Annals of 3D printed medicine最新文献_第2页

Conversion of an FDM printer to direct ink write 3D bioprinter utilizing an efficient and cost-effective extrusion system 利用高效且具有成本效益的挤出系统将FDM打印机转换为直接墨水写入3D生物打印机

Annals of 3D printed medicine Pub Date : 2025-08-01 Epub Date: 2025-06-06 DOI: 10.1016/j.stlm.2025.100212

Y.  H. Dang, Elise Dauzat, Asif Istiak, Kevin Jackson, Victoria Songe, Luke West, Md Imrul Kayes, Md Saiful Islam, Tanvir R. Faisal

{"title":"Conversion of an FDM printer to direct ink write 3D bioprinter utilizing an efficient and cost-effective extrusion system","authors":"Y.  H. Dang, Elise Dauzat, Asif Istiak, Kevin Jackson, Victoria Songe, Luke West, Md Imrul Kayes, Md Saiful Islam, Tanvir R. Faisal","doi":"10.1016/j.stlm.2025.100212","DOIUrl":"10.1016/j.stlm.2025.100212","url":null,"abstract":"<div><div>3D bioprinting has emerged as a transformative technology in biomedical engineering, enabling the fabrication of functional tissues through the precise deposition of cell-laden biomaterials. However, the widespread adoption of this technology is constrained by the prohibitive costs of commercial bioprinting systems. We present a cost-effective solution through the conversion of an open-source fused deposition modeling (FDM) 3D printer into a direct ink write bioprinter by integrating a peristaltic pump-based extrusion system. The modified dual-extruder system demonstrates successful deposition of hydrogel-based bioinks across varying viscosities, producing well-defined scaffold architectures. The printer's open-source control architecture facilitates retraction capabilities, high-speed movements, and customizable printing parameters, enhancing operational flexibility. This development represents a significant step toward democratizing low-cost bioprinting technology, making it accessible to academic institutions and research facilities with limited resources.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"19 ","pages":"Article 100212"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144288849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pioneering era in paediatric tuberculosis: Utilization of 3D printing technology 儿科结核病的先驱时代：3D打印技术的应用

Annals of 3D printed medicine Pub Date : 2025-08-01 Epub Date: 2025-06-08 DOI: 10.1016/j.stlm.2025.100214

Shubham Singh , Mohit Kumar , Deeksha Choudhary , Devesh Kumar , Dikshant , Shital Zambad , Shruti Chopra , Manjeet Bansal , Amit Bhatia

{"title":"Pioneering era in paediatric tuberculosis: Utilization of 3D printing technology","authors":"Shubham Singh , Mohit Kumar , Deeksha Choudhary , Devesh Kumar , Dikshant , Shital Zambad , Shruti Chopra , Manjeet Bansal , Amit Bhatia","doi":"10.1016/j.stlm.2025.100214","DOIUrl":"10.1016/j.stlm.2025.100214","url":null,"abstract":"<div><div>The management of paediatric tuberculosis (TB) poses substantial clinical challenges necessitating innovative approaches. The advent of 3D printing technology has ushered in a pioneering era in paediatric TB care, revolutionizing diagnostics, treatment strategies, and medical education. This abstract explores the multifaceted utilization of 3D printing in addressing these challenges. The 3D printing enables the creation of anatomically accurate models derived from patient-specific imaging data. These models aid clinicians in preoperative planning, facilitating precise surgical interventions for complicated TB cases in children. Such personalized anatomical replicas enhance surgical outcomes by allowing surgeons to simulate procedures and anticipate challenges unique to paediatric TB. Furthermore, 3D printing supports medical education by providing tangible, interactive learning tools. Complex TB pathology and treatment concepts can be visually and haptically represented through 3D printed models, enhancing understanding among healthcare professionals and students. Hands-on training with these models fosters proficiency in paediatric TB management, ensuring competent care delivery. Using 3D printing technology marks a transformative shift in paediatric TB management, offering personalized treatment modalities, enhancing surgical precision, and advancing medical education. As this technology continues to evolve, its integration into clinical practice holds promise for improving outcomes and quality of life for young TB patients globally. In this paper, the authors underscore the significant contributions of 3D printing in shaping the future of paediatric TB care, illustrating its potential to redefine standards in paediatric infectious disease management.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"19 ","pages":"Article 100214"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144280077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D-printed drug delivery system from food waste: A sustainable approach for the development of novel drug delivery systems 从食物垃圾中3d打印药物输送系统：一种开发新型药物输送系统的可持续方法

Annals of 3D printed medicine Pub Date : 2025-08-01 Epub Date: 2025-05-29 DOI: 10.1016/j.stlm.2025.100209

Sejal Porwal , Rishabha Malviya , Sathvik Belagodu Sridhar , Dhanalekshmi Unnikrishnan Meenakshi , Tarun Wadhwa , Javedh Shareef , Musarrat Husain Warsi

