Adipocyte最新文献_第2页

Adipose tissue and androgens: the ins and outs. 脂肪组织和雄激素：来龙去脉。

IF 3.5 4区生物学

Adipocyte Pub Date : 2025-12-01 Epub Date: 2025-06-09 DOI: 10.1080/21623945.2025.2508885

Yiyue Jia, Mathilde Lacombe, Catherine Muller, Delphine Milhas

引用次数: 0

A nomogram based on radiomic features from peri-prostatic adipose tissue for predicting bone metastasis in first-time diagnosed prostate cancer patients. 基于前列腺周围脂肪组织放射学特征预测首次诊断前列腺癌患者骨转移的影像学研究。

IF 3.5 4区生物学

Adipocyte Pub Date : 2025-12-01 Epub Date: 2025-06-19 DOI: 10.1080/21623945.2025.2517583

Bohao Liu, Qian Cai, Xiao Zhao, Huabin Su, Zhengxu Lin, Jialin Wu, Xiaoyang Li, Weian Zhu, Chen Zou, Yun Luo

{"title":"A nomogram based on radiomic features from peri-prostatic adipose tissue for predicting bone metastasis in first-time diagnosed prostate cancer patients.","authors":"Bohao Liu, Qian Cai, Xiao Zhao, Huabin Su, Zhengxu Lin, Jialin Wu, Xiaoyang Li, Weian Zhu, Chen Zou, Yun Luo","doi":"10.1080/21623945.2025.2517583","DOIUrl":"10.1080/21623945.2025.2517583","url":null,"abstract":"Purpose: To evaluate a radiomics-based nomogram using peri-prostatic adipose tissue (PPAT) features for predicting bone metastasis (BM) in newly diagnosed prostate cancer (PCa) patients.Methods: A retrospective study of 151 PCa patients (October 2010-November 2022) was conducted. Radiomic features were extracted from axial T2-weighted MRI of PPAT, and normalized PPAT was calculated as the ratio of PPAT volume to prostate volume. A radiomics score (Radscore) was developed using logistic regression with 16 features selected via LASSO regression. Independent predictors identified through univariate and multivariate logistic regression were used to construct a nomogram. Predictive performance was assessed using ROC curves, and internal validation involved 1000 bootstrapped iterations.Results: The Radscore, based on 16 features, showed significant association with BM and outperformed normalized PPAT in predictive value. Independent predictors of BM included Radscore, alkaline phosphatase (ALP), and clinical N stage (cN). A nomogram integrating these factors demonstrated strong discrimination (C-index: 0.908; 95% CI: 0.851-0.966) and calibration, with consistent results in validation (C-index: 0.903; 95% CI: 0.897-0.916). Decision curve analysis confirmed its clinical utility.Conclusions: Radscore, cN, and ALP were identified as independent BM predictors. The developed nomogram enables accurate risk stratification and personalized BM predictions for newly diagnosed PCa patients.","PeriodicalId":7226,"journal":{"name":"Adipocyte","volume":"14 1","pages":"2517583"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12184149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of vascularized adipose organoids from PBMSCs and their application in evaluating Celastrol's effects. PBMSCs血管化脂肪类器官的开发及其在Celastrol疗效评价中的应用。

IF 3.1 4区生物学

Adipocyte Pub Date : 2025-12-01 Epub Date: 2025-08-29 DOI: 10.1080/21623945.2025.2548787

