Adipose tissue and androgens: the ins and outs.

IF 3.5 4区 生物学 Q2 ENDOCRINOLOGY & METABOLISM
Adipocyte Pub Date : 2025-12-01 Epub Date: 2025-06-09 DOI:10.1080/21623945.2025.2508885
Yiyue Jia, Mathilde Lacombe, Catherine Muller, Delphine Milhas
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引用次数: 0

Abstract

Adipose tissue (AT), one of the largest endocrine tissues in the human body, is an important site for the storage and production of steroid hormones. In particular, AT's capacity to produce androgens could enable it to have a regulatory role in local or general hormone homoeostasis. The links between obesity, polycystic ovary syndrome (PCOS), metabolic disorders, and hormonal balance emphasise the importance of understanding the intricate relationships between AT and androgen dynamics within AT. This review, focusing on androgen metabolism, summarises the androgen profile in white adipose tissue (WAT) and brown adipose tissue (BAT) of humans and animal models, along with the androgen-metabolising enzymes present in WAT, and explores the role of androgens on AT physiology.

脂肪组织和雄激素:来龙去脉。
脂肪组织(AT)是人体最大的内分泌组织之一,是储存和产生类固醇激素的重要部位。特别是,AT产生雄激素的能力可能使其在局部或整体激素平衡中具有调节作用。肥胖、多囊卵巢综合征(PCOS)、代谢紊乱和激素平衡之间的联系强调了理解AT和AT内雄激素动力学之间复杂关系的重要性。本文以雄激素代谢为重点,综述了人类和动物模型中白色脂肪组织(WAT)和棕色脂肪组织(BAT)中的雄激素特征,以及WAT中存在的雄激素代谢酶,并探讨了雄激素在AT生理学中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Adipocyte
Adipocyte Medicine-Histology
CiteScore
6.50
自引率
3.00%
发文量
46
审稿时长
32 weeks
期刊介绍: Adipocyte recognizes that the adipose tissue is the largest endocrine organ in the body, and explores the link between dysfunctional adipose tissue and the growing number of chronic diseases including diabetes, hypertension, cardiovascular disease and cancer. Historically, the primary function of the adipose tissue was limited to energy storage and thermoregulation. However, a plethora of research over the past 3 decades has recognized the dynamic role of the adipose tissue and its contribution to a variety of physiological processes including reproduction, angiogenesis, apoptosis, inflammation, blood pressure, coagulation, fibrinolysis, immunity and general metabolic homeostasis. The field of Adipose Tissue research has grown tremendously, and Adipocyte is the first international peer-reviewed journal of its kind providing a multi-disciplinary forum for research focusing exclusively on all aspects of adipose tissue physiology and pathophysiology. Adipocyte accepts high-profile submissions in basic, translational and clinical research.
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