaffold based on polyvinyl alcohol/polypyrrole/magnetite composite for neural tissue engineering.","authors":"Mohammad Hossein Golbabaei, Fatemehsadat Pishbin, S A Seyyed Ebrahimi, Nooshin Haghighipour","doi":"10.1088/1748-605X/add06d","DOIUrl":"https://doi.org/10.1088/1748-605X/add06d","url":null,"abstract":"The incorporation of electroconductive and magnetic materials into scaffolds for tissue engineering has emerged as an innovative approach to enhance nerve tissue regeneration. In this study, the freeze-drying technique was used to fabricate a bifunctional 3D neural scaffold based on biodegradable polyvinyl alcohol (PVA), incorporating magnetite nanoparticles (Fe3O4NPs) and the conductive polymer polypyrrole (PPy). Microstructural and chemical analyses using field emission scanning electron microscopy/energy-dispersive spectrophotometer, x-ray diffraction, and Fourier transform infrared spectroscopy revealed scaffolds with a homogeneous structure, interconnected pores averaging 100 µm, and over 80% porosity, with magnetite evenly distributed in the PVA matrix. The incorporation of Fe3O4nanoparticles significantly enhanced the scaffold's compressive strength and elastic modulus, while PPy increased conductivity to levels comparable to those of native neural tissue. The scaffold also exhibited superparamagnetic properties due to Fe3O4NPs, as confirmed by vibrating-sample magnetometry analysis. PBS submersion demonstrated water absorption and a 30% weight loss over 24 d.In vitrocytotoxicity tests on SH-SY5Y human neuroblastoma cells cultured on composite scaffolds confirmed cell viability, both with and without pulsed electromagnetic field stimulation. Overall, these results suggest that this scaffold is a promising candidate for neural tissue regeneration.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":"20 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroprotective effects ofGarcinia kolaand curcumin on diabetic transected sciatic nerve. 藤黄和姜黄素对糖尿病坐骨神经横断的保护作用。

Biomedical materials (Bristol, England) Pub Date : 2025-05-06 DOI: 10.1088/1748-605X/adcfe3

Hala Mahgoub Hamour, Abdullah Hilmi Marangoz, Gamze Altun, Süleyman Kaplan

{"title":"Neuroprotective effects ofGarcinia kolaand curcumin on diabetic transected sciatic nerve.","authors":"Hala Mahgoub Hamour, Abdullah Hilmi Marangoz, Gamze Altun, Süleyman Kaplan","doi":"10.1088/1748-605X/adcfe3","DOIUrl":"https://doi.org/10.1088/1748-605X/adcfe3","url":null,"abstract":"The growing interest in peripheral nerve regeneration and developing post-traumatic repair methods under diabetes was the impetus for this study, which aims to investigate the effect of curcumin andGarcinia kola(GK) on the transected and diabetic sciatic nerves. Thirty-five male Wistar albino rats were used. The animals were divided into five groups; each consisted of seven rats. The sciatic nerve was transected in all groups of rats except the control (Cont) group, which underwent no treatment. In the transected animals, a 10 mm nerve stump was removed from the 2 cm distal to the sciatic notch. The external jugular vein was used as a conduit to repair the gap between the two ends of the sciatic nerve. Diabetes was induced in the transected + diabetes mellitus (T + DM), the transected + diabetes mellitus + GK (T + DM + GK), and the transected + diabetes mellitus + Curcumin (T + DM + Cur) groups except for the sham group. A dose of 300 mg kg-1d-1of curcumin dissolved in olive oil was administered to the T + DM + Cur group (via oral gavage every day for 28 d) and 200 mg kg-1d-1of GK to the T + DM + GK group (via oral gavage every day for 7 d). All animals were sacrificed after three months. Stereological analysis and functional and microscopic evaluations were done to evaluate the sciatic nerve regeneration and function. In the T + DM + GK and the sham groups, the number of axons increased. A slight improvement in the axonal area in the T + DM + Cur and the sham groups was also observed, and an increase in the myelin sheath thickness was found in the T + DM + GK and the sham group. When the SFI test results were evaluated, it was seen that GK had a stronger effect than curcumin in terms of functional regeneration. Additionally, no significant difference was observed between T + DM and Cont groups when the electrophysiological results were examined. The study showed GK's efficiency in treating diabetic peripheral nerve regeneration.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":"20 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of size scales and orientations of polymeric scaffold architectural cues on human macrophage polarisation. 聚合物支架结构线索的大小尺度和取向对人巨噬细胞极化的影响。

