Annals of 3D printed medicine最新文献

{"title":"StemCurCol – 3D printed scaffold for diabetic wound regeneration","authors":"Henrique Luis Piva ,&nbsp;Mariana Santos de Queiroz ,&nbsp;Flavia Sayuri Matsuo ,&nbsp;Hiago Salge Borges ,&nbsp;Mariana Kiomy Osako ,&nbsp;Antonio Claudio Tedesco","doi":"10.1016/j.stlm.2025.100203","DOIUrl":"10.1016/j.stlm.2025.100203","url":null,"abstract":"<div><div>Diabetic wounds, particularly diabetic foot ulcers, pose a significant challenge for treatment due to impaired healing and susceptibility to complications. The complex pathophysiology of wounds involves dysregulated cellular and molecular processes. Advanced therapeutic strategies are needed to address the different stages of wound healing. Curcumin, a natural polyphenol, has been shown to enhance epidermal re-epithelialization, mobilize cellular participants in wound repair, and improve different stages of wound healing. In this work curcumin-chitosan nanoparticles have been prepared and characterized, and incorporated in collagen with stem cells and were implanted into normal and diabetic mice with induced wounds and their effects on wound healing were evaluated over 14 days. Animals treated with StemCurCol scaffolds presented faster closure rates and enhanced re-epithelialization than the controls, and the cells contributed to regeneration by forming new tissues, and rapidly closing wounds.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"18 ","pages":"Article 100203"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Affordable multicolor 3D printing solution for biomedical education in low- and middle-income countries","authors":"Dat Minh Lu ,&nbsp;Phong Van Dong ,&nbsp;Hien Bui Thu Hoang ,&nbsp;Dang Ngoc Tran ,&nbsp;Khiem Tran Dang ,&nbsp;Linh Thanh Duy Tran ,&nbsp;An Le Pham","doi":"10.1016/j.stlm.2025.100201","DOIUrl":"10.1016/j.stlm.2025.100201","url":null,"abstract":"<div><div>3D printing for biomedical education in universities remains largely inaccessible in low- and middle-income countries (LMICs) due to the high cost of commercial material jetting and powder bed fusion 3D printers. To address this barrier, we have developed an affordable multicolor fused deposition modeling (FDM) 3D printer capable of producing biomedical models with intricate geometries. The key innovation of our printer is the novel integration of two distinct hybrid printhead configurations to enable simultaneous multicolor printing and water-soluble support material deposition. Positioned along the same X-axis, the first printhead employs a filament cutting, retracting, and purging mechanism to print in seven colors, while the second printhead is dedicated to printing water-soluble support material. The printer utilizes a hybrid CoreXY kinematic system and offers a 30 × 30 × 30 cm print volume. Its operations are controlled by two MKS Monster8 V2.0 boards and an MKS Pi V1.1 running Klipper firmware, with Orca Slicer software converting 3D model data into printer-readable instructions. Our printer successfully operated for up to 45 h, producing four detailed heart models (18 × 15 × 10 cm) and a multicolor DNA polymerase model from online databases and CT scan images. Support structures were removed by immersing the prints in warm water for 24 h, ensuring precise structural integrity for complex models. By combining multicolor printing with water-soluble support material, our cost-effective, frugal innovation allows the fabrication of intricate, vibrant biomedical models, making 3D printing more feasible for biomedical education and research in LMICs.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"18 ","pages":"Article 100201"},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Powder bed fusion 3D printing for drug delivery and healthcare applications","authors":"Suraj Kumar ,&nbsp;Rishabha Malviya ,&nbsp;Sathvik Belagodu Sridhar ,&nbsp;Tarun Wadhwa ,&nbsp;Umme Hani ,&nbsp;Sirajunisa Talath ,&nbsp;Musarrat Husain Warsi","doi":"10.1016/j.stlm.2025.100200","DOIUrl":"10.1016/j.stlm.2025.100200","url":null,"abstract":"<div><div>Powder Bed Fusion (PBF) is a 3D printing technique that uses powdered materials, fused through various ignition sources, to create complex structures. Over time, PBF has evolved into several methods, including selective laser sintering/melting, direct metal laser sintering, electron beam melting, and multi-jet fusion. These advancements offer benefits such as improved resolution, faster printing speeds, and the ability to produce intricate designs without the need for additional support structures. This review examines the distinct roles and potential applications of PBF in pharmacology and biomedicine, focusing on the mechanisms behind the technology and its impact on personalized drug-loaded formulations, medical devices, and implants. PBF's versatility makes it ideal for biomedical applications, where precision and customization are essential. Its high resolution and speed enable the fabrication of detailed, individualized items, driving advancements in drug delivery and implant design. However, challenges remain, such as material constraints and the requirement for specific environmental conditions, which can influence product quality. This review emphasizes the innovative applications of PBF in pharmacology and biology and highlights its transformative potential in personalized medicine. By overcoming current limitations, PBF technology could further contribute to the development of advanced biomedicine and personalized treatment solutions.