Sen Li, Fangming Kan, Shuhui Ji, Dingding Cao, Haiyang Liu, Jianxin Wu

{"title":"Development of vascularized adipose organoids from PBMSCs and their application in evaluating Celastrol's effects.","authors":"Sen Li, Fangming Kan, Shuhui Ji, Dingding Cao, Haiyang Liu, Jianxin Wu","doi":"10.1080/21623945.2025.2548787","DOIUrl":"10.1080/21623945.2025.2548787","url":null,"abstract":"Obesity lacks physiologically relevant human models, which constrains in-depth investigation into its underlying mechanisms and hampers the development of effective therapeutic strategies for obesity and its associated comorbidities. Here, we developed vascularized adipose organoids (VAOs) from peripheral blood mesenchymal stem cells (PBMSCs) using a standardized three-dimensional dynamic culture system that sequentially induces angiogenesis and adipogenesis. These VAOs mimic native adipose tissue with coexisting adipocytes and endothelial cells. Transcriptomic analysis shows that vascularization alters genes linked to inflammation and redox homoeostasis, yielding distinct metabolic and inflammatory profiles in VAOs versus non-vascularized controls. Notably, upon TNF-α stimulation, VAOs exhibit markedly reduced IL-6 secretion relative to non-vascularized adipose organoids (NVAOs). Importantly, Celastrol simultaneously inhibits angiogenesis and adipogenesis in VAOs and broadly modulates the expression of genes associated with mitochondrial metabolic processes. This study establishes PBMSC-derived VAOs as a scalable, patient-accessible model for investigating adipose development, metabolism, and inflammation. The system also provides a platform for mechanistic research and high-throughput drug screening in obesity and related metabolic diseases.","PeriodicalId":7226,"journal":{"name":"Adipocyte","volume":"14 1","pages":"2548787"},"PeriodicalIF":3.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12407818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A compendium of adipocyte morphologies across different breast pathologies. 不同乳腺病理的脂肪细胞形态纲要。

IF 3.1 4区生物学

Adipocyte Pub Date : 2025-12-01 Epub Date: 2025-10-07 DOI: 10.1080/21623945.2025.2568540

Abigail Dodson, Katie Hanna, Kerri Palmer, Hafeez Ibrahim, Katharina Kusserow, Rasha Abu-Eid, Gerald Lip, Nicola Spence, Ehab Husain, Beatrix Elsberger, Justin J Rochford, Valerie Speirs

{"title":"A compendium of adipocyte morphologies across different breast pathologies.","authors":"Abigail Dodson, Katie Hanna, Kerri Palmer, Hafeez Ibrahim, Katharina Kusserow, Rasha Abu-Eid, Gerald Lip, Nicola Spence, Ehab Husain, Beatrix Elsberger, Justin J Rochford, Valerie Speirs","doi":"10.1080/21623945.2025.2568540","DOIUrl":"https://doi.org/10.1080/21623945.2025.2568540","url":null,"abstract":"Adipocytes are abundant in the breast tissue microenvironment. In breast cancer, they can change morphologically according to their proximity to tumour cells, with the closest becoming cancer-associated adipocytes (CAAs). It remains unclear whether breast cancer risk factors, including menopausal status, body mass index (BMI), and mammographic density (MD), influence CAAs morphology in breast carcinogenesis. This study aimed to quantify morphological differences in adipocytes across breast cancer pathologies and associated risk factors. Whole slide images of haematoxylin and eosin stained cancer (n = 149) and normal (n = 182) breast tissue samples were analysed. Parameters representative of adipocyte morphology: perimeter, area, concavity, and aspect ratio, were measured using ImageJ. Adipocytes were considered close (≤2 mm) or distant ( > 2 mm) to cancer cells in cancer samples or breast epithelial cells in normal samples. Close adipocytes in cancer samples were designated CAAs. CAAs decreased in size compared to distant adipocytes (p≤0.0001). A similar trend was observed between close and distant adipocytes in normal (p≤0.0001). CAAs size increased post menopause (p ≤ 0.0001). CAAs size positively correlated with BMI (p ≤ 0.0001). In cancer cases, distant adipocyte size increased and concavity decreased with increasing MD (p ≤ 0.01). Smaller CAAs were associated with poorer survival (p≤0.05). Morphological differences were identified in adipocytes dependent on location within the breast, tissue, pathology and risk factors. Understanding what drives these morphological differences could provide mechanistic insight into whether risk factor-induced alterations in adipocytes influence their role in breast carcinogenesis.","PeriodicalId":7226,"journal":{"name":"Adipocyte","volume":"14 1","pages":"2568540"},"PeriodicalIF":3.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145237525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacological inhibition of SUMOylation with TAK-981 mimics genetic HypoSUMOylation in murine perigonadal white adipose tissue. TAK-981在小鼠性腺周围白色脂肪组织中模拟基因低SUMOylation的药理抑制作用。

