Annals of 3D printed medicine最新文献

{"title":"The future of 3D printing in instrumented implantable polymer meta-stents","authors":"C. Brosseau ,&nbsp;G. Nocchiero ,&nbsp;J. Ville","doi":"10.1016/j.stlm.2025.100211","DOIUrl":"10.1016/j.stlm.2025.100211","url":null,"abstract":"<div><div>An increasing diversity of performance demands are being put on devices for medical applications. These include the need for the best mechanical, thermal, electromagnetic, chemical, and flow properties, biological compatibility, and low weight of such material systems. In this review article, we discuss three features that can confer advantages for new instrumented implementable stents. Firstly, we examine the benefits of using 3D-printed polymer stents by comparing their characteristics with metallic devices. One challenge of designing mechanical metamaterial-based stents is choosing their complex geometric structure. Secondly, we report progress in the design of printed antennas for wireless communication with implantable stents capable of monitoring real-time biological signals. This could be very important for early diagnosis of in-stent restenosis and real-time monitoring of intravascular blood conditions. Thirdly, virtual replica digital twin technology can facilitate personalized stent design based on individual patient characteristics, medical history, and real-time physiological data. This new predictive analysis in healthcare systems relies largely on the use of deep learning algorithms, appropriate for managing massive data integration. Finally, we summarize some of the major outstanding challenges that, if addressed, would move us substantially closer to realizing practically useful instrumented implantable polymer meta-stents that are integrated systems. Looking to the future, the conclusions of this review will be beneficial for researchers, clinicians, and engineers in the development and application of 3D printing for improved instrumented polymer stents.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"19 ","pages":"Article 100211"},"PeriodicalIF":0.0,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144261443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pioneering era in paediatric tuberculosis: Utilization of 3D printing technology","authors":"Shubham Singh ,&nbsp;Mohit Kumar ,&nbsp;Deeksha Choudhary ,&nbsp;Devesh Kumar ,&nbsp;Dikshant ,&nbsp;Shital Zambad ,&nbsp;Shruti Chopra ,&nbsp;Manjeet Bansal ,&nbsp;Amit Bhatia","doi":"10.1016/j.stlm.2025.100214","DOIUrl":"10.1016/j.stlm.2025.100214","url":null,"abstract":"<div><div>The management of paediatric tuberculosis (TB) poses substantial clinical challenges necessitating innovative approaches. The advent of 3D printing technology has ushered in a pioneering era in paediatric TB care, revolutionizing diagnostics, treatment strategies, and medical education. This abstract explores the multifaceted utilization of 3D printing in addressing these challenges. The 3D printing enables the creation of anatomically accurate models derived from patient-specific imaging data. These models aid clinicians in preoperative planning, facilitating precise surgical interventions for complicated TB cases in children. Such personalized anatomical replicas enhance surgical outcomes by allowing surgeons to simulate procedures and anticipate challenges unique to paediatric TB. Furthermore, 3D printing supports medical education by providing tangible, interactive learning tools. Complex TB pathology and treatment concepts can be visually and haptically represented through 3D printed models, enhancing understanding among healthcare professionals and students. Hands-on training with these models fosters proficiency in paediatric TB management, ensuring competent care delivery. Using 3D printing technology marks a transformative shift in paediatric TB management, offering personalized treatment modalities, enhancing surgical precision, and advancing medical education. As this technology continues to evolve, its integration into clinical practice holds promise for improving outcomes and quality of life for young TB patients globally. In this paper, the authors underscore the significant contributions of 3D printing in shaping the future of paediatric TB care, illustrating its potential to redefine standards in paediatric infectious disease management.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"19 ","pages":"Article 100214"},"PeriodicalIF":0.0,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144280077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel 3D printed jig design for a smooth and accurate dome osteotomy: A case report","authors":"Ervin Sethi,&nbsp;Sze Ern Tan,&nbsp;Michael Yam","doi":"10.1016/j.stlm.2025.100210","DOIUrl":"10.1016/j.stlm.2025.100210","url":null,"abstract":"<div><div>Femoral malunion with associated sagittal and coronal deformity poses significant challenges in achieving anatomical realignment and functional restoration. This case report describes a novel surgical technique utilizing patient-specific 3D planning and a custom-designed, 3D-printed curved cutting jig to perform a dome osteotomy for deformity correction in a 69-year-old male with a history of childhood femoral fracture and recent atypical femoral fracture associated with bisphosphonate