Biomedical materials (Bristol, England) Pub Date : 2025-05-06 DOI: 10.1088/1748-605X/add06e

Akhil T Thilakan, Niji Nandakumar, Revathy S Menon, Shantikumar V Nair, Veena Shenoy, Binulal Nelson Sathy

{"title":"The impact of size scales and orientations of polymeric scaffold architectural cues on human macrophage polarisation.","authors":"Akhil T Thilakan, Niji Nandakumar, Revathy S Menon, Shantikumar V Nair, Veena Shenoy, Binulal Nelson Sathy","doi":"10.1088/1748-605X/add06e","DOIUrl":"https://doi.org/10.1088/1748-605X/add06e","url":null,"abstract":"Macrophage polarisation is crucial for initiating inflammation in response to biomaterial scaffolds, significantly influencing tissue integration and regenerationin vivo. Modulating macrophage polarisation towards a tissue-regeneration-favouring phenotype through the physical properties of scaffolds offers a promising strategy to enhance tissue regeneration while minimising unfavourable immune responses. However, the critical impact of scaffold physical properties, such as size-scale dimensions, orientation of architectural cues, and local-stiffness of these cues on macrophage polarisation, remains largely unexplored and inadequately understood. This study investigates the combinatorial effects of the physical properties of 3D scaffolds made from poly (ϵ-caprolactone) on human macrophage polarisation. Our findings indicate that the size-scale dimensions and orientation of the architectural cues of the scaffold play crucial roles in determining cell shape, attachment, and the modulation of key gene expression (iNOS, IL-1β, MRC1, ARG), as well as cytokines (TNF-α, IL-10) release associated with the polarisation of human macrophages. Specifically, in scaffolds with architectural cues at larger scales (⩾300 µm diameter), macrophage polarisation is primarily determined by the size-scale of the architectural cues and scaffold stiffness, rather than orientation. Conversely, at smaller scales (⩽15 µm), the orientation of the scaffold's architectural cues plays a more critical role. These insights underscore the pivotal role of scaffold design in modulating immune responses for enhanced tissue regeneration, offering valuable guidance for the rational development of biomaterial scaffolds in regenerative medicine.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":"20 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional nanocomposite hydrogels: an effective approach to promote diabetic wound healing. 多功能纳米复合水凝胶：促进糖尿病伤口愈合的有效途径。

Biomedical materials (Bristol, England) Pub Date : 2025-05-06 DOI: 10.1088/1748-605X/add06f

Yuchen Hu, Junchao Zhou, Yuhang Gao, Ying Fan, Ban Chen, Jiangtao Su, Hong Li

{"title":"Multifunctional nanocomposite hydrogels: an effective approach to promote diabetic wound healing.","authors":"Yuchen Hu, Junchao Zhou, Yuhang Gao, Ying Fan, Ban Chen, Jiangtao Su, Hong Li","doi":"10.1088/1748-605X/add06f","DOIUrl":"https://doi.org/10.1088/1748-605X/add06f","url":null,"abstract":"Diabetes, a metabolic disease that is becoming increasingly severe globally, presents a significant challenge in the medical field. Diabetic wounds are characterized by their chronicity, difficulty healing, and complex microenvironment that harbors multiple adverse factors, including elevated hyperglycemia, persistent inflammation, susceptibility to infections, and oxidative stress, all of which contribute to the impaired healing process. Nanocomposite hydrogels, as materials with unique physicochemical properties and biocompatibility, have gained growing attention in recent years for their potential applications in diabetic wound healing. These hydrogels provide a moist healing environment for wounds and regulate cellular behavior and signaling pathways, promoting wound repair and healing. By introducing specific functional groups and nanoparticles, nanocomposite hydrogels can respond to pathological features of wounds, enabling adaptive drug release. Owing to their diverse bioactive functions, nanocomposite hydrogels are powerful tools for the treatment of diabetic wounds. Thus, this article provides an overview of recent progress in the use of nanocomposite hydrogels for diabetic wound healing.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":"20 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improved apoptosis and mitochondrial dysfunction: the potential of carmofur-platinum nanoparticles. 改善细胞凋亡和线粒体功能障碍：卡摩福-铂纳米颗粒的潜力。