IF 3.5 4区生物学

Adipocyte Pub Date : 2025-12-01 Epub Date: 2025-03-06 DOI: 10.1080/21623945.2025.2474107

Damien Dufour, Xu Zhao, Florian Chaleil, Patrizia Maria Christiane Nothnagel, Magnar Bjørås, Anne-Marie Lefrançois-Martinez, Antoine Martinez, Pierre Chymkowitch

{"title":"Pharmacological inhibition of SUMOylation with TAK-981 mimics genetic HypoSUMOylation in murine perigonadal white adipose tissue.","authors":"Damien Dufour, Xu Zhao, Florian Chaleil, Patrizia Maria Christiane Nothnagel, Magnar Bjørås, Anne-Marie Lefrançois-Martinez, Antoine Martinez, Pierre Chymkowitch","doi":"10.1080/21623945.2025.2474107","DOIUrl":"10.1080/21623945.2025.2474107","url":null,"abstract":"Post-translational modification by the small ubiquitin-like modifier (SUMO) is essential for cellular differentiation and homeostasis. Here, we investigate the role of SUMOylation in adipose tissue development using TAK-981, a pharmacological inhibitor of SUMOylation. Administration of TAK-981 to mice resulted in significant defect in weight gain and adipocyte atrophy in perigonadal white adipose tissue (gWAT) depots. Gene expression analyses revealed a marked downregulation of adipogenic genes, including Pparg, Cebpa, and Fasn. Our data thus indicate that TAK-981 treatment impaired adipogenesis in gWAT, consistent with prior findings that SUMOylation supports transcriptional regulation of adipogenesis and lipid metabolism. We also found significant infiltration of immune cells and efferocytosis in gWAT. Our results thus indicate that SUMOylation inhibition using a small molecule phenocopies genetic hypoSUMOylation models, highlighting its critical role in maintaining adipocyte functionality and immune environment. These findings provide evidence that SUMOylation is essential for fat accumulation in vivo. Furthermore, given that TAK-981 is currently under clinical evaluation for the treatment of solid tumors, our results underscore the importance of considering the potential unintended effects of SUMOylation inhibition on adipose tissue in patients.","PeriodicalId":7226,"journal":{"name":"Adipocyte","volume":"14 1","pages":"2474107"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11901380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143565578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adipogenic dedifferentiation enhances survival of human umbilical cord-derived mesenchymal stem cells under oxidative stress. 脂肪源性去分化增强氧化应激下人脐带间充质干细胞的存活。

IF 3.5 4区生物学

Adipocyte Pub Date : 2025-12-01 Epub Date: 2025-02-20 DOI: 10.1080/21623945.2025.2467150

Yin Yuan, Meina Kuang, Tengye Yu, Sirui Huang, Fujie Jiang, Biyi Lu, Mingen Cai, Xin Lu