use. Preoperative CT-based 3D modeling allowed accurate assessment of the deformity and precise planning of the osteotomy. A customized jig was engineered with a hemispherical slot to guide a smooth curved osteotomy, enabling biplanar correction while preserving limb length and optimizing bony contact for healing. Intraoperative execution was streamlined by jig-guided drilling and osteotomy, followed by intramedullary nail fixation. Postoperative recovery was uneventful, with early mobilization and successful alignment and union confirmed radiographically. This approach demonstrated the value of advanced 3D technologies in enhancing surgical precision, reducing operative time and radiation exposure, and improving clinical outcomes. It represents a promising option for complex femoral deformity correction when institutional resources permit.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"19 ","pages":"Article 100210"},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144313813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conversion of an FDM printer to direct ink write 3D bioprinter utilizing an efficient and cost-effective extrusion system","authors":"Y.  H. Dang,&nbsp;Elise Dauzat,&nbsp;Asif Istiak,&nbsp;Kevin Jackson,&nbsp;Victoria Songe,&nbsp;Luke West,&nbsp;Md Imrul Kayes,&nbsp;Md Saiful Islam,&nbsp;Tanvir R. Faisal","doi":"10.1016/j.stlm.2025.100212","DOIUrl":"10.1016/j.stlm.2025.100212","url":null,"abstract":"<div><div>3D bioprinting has emerged as a transformative technology in biomedical engineering, enabling the fabrication of functional tissues through the precise deposition of cell-laden biomaterials. However, the widespread adoption of this technology is constrained by the prohibitive costs of commercial bioprinting systems. We present a cost-effective solution through the conversion of an open-source fused deposition modeling (FDM) 3D printer into a direct ink write bioprinter by integrating a peristaltic pump-based extrusion system. The modified dual-extruder system demonstrates successful deposition of hydrogel-based bioinks across varying viscosities, producing well-defined scaffold architectures. The printer's open-source control architecture facilitates retraction capabilities, high-speed movements, and customizable printing parameters, enhancing operational flexibility. This development represents a significant step toward democratizing low-cost bioprinting technology, making it accessible to academic institutions and research facilities with limited resources.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"19 ","pages":"Article 100212"},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144288849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D-printed drug delivery system from food waste: A sustainable approach for the development of novel drug delivery systems","authors":"Sejal Porwal ,&nbsp;Rishabha Malviya ,&nbsp;Sathvik Belagodu Sridhar ,&nbsp;Dhanalekshmi Unnikrishnan Meenakshi ,&nbsp;Tarun Wadhwa ,&nbsp;Javedh Shareef ,&nbsp;Musarrat Husain Warsi","doi":"10.1016/j.stlm.2025.100209","DOIUrl":"10.1016/j.stlm.2025.100209","url":null,"abstract":"<div><h3>Background</h3><div>3DP has emerged as an innovative technology in various industries, including pharmaceuticals and food. Notably, food waste is a useful resource for 3DP in drug delivery applications, helping to meet sustainability goals by recycling agricultural by-products. This concept is consistent with the circular economy since it uses elements from food waste, such as cellulose and lignin, to make bio-inks that may be used to fabricate customised drug delivery systems.</div></div><div><h3>Aim</h3><div>The study investigates the use of food waste-derived biopolymers for developing 3D-printed drug delivery systems, addressing both medical and environmental problems.</div></div><div><h3>Discussion</h3><div>Utilising food waste in 3DP drug delivery systems offers several advantages, including cost savings and reduced environmental effects. Biopolymers made from rice husk, soy protein, and eggshells improve the biodegradability and biocompatibility of pharmaceutical delivery systems. Furthermore, these food-derived biopolymers have intriguing properties such as regulated drug release and compatibility with patient-specific applications. However, there are issues in guaranteeing material consistency and stability, particularly in long-term drug release applications. Copolymerization and mixing with other biocompatible materials have the potential to improve mechanical stability and longevity, both of which are required for efficient drug administration.</div></div><div><h3>Conclusion</h3><div>Food waste-derived 3D-printed medicine delivery devices are an innovative and sustainable approach to healthcare, but further study is needed to increase scalability and consistency for broad utilization in clinical settings.