Biomedical materials (Bristol, England)最新文献

{"title":"Stimuli-responsive hydrogels: orchestrating microenvironment remodeling in musculoskeletal therapeutics.","authors":"Xin Tian, Yixi Zhang, Chenyuan Zhang, Xiaoyuan Qu, Xianghong Meng, Xiaoran Wang, Zhi Wang","doi":"10.1088/1748-605X/aea5c5","DOIUrl":"10.1088/1748-605X/aea5c5","url":null,"abstract":"<p><p>The pronounced heterogeneity of the pathological microenvironment in musculoskeletal disorders poses significant challenges to the spatiotemporal regulation capabilities of conventional therapeutic strategies. Stimuli-responsive hydrogels have exhibited immense potential for the treatment of musculoskeletal disorders owing to their excellent intelligent response characteristics and versatile design. This review systematically summarizes the major response mechanisms of stimuli-responsive hydrogels and analyzes the characteristics of their structural and functional design. It further focuses on recent advances of their applications in typical musculoskeletal disorders, including degenerative diseases such as osteoarthritis (OA); autoimmune diseases such as rheumatoid arthritis (RA); traumatic injuries such as fractures and cartilage injury; infectious diseases such as infected bone defects; metabolism-related bone disorders such as diabetic bone injury and hyperlipidemia bone injury; as well as soft tissue complications such as tendon adhesion and rotator cuff injury. Finally, this review proposes a design concept for multimodal stimuli-responsive hydrogels and discusses the key challenges in their clinical translation. We hope this review will serve as a reference for promoting the treatment of musculoskeletal disorders from passive repair to active regulation.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148931947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CORRIGENDUM: Hybrid additive manufacturing and data-guided design of graded scaffolds for soft-to-hard tissues engineering (2026<i>Biomed. Mater.</i> 21 015013).","authors":"Simone Micalizzi, Alberto Bevilacqua, Luca Di Stefano, Francesco De Gaetano, Federica Potere, Arianna Callera, Edoardo D'Imprima, Martin Centola, Alberto Favaro, Daniele D'Arrigo, Tommaso Bonanzinga, Maurilio Marcacci, Paolo Oliva","doi":"10.1088/1748-605X/aea25d","DOIUrl":"https://doi.org/10.1088/1748-605X/aea25d","url":null,"abstract":"","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":"21 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149013297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatially controlled polymicrobial human airway model recapitulates complex interactions between<i>Pseudomonas aeruginosa</i>and lung commensals.","authors":"Sarah M Spencer, Karla N Valenzuela-Valderas, Zhenyu Cheng, Brendan M Leung","doi":"10.1088/1748-605X/aea1cc","DOIUrl":"10.1088/1748-605X/aea1cc","url":null,"abstract":"<p><p>Airway barrier dysfunction is a hallmark of chronic lung diseases including cystic fibrosis, asthma, and chronic obstructive pulmonary disease, and is often shaped by polymicrobial rather than single-species interactions with the host tissue. However, extended host-microbe co-culture with rapid-colonizing airway pathogens such as Pseudomonas aeruginosa<i>(P. aeruginosa)</i>is difficult to sustain in accessible<i>in vitro</i>systems, limiting mechanistic study of polymicrobial barrier and inflammatory dynamics. Here we developed and validated an aqueous two-phase system (ATPS) that spatially confines bacterial communities over a human bronchial epithelial-endothelial transwell co-culture, extending the stable co-culture window to 24 h while preserving assayable barrier and cytokine readouts. Using a validation-by-recapitulation approach, the platform reproduced established<i>in vivo</i>phenomena:<i>P. aeruginosa</i>-driven barrier disruption, attenuation of pathogenic effects by the commensals<i>Rothia mucilaginosa</i>and<i>Lactobacillus casei</i>with preserved junctional architecture, and<i>Streptococcus pneumoniae</i>exacerbation of barrier permeability accompanied by elevated IL-8 despite apparent junctional preservation. This accessible ATPS-based biomaterials platform requires no microfluidic or induced pluripotent stem cell-derived components and provides a tractable foundation for mechanistic studies of polymicrobial interactions at the airway epithelial barrier.