Annals of 3D printed medicine最新文献

{"title":"Impact of dry heat sterilization on the mechanical and functional performance of 3D printed medical devices for image-guided intervention","authors":"Mary Chase Sheehan ,&nbsp;Sarah Kim ,&nbsp;Sunandita Sarker ,&nbsp;Govindarajan Srimathveeravalli","doi":"10.1016/j.stlm.2025.100216","DOIUrl":"10.1016/j.stlm.2025.100216","url":null,"abstract":"<div><div>Polymer additive manufacturing (AM) is a powerful method for medical device prototyping, producing low-cost medical devices for resource limited settings and patient-specific customization. Plastic medical devices created with AM must undergo sterilization prior to in vivo experiments or use with patients. While prior studies have verified the feasibility and safety of sterilization of such devices, the impact on mechanical performance has not been studied. Temperatures during autoclave sterilization, a commonly used and widely available method, can match or exceed the melt temperature of Nylon-12 used for selective laser sintering. Here we tested the impact of single or multiple cycles of autoclave sterilization on the mechanical and functional performance of plastic components used with interventional radiology related medical devices (catheter hub, ablation probe handle, and implantable port). We found that up to 2 cycles of sterilization did not tangibly impact the manufacturability, function or surface finish of these devices. However, we found that more than one cycle of sterilization can compromise the mechanical strength of the devices, with geometric-linked variations in the level of change in stiffness (ranging from 12 – 23 %). In conclusion, autoclave sterilization is safe for single use AM medical devices, where repetition of the sterilization for device reuse can compromise mechanical performance.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"19 ","pages":"Article 100216"},"PeriodicalIF":0.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144523583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement of pedicle screw placement with first-time use of patient specific drill guides by novice surgeon","authors":"Kyle Walker ,&nbsp;Kunal Verma ,&nbsp;Michael Silverstein ,&nbsp;David Gurd","doi":"10.1016/j.stlm.2025.100215","DOIUrl":"10.1016/j.stlm.2025.100215","url":null,"abstract":"<div><h3>Purpose</h3><div>Accurate placement of pedicle screws is a key component of spine surgery. The goal of this study is to evaluate the accuracy and precision of a 3-dimensional (3D) printed patient-specific instrumentation (PSI) guide in improving pedicle screw trajectory placement for a first-time user.</div></div><div><h3>Methods</h3><div>A computed tomography scan of a cadaveric spine was obtained and 3D reconstructed virtually. One pedicle at each vertebra was randomized to the PSI or freehand (FH) grouping. Screw trajectories were virtually planned for T1-L5 vertebral levels. A junior orthopaedic surgery resident used the PSI to place a screw at 17 vertebral levels and then returned on a separate day to place screws using FH technique. No adjustments from the initial placement were allowed. Postoperatively the spine was rescanned and analyzed by a blinded senior attending surgeon for perforation, adequacy of placement, and likelihood of unfavorable outcome. The PSI grouping was analyzed objectively for deviation from the preoperative plan.</div></div><div><h3>Results</h3><div>Five of the FH screws were deemed to likely result in paralysis or major neurovascular injury vs zero in the PSI grouping (p-value 0.045). The mean PSI placement time was 47.9 s faster per level than the FH placement time (145.2 ± 74.4 vs 193.1 ± 43.0 s; p-value 0.032). The PSI trajectories were accurate within 2.75 mm and 9.0 degrees of the planned trajectories (p-value 0.045; p-value 0.036).</div></div><div><h3>Conclusions</h3><div>The PSI system appears to offer a relatively inexpensive, user-friendly, and sufficiently accurate solution to pedicle screw placement for even a novice surgeon using the technology for the first time.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"19 ","pages":"Article 100215"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applications of 3D printing in the teaching of human anatomy: An integrative review","authors":"Keila Danira Paim e Silva Cadete Tomás,&nbsp;Maíza Rodrigues Silva,&nbsp;Vanessa Namieh Garicoix,&nbsp;Lilian Navarro Wenceslau Giacometti,&nbsp;Victor Giovanni Ramos Cardoso,&nbsp;Josemar Santos de Matos,&nbsp;Braulio Henrique Magnani Branco,&nbsp;Lucas França Garcia,&nbsp;Audrei Pavanello,&nbsp;Karina Miura da Costa","doi":"10.1016/j.stlm.2025.100213","DOIUrl":"10.1016/j.stlm.2025.100213","url":null,"abstract":"<div><div>This study consists of a review that explores the application of three-dimensional (3D) printing in the teaching of human anatomy. A search was conducted in the PubMed, Scopus, and Web of Science databases, using the terms \"3D Printing\", \"Health\", \"Education\", and \"Anatomy\". Articles published between 2019 and 2024 addressing the use of 3D printing for the production of anatomical models in the teaching of human anatomy were selected. The review included 15 articles, covering printed models from the circulatory, skeletal, nervous, and reproductive systems. 