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"19 ","pages":"Article 100209"},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144261445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dimensional accuracy and resolution assessment of the formlabs form 3B 3D printer for medical applications","authors":"Vera Lagerburg ,&nbsp;Anne Vrancken ,&nbsp;Sietske Bergsma ,&nbsp;Janita Dekker ,&nbsp;Wouter Diemer ,&nbsp;Judith Waldner-Troost ,&nbsp;Maaike Koenrades","doi":"10.1016/j.stlm.2025.100204","DOIUrl":"10.1016/j.stlm.2025.100204","url":null,"abstract":"<div><h3>Introduction</h3><div>For quality management of in-hospital 3D printing, it is essential to have detailed knowledge on the accuracy and reproducibility of the 3D printing process. In this study, the influence of several printing and post-processing parameters on dimensional accuracy and resolution were evaluated in three different hospitals to provide a reference for printer performance for medical applications.</div></div><div><h3>Methods</h3><div>A custom phantom was designed comprising features to assess accuracy and resolution of the Form 3B printer (Formlabs, Somerville, MA, USA). Specific features common for surgical guides were included, such as slits, flanges, and cylinders. The phantoms were 3D printed using a medical grade resin (Formlabs Biomed Clear resin) and evaluated after postprocessing and sterilization. Dimensional accuracy was defined as the deviation between the actual measurement and the known feature dimension and evaluated in x-, y- and z-direction. Resolution was defined as the smallest complete feature.</div></div><div><h3>Results</h3><div>The accuracy of the prints in the x-direction varied between -0.1 mm and 0.1 mm, in the y-direction between -0.25 mm and 0.4 mm and in the z-direction between -0.2 mm and 0.4 mm. The influence of sterilization on the accuracy was negligible. The smallest slit that was always open when printing in the x-direction was 0.3 mm and in the y-direction 0.4 mm.</div></div><div><h3>Conclusion</h3><div>This study provides hospitals with a reference for the printing accuracy and resolution for a medical grade resin. The phantom designed can be used in every hospital to determine their own printing accuracy and tolerances thereby optimizing product design for the intended clinical application.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"19 ","pages":"Article 100204"},"PeriodicalIF":0.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144116537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare professionals’ initial attitudes towards 3D printing and effects of a short educational briefing: A pre-post pilot study utilising the technology acceptance model","authors":"Una M. Cronin ,&nbsp;EmmaJude Lyons ,&nbsp;Aidan O’ Sullivan ,&nbsp;Niamh M. Cummins ,&nbsp;Leonard O’Sullivan","doi":"10.1016/j.stlm.2025.100205","DOIUrl":"10.1016/j.stlm.2025.100205","url":null,"abstract":"<div><h3>Purpose</h3><div>Adopting 3D printing technology in healthcare is variable across clinical settings and has considerable geographical differences. To advance the application of 3D printing in healthcare it is necessary to research factors inhibiting its adoption, notably in areas of low uptake. The aim of this study was to investigate attitudes toward 3D printing in Healthcare Professionals (HCPs) with low experience of the technology and to assess the effectiveness of a Short Educational Video (SEV) on these perceptions in the context of the Technology Acceptance Model (TAM).</div></div><div><h3>Design/Methodology/Approach</h3><div>This was a pre-post intervention study in a convenience sample of HCPs. A 5-minute video was developed to introduce and inform HCPs regarding 3D printing in healthcare. Participants (<em>n</em> = 52) completed an online survey grounded on the TAM before and after watching the video. Wilcoxon signed rank <em>t</em>-tests were used to analyse pre- and post-video scores. Perceptions post-intervention increased significantly for the TAM dimensions perceived usefulness (<em>p</em> &lt; 0.05), perceived ease of use (<em>p</em> &lt; 0.001), attitude toward use (<em>p</em> &lt; 0.001) and behavioural intention to use (<em>p</em> &lt; 0.001).</div></div><div><h3>Findings</h3><div>This study demonstrated that a brief introduction to the technology increased perceptual factors which may be related to the initial phase of adoption of such technology. An inference from the findings is that for HCPs with low previous experience of 3D printing, this may be a suitable model to provide education on the technology and potentially increase the adoption of 3D printing in the clinical setting. Increased perception is expected to contribute to increased likelihood of eventual adoption in healthcare.</div></div><div><h3>Originality/value</h3><div>This study addresses a literature gap in adopting 3D printing within healthcare. The study demonstrated that even brief educational interventions can substantially shift perceptions among HCPs. This suggests that the SEV is a scalable and cost-effective strategy to initially promote the adoption of 3D printing within healthcare.