{"title":"3D-printed drug delivery system from food waste: A sustainable approach for the development of novel drug delivery systems","authors":"Sejal Porwal , Rishabha Malviya , Sathvik Belagodu Sridhar , Dhanalekshmi Unnikrishnan Meenakshi , Tarun Wadhwa , Javedh Shareef , Musarrat Husain Warsi","doi":"10.1016/j.stlm.2025.100209","DOIUrl":"10.1016/j.stlm.2025.100209","url":null,"abstract":"<div><h3>Background</h3><div>3DP has emerged as an innovative technology in various industries, including pharmaceuticals and food. Notably, food waste is a useful resource for 3DP in drug delivery applications, helping to meet sustainability goals by recycling agricultural by-products. This concept is consistent with the circular economy since it uses elements from food waste, such as cellulose and lignin, to make bio-inks that may be used to fabricate customised drug delivery systems.</div></div><div><h3>Aim</h3><div>The study investigates the use of food waste-derived biopolymers for developing 3D-printed drug delivery systems, addressing both medical and environmental problems.</div></div><div><h3>Discussion</h3><div>Utilising food waste in 3DP drug delivery systems offers several advantages, including cost savings and reduced environmental effects. Biopolymers made from rice husk, soy protein, and eggshells improve the biodegradability and biocompatibility of pharmaceutical delivery systems. Furthermore, these food-derived biopolymers have intriguing properties such as regulated drug release and compatibility with patient-specific applications. However, there are issues in guaranteeing material consistency and stability, particularly in long-term drug release applications. Copolymerization and mixing with other biocompatible materials have the potential to improve mechanical stability and longevity, both of which are required for efficient drug administration.</div></div><div><h3>Conclusion</h3><div>Food waste-derived 3D-printed medicine delivery devices are an innovative and sustainable approach to healthcare, but further study is needed to increase scalability and consistency for broad utilization in clinical settings.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"19 ","pages":"Article 100209"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144261445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of dry heat sterilization on the mechanical and functional performance of 3D printed medical devices for image-guided intervention 干热灭菌对用于图像引导干预的3D打印医疗设备机械和功能性能的影响

Annals of 3D printed medicine Pub Date : 2025-08-01 Epub Date: 2025-07-02 DOI: 10.1016/j.stlm.2025.100216

Mary Chase Sheehan , Sarah Kim , Sunandita Sarker , Govindarajan Srimathveeravalli

{"title":"Impact of dry heat sterilization on the mechanical and functional performance of 3D printed medical devices for image-guided intervention","authors":"Mary Chase Sheehan , Sarah Kim , Sunandita Sarker , Govindarajan Srimathveeravalli","doi":"10.1016/j.stlm.2025.100216","DOIUrl":"10.1016/j.stlm.2025.100216","url":null,"abstract":"<div><div>Polymer additive manufacturing (AM) is a powerful method for medical device prototyping, producing low-cost medical devices for resource limited settings and patient-specific customization. Plastic medical devices created with AM must undergo sterilization prior to in vivo experiments or use with patients. While prior studies have verified the feasibility and safety of sterilization of such devices, the impact on mechanical performance has not been studied. Temperatures during autoclave sterilization, a commonly used and widely available method, can match or exceed the melt temperature of Nylon-12 used for selective laser sintering. Here we tested the impact of single or multiple cycles of autoclave sterilization on the mechanical and functional performance of plastic components used with interventional radiology related medical devices (catheter hub, ablation probe handle, and implantable port). We found that up to 2 cycles of sterilization did not tangibly impact the manufacturability, function or surface finish of these devices. However, we found that more than one cycle of sterilization can compromise the mechanical strength of the devices, with geometric-linked variations in the level of change in stiffness (ranging from 12 – 23 %). In conclusion, autoclave sterilization is safe for single use AM medical devices, where repetition of the sterilization for device reuse can compromise mechanical performance.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"19 ","pages":"Article 100216"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144523583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improvement of pedicle screw placement with first-time use of patient specific drill guides by novice surgeon 新手外科医生首次使用患者专用钻头导引改善椎弓根螺钉置入

Annals of 3D printed medicine Pub Date : 2025-08-01 Epub Date: 2025-06-30 DOI: 10.1016/j.stlm.2025.100215

