Medical adhesives for soft tissue wound repair with good biocompatibility, flexibility, and high adhesive strength.

Abstract

Compared with traditional soft tissue wound closure methods such as sutures and staplers, bioadhesives have significant advantages in terms of tissue compatibility, ease of use, and wound adaptability, making them a hot topic among current wound repair materials. This study aimed to select polyurethane materials with good biocompatibility and high mechanical strength, optimize the prepolymer formula, develop new curing agents, and obtain a new dual-component polyurethane bioadhesive. Furthermore, key research will be conducted on its mechanical properties and tissue adhesion performance. The results show that through the optimization of prepolymer formulations and the development of novel curing agents, a dual-component polyurethane bioadhesive with good biocompatibility, flexibility, and high adhesive strength was obtained. This adhesive can quickly and effectively bond common soft tissue (skin, muscle) traumatic wounds, with an adhesive strength of up to 72 kPa. This adhesive matches well with the mechanical properties of soft tissues and safely and tightly adheres to the surface of soft tissues. Additionally, this dual-component polyurethane adhesive holds promise for repairing other soft tissues, such as the lungs and intestines, with broad application prospects.