Adipocyte最新文献_第3页

Disease-associated adipose browning: current evidence and perspectives. 疾病相关脂肪褐变：目前的证据和观点。

IF 3.3 4区生物学

Adipocyte Pub Date : 2026-12-01 Epub Date: 2026-01-07 DOI: 10.1080/21623945.2025.2610540

Xiyue Zhang, Xue Han, Jiesi Xu, Guoping Li

{"title":"Disease-associated adipose browning: current evidence and perspectives.","authors":"Xiyue Zhang, Xue Han, Jiesi Xu, Guoping Li","doi":"10.1080/21623945.2025.2610540","DOIUrl":"10.1080/21623945.2025.2610540","url":null,"abstract":"Brown and beige adipose tissue represent evolutionary adaptations in mammals, functioning as specialized thermogenic organs to maintain body temperature. Over the past two decades, researches have demonstrated that white adipose tissue (WAT) browning is an effective strategy to enhance energy expenditure. However, a growing body of evidence indicates that the browning process frequently occurs in a variety of chronic disease states, though its pathophysiological significance remains unclear. This review summarized evidence of pathological browning observed in human diseases and animal models, including breast cancer, colorectal cancer (CRC), clear cell renal cell carcinoma (ccRCC), kidney health, burn injury, atherosclerotic, SARS-CoV-2 and sepsis. Despite distinct pathological contexts, adipose tissue browning is consistently observed. This suggests that browning may not simply serve its classical metabolically protective role, but instead reflect an atypical response to pathological stress. It is currently unclear whether this is a compensatory mechanism by the organism in a diseased state or merely a byproduct of the disease process. Whether this response is adaptive or a cause of disease progression remains unresolved. Future research should therefore focus on identifying the triggers and functional outcomes of pathological browning to better understand adipocyte plasticity and its role in disease progression.","PeriodicalId":7226,"journal":{"name":"Adipocyte","volume":"15 1","pages":"2610540"},"PeriodicalIF":3.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12785212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145909710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erianin inhibits 3T3-L1 adipocyte differentiation through downregulation of CCAAT-enhancer binding protein-α and peroxisome proliferator-activated receptor-γ, lipogenic genes and impairment of mitochondrial respiration. Erianin通过下调ccaat增强子结合蛋白-α和过氧化物酶体增殖物激活受体-γ、脂质基因和线粒体呼吸损伤来抑制3T3-L1脂肪细胞分化。

IF 3.1 4区生物学

Adipocyte Pub Date : 2026-12-01 Epub Date: 2025-12-19 DOI: 10.1080/21623945.2025.2601405

Hathaichanok Yimpreeda, Chayanee Laowittawat, Siraprapa Siritutsoontorn, Pinnara Rojvirat, Sarawut Kumphune, Sarawut Jitrapakdee