Biomedical materials (Bristol, England) Pub Date : 2025-04-23 DOI: 10.1088/1748-605X/adcbfa

Gökçe Erdemir-Cilasun, Dilşad Özerkan, İshak Afşin Kariper, Esra Sert, Işık Neslişah Korkut, Ferdane Danışman-Kalındemirtaş

{"title":"Improved apoptosis and mitochondrial dysfunction: the potential of carmofur-platinum nanoparticles.","authors":"Gökçe Erdemir-Cilasun, Dilşad Özerkan, İshak Afşin Kariper, Esra Sert, Işık Neslişah Korkut, Ferdane Danışman-Kalındemirtaş","doi":"10.1088/1748-605X/adcbfa","DOIUrl":"https://doi.org/10.1088/1748-605X/adcbfa","url":null,"abstract":"Despite their impact on cancer therapy, limitations such as systemic toxicity and drug resistance are encountered with platinum-based drugs. This study explores the potential of combining PtIV-based NP with carmofur (Car) to address these issues. In this study, platinum nanoparticles (PtNPs) and Car-loaded PtNP (Car@PtNP) were synthesized and their cytotoxic and apoptotic effects on colorectal and breast cancer cells were evaluated. Following characterization of the synthesized NPs by dynamic light scattering, UV-VIS spectroscopy, FTIR, and STEM, it was found that the average size of PtNPs was 55.42 nm and the size increased to approximately 186.06 nm upon synthesis of Car@PtNP. MTT assays demonstrated that Car@PtNP exhibited higher levels of cellular toxicity than carmofur alone. While it significantly decreased cell viability in both colon and breast cancer cells, its toxicity to HUVEC cells was minimal. Treatment of MCF-7 and HCT116 cells with 50 µg ml-1of free Car resulted in cell viabilities of 65.2% and 76.93%, respectively, whereas the viability of cells treated with Car@PtNP decreased to 49.60% and 55.47%. Flow cytometric analysis confirmed that apoptosis was increased in healthy HCT116 cells treated with Car@PtNP, with a marked increase in both early and late apoptotic cell populations. Furthermore, these results were confirmed by Hoescht and Rhodamin123 immunofluorescence staining, and significant mitochondrial dysfunction and apoptotic morphological changes were observed in treated cells. The findings underscore the promise of Car@PtNP as a novel chemotherapeutic approach, integrating the benefits of PtIVcomplexes and Car to enhance antitumor efficacy while mitigating the drawbacks of conventional platinum-based therapies.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":"20 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in manufacturing technologies in the small-diameter artificial blood vessels field. 小直径人工血管制造技术进展。

Biomedical materials (Bristol, England) Pub Date : 2025-04-22 DOI: 10.1088/1748-605X/adca7b

Di Xiao, Xuelian Mi, Qian Wang, Shaojun Chen, Rongtao Chen, Yongjie Zhao, Yihao Liu, Dongmei Wei

引用次数: 0

I-PRF functionalized gelatin methacrylate microspheres for improving the proliferation and osteogenic differentiation of human periodontal ligament stem cells. I-PRF功能化甲基丙烯酸明胶微球促进人牙周韧带干细胞增殖和成骨分化。

Biomedical materials (Bristol, England) Pub Date : 2025-04-22 DOI: 10.1088/1748-605X/adc52a