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"18 ","pages":"Article 100200"},"PeriodicalIF":0.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymeric hydrogels for bioprinting: A comprehensive review","authors":"Mohammad Amir Qureshi ,&nbsp;Basree ,&nbsp;Raqeeba Aziz ,&nbsp;Yasser Azim ,&nbsp;Musheer Ahmad","doi":"10.1016/j.stlm.2025.100198","DOIUrl":"10.1016/j.stlm.2025.100198","url":null,"abstract":"<div><div>Bio-printing; It is a technique to make bio-structure, has been steadily increasing the impact on society and it is transforming the science of biomaterials. It allows the direct production of customized products from biomaterials. This article is based on hydrogels for bioprinting. So, this article included a detailed discussion on different methods of bioprinting. Different characteristics of hydrogels for 3D bioprinting also discussed. Explanation regarding different types of crosslinking for the preparation of hydrogels is also featured. This review is also contains information regarding the use of different types of bio-polymeric and non-bio-polymeric hydrogels for 3D bioprinting. To last, this review has also discussed drawbacks of 3D bioprinting, transformation of 3D bioprinting to 4D bioprinting, expected steps in 4D bioprinting, and to last advantages of 4D bioprinting. This work will provide ample base for future work as it has the latest and ongoing information which researchers could use in tissue engineering and bioprinting domain.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"18 ","pages":"Article 100198"},"PeriodicalIF":0.0,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a fully digital design process for customized mandibular advancement and its precision additive manufacturing","authors":"Chinmai Bhat ,&nbsp;Yulius Shan Romario ,&nbsp;I-Ching Chou ,&nbsp;Wan-Rong Jiang ,&nbsp;Yu-Yan Wu ,&nbsp;Maziar Ramezani ,&nbsp;Cho-Pei Jiang","doi":"10.1016/j.stlm.2025.100199","DOIUrl":"10.1016/j.stlm.2025.100199","url":null,"abstract":"<div><div>This study aims to develop a fully digital workflow for the fabrication of customized mandibular advancement devices (MAD). MADs are used to treat obstructive sleep apnea and typically require 8–10 days to fabricate as per the patient's specifications. The currently designed digital methodology considerably shortens this timescale to 2–3 days, providing a viable alternative to traditional methods. The process integrates digital intraoral scanning, computer-aided modeling, and additive manufacturing using DD guide material through digital light processing technology. Along with the integration, the workflow also optimizes scanning accuracy, printing orientation, precision, and usability. The precision of fabrication was examined by scanning the fabricated part with the stereolithography file. The root mean square value of 0.0287 mm indicates that the fabricated device is within the clinical accuracy and thus can be used for mandibular advancement. Furthermore, the analysis indicates that printing orientations of 0° and 45° deliver higher precision and surface quality, with the 45° proving to be most cost-effective for grinding and post-processing. The post-processing greatly reduced the surface roughness thereby increasing the comfortability and hygiene. The durability of the fabricated MADs was proved through the unaffected mechanical properties even after washing &gt;1000 times (equivalent to 3 years). Contributing to the wider adoption of digital procedures in dental clinics and coinciding with current market trends toward patient-specific solutions, this study highlights the viability of an efficient, adaptable, and hygienic digital workflow for MADs.