{"title":"Erianin inhibits 3T3-L1 adipocyte differentiation through downregulation of CCAAT-enhancer binding protein-α and peroxisome proliferator-activated receptor-γ, lipogenic genes and impairment of mitochondrial respiration.","authors":"Hathaichanok Yimpreeda, Chayanee Laowittawat, Siraprapa Siritutsoontorn, Pinnara Rojvirat, Sarawut Kumphune, Sarawut Jitrapakdee","doi":"10.1080/21623945.2025.2601405","DOIUrl":"10.1080/21623945.2025.2601405","url":null,"abstract":"Erianin, a natural bibenzyl compound, has recently garnered attention owing to its diverse biological activities. In the present study, we investigated the effects of Erianin on adipocyte differentiation, lipid metabolism, and mitochondrial respiration in murine 3T3-L1 cells. Cytotoxicity assays indicated that Erianin exhibited low toxicity towards preadipocytes at concentrations up to 200 μM. Treatment with 20 μM Erianin completely inhibited the differentiation of 3T3-L1 preadipocytes into mature adipocytes and reduced lipid droplets. Western blot analysis revealed that Erianin attenuated Akt and p38 MAPK signalling without inducing apoptosis, suppressed the expression of key pro-adipogenic transcription factors, C/EBPα and PPARγ during the early stages of differentiation. This suppression was accompanied by the downregulation of lipogenic enzymes, including acetyl-CoA carboxylase 1 (ACC1), fatty acid synthase (FASN), pyruvate carboxylase (PC) and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR). While early-stage differentiation was robustly inhibited, higher concentrations (≥25 μM) were required to suppress terminal differentiation of immature adipocytes. This late-stage inhibition was accompanied by decreased expression of PPARγ, PC, and HMGCR, with minimal effects on ACC1 and FASN, suggesting a more modest role for Erianin in terminal adipogenesis. Assessment of mitochondrial metabolism of 3T3-L1 cells following 24-hour treatment of Erianin showed that it modestly impaired ATP-linked respiration, maximal respiration, spare respiratory capacity and intracellular ATP levels while basal respiration was unaffected. Collectively, these findings indicated that Erianin predominantly targets early adipogenic differentiation and mitochondrial bioenergetics.","PeriodicalId":7226,"journal":{"name":"Adipocyte","volume":"15 1","pages":"2601405"},"PeriodicalIF":3.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12721086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145792858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Normalized periprostatic adipose tissue thickness: an imaging marker associated with prostate biopsy outcomes among patients with PI-RADS and PSA double gray zone. 标准化前列腺周围脂肪组织厚度：与PI-RADS和PSA双灰色区患者前列腺活检结果相关的影像学标志物

IF 3.3 4区生物学

Adipocyte Pub Date : 2026-12-01 Epub Date: 2026-06-02 DOI: 10.1080/21623945.2026.2683754

Tianyu Xiong, Liting Shen, Yunpeng Fan, Zhanliang Liu, Song Jin, Haoyu Wu, Zhenghan Yang, Yinong Niu

{"title":"Normalized periprostatic adipose tissue thickness: an imaging marker associated with prostate biopsy outcomes among patients with PI-RADS and PSA double gray zone.","authors":"Tianyu Xiong, Liting Shen, Yunpeng Fan, Zhanliang Liu, Song Jin, Haoyu Wu, Zhenghan Yang, Yinong Niu","doi":"10.1080/21623945.2026.2683754","DOIUrl":"10.1080/21623945.2026.2683754","url":null,"abstract":"Periprostatic adipose tissue (PPAT) is a potential factor closely associated with prostate cancer (PCa) development. This study aimed to introduce normalized PPAT thickness, a novel imaging biomarker, as a PCa predictor for patients within the diagnostic 'double gray zone', defined as the combination of Prostate Imaging Reporting and Data System (PI-RADS) score 3 lesions and serum prostate-specific antigen (PSA) levels of 4-10 ng/mL. A total of 219 patients were retrospectively enrolled. PPAT thickness was measured on pre-biopsy MRI. Pearson correlation analysis was performed to assess the relationship between BMI and PPAT thickness. Independent predictors of PCa were investigated by logistic regression analysis. Normalized PPAT thickness was defined as the ratio of PPAT thickness to prostate volume, and its predictive performance was compared with PSA density (PSAD). Restricted cubic spline analysis was performed to determine its optimal threshold for PCa prediction. A negative correlation was observed between PPAT thickness and BMI (ρ = -0.154, p = 0.023), suggesting that PPAT is less affected by overall obesity. PPAT thickness was significantly higher in PCa patients (0.52 vs. 0.36 cm, p < 0.001) and was identified as an independent PCa predictor (OR 1.523, 95% CI 1.252-1.853, p < 0.001). Normalized PPAT thickness outperformed PSAD for predicting clinically significant PCa (csPCa) (AUC 0.819 vs. 0.690, p = 0.003), and its threshold of 14 outperformed the traditional PSAD threshold > 0.15 (csPCa detection rate 39.2% vs. 21.7%). In conclusion, we proposed normalized PPAT thickness as a novel PCa predictor in the diagnostically challenging 'double gray zone' cohort.","PeriodicalId":7226,"journal":{"name":"Adipocyte","volume":"15 1","pages":"2683754"},"PeriodicalIF":3.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13240959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148147878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wt1 facilitates visceral beige fat formation to combat abdominal obesity. Wt1促进内脏米色脂肪的形成，以对抗腹部肥胖。