{"title":"Adipogenic dedifferentiation enhances survival of human umbilical cord-derived mesenchymal stem cells under oxidative stress.","authors":"Yin Yuan, Meina Kuang, Tengye Yu, Sirui Huang, Fujie Jiang, Biyi Lu, Mingen Cai, Xin Lu","doi":"10.1080/21623945.2025.2467150","DOIUrl":"10.1080/21623945.2025.2467150","url":null,"abstract":"Mesenchymal stem cells (MSCs) serve as ideal candidates for a broad range of cell-based therapies. However, cell ageing caused by long-term in vitro expansion and poor survival after in vivo delivery greatly limits their success in preclinical and clinical applications. Dedifferentiation represents a potential strategy for enhancing the retention and function of MSCs in hostile environments. In this study, we evaluated the cell phenotype, proliferation, and differentiation potential, as well as the anti-oxidative stress ability of human umbilical cord-derived MSCs (hMSCs) manipulated with adipogenic priming and subsequent dedifferentiation. After an in vitro differentiation and dedifferentiation procedure, the resultant dedifferentiated hMSCs (De-hMSCs) displayed properties similar to their original counterparts, including immunophenotype and mesodermal potential. Upon re-induction, De-hMSCs exhibited a significantly higher adipogenic differentiation capability than unmanipulated hMSCs. Importantly, De-hMSCs showed a significantly enhanced ability to resist tert-butyl hydroperoxide (t-BHP) induced apoptosis compared to undifferentiated hMSCs. Mechanisms involving bcl-2 family proteins and autophagy may contribute to the demonstrated advantages of dedifferentiation-reprogrammed hMSCs. These results indicate that adipogenic dedifferentiation promotes adipogenesis and cell persistence, as well as preserves the stemness of human umbilical cord-derived MSCs that have been committed to the adipocytic lineage. As a unique stem cell population, dedifferentiated MSCs may represent an attractive and promising candidate for MSC-based therapy.","PeriodicalId":7226,"journal":{"name":"Adipocyte","volume":"14 1","pages":"2467150"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of adipose tissue infiltration with cardiac function: scoping review. 脂肪组织浸润与心脏功能的关系：范围回顾。

IF 3.5 4区生物学

Adipocyte Pub Date : 2025-12-01 Epub Date: 2025-04-10 DOI: 10.1080/21623945.2025.2489467

Mansour M Alotaibi, Naif Z Alrashdi, Marzouq K Almutairi Pt, Mohammed M Alqahtani, Anwar B Almutairi, Sami M Alqahtani, Hamoud M Alajel, Amani K Bajunayd

{"title":"Association of adipose tissue infiltration with cardiac function: scoping review.","authors":"Mansour M Alotaibi, Naif Z Alrashdi, Marzouq K Almutairi Pt, Mohammed M Alqahtani, Anwar B Almutairi, Sami M Alqahtani, Hamoud M Alajel, Amani K Bajunayd","doi":"10.1080/21623945.2025.2489467","DOIUrl":"https://doi.org/10.1080/21623945.2025.2489467","url":null,"abstract":"Evidence suggests that adipose tissue (AT) infiltration in skeletal muscles may negatively influence cardiac function, yet its use as a biomarker remains unclear. This scoping review examined the relationship between AT infiltration and cardiac function in adults. A systematic search of PubMed, CINAHL and SCOPUS identified peer-reviewed studies reporting AT infiltration and cardiac function measures. Excluded were review-type studies, animal studies, abstracts and case series. Study quality was assessed using the Study Quality Assessment Tool (SQAT). Three good-quality studies were included. Findings demonstrated a negative association between AT infiltration and cardiac function parameters, including exercise capacity, left ventricular ejection fraction (LVEF) and heart failure events, in cancer survivors and healthy individuals. There is evidence supporting an association between increased AT infiltration of skeletal muscles and impaired cardiac function, highlighting the need for further research to validate AT infiltration as a potential biomarker. Despite the limited available studies, our findings highlight a distinct association between skeletal muscle AT infiltration and cardiac dysfunction, independent of general obesity.","PeriodicalId":7226,"journal":{"name":"Adipocyte","volume":"14 1","pages":"2489467"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11988230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioactive peptides PDBSN improve mitochondrial function and suppression the oxidative stress in human adiposity cells. 生物活性肽PDBSN改善人类脂肪细胞的线粒体功能并抑制氧化应激。