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and optimization of Pt@ZIF-8 nanostructures via QbD approach: structural characterization and cytotoxic insights.","authors":"Dhara Pandey, Sarvesh Rahate, Kunal M Gokhale","doi":"10.1088/1748-605X/aea3d5","DOIUrl":"10.1088/1748-605X/aea3d5","url":null,"abstract":"<p><p>Platinum nanoparticles (Pt NPs) exhibit inherent anticancer properties; however, their therapeutic application is limited by poor colloidal stability, ineffective cellular uptake, and inconsistent formulation reproducibility. While zeolitic imidazolate framework-8 (ZIF-8) has shown promise as a pH-responsive nanocarrier, thorough optimization of Pt-encapsulated ZIF-8 (Pt@ZIF-8) nanostructures guided by quality by design (QbD) principles, as well as a mechanistic assessment of their biological effectiveness, remains insufficiently addressed. In this research, Pt@ZIF-8 NPs were fabricated using a QbD strategy based on a central composite design to elucidate the relationships between formulation parameters and essential quality attributes. The optimized formulation exhibited nanoscale particle sizes, stable colloidal behaviour, and effective integration of platinum into the ZIF-8 structure. Compared with uncoated Pt NPs, Pt@ZIF-8 exhibited improved cellular uptake and greater anticancer efficacy against human cancer cells. Investigation revealed that oxidative stress induced cell death is associated with high reactive oxygen species levels inside cells, low reduced glutathione concentration, low superoxide dismutase activity, and apoptosis. Overall, this study provides an optimization and mechanistic rationale to synthesize the Pt@ZIF-8 NPs and provides a rationale to design a multi-functional MOF-based nanomedical system for cancer therapy.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148908348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reactive oxygen species-scavenging hydrogels loaded with tempol exert anti-oxidative effects in spinal cord injury rat models.","authors":"Gushang Xia, Renjie Shuai, Ze Li, Changlin Tang, Yaowen Zhang, Qingli Kong, Wanyou Li, Fangfang Ma, Xianglin Li, Yan Du","doi":"10.1088/1748-605X/aea1b3","DOIUrl":"10.1088/1748-605X/aea1b3","url":null,"abstract":"<p><p>Traumatic spinal cord injury (SCI) is characterized by excessive reactive oxygen species (ROS) accumulation coupled with a sustained acidic lesion microenvironment, both of which severely hinder endogenous neural tissue repair. This study reports the fabrication and comprehensive<i>in vitro</i>and<i>in vivo</i>validation of a thermosensitive injectable hydrogel embedded with ROS-eliminating nanoparticles (DHA-PLL-TPL nanoparticles hydrogel, DT NP-Hydrogel) for localized SCI treatment. In hydrogen peroxide-challenged primary spinal cord neuron cultures and weight-drop contusion rat SCI models, locally injected DT NP-Hydrogel significantly reduced oxidative stress marker 4-hydroxynonenal (4HNE), pro-apoptotic Caspase-3 (Casp3) expression, and gap junction protein connexin 43 (Cx43) levels, while simultaneously upregulating the neuron-specific marker class III<i>β</i>-tubulin (Tuj1). Collectively, our<i>in vitro</i>and<i>in vivo</i>data demonstrate that DT NP-Hydrogel mitigates secondary spinal cord damage and delivers potent neuroprotective activity, establishing it as a promising therapeutic strategy for SCI.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biphasic scaffolds produced by melt electrowriting and fused filament fabrication for osteochondral defect repair.","authors":"Rory Gibney, Marcin Kotlarz, Kian Eichholz, Xavier Barceló, Gabriela S Kronemberger, Orquidea Garcia, Pieter J Brama, Daniel J Kelly","doi":"10.1088/1748-605X/ae9b58","DOIUrl":"10.1088/1748-605X/ae9b58","url":null,"abstract":"<p><p>Repairing osteochondral defects remains a significant clinical challenge due to the distinct requirements for regenerating both articular cartilage and the underlying subchondral bone. The goal of this study was to evaluate a multi-phase scaffold that combined melt electrowriting (MEW) and fused filament fabrication (FFF) to direct simultaneous subchondral bone and articular cartilage regeneration. To determine the optimal architecture for the chondral phase of the scaffold, an<i>in vitro</i>study first assessed chondrogenesis of mesenchymal stem/stromal cells within MEW polycaprolactone scaffolds with a range of pore sizes. All pore sizes supported cartilage-specific extracellular matrix deposition without significant differences in overall matrix accumulation. Subsequently, a hybrid scaffold was fabricated, comprising a supportive FFF shell and a bi-zonal MEW insert featuring a 600 µm pore architecture. The osseous region of the scaffold was selectively functionalised with an osteoconductive nano-needle hydroxyapatite (nnHA) coating. These constructs were implanted into critically sized caprine osteochondral defects and evaluated after six months<i>in vivo</i>. Histological analysis revealed that the hybrid MEW-FFF scaffolds promoted significantly more new subchondral bone formation compared to empty controls (40.2 ± 12.9% vs 22.2 ± 13.1%). Furthermore, the hybrid scaffold supported more continuous bone regeneration throughout the defect depth, with immunohistochemical staining for collagen type II and X suggesting endochondral bone formation. Despite the enhanced subchondral bone healing, the scaffold did not significantly improve the quality of hyaline cartilage repair within the chondral region of the defect. These findings demonstrate the potential of nnHA-coated MEW-FFF hybrid scaffolds to stimulate robust subchondral bone regeneration in osteochondral defects, while underscoring the significant challenge of achieving simultaneous high-quality regeneration of both bone and articular cartilage.