IF 3.3 4区生物学

Adipocyte Pub Date : 2026-12-01 Epub Date: 2026-05-13 DOI: 10.1080/21623945.2026.2658408

Lin-Fei He, Zhi-Mei Liao, Jun-Ling Chen, Zhi-Chun Yang

{"title":"Wt1 facilitates visceral beige fat formation to combat abdominal obesity.","authors":"Lin-Fei He, Zhi-Mei Liao, Jun-Ling Chen, Zhi-Chun Yang","doi":"10.1080/21623945.2026.2658408","DOIUrl":"10.1080/21623945.2026.2658408","url":null,"abstract":"Visceral fat has weaker beige adipogenesis than subcutaneous fat with unclear mechanisms. The Wilms tumour gene (Wt1), a visceral adipocyte marker, is highly expressed in visceral adipose tissue (VAT) and visceral adipose-derived stem cells (vADSCs). In our present study, we found its protein levels in VAT decreased under high-fat diet or dexamethasone treatment, but rised in cold exposure or β3-adrenergic receptor agonist treatment, and positively correlate with uncoupling protein-1 (UCP1). Wt1 knockdown in vADSCs elevated PR domain containing 16 (PRDM16) and UCP1 mRNA but reduced their protein levels, alongside decreased ubiquitin-conjugating enzyme 9 (UBC9). Knockdown of UBC9 did not affect the mRNA levels of Wt1, PRDM16 or UCP1, but significantly reduced PRDM16 and UCP1 protein levels. Glucocorticoids including hydrocortisone, methylprednisolone and dexamethasone (Dex) dose-dependently suppress Wt1, UCP1, Alpha-enolase (ENO1) and Pyruvate kinase muscle isozyme M2 (PKM2) levels, which could be reversed by Wt1 overexpression. These findings explore the effects of Wt1 on beige remodelling of visceral adipose which might be related to the up-regulation of UBC9, and provide clues for treating abdominal obesity caused either by HFD or by glucocorticoids in a non-sympathetic-dependent manner.","PeriodicalId":7226,"journal":{"name":"Adipocyte","volume":"15 1","pages":"2658408"},"PeriodicalIF":3.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13174006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147925543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The transcription elongation factors Spt4 and Spt6 promote dermal adipocyte differentiation. 转录延伸因子Spt4和Spt6促进真皮脂肪细胞分化。

IF 3.3 4区生物学

Adipocyte Pub Date : 2026-12-01 Epub Date: 2026-03-27 DOI: 10.1080/21623945.2026.2650002

Julian Gomez, Samiksha Mahapatra, Uyanga Batzorig, Ye Liu, Celia Fernández-Méndez, Neha Quadir, George L Sen

{"title":"The transcription elongation factors Spt4 and Spt6 promote dermal adipocyte differentiation.","authors":"Julian Gomez, Samiksha Mahapatra, Uyanga Batzorig, Ye Liu, Celia Fernández-Méndez, Neha Quadir, George L Sen","doi":"10.1080/21623945.2026.2650002","DOIUrl":"10.1080/21623945.2026.2650002","url":null,"abstract":"Regulation of adipogenesis has classically been viewed through the lens of transcription initiation driven by lineage defining transcription factors. In this study, we uncover transcription elongation as a critical and previously underappreciated regulatory layer controlling adipocyte cell fate. We demonstrate that the elongation factors Spt4 and Spt6 are indispensable for adipogenic differentiation, as their depletion severely impairs adipogenic gene induction and perilipin expression. Spt4 and Spt6 directly regulate the genes coding for core adipogenic transcription factors, including Cebpa, Pparg, Krox20, and Stat3, by promoting RNA polymerase II (Pol II) progression through their gene bodies. In the absence of these factors, Pol II becomes stalled at the transcriptional start sites of these adipogenic genes. These data support a post transcription initiation requirement for Spt4 and Spt6 in productive elongation rather than promoter loading. Our findings identify transcription elongation control as a key determinant of adipogenic fate.","PeriodicalId":7226,"journal":{"name":"Adipocyte","volume":"15 1","pages":"2650002"},"PeriodicalIF":3.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13034627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147525286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The adiponectin/leptin ratio as a biomarker of adiposopathy and visceral adipose tissue accumulation: sex-specific mechanisms. 脂联素/瘦素比率作为脂肪病和内脏脂肪组织积累的生物标志物：性别特异性机制。

