脂肪组织浸润与心脏功能的关系:范围回顾。

IF 3.5 4区 生物学 Q2 ENDOCRINOLOGY & METABOLISM
Adipocyte Pub Date : 2025-12-01 Epub Date: 2025-04-10 DOI:10.1080/21623945.2025.2489467
Mansour M Alotaibi, Naif Z Alrashdi, Marzouq K Almutairi Pt, Mohammed M Alqahtani, Anwar B Almutairi, Sami M Alqahtani, Hamoud M Alajel, Amani K Bajunayd
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引用次数: 0

摘要

有证据表明,骨骼肌中的脂肪组织(AT)浸润可能对心功能产生负面影响,但其作为生物标志物的用途尚不清楚。本综述研究了成人AT浸润与心功能之间的关系。对PubMed、CINAHL和SCOPUS进行系统搜索,确定了同行评审的研究报告AT浸润和心功能测量。排除综述型研究、动物研究、摘要和病例系列。使用研究质量评估工具(SQAT)评估研究质量。纳入了三项高质量的研究。研究结果表明,在癌症幸存者和健康个体中,AT浸润与心功能参数(包括运动能力、左心室射血分数(LVEF)和心力衰竭事件)呈负相关。有证据支持骨骼肌AT浸润增加与心功能受损之间的关联,强调需要进一步研究以验证AT浸润作为潜在的生物标志物。尽管现有的研究有限,但我们的研究结果强调了骨骼肌AT浸润与心功能障碍之间的明显关联,与一般肥胖无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of adipose tissue infiltration with cardiac function: scoping review.

Evidence suggests that adipose tissue (AT) infiltration in skeletal muscles may negatively influence cardiac function, yet its use as a biomarker remains unclear. This scoping review examined the relationship between AT infiltration and cardiac function in adults. A systematic search of PubMed, CINAHL and SCOPUS identified peer-reviewed studies reporting AT infiltration and cardiac function measures. Excluded were review-type studies, animal studies, abstracts and case series. Study quality was assessed using the Study Quality Assessment Tool (SQAT). Three good-quality studies were included. Findings demonstrated a negative association between AT infiltration and cardiac function parameters, including exercise capacity, left ventricular ejection fraction (LVEF) and heart failure events, in cancer survivors and healthy individuals. There is evidence supporting an association between increased AT infiltration of skeletal muscles and impaired cardiac function, highlighting the need for further research to validate AT infiltration as a potential biomarker. Despite the limited available studies, our findings highlight a distinct association between skeletal muscle AT infiltration and cardiac dysfunction, independent of general obesity.

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来源期刊
Adipocyte
Adipocyte Medicine-Histology
CiteScore
6.50
自引率
3.00%
发文量
46
审稿时长
32 weeks
期刊介绍: Adipocyte recognizes that the adipose tissue is the largest endocrine organ in the body, and explores the link between dysfunctional adipose tissue and the growing number of chronic diseases including diabetes, hypertension, cardiovascular disease and cancer. Historically, the primary function of the adipose tissue was limited to energy storage and thermoregulation. However, a plethora of research over the past 3 decades has recognized the dynamic role of the adipose tissue and its contribution to a variety of physiological processes including reproduction, angiogenesis, apoptosis, inflammation, blood pressure, coagulation, fibrinolysis, immunity and general metabolic homeostasis. The field of Adipose Tissue research has grown tremendously, and Adipocyte is the first international peer-reviewed journal of its kind providing a multi-disciplinary forum for research focusing exclusively on all aspects of adipose tissue physiology and pathophysiology. Adipocyte accepts high-profile submissions in basic, translational and clinical research.
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