Kyle Walker , Kunal Verma , Michael Silverstein , David Gurd

{"title":"Improvement of pedicle screw placement with first-time use of patient specific drill guides by novice surgeon","authors":"Kyle Walker , Kunal Verma , Michael Silverstein , David Gurd","doi":"10.1016/j.stlm.2025.100215","DOIUrl":"10.1016/j.stlm.2025.100215","url":null,"abstract":"<div><h3>Purpose</h3><div>Accurate placement of pedicle screws is a key component of spine surgery. The goal of this study is to evaluate the accuracy and precision of a 3-dimensional (3D) printed patient-specific instrumentation (PSI) guide in improving pedicle screw trajectory placement for a first-time user.</div></div><div><h3>Methods</h3><div>A computed tomography scan of a cadaveric spine was obtained and 3D reconstructed virtually. One pedicle at each vertebra was randomized to the PSI or freehand (FH) grouping. Screw trajectories were virtually planned for T1-L5 vertebral levels. A junior orthopaedic surgery resident used the PSI to place a screw at 17 vertebral levels and then returned on a separate day to place screws using FH technique. No adjustments from the initial placement were allowed. Postoperatively the spine was rescanned and analyzed by a blinded senior attending surgeon for perforation, adequacy of placement, and likelihood of unfavorable outcome. The PSI grouping was analyzed objectively for deviation from the preoperative plan.</div></div><div><h3>Results</h3><div>Five of the FH screws were deemed to likely result in paralysis or major neurovascular injury vs zero in the PSI grouping (p-value 0.045). The mean PSI placement time was 47.9 s faster per level than the FH placement time (145.2 ± 74.4 vs 193.1 ± 43.0 s; p-value 0.032). The PSI trajectories were accurate within 2.75 mm and 9.0 degrees of the planned trajectories (p-value 0.045; p-value 0.036).</div></div><div><h3>Conclusions</h3><div>The PSI system appears to offer a relatively inexpensive, user-friendly, and sufficiently accurate solution to pedicle screw placement for even a novice surgeon using the technology for the first time.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"19 ","pages":"Article 100215"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Applications of 3D printing in the teaching of human anatomy: An integrative review 3D打印技术在人体解剖学教学中的应用综述

Annals of 3D printed medicine Pub Date : 2025-08-01 Epub Date: 2025-06-26 DOI: 10.1016/j.stlm.2025.100213

Keila Danira Paim e Silva Cadete Tomás, Maíza Rodrigues Silva, Vanessa Namieh Garicoix, Lilian Navarro Wenceslau Giacometti, Victor Giovanni Ramos Cardoso, Josemar Santos de Matos, Braulio Henrique Magnani Branco, Lucas França Garcia, Audrei Pavanello, Karina Miura da Costa

{"title":"Applications of 3D printing in the teaching of human anatomy: An integrative review","authors":"Keila Danira Paim e Silva Cadete Tomás, Maíza Rodrigues Silva, Vanessa Namieh Garicoix, Lilian Navarro Wenceslau Giacometti, Victor Giovanni Ramos Cardoso, Josemar Santos de Matos, Braulio Henrique Magnani Branco, Lucas França Garcia, Audrei Pavanello, Karina Miura da Costa","doi":"10.1016/j.stlm.2025.100213","DOIUrl":"10.1016/j.stlm.2025.100213","url":null,"abstract":"<div><div>This study consists of a review that explores the application of three-dimensional (3D) printing in the teaching of human anatomy. A search was conducted in the PubMed, Scopus, and Web of Science databases, using the terms \"3D Printing\", \"Health\", \"Education\", and \"Anatomy\". Articles published between 2019 and 2024 addressing the use of 3D printing for the production of anatomical models in the teaching of human anatomy were selected. The review included 15 articles, covering printed models from the circulatory, skeletal, nervous, and reproductive systems. 3D printing has been used to create detailed and customized anatomical models, offering three-dimensional visualization, anatomically precise details, and tactile feedback, assisting in memorizing anatomical structures. In addition, 3D printing can stimulate student engagement, resulting in better academic performance. Studies indicate that the novelty of the technology can increase student interest, leading to more effective learning. The customization of printed models allows for specific adaptations to the needs of students, improving the effectiveness of teaching. In conclusion, 3D printing has the potential to overcome the challenges of traditional anatomy teaching. As technology evolves, even more innovative applications in the field of anatomy education are likely to emerge. This study highlights the importance of integrating new technologies into the educational curriculum to improve student understanding and interest in subjects such as human anatomy.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"19 ","pages":"Article 100213"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A neo-sternal reconstruction using titanium additive manufacturing; a South African case report 钛增材制造技术用于新胸骨重建一份南非病例报告

Annals of 3D printed medicine Pub Date : 2025-05-01 Epub Date: 2025-03-20 DOI: 10.1016/j.stlm.2025.100197

S van der Westhuizen , JT Janson , RF Nel , WB du Preez , GJ Booysen

引用次数: 0

Polymeric hydrogels for bioprinting: A comprehensive review 生物打印用高分子水凝胶：综述

Annals of 3D printed medicine Pub Date : 2025-05-01 Epub Date: 2025-03-29 DOI: 10.1016/j.stlm.2025.100198