IF 3.3 4区生物学

Adipocyte Pub Date : 2026-12-01 Epub Date: 2026-04-07 DOI: 10.1080/21623945.2026.2653961

Aida Medina-Urrutia, Iván Torre-Villalvazo, Andrea Díaz-Villaseñor, Esteban Jorge-Galarza, Luz Graciela Cervantes-Pérez, Neftali Eduardo Antonio-Villa, Felipe Santibañez-Escobar, Gabriela Leal-Escobar, Brenda Marquina-Castillo, Froylan David Martínez-Sánchez, Juan Gabriel Juárez-Rojas

{"title":"The adiponectin/leptin ratio as a biomarker of adiposopathy and visceral adipose tissue accumulation: sex-specific mechanisms.","authors":"Aida Medina-Urrutia, Iván Torre-Villalvazo, Andrea Díaz-Villaseñor, Esteban Jorge-Galarza, Luz Graciela Cervantes-Pérez, Neftali Eduardo Antonio-Villa, Felipe Santibañez-Escobar, Gabriela Leal-Escobar, Brenda Marquina-Castillo, Froylan David Martínez-Sánchez, Juan Gabriel Juárez-Rojas","doi":"10.1080/21623945.2026.2653961","DOIUrl":"10.1080/21623945.2026.2653961","url":null,"abstract":"Adipose tissue (AT) dysfunction can lead to increased visceral AT (VAT) and metabolic damage. The adiponectin/leptin ratio (ALR) has been proposed as a biomarker of AT functionality. However, its participation in VAT accumulation and the impact of sex on these associations have not been evaluated. In an analytical cross-sectional study, 54 adults (29 male, 25 postmenopausal females, aged 30-70 years, BMI 19-31 kg/m2) were analysed. Anthropometric data, fasting serum samples, and subcutaneous AT (SAT) biopsies were obtained. Morpho-functional AT characteristics included ALR, adipocyte size, macrophage content and AT insulin resistance (ADIPO-IR). Using multivariate and mediation models, we evaluated the associations of SAT characteristics with systemic IR (TyG index), systemic inflammation (C-reactive protein), and VAT area. In postmenopausal females, ALR was inversely associated with adipocyte size, macrophage number, TyG index, CRP, and VAT area. SAT inflammation and ADIPO-IR were independently associated with VAT, and a mediation model suggested ALR as a possible precursor of VAT. Among males, ADIPO-IR and ALR were independently associated with VAT. These findings emphasize the importance of considering sex differences in the prevention and treatment strategies for metabolic diseases among Mexican-Mestizo populations, although these results should be confirmed by prospective studies.","PeriodicalId":7226,"journal":{"name":"Adipocyte","volume":"15 1","pages":"2653961"},"PeriodicalIF":3.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13064561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147631951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autofluorescence profiles define depot-specific adipocyte phenotypes in perivascular and non-perivascular adipose tissue. 自体荧光谱定义了血管周围和非血管周围脂肪组织中储存特异性脂肪细胞表型。

IF 3.3 4区生物学

Adipocyte Pub Date : 2026-12-01 Epub Date: 2026-08-18 DOI: 10.1080/21623945.2026.2718625