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"19 ","pages":"Article 100205"},"PeriodicalIF":0.0,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144069685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"StemCurCol – 3D printed scaffold for diabetic wound regeneration","authors":"Henrique Luis Piva ,&nbsp;Mariana Santos de Queiroz ,&nbsp;Flavia Sayuri Matsuo ,&nbsp;Hiago Salge Borges ,&nbsp;Mariana Kiomy Osako ,&nbsp;Antonio Claudio Tedesco","doi":"10.1016/j.stlm.2025.100203","DOIUrl":"10.1016/j.stlm.2025.100203","url":null,"abstract":"<div><div>Diabetic wounds, particularly diabetic foot ulcers, pose a significant challenge for treatment due to impaired healing and susceptibility to complications. The complex pathophysiology of wounds involves dysregulated cellular and molecular processes. Advanced therapeutic strategies are needed to address the different stages of wound healing. Curcumin, a natural polyphenol, has been shown to enhance epidermal re-epithelialization, mobilize cellular participants in wound repair, and improve different stages of wound healing. In this work curcumin-chitosan nanoparticles have been prepared and characterized, and incorporated in collagen with stem cells and were implanted into normal and diabetic mice with induced wounds and their effects on wound healing were evaluated over 14 days. Animals treated with StemCurCol scaffolds presented faster closure rates and enhanced re-epithelialization than the controls, and the cells contributed to regeneration by forming new tissues, and rapidly closing wounds.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"18 ","pages":"Article 100203"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Affordable multicolor 3D printing solution for biomedical education in low- and middle-income countries","authors":"Dat Minh Lu ,&nbsp;Phong Van Dong ,&nbsp;Hien Bui Thu Hoang ,&nbsp;Dang Ngoc Tran ,&nbsp;Khiem Tran Dang ,&nbsp;Linh Thanh Duy Tran ,&nbsp;An Le Pham","doi":"10.1016/j.stlm.2025.100201","DOIUrl":"10.1016/j.stlm.2025.100201","url":null,"abstract":"<div><div>3D printing for biomedical education in universities remains largely inaccessible in low- and middle-income countries (LMICs) due to the high cost of commercial material jetting and powder bed fusion 3D printers. To address this barrier, we have developed an affordable multicolor fused deposition modeling (FDM) 3D printer capable of producing biomedical models with intricate geometries. The key innovation of our printer is the novel integration of two distinct hybrid printhead configurations to enable simultaneous multicolor printing and water-soluble support material deposition. Positioned along the same X-axis, the first printhead employs a filament cutting, retracting, and purging mechanism to print in seven colors, while the second printhead is dedicated to printing water-soluble support material. The printer utilizes a hybrid CoreXY kinematic system and offers a 30 × 30 × 30 cm print volume. Its operations are controlled by two MKS Monster8 V2.0 boards and an MKS Pi V1.1 running Klipper firmware, with Orca Slicer software converting 3D model data into printer-readable instructions. Our printer successfully operated for up to 45 h, producing four detailed heart models (18 × 15 × 10 cm) and a multicolor DNA polymerase model from online databases and CT scan images. Support structures were removed by immersing the prints in warm water for 24 h, ensuring precise structural integrity for complex models. By combining multicolor printing with water-soluble support material, our cost-effective, frugal innovation allows the fabrication of intricate, vibrant biomedical models, making 3D printing more feasible for biomedical education and research in LMICs.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"18 ","pages":"Article 100201"},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Powder bed fusion 3D printing for drug delivery and healthcare applications","authors":"Suraj Kumar ,&nbsp;Rishabha Malviya ,&nbsp;Sathvik Belagodu Sridhar ,&nbsp;Tarun Wadhwa ,&nbsp;Umme Hani ,&nbsp;Sirajunisa Talath ,&nbsp;Musarrat Husain Warsi","doi":"10.1016/j.stlm.2025.100200","DOIUrl":"10.1016/j.stlm.2025.100200","url":null,"abstract":"<div><div>Powder Bed Fusion (PBF) is a 3D printing technique that uses powdered materials, fused through various ignition sources, to create complex structures. Over time, PBF has evolved into several methods, including selective laser sintering/melting, direct metal laser sintering, electron beam melting, and multi-jet fusion. These advancements offer benefits such as improved resolution, faster printing speeds, and the ability to produce intricate designs without the need for additional support structures. This review examines the distinct roles and potential applications of PBF in pharmacology and biomedicine, focusing on the mechanisms behind the technology and its impact on personalized drug-loaded formulations, medical devices, and implants. PBF's versatility makes it ideal for biomedical applications, where precision and customization are essential. Its high resolution and speed enable the fabrication of detailed, individualized items, driving advancements in drug delivery and implant design. However, challenges remain, such as material constraints and the requirement for specific environmental conditions, which can influence product quality. This review emphasizes the innovative applications of PBF in pharmacology and biology and highlights its transformative potential in personalized medicine. By overcoming current limitations, PBF technology could further contribute to the development of advanced biomedicine and personalized treatment solutions.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"18 ","pages":"Article 100200"},"PeriodicalIF":0.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}