3D printing has been used to create detailed and customized anatomical models, offering three-dimensional visualization, anatomically precise details, and tactile feedback, assisting in memorizing anatomical structures. In addition, 3D printing can stimulate student engagement, resulting in better academic performance. Studies indicate that the novelty of the technology can increase student interest, leading to more effective learning. The customization of printed models allows for specific adaptations to the needs of students, improving the effectiveness of teaching. In conclusion, 3D printing has the potential to overcome the challenges of traditional anatomy teaching. As technology evolves, even more innovative applications in the field of anatomy education are likely to emerge. This study highlights the importance of integrating new technologies into the educational curriculum to improve student understanding and interest in subjects such as human anatomy.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"19 ","pages":"Article 100213"},"PeriodicalIF":0.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The future of 3D printing in instrumented implantable polymer meta-stents","authors":"C. Brosseau ,&nbsp;G. Nocchiero ,&nbsp;J. Ville","doi":"10.1016/j.stlm.2025.100211","DOIUrl":"10.1016/j.stlm.2025.100211","url":null,"abstract":"<div><div>An increasing diversity of performance demands are being put on devices for medical applications. These include the need for the best mechanical, thermal, electromagnetic, chemical, and flow properties, biological compatibility, and low weight of such material systems. In this review article, we discuss three features that can confer advantages for new instrumented implementable stents. Firstly, we examine the benefits of using 3D-printed polymer stents by comparing their characteristics with metallic devices. One challenge of designing mechanical metamaterial-based stents is choosing their complex geometric structure. Secondly, we report progress in the design of printed antennas for wireless communication with implantable stents capable of monitoring real-time biological signals. This could be very important for early diagnosis of in-stent restenosis and real-time monitoring of intravascular blood conditions. Thirdly, virtual replica digital twin technology can facilitate personalized stent design based on individual patient characteristics, medical history, and real-time physiological data. This new predictive analysis in healthcare systems relies largely on the use of deep learning algorithms, appropriate for managing massive data integration. Finally, we summarize some of the major outstanding challenges that, if addressed, would move us substantially closer to realizing practically useful instrumented implantable polymer meta-stents that are integrated systems. Looking to the future, the conclusions of this review will be beneficial for researchers, clinicians, and engineers in the development and application of 3D printing for improved instrumented polymer stents.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"19 ","pages":"Article 100211"},"PeriodicalIF":0.0,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144261443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pioneering era in paediatric tuberculosis: Utilization of 3D printing technology","authors":"Shubham Singh ,&nbsp;Mohit Kumar ,&nbsp;Deeksha Choudhary ,&nbsp;Devesh Kumar ,&nbsp;Dikshant ,&nbsp;Shital Zambad ,&nbsp;Shruti Chopra ,&nbsp;Manjeet Bansal ,&nbsp;Amit Bhatia","doi":"10.1016/j.stlm.2025.100214","DOIUrl":"10.1016/j.stlm.2025.100214","url":null,"abstract":"<div><div>The management of paediatric tuberculosis (TB) poses substantial clinical challenges necessitating innovative approaches. The advent of 3D printing technology has ushered in a pioneering era in paediatric TB care, revolutionizing diagnostics, treatment strategies, and medical education. This abstract explores the multifaceted utilization of 3D printing in addressing these challenges. The 3D printing enables the creation of anatomically accurate models derived from patient-specific imaging data. These models aid clinicians in preoperative planning, facilitating precise surgical interventions for complicated TB cases in children. Such personalized anatomical replicas enhance surgical outcomes by allowing surgeons to simulate procedures and anticipate challenges unique to paediatric TB. Furthermore, 3D printing supports medical education by providing tangible, interactive learning tools. Complex TB pathology and treatment concepts can be visually and haptically represented through 3D printed models, enhancing understanding among healthcare professionals and students. Hands-on training with these models fosters proficiency in paediatric TB management, ensuring competent care delivery. Using 3D printing technology marks a transformative shift in paediatric TB management, offering personalized treatment modalities, enhancing surgical precision, and advancing medical education. As this technology continues to evolve, its integration into clinical practice holds promise for improving outcomes and quality of life for young TB patients globally. In this paper, the authors underscore the significant contributions of 3D printing in shaping the future of paediatric TB care, illustrating its potential to redefine standards in paediatric infectious disease management.