Ke Yi, Huilin Zhu, Xiaodong Lian, Zhihui Tang, Qing Li

引用次数: 0

A review on pancreatic duct stents: materials and emerging trends. 胰管支架的研究进展：材料和发展趋势。

Biomedical materials (Bristol, England) Pub Date : 2025-04-22 DOI: 10.1088/1748-605X/adcb7d

Huijuan Fan, Nan Li, Xingguang Zhang, Wei Xu, Wencheng Zhang, Yangjuan Ding, Lingjian Li, Taotao Liu, Shihai Xia

{"title":"A review on pancreatic duct stents: materials and emerging trends.","authors":"Huijuan Fan, Nan Li, Xingguang Zhang, Wei Xu, Wencheng Zhang, Yangjuan Ding, Lingjian Li, Taotao Liu, Shihai Xia","doi":"10.1088/1748-605X/adcb7d","DOIUrl":"https://doi.org/10.1088/1748-605X/adcb7d","url":null,"abstract":"Pancreatic duct strictures, which can arise from trauma, inflammation, or malignancy, often result in complications such as duct obstruction, pancreatic parenchymal hypertension, and ischemia. Endoscopic stenting is an effective therapeutic approach for managing these strictures. However, traditional plastic pancreatic duct stents fail to conform to the physiological curvature of the pancreas, while metal pancreatic duct stents with flared ends reduce migration but are associated with complications such as de novo strictures. Additionally, plastic and metal pancreatic duct stents require surgical removal. Whereas biodegradable pancreatic duct stents present a promising alternative due to their superior biocompatibility and ability to decompose into non-toxic materials, potentially eliminating the need for additional surgeries. Despite these advantages, biodegradable pancreatic duct stents remain in the experiment stage. This review assesses current materials of pancreatic duct stents, and emphasizes recent advancements in biodegradable options and emerging trends in clinical applications.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":"20 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of the advances in implant technology: accomplishments and challenges for the design of functionalized surface structures. 植入体技术的进展综述：功能化表面结构设计的成就和挑战。

Biomedical materials (Bristol, England) Pub Date : 2025-04-17 DOI: 10.1088/1748-605X/adca7c

Ming-Feng Wang, Tao Yan, Ming-Cen Gao, Cheng-Wei Han, Zhuo-Qun Yan, Yu-Zhong Gao, Wei Zhang, Zhe Yi

{"title":"A review of the advances in implant technology: accomplishments and challenges for the design of functionalized surface structures.","authors":"Ming-Feng Wang, Tao Yan, Ming-Cen Gao, Cheng-Wei Han, Zhuo-Qun Yan, Yu-Zhong Gao, Wei Zhang, Zhe Yi","doi":"10.1088/1748-605X/adca7c","DOIUrl":"10.1088/1748-605X/adca7c","url":null,"abstract":"Biomedical implants are extensively utilized to replace hard-tissue defects owing to their biocompatibility and remarkable tissue-affinity. The materials and functional design are selected based on the resultant osseointegration level and resistance to infection, and these considerations constitute the dominant research topic in this field. However, high rates of implantation failure and peri-implantitis have been reported. Current research on biomedical-implant design encompasses enhancement of the implant surface properties, such as the roughness, nano/micro topography, and hydrophilicity, along with the realization of advanced features including antibacterial properties and cell and immunomodulation regulation. This review considers the two achievements of contemporary implant manufacturing; namely, osseointegration and the realization of antibacterial properties. Present mainstream surface modifications and coatings are discussed, along with functional design technologies and achievements. The impacts of direct surface-treatment techniques and osteogenic functional coatings on osseointegration performance and antibacterial surface structures are elucidated, considering inorganic and organic coatings with antibacterial properties as well as antibiotic-releasing coatings. Furthermore, this review highlights recent advancements in physically driven antimicrobial strategies. Expanding upon existing research, future directions for implant studies are proposed, including the realization of comprehensive functionality that integrates osseointegration and antibacterial properties, as well as patient-specific design. Our study presents a comprehensive review and offers a novel perspective on the design of biomedical implants for enhanced versatility. An in-depth exploration of future research directions will also stimulate subsequent investigations.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0