C Javier Rendon, Allison D Redondo-Aguilar, Daniel Vocelle, Matthew P Bernard, D Adam Lauver, Stephanie W Watts, G Andres Contreras

{"title":"Autofluorescence profiles define depot-specific adipocyte phenotypes in perivascular and non-perivascular adipose tissue.","authors":"C Javier Rendon, Allison D Redondo-Aguilar, Daniel Vocelle, Matthew P Bernard, D Adam Lauver, Stephanie W Watts, G Andres Contreras","doi":"10.1080/21623945.2026.2718625","DOIUrl":"https://doi.org/10.1080/21623945.2026.2718625","url":null,"abstract":"Perivascular adipose tissue (PVAT) is recognized as the functional fourth layer of the vasculature. Unlike non-PVAT depots, PVAT is continuously exposed to haemodynamic forces, potentially altering the morphometry of its adipocytes. While transcriptomics studies have identified diverse adipocyte populations, characterizing these cells remains difficult because their inherent fragility limits standard antibody-based phenotyping. Autofluorescence has emerged as a label-free alternative for characterizing cellular heterogeneity. However, autofluorescence-based characterization of PVAT adipocytes remains unexplored, and it is unknown if these cells exhibit distinct profiles reflecting their specific anatomical location. This study aimed to define the autofluorescence profiles of PVAT and non-PVAT adipocytes. Using Sprague-Dawley rats (n = 6), we assessed intrinsic fluorescence in adipocytes from PVATs of thoracic and abdominal aorta, and from mesenteric arteries alongside phenotype-matched non-PVAT counterparts: interscapular brown, subcutaneous, and retroperitoneal tissues. Using optimized methods to maintain adipocyte integrity, we demonstrate that thoracic and intrascapular exhibit similar autofluorescence profiles. In contrast, PVAT sites mesenteric and abdominal diverge across the yellow, red, and violet channels compared with non-PVAT depots, retroperitoneal and subcutaneous. In conclusion, PVAT and non-PVAT adipocytes exhibit depot-specific spectral patterns, with higher autofluorescence observed in PVAT cells, validating autofluorescence as a marker-independent approach for identifying adipocyte differences.","PeriodicalId":7226,"journal":{"name":"Adipocyte","volume":"15 1","pages":"2718625"},"PeriodicalIF":3.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13488464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role and mechanism of UPRmt in adipocytes. UPRmt在脂肪细胞中的作用及机制。

IF 3.3 4区生物学

Adipocyte Pub Date : 2026-12-01 Epub Date: 2026-04-13 DOI: 10.1080/21623945.2026.2651605

Hao Liu, Jie Chen, Dan-Qi Qiu, Miao-Wei Jiang, Hao-Qi Chen, Li Li, Shu-Qin Chen

引用次数: 0

Lack of receptor for advanced glycation end products attenuates obesity-induced adipose tissue senescence in mice. 缺乏晚期糖基化终产物受体可减轻小鼠肥胖诱导的脂肪组织衰老。

IF 3.3 4区生物学

Adipocyte Pub Date : 2026-12-01 Epub Date: 2026-01-09 DOI: 10.1080/21623945.2025.2611481

Zuoqin Du, Jiaqi Wu, Tao Zhang, Xiaoyu Ma, Ziyu Li, Jin Xu, Jingcan You, Ni Chen, Jianbo Wu