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"19 ","pages":"Article 100214"},"PeriodicalIF":0.0,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144280077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel 3D printed jig design for a smooth and accurate dome osteotomy: A case report","authors":"Ervin Sethi,&nbsp;Sze Ern Tan,&nbsp;Michael Yam","doi":"10.1016/j.stlm.2025.100210","DOIUrl":"10.1016/j.stlm.2025.100210","url":null,"abstract":"<div><div>Femoral malunion with associated sagittal and coronal deformity poses significant challenges in achieving anatomical realignment and functional restoration. This case report describes a novel surgical technique utilizing patient-specific 3D planning and a custom-designed, 3D-printed curved cutting jig to perform a dome osteotomy for deformity correction in a 69-year-old male with a history of childhood femoral fracture and recent atypical femoral fracture associated with bisphosphonate use. Preoperative CT-based 3D modeling allowed accurate assessment of the deformity and precise planning of the osteotomy. A customized jig was engineered with a hemispherical slot to guide a smooth curved osteotomy, enabling biplanar correction while preserving limb length and optimizing bony contact for healing. Intraoperative execution was streamlined by jig-guided drilling and osteotomy, followed by intramedullary nail fixation. Postoperative recovery was uneventful, with early mobilization and successful alignment and union confirmed radiographically. This approach demonstrated the value of advanced 3D technologies in enhancing surgical precision, reducing operative time and radiation exposure, and improving clinical outcomes. It represents a promising option for complex femoral deformity correction when institutional resources permit.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"19 ","pages":"Article 100210"},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144313813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conversion of an FDM printer to direct ink write 3D bioprinter utilizing an efficient and cost-effective extrusion system","authors":"Y.  H. Dang,&nbsp;Elise Dauzat,&nbsp;Asif Istiak,&nbsp;Kevin Jackson,&nbsp;Victoria Songe,&nbsp;Luke West,&nbsp;Md Imrul Kayes,&nbsp;Md Saiful Islam,&nbsp;Tanvir R. Faisal","doi":"10.1016/j.stlm.2025.100212","DOIUrl":"10.1016/j.stlm.2025.100212","url":null,"abstract":"<div><div>3D bioprinting has emerged as a transformative technology in biomedical engineering, enabling the fabrication of functional tissues through the precise deposition of cell-laden biomaterials. However, the widespread adoption of this technology is constrained by the prohibitive costs of commercial bioprinting systems. We present a cost-effective solution through the conversion of an open-source fused deposition modeling (FDM) 3D printer into a direct ink write bioprinter by integrating a peristaltic pump-based extrusion system. The modified dual-extruder system demonstrates successful deposition of hydrogel-based bioinks across varying viscosities, producing well-defined scaffold architectures. The printer's open-source control architecture facilitates retraction capabilities, high-speed movements, and customizable printing parameters, enhancing operational flexibility. This development represents a significant step toward democratizing low-cost bioprinting technology, making it accessible to academic institutions and research facilities with limited resources.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"19 ","pages":"Article 100212"},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144288849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D-printed drug delivery system from food waste: A sustainable approach for the development of novel drug delivery systems","authors":"Sejal Porwal ,&nbsp;Rishabha Malviya ,&nbsp;Sathvik Belagodu Sridhar ,&nbsp;Dhanalekshmi Unnikrishnan Meenakshi ,&nbsp;Tarun Wadhwa ,&nbsp;Javedh Shareef ,&nbsp;Musarrat Husain Warsi","doi":"10.1016/j.stlm.2025.100209","DOIUrl":"10.1016/j.stlm.2025.100209","url":null,"abstract":"<div><h3>Background</h3><div>3DP has emerged as an innovative technology in various industries, including pharmaceuticals and food. Notably, food waste is a useful resource for 3DP in drug delivery applications, helping to meet sustainability goals by recycling agricultural by-products. This concept is consistent with the circular economy since it uses elements from food waste, such as cellulose and lignin, to make bio-inks that may be used to fabricate customised drug delivery systems.</div></div><div><h3>Aim</h3><div>The study investigates the use of food waste-derived biopolymers for developing 3D-printed drug delivery systems, addressing both medical and environmental problems.