IF 3.5 4区生物学

Adipocyte Pub Date : 2025-12-01 Epub Date: 2025-06-17 DOI: 10.1080/21623945.2023.2278213

Huiping Shen, Yong Lei, Wen Xie, Tieliang Ma, Li Bao, Qin Gao, Bingyu Chen, Biao Dai, Dani Qin

{"title":"Bioactive peptides PDBSN improve mitochondrial function and suppression the oxidative stress in human adiposity cells.","authors":"Huiping Shen, Yong Lei, Wen Xie, Tieliang Ma, Li Bao, Qin Gao, Bingyu Chen, Biao Dai, Dani Qin","doi":"10.1080/21623945.2023.2278213","DOIUrl":"10.1080/21623945.2023.2278213","url":null,"abstract":"Mitochondria are essential for generating cellular energy and are significant in the pathogenesis of obesity. Human visceral and subcutaneous preadipocytes (HPA-v and HPA-s) were cultured into mature adipocytes. Intracellular triglyceride (TG) content was assessed using oil-red O staining and tissue triglyceride determination. Mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) levels were measured with fluorescent indicators. Gene and protein expression related to mitochondrial biogenesis were analyzed by real-time quantitative PCR and Western blotting. Morphological changes were observed via electron microscopy. Results show that PDBSN significantly increased MMP while decreasing TG and ROS levels. The transcription and protein levels of PGC1-α and MTFA were upregulated, and mitochondrial fusion and fission markers (MFN1, MFN2, NRF1, DRP1) were elevated. Additionally, PDBSN enhanced maximum respiratory capacity and reduced ROS. These findings suggest that PDBSN improves mitochondrial function, providing insights for obesity treatment and metabolic disease management.","PeriodicalId":7226,"journal":{"name":"Adipocyte","volume":" ","pages":"2278213"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12184117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71520168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One-year metreleptin in Colombian sisters with congenital leptin deficiency. 患有先天性瘦素缺乏症的哥伦比亚姐妹服用一年的美曲瘦素。

IF 3.1 4区生物学

Adipocyte Pub Date : 2025-12-01 Epub Date: 2025-05-26 DOI: 10.1080/21623945.2025.2508188

Hernan Yupanqui-Lozno, Jancy Andrea Huertas-Quintero, Maria E Yupanqui-Velazco, Rocío A Salinas-Osornio, Carlos M Restrepo, Adriana Gonzalez, Edna J Nava-Gonzalez, Luis G Celis-Regalado, Constanza Neri Morales, Victor M Hernandez-Escalante, Julio Licinio, Hugo A Laviada-Molina, Ernesto Rodriguez-Ayala, Carlos Arango, Raul A Bastarrachea

{"title":"One-year metreleptin in Colombian sisters with congenital leptin deficiency.","authors":"Hernan Yupanqui-Lozno, Jancy Andrea Huertas-Quintero, Maria E Yupanqui-Velazco, Rocío A Salinas-Osornio, Carlos M Restrepo, Adriana Gonzalez, Edna J Nava-Gonzalez, Luis G Celis-Regalado, Constanza Neri Morales, Victor M Hernandez-Escalante, Julio Licinio, Hugo A Laviada-Molina, Ernesto Rodriguez-Ayala, Carlos Arango, Raul A Bastarrachea","doi":"10.1080/21623945.2025.2508188","DOIUrl":"10.1080/21623945.2025.2508188","url":null,"abstract":"We discovered two adult sisters in Colombia, lineally consanguineous, with severe obesity and undetectable serum leptin levels despite markedly elevated body fat. Their clinical profile included childhood-onset extreme weight gain, intense hunger, hyperphagia, hypogonadotropic hypogonadism, and family history of obesity. Direct sequencing of the LEP gene revealed a novel homozygous missense mutation in exon 3 (c.350G>T [p.C117F]). The presence of this mutation, undetectable leptin, and severe obesity confirmed a diagnosis of monogenic leptin deficiency. Here we describe the clinical outcomes of a 12-month treatment with recombinant human leptin (metreleptin). Metabolic and endocrine assessments were conducted before and after therapy. Metreleptin therapy significantly reduced BMI: from 59 to 38 kg/m2 (OBX1, age 27) and 60 to 48 kg/m2 (OBX2, age 24). Total body fat mass decreased, serum lipids normalized, and insulin sensitivity improved. Hypogonadotropic hypogonadism reversed, and menstruation resumed. Thus, metreleptin reversed the major metabolic and endocrine abnormalities associated with leptin deficiency in these sisters. Limitations include the small sample size, absence of a control group, and lack of anti-metreleptin antibody measurements. Nevertheless, our findings support that leptin replacement with metreleptin is currently the only effective hormonal treatment for this monogenic form of human obesity.","PeriodicalId":7226,"journal":{"name":"Adipocyte","volume":"14 1","pages":"2508188"},"PeriodicalIF":3.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-inflammatory effect of Angiotensin 1-7 in white adipose tissue. 血管紧张素1-7在白色脂肪组织中的抗炎作用。