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"18 ","pages":"Article 100199"},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virtual surgical planning for mandibular ramus distraction osteogenesis","authors":"Amir Sufian Ismail,&nbsp;Jonathan Rengarajoo,&nbsp;Lee Chee Wei,&nbsp;Md Arad Jelon,&nbsp;Nur Ikram Hanim,&nbsp;Muhammad Adzwin Yahya,&nbsp;Kok Tuck Choon","doi":"10.1016/j.stlm.2025.100202","DOIUrl":"10.1016/j.stlm.2025.100202","url":null,"abstract":"<div><div>Virtual surgical planning (VSP) is becoming a standard procedure in managing patient indicated for distraction osteogenesis as part of the surgical management. In general, the use of VSP is not part of the routine treatment protocol due to the high cost and steep learning curve associated with it. In this case report, we would like to share our experience in managing patients with hemi-micrognathia secondary to ankylosed temporomandibular joint via distraction osteogenesis. Preoperatively, the patient's Digital Imaging and Communication in Medicine (DICOM) is used to create a stereoscopic simulation image. The ramus distractors were scanned to create a virtual ramus distractor. All this data is then appended into the software to decide on the osteotomy site as well as vector placement of the distractors virtually. This allows for virtual simulation of the proposed surgical plan. Once the osteotomy site and the vector for the ramus distractor has been finalised, a hybrid guide is created to aid in both osteotomy as well as identifying the vector for the distractor. Post-operatively, distraction devices were activated twice daily until distraction length was achieved followed by a consolidation period. VSP and hybrid guide allows surgeons to better understand the pitfalls of the case, simulate multiple possibilities virtually and also a as a good communication tool during patient consultation.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"18 ","pages":"Article 100202"},"PeriodicalIF":0.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143845095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A neo-sternal reconstruction using titanium additive manufacturing; a South African case report","authors":"S van der Westhuizen ,&nbsp;JT Janson ,&nbsp;RF Nel ,&nbsp;WB du Preez ,&nbsp;GJ Booysen","doi":"10.1016/j.stlm.2025.100197","DOIUrl":"10.1016/j.stlm.2025.100197","url":null,"abstract":"","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"18 ","pages":"Article 100197"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143705695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of 3D-printed flow-diverting stents for studying the effect of aneurysm treatment in vitro","authors":"Lana Bautz ,&nbsp;Oluwabusayo A. Oni ,&nbsp;Tamim Sarwar ,&nbsp;Hivnu Toraman ,&nbsp;Olav Jansen ,&nbsp;Jan-Bernd Hövener ,&nbsp;Naomi Larsen ,&nbsp;Mariya S. Pravdivtseva","doi":"10.1016/j.stlm.2025.100196","DOIUrl":"10.1016/j.stlm.2025.100196","url":null,"abstract":"<div><h3>Background</h3><div>Intracranial aneurysms (IAs) are preventively treated with flow-diverting stents (FDs), but complications persist, necessitating safer, customized FDs. While 4D flow magnetic resonance imaging (MRI) can evaluate FD treatment efficiency, metal artifacts from FDs compromise flow assessments.</div></div><div><h3>Purpose</h3><div>This study developed a protocol for fabricating 3D-printed FD replicas to test customized FDs and support MR imaging development by providing a metal-free testing platform.</div></div><div><h3>Methods</h3><div>Simplified mesh models with varying wire diameters (0.05–0.5 mm) and cell lengths (0.07–4.74 mm) were 3D printed using stereolithography and tested under gravity. A patient-specific aneurysm model was created, with 3D-printed FDs featuring 6, 16, and 20 wires covering the aneurysm entrance. Flow reduction caused by 3D printed FDs was evaluated with 4D flow MRI and compared to a commercial FD.</div></div><div><h3>Results</h3><div>Printable meshes had wire diameters ≥ 0.05 mm, with porosities over 14 % ensuring permeability. Lower porosities reduced gravity flow (4.93 ml/s vs. 28.57 ml/s for 14 % and 54 % porosity). Only wire sizes of 0.25 mm and 0.5 mm were accurately 3D-printed. The 3D-printed FDs reduced flow into the aneurysm sac without metal artifacts on MR images. The 20-wire FD fully occluded aneurysm flow, while the 16-wire and 6-wire FDs achieved 94 % and 76 % reductions, comparable to the 65 % reduction of the commercial FD.</div></div><div><h3>Conclusion</h3><div>The proposed workflow enables efficient 3D printing of FD replicas that match commercial FDs in performance. These 3D-printed FDs can optimize initial design parameters and support artifact-free MR imaging development for aneurysm treatment evaluation.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"18 ","pages":"Article 100196"},"PeriodicalIF":0.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143621249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D printed aneurysm training before treatment: A case control retrospective study","authors":"Mishel Manashirov ,&nbsp;Ran Brauner ,&nbsp;Yarden Mor ,&nbsp;Guy Raphaeli ,&nbsp;Sagi Harnof ,&nbsp;Alain Perlow ,&nbsp;Eitan Auriel ,&nbsp;Michael Findler","doi":"10.1016/j.stlm.2025.100195","DOIUrl":"10.1016/j.stlm.2025.100195","url":null,"abstract":"<div><h3>Background</h3><div>Intracranial aneurysms are abnormal dilatations of arteries in the brain, often necessitating intricate endovascular interventions. Preoperative planning using 3D-printed models can enhance the understanding of complex aneurysm anatomy and improve treatment strategies. This study aims to evaluate the impact of patient-specific 3D-printed aneurysm models on procedural planning, treatment efficacy, and clinical outcomes.