肿瘤反应性纳米药物用于癌症治疗:设计原则和治疗进展。

Yan Liu, Yinan Wang, Ahequeli Gemingnuer, Hailing Wang, Xin Meng
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引用次数: 0

摘要

肿瘤微环境(TME)反应纳米药物已成为一种很有前景的癌症精准治疗策略。通过结合刺激反应特性,这些纳米药物可以在肿瘤部位实现靶向递送和控制释放,从而提高治疗效果,同时最大限度地减少副作用。本文综述了用于肿瘤免疫治疗的tme反应性纳米药物的最新进展,包括各种刺激反应机制(如pH、活性氧、缺氧、酶和ATP)及其在提高免疫疗效和减少免疫相关不良反应方面的应用。此外,讨论了这些纳米药物临床转化的关键挑战,并提出了未来的研究方向。本研究旨在为肿瘤反应性纳米药物的进一步开发和应用提供理论基础和设计参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Tumor-responsive nanomedicines for cancer therapy: design principles and therapeutic advances.

Tumor microenvironment (TME)-responsive nanomedicines have emerged as a promising precision therapeutic strategy in cancer treatment. By incorporating stimuli-responsive properties, these nanomedicines can achieve targeted delivery and controlled release at tumor sites, thereby enhancing therapeutic efficacy while minimizing side effects. This review provides a comprehensive overview of the latest advancements in TME-responsive nanomedicines for cancer immunotherapy, covering various stimulus-responsive mechanisms (such as pH, reactive oxygen species, hypoxia, enzymes, and ATP) and their applications in improving immune efficacy and reducing immune-related adverse effects. In addition to discusses the key challenges associated with the clinical translation of these nanomedicines and proposes future research directions. This work aims to offer a theoretical foundation and design reference for the further development and application of tumor-responsive nanomedicines.

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