IF 3.5 4区生物学

Adipocyte Pub Date : 2025-12-01 Epub Date: 2025-01-13 DOI: 10.1080/21623945.2024.2449027

Nozomi Nishida, Satoru Sugimoto, Satoshi Miyagaki, Chiharu Cho, Madoka Konishi, Takeshi Goda, Mihoko Yamaguchi, Yasuhiro Kawabe, Hidechika Morimoto, Joji Kusuyama, Takuro Okamura, Masahide Hamaguchi, Jun Mori, Hisakazu Nakajima, Michiaki Fukui, Tomoko Iehara

{"title":"Anti-inflammatory effect of Angiotensin 1-7 in white adipose tissue.","authors":"Nozomi Nishida, Satoru Sugimoto, Satoshi Miyagaki, Chiharu Cho, Madoka Konishi, Takeshi Goda, Mihoko Yamaguchi, Yasuhiro Kawabe, Hidechika Morimoto, Joji Kusuyama, Takuro Okamura, Masahide Hamaguchi, Jun Mori, Hisakazu Nakajima, Michiaki Fukui, Tomoko Iehara","doi":"10.1080/21623945.2024.2449027","DOIUrl":"10.1080/21623945.2024.2449027","url":null,"abstract":"Obesity is a global health concern that promotes chronic low-grade inflammation, leading to insulin resistance, a key factor in many metabolic diseases. Angiotensin 1-7 (Ang 1-7), a component of the renin-angiotensin system (RAS), exhibits anti-inflammatory effects in obesity and related disorders, though its mechanisms remain unclear. In this study, we examined the effect of Ang 1-7 on inflammation of white adipose tissue (WAT) in dietary-induced obese mice. Monocyte chemoattractant protein-1 (MCP-1) produced by white adipocytes and tumour necrosis factor-α (TNF-α) produced by macrophages are pro-inflammatory cytokines and interact to form a pathogenic loop to exacerbate obesity-induced inflammation. We found that Ang 1-7 reduced MCP-1 and TNF-α gene expressions and the number of crown-like structures, which are histological hallmarks of the pro-inflammatory process, in visceral epididymal WAT (eWAT) and reduced circulating MCP-1 and TNF-α levels, accompanied by improvement in insulin resistance, in dietary-induced obese mice. Furthermore, Ang 1-7 reduced MCP-1 and TNF-α secretions in 3T3-L1 white adipocytes and RAW 264.7 macrophages, respectively, which are in vitro experimental models mimicking obesity condition. Our results suggest that Ang 1-7 directly acts on WAT to mitigate obesity-induced inflammation. Thus, this study provides novel insights into the underlying mechanism of anti-obesity effects of Ang 1-7.","PeriodicalId":7226,"journal":{"name":"Adipocyte","volume":"14 1","pages":"2449027"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11730366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0