</div></div><div><h3>Methods</h3><div>We conducted a retrospective analysis of patients treated for non-ruptured intracranial aneurysms at our institution between 2021 and 2023. Nine patients underwent preoperative simulation using 3D-printed models, while 32 patients received standard care without simulation. The vascular models were created using 3D Slicer for segmentation and Meshmixer for model refinement. The simulations were performed on a biplane Allura system. Data on demographics, aneurysm characteristics, hospitalization duration, procedure times, treatment changes, and unused materials were collected and analyzed using SPSS software. Statistical significance was assessed with independent one-tail <em>t</em>-tests, with a p-value &lt; 0.05 considered significant.</div></div><div><h3>Results</h3><div>The experimental group (nine patients) showed a trend towards reduced procedure times compared to the control group (126 ± 48 mins vs. 142 ± 68 mins, <em>p</em> = 0.253). There was no significant difference in mean hospitalization days between the groups (4 ± 0.9 days vs. 4 ± 1.7 days, <em>p</em> = 0.502). Interestingly, the treatment strategy was altered in four cases based on 3D simulation insights. The 3D simulation group also experienced fewer procedural complications (22.2 % vs. 31.2 %).</div></div><div><h3>Conclusions</h3><div>simulation using 3D-printed models shows potential in enhancing procedural planning and reducing complication rates in the treatment of intracranial aneurysms. While the study did not demonstrate statistically significant differences in procedure time and hospitalization days, the observed trends and changes in treatment strategies suggest that 3D printing technology can provide valuable insights for neurointerventionists. Further research with larger sample sizes and prospective designs is warranted to validate these findings and establish standardized protocols for integrating 3D printing into clinical practice.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"18 ","pages":"Article 100195"},"PeriodicalIF":0.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143549260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical characterization of low-cost 3D FDM printed scaffolds fabricated with synthesized PLA/HA bio-composite filament","authors":"Mynmayh Khamvongsa ,&nbsp;Kent Milton ,&nbsp;Tanvir R. Faisal","doi":"10.1016/j.stlm.2025.100194","DOIUrl":"10.1016/j.stlm.2025.100194","url":null,"abstract":"<div><div>Bone tissue engineering has gained popularity as a potential alternative in bone defect treatment, where the synthetic graft can be generated by a 3D biomaterial framework (scaffold) that yields shape and initial mechanical strength to facilitate cell bone formation. Biopolymer-based, Poly Lactic Acid (PLA)/Hydroxyapatite (HA) scaffolds were found to have a similar structure, composition, and mechanical properties as natural bone. The objective of this work was to fabricate 3D scaffolds with PLA and HA using a low-cost fabrication process such as Fused Deposition Modeling (FDM), which can be used to construct scaffolds tailored to an individual's specific need in a controlled and customizable process. The study primarily focuses on the synthesis, and mechanical and morphological characterization of PLA/HA filament and its scaffolds. The fabricated 3D printed PLA/HA scaffolds had an interconnected and highly porous structure, resembling natural bone porosity. The addition of HA had a significant effect on the PLA/HA composites although there are no notable differences in mechanical properties between 10–15 % PLA/HA composites. The microstructural morphology of the PLA and PLA/HA composite filaments observed under Scanning Electron Microscopy (SEM) showed a relatively well mixed and homogenous mixture and Energy-dispersive X-ray Spectroscopy (EDS) testing of the filaments’ surface topography further showed a mostly homogeneous presence of HA throughout. The 3D printed scaffolds showed a larger pore size due to the inclusion of HA. Additionally, with the increased percentage of HA, the pores became more uneven and irregular. The preliminary results of this study show a promising potential for personalized scaffold design for bone tissue regeneration.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"18 ","pages":"Article 100194"},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}