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of biomaterials in ovarian tissue cryopreservation and transplantation: a scoping review.","authors":"Inês Dias, Gabriela Correia-Barros, Carlos Miguel Marto, Beatriz Serambeque, Maria Filomena Botelho, Teresa Almeida Santos, Ana Sofia Pais, Mafalda Laranjo","doi":"10.1088/1748-605X/ae98cf","DOIUrl":"10.1088/1748-605X/ae98cf","url":null,"abstract":"<p><p>Fertility preservation for women undergoing gonadotoxic treatments remains a critical clinical challenge. Ovarian tissue (OT) cryopreservation and transplantation are promising strategies. This review aims to map the biomaterials used in OT culture and cryopreservation, identify key knowledge gaps, and outline future research directions. Following the Arksey & O'Malley's (2005) framework and the PRISMA-ScR guidelines, a literature search was conducted on PubMed and Web of Science. The review protocol was prospectively registered on the Open Science Framework (OSF.IO/NRZM7). Of 3217 studies, 41 were included in the analysis: 32 were<i>in vivo</i>studies, 8 were<i>in vitro</i>, and 1 was clinical. The main biomaterials used for OT culture and cryopreservation included fibrin, alginate, collagen, hyaluronic acid, and extracellular matrix. Key preservation strategies involve encapsulating OT within biomaterial-based systems and enriching culture media with biomaterials. Hydrogels have demonstrated advantages by providing structural scaffolding and facilitating the diffusion of oxygen, nutrients, and bioactive supplements, thereby promoting angiogenesis and supporting OT functional restoration. Growing interest has focused on combinatorial approaches that integrate multiple biomaterials with stem cells, plasma proteins, and growth or antioxidant factors to enhance folliculogenesis and restore oestrous cycles. Despite progress, critical challenges persist, including capsule disintegration and the associated risk of immune sensitisation, as well as limited understanding of long-term tissue revascularisation and OT-biomaterial interactions. Overall, biobased materials strategies, particularly hydrogels, show promise for improving OT preservation and functionality, but further research is needed to optimise these materials and understand their long-term implications for fertility outcomes. Among the included studies, only one was a clinical study; the rest consisted of<i>in vivo</i>animal models and<i>in vitro</i>experiments. This limitation should be recognised, as it prevents direct application of the results to clinical practice. Consequently, further clinical research is crucial to confirm these strategies and facilitate their safe and effective implementation in fertility preservation protocols.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148723497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MnO₂-loaded hydrogel nerve guidance conduit for peripheral nerve regeneration: an<i>in vivo</i>study in the rat sciatic nerve defect model.","authors":"Juan Wang, Liang Pan, Jiahe Gu, Shang Wang, Dan Zhou, Qian Wang, Yue Liu, Yu Feng, Yongbin Ma, Kai Zhao","doi":"10.1088/1748-605X/aea2fc","DOIUrl":"10.1088/1748-605X/aea2fc","url":null,"abstract":"<p><p>Peripheral nerve defect repair remains a clinical challenge. Nerve guidance conduits (NGCs) are potential alternatives to autografts, but their performance can be compromised by the oxidative and inflammatory microenvironment after injury. Here, we fabricated MnO₂-loaded hydrogel NGCs at concentrations of 10, 50, and 100 μg ml^-1and evaluated them in a rat model of a 10-mm sciatic nerve defect. Among the three concentrations, the MnO₂@NMgel-10 (10 μg ml^-1) group yielded a higher sciatic functional index, denser and more orderly regenerated nerve tissue, and less gastrocnemius muscle atrophy than the hydrogel-only and higher-dose conduit groups. Early tissue analysis showed that the MnO₂@NMgel-10 group exhibited increased infiltration of CD86⁺CD206⁺cells, upregulated expression of IL-10, and significantly downregulated expression of IL-1<i>β</i>, TNF-<i>α</i>, and 4-HNE. Furthermore, the MnO₂@NMgel-10 group showed satisfactory biosafety and biocompatibility. These findings reveal a non-monotonic concentration response and preliminarily confirm the feasibility of low-dose MnO₂-functionalized hydrogel NGCs for repairing peripheral nerve defects, providing new insights into the application of MnO₂as a supplementary material for NGC fabrication.