{"title":"Lack of receptor for advanced glycation end products attenuates obesity-induced adipose tissue senescence in mice.","authors":"Zuoqin Du, Jiaqi Wu, Tao Zhang, Xiaoyu Ma, Ziyu Li, Jin Xu, Jingcan You, Ni Chen, Jianbo Wu","doi":"10.1080/21623945.2025.2611481","DOIUrl":"10.1080/21623945.2025.2611481","url":null,"abstract":"The receptor for advanced glycation end products (RAGE) and its ligands are critical drivers of adipose tissue inflammation. While RAGE expression increases in ageing cells and pathological conditions, its specific role in high-fat diet (HFD)-induced adipose tissue senescence remains to be fully elucidated. In this study, we investigated the function of RAGE in the development of adipose tissue senescence associated with obesity. We observed that HFD-fed RAGE-deficient (RAGE-/-) mice exhibited significantly reduced body weight and adipocyte hypertrophy compared to wild-type (WT) controls. At the molecular level, RAGE-/- mice displayed lower mRNA expression of cell cycle regulators and markers of the senescence-associated secretory phenotype. This anti-senescent phenotype was accompanied by decreased reactive oxygen species (ROS) production and elevated expression of anti-oxidant genes. Mechanistically, the lack of RAGE resulted in the upregulation of silent information regulator type 1 (SIRT1) in adipose tissues. Notably, the inhibition of SIRT1 reversed these anti-senescent effects and attenuated anti-oxidant gene expression in RAGE-deficient mice. Furthermore, while antioxidant treatment with N-acetylcysteine (NAC) reduced p53 in WT mice, it failed to fully suppress p16 and p21, whereas NAC treatment in RAGE-/- mice significantly downregulated all senescence markers, suggesting a synergistic protective effect. In conclusion, our results demonstrated that RAGE deficiency improved anti-oxidant properties and prevents adipocyte senescence via the SIRT1 signalling pathway, highlighting a potential therapeutic target for obesity-associated tissue dysfunction.","PeriodicalId":7226,"journal":{"name":"Adipocyte","volume":"15 1","pages":"2611481"},"PeriodicalIF":3.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12795267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145931835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioinformatics analysis identifies key secretory protein-encoding differentially expressed genes in adipose tissue of metabolic syndrome. 生物信息学分析鉴定代谢综合征脂肪组织中关键分泌蛋白编码差异表达基因。

IF 3.1 4区生物学

Adipocyte Pub Date : 2025-12-01 Epub Date: 2025-01-16 DOI: 10.1080/21623945.2024.2446243

Jiandong Zhou, Yunshan Guo, Xuan Liu, Weijie Yuan

{"title":"Bioinformatics analysis identifies key secretory protein-encoding differentially expressed genes in adipose tissue of metabolic syndrome.","authors":"Jiandong Zhou, Yunshan Guo, Xuan Liu, Weijie Yuan","doi":"10.1080/21623945.2024.2446243","DOIUrl":"10.1080/21623945.2024.2446243","url":null,"abstract":"The objective of this study was to identify key secretory protein-encoding differentially expressed genes (SP-DEGs) in adipose tissue in female metabolic syndrome, thus detecting potential targets in treatment. We examined gene expression profiles in 8 women with metabolic syndrome and 7 healthy, normal body weight women. A total of 143 SP-DEGs were screened, including 83 upregulated genes and 60 downregulated genes. GO analyses of these SP-DEGs included proteolysis, angiogenesis, positive regulation of endothelial cell proliferation, immune response, protein processing, positive regulation of neuroblast proliferation, cell adhesion and ER to Golgi vesicle-mediated transport. KEGG pathway analysis of the SP-DEGs were involved in the TGF-beta signalling pathway, cytokine‒cytokine receptor interactions, the hippo signalling pathway, Malaria. Two modules were identified from the PPI network, namely, Module 1 (DNMT1, KDM1A, NCoR1, and E2F1) and Module 2 (IL-7 R, IL-12A, and CSF3). The gene DNMT1 was shared between the network modules and the WGCNA brown module. According to the single-gene GSEA results, DNMT1 was significantly positively correlated with histidine metabolism and phenylalanine metabolism. This study identified 7 key SP-DEGs in adipose tissue. DNMT1 was selected as the central gene in the development of metabolic syndrome and might be a potential therapeutic target.","PeriodicalId":7226,"journal":{"name":"Adipocyte","volume":"14 1","pages":"2446243"},"PeriodicalIF":3.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12885428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0