Mohammad Amir Qureshi , Basree , Raqeeba Aziz , Yasser Azim , Musheer Ahmad

引用次数: 0

Development of a fully digital design process for customized mandibular advancement and its precision additive manufacturing 开发用于定制下颌推进及其精密增材制造的全数字化设计流程

Annals of 3D printed medicine Pub Date : 2025-05-01 Epub Date: 2025-03-28 DOI: 10.1016/j.stlm.2025.100199

Chinmai Bhat , Yulius Shan Romario , I-Ching Chou , Wan-Rong Jiang , Yu-Yan Wu , Maziar Ramezani , Cho-Pei Jiang

{"title":"Development of a fully digital design process for customized mandibular advancement and its precision additive manufacturing","authors":"Chinmai Bhat , Yulius Shan Romario , I-Ching Chou , Wan-Rong Jiang , Yu-Yan Wu , Maziar Ramezani , Cho-Pei Jiang","doi":"10.1016/j.stlm.2025.100199","DOIUrl":"10.1016/j.stlm.2025.100199","url":null,"abstract":"<div><div>This study aims to develop a fully digital workflow for the fabrication of customized mandibular advancement devices (MAD). MADs are used to treat obstructive sleep apnea and typically require 8–10 days to fabricate as per the patient's specifications. The currently designed digital methodology considerably shortens this timescale to 2–3 days, providing a viable alternative to traditional methods. The process integrates digital intraoral scanning, computer-aided modeling, and additive manufacturing using DD guide material through digital light processing technology. Along with the integration, the workflow also optimizes scanning accuracy, printing orientation, precision, and usability. The precision of fabrication was examined by scanning the fabricated part with the stereolithography file. The root mean square value of 0.0287 mm indicates that the fabricated device is within the clinical accuracy and thus can be used for mandibular advancement. Furthermore, the analysis indicates that printing orientations of 0° and 45° deliver higher precision and surface quality, with the 45° proving to be most cost-effective for grinding and post-processing. The post-processing greatly reduced the surface roughness thereby increasing the comfortability and hygiene. The durability of the fabricated MADs was proved through the unaffected mechanical properties even after washing >1000 times (equivalent to 3 years). Contributing to the wider adoption of digital procedures in dental clinics and coinciding with current market trends toward patient-specific solutions, this study highlights the viability of an efficient, adaptable, and hygienic digital workflow for MADs.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"18 ","pages":"Article 100199"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical characterization of low-cost 3D FDM printed scaffolds fabricated with synthesized PLA/HA bio-composite filament 用合成聚乳酸/HA 生物复合丝制造的低成本三维 FDM 打印支架的力学性能表征

Annals of 3D printed medicine Pub Date : 2025-05-01 Epub Date: 2025-02-07 DOI: 10.1016/j.stlm.2025.100194

Mynmayh Khamvongsa , Kent Milton , Tanvir R. Faisal

{"title":"Mechanical characterization of low-cost 3D FDM printed scaffolds fabricated with synthesized PLA/HA bio-composite filament","authors":"Mynmayh Khamvongsa , Kent Milton , Tanvir R. Faisal","doi":"10.1016/j.stlm.2025.100194","DOIUrl":"10.1016/j.stlm.2025.100194","url":null,"abstract":"<div><div>Bone tissue engineering has gained popularity as a potential alternative in bone defect treatment, where the synthetic graft can be generated by a 3D biomaterial framework (scaffold) that yields shape and initial mechanical strength to facilitate cell bone formation. Biopolymer-based, Poly Lactic Acid (PLA)/Hydroxyapatite (HA) scaffolds were found to have a similar structure, composition, and mechanical properties as natural bone. The objective of this work was to fabricate 3D scaffolds with PLA and HA using a low-cost fabrication process such as Fused Deposition Modeling (FDM), which can be used to construct scaffolds tailored to an individual's specific need in a controlled and customizable process. The study primarily focuses on the synthesis, and mechanical and morphological characterization of PLA/HA filament and its scaffolds. The fabricated 3D printed PLA/HA scaffolds had an interconnected and highly porous structure, resembling natural bone porosity. The addition of HA had a significant effect on the PLA/HA composites although there are no notable differences in mechanical properties between 10–15 % PLA/HA composites. The microstructural morphology of the PLA and PLA/HA composite filaments observed under Scanning Electron Microscopy (SEM) showed a relatively well mixed and homogenous mixture and Energy-dispersive X-ray Spectroscopy (EDS) testing of the filaments’ surface topography further showed a mostly homogeneous presence of HA throughout. The 3D printed scaffolds showed a larger pore size due to the inclusion of HA. Additionally, with the increased percentage of HA, the pores became more uneven and irregular. The preliminary results of this study show a promising potential for personalized scaffold design for bone tissue regeneration.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"18 ","pages":"Article 100194"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0