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinspired functionally graded TPU gyroid structures for intervertebral disc replacement fabricated by multimaterial 3D printing.","authors":"Leandro Hippel, Martin Peter Pichotka, Dirk Velten, Sunil Shetty, Bernd Rolauffs, Melanie Lynn Hart, Hagen Schmal, Michael Seidenstuecker","doi":"10.1088/1748-605X/aea047","DOIUrl":"10.1088/1748-605X/aea047","url":null,"abstract":"<p><p>Degenerative disc disease remains a primary cause of chronic back pain, yet current surgical treatments are often limited by the mechanical mismatch between implants and native intervertebral disc (IVD) tissue. This study investigates additively manufactured functionally graded Gyroid structures based on thermoplastic polyurethane (TPU) as biomimetic IVD replacements, focusing on the influence of geometry and material gradients on mechanical performance. Gyroid-based constructs were fabricated by multi-material fused filament fabrication using TPU filaments of different stiffness. Their mechanical performance was evaluated under static and dynamic compressive loading. Finite element analysis was performed to investigate stress distribution within the Gyroid architecture, while micro-computed tomography (µCT) was used to assess manufacturing-related defects and structural integrity before and after 700 000 loading cycles. All investigated structures exhibited stable and reproducible mechanical behavior. However, only a single geometric configuration reached the targeted physiological load range of 4000-8000 N, irrespective of the material combination. The incorporation of an additional compliant TPU phase did not significantly alter the global force-deformation response compared with two-material configurations, indicating that structural geometry predominantly governs the compressive mechanical behavior. Dynamic testing demonstrated consistent damping capacities of approximately 20% across all configurations together with stable stiffness, storage modulus, and loss modulus during fatigue loading. Finite element analysis revealed homogeneous load distribution with localized stress concentrations at the curved Gyroid junctions. Quantitative µCT analysis showed no measurable increase in micro-porosity, void fraction, or interfacial defects after 600 000 loading cycles. The findings demonstrate that the mechanical performance of TPU-based Gyroid IVD constructs is primarily governed by architectural design rather than material gradients under compressive loading. The combined experimental, numerical, and µCT analyses confirm the mechanical robustness and structural stability of the proposed functionally graded Gyroid structures, highlighting architecture-driven design as a promising strategy for mechanically compatible IVD replacements.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148852008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress and future trends in advanced biomaterials for the treatment of liver fibrosis.","authors":"Benteng Li, Ruisi Zhu, Yonggang Lv, Guobao Chen","doi":"10.1088/1748-605X/aea1cd","DOIUrl":"10.1088/1748-605X/aea1cd","url":null,"abstract":"<p><p>Liver fibrosis is a hallmark pathological feature of chronic liver diseases and poses a major threat to the health of millions of people worldwide. Without timely diagnosis and effective intervention, liver fibrosis can progress to cirrhosis, liver failure, and even hepatocellular carcinoma (HCC). The limited availability of donor organs for orthotopic liver transplantation has driven the continuous search for alternative therapeutic strategies. However, conventional approaches, including pharmacotherapy, RNA-based therapies, and cell therapy, are often limited by insufficient therapeutic efficacy, poor targeting, and significant adverse effects, underscoring the urgent need for more effective treatment strategies. In recent years, biomaterials have emerged as promising platforms for liver fibrosis therapy owing to their excellent biocompatibility and tunable physicochemical properties. This review summarizes the recent advances in biomaterial-based therapeutic strategies for liver fibrosis, with a particular focus on nanomaterials, hydrogels, and microsphere-based delivery systems. The advantages and limitations of these biomaterial platforms are systematically discussed. Furthermore, we highlight the dual role of biomaterials not only as delivery vehicles for antifibrotic drugs, nucleic acids, and therapeutic cells but also as active platforms that modulate the fibrotic microenvironment and promote liver regeneration. Finally, the current status and future perspectives of biomaterial-based approaches in liver tissue engineering are discussed.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}