{"title":"A brief overview of hyaluronic acid research and its applications in cell culture.","authors":"Huanyu Zhu, Na Zhao, Xueping Guo","doi":"10.1088/1748-605X/adecd1","DOIUrl":null,"url":null,"abstract":"<p><p>Hyaluronic acid (HA) is a large molecular acidic glycosaminoglycan that is widely present in the extracellular matrix (ECM) of cells. Aside from being an important component of the ECM, HA is an excellent biomaterial that is known for its good biocompatibility and mechanical properties. This study aimed to investigate the employment and effectiveness of HA in cell culture. We performed a review on the physicochemical properties of HA and its application in cell culture. HA is widely used in a number of<i>in vitro</i>cell cultures, especially in stem cell cultivation and differentiation and in tissue-engineering applications, which has greatly expanded the scope and field of its applications. This article provides a brief overview of the applications of HA in various cell culture fields, thereby providing a reference for related research on HA.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical materials (Bristol, England)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1088/1748-605X/adecd1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Hyaluronic acid (HA) is a large molecular acidic glycosaminoglycan that is widely present in the extracellular matrix (ECM) of cells. Aside from being an important component of the ECM, HA is an excellent biomaterial that is known for its good biocompatibility and mechanical properties. This study aimed to investigate the employment and effectiveness of HA in cell culture. We performed a review on the physicochemical properties of HA and its application in cell culture. HA is widely used in a number ofin vitrocell cultures, especially in stem cell cultivation and differentiation and in tissue-engineering applications, which has greatly expanded the scope and field of its applications. This article provides a brief overview of the applications of HA in various cell culture fields, thereby providing a reference for related research on HA.
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