</div></div><div><h3>Discussion</h3><div>Utilising food waste in 3DP drug delivery systems offers several advantages, including cost savings and reduced environmental effects. Biopolymers made from rice husk, soy protein, and eggshells improve the biodegradability and biocompatibility of pharmaceutical delivery systems. Furthermore, these food-derived biopolymers have intriguing properties such as regulated drug release and compatibility with patient-specific applications. However, there are issues in guaranteeing material consistency and stability, particularly in long-term drug release applications. Copolymerization and mixing with other biocompatible materials have the potential to improve mechanical stability and longevity, both of which are required for efficient drug administration.</div></div><div><h3>Conclusion</h3><div>Food waste-derived 3D-printed medicine delivery devices are an innovative and sustainable approach to healthcare, but further study is needed to increase scalability and consistency for broad utilization in clinical settings.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"19 ","pages":"Article 100209"},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144261445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dimensional accuracy and resolution assessment of the formlabs form 3B 3D printer for medical applications","authors":"Vera Lagerburg ,&nbsp;Anne Vrancken ,&nbsp;Sietske Bergsma ,&nbsp;Janita Dekker ,&nbsp;Wouter Diemer ,&nbsp;Judith Waldner-Troost ,&nbsp;Maaike Koenrades","doi":"10.1016/j.stlm.2025.100204","DOIUrl":"10.1016/j.stlm.2025.100204","url":null,"abstract":"<div><h3>Introduction</h3><div>For quality management of in-hospital 3D printing, it is essential to have detailed knowledge on the accuracy and reproducibility of the 3D printing process. In this study, the influence of several printing and post-processing parameters on dimensional accuracy and resolution were evaluated in three different hospitals to provide a reference for printer performance for medical applications.</div></div><div><h3>Methods</h3><div>A custom phantom was designed comprising features to assess accuracy and resolution of the Form 3B printer (Formlabs, Somerville, MA, USA). Specific features common for surgical guides were included, such as slits, flanges, and cylinders. The phantoms were 3D printed using a medical grade resin (Formlabs Biomed Clear resin) and evaluated after postprocessing and sterilization. Dimensional accuracy was defined as the deviation between the actual measurement and the known feature dimension and evaluated in x-, y- and z-direction. Resolution was defined as the smallest complete feature.</div></div><div><h3>Results</h3><div>The accuracy of the prints in the x-direction varied between -0.1 mm and 0.1 mm, in the y-direction between -0.25 mm and 0.4 mm and in the z-direction between -0.2 mm and 0.4 mm. The influence of sterilization on the accuracy was negligible. The smallest slit that was always open when printing in the x-direction was 0.3 mm and in the y-direction 0.4 mm.</div></div><div><h3>Conclusion</h3><div>This study provides hospitals with a reference for the printing accuracy and resolution for a medical grade resin. The phantom designed can be used in every hospital to determine their own printing accuracy and tolerances thereby optimizing product design for the intended clinical application.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"19 ","pages":"Article 100204"},"PeriodicalIF":0.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144116537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare professionals’ initial attitudes towards 3D printing and effects of a short educational briefing: A pre-post pilot study utilising the technology acceptance model","authors":"Una M. Cronin ,&nbsp;EmmaJude Lyons ,&nbsp;Aidan O’ Sullivan ,&nbsp;Niamh M. Cummins ,&nbsp;Leonard O’Sullivan","doi":"10.1016/j.stlm.2025.100205","DOIUrl":"10.1016/j.stlm.2025.100205","url":null,"abstract":"<div><h3>Purpose</h3><div>Adopting 3D printing technology in healthcare is variable across clinical settings and has considerable geographical differences. To advance the application of 3D printing in healthcare it is necessary to research factors inhibiting its adoption, notably in areas of low uptake. The aim of this study was to investigate attitudes toward 3D printing in Healthcare Professionals (HCPs) with low experience of the technology and to assess the effectiveness of a Short Educational Video (SEV) on these perceptions in the context of the Technology Acceptance Model (TAM).</div></div><div><h3>Design/Methodology/Approach</h3><div>This was a pre-post intervention study in a convenience sample of HCPs. A 5-minute video was developed to introduce and inform HCPs regarding 3D printing in healthcare. Participants (<em>n</em> = 52) completed an online survey grounded on the TAM before and after watching the video. Wilcoxon signed rank <em>t</em>-tests were used to analyse pre- and post-video scores. Perceptions post-intervention increased significantly for the TAM dimensions perceived usefulness (<em>p</em> &lt; 0.05), perceived ease of use (<em>p</em> &lt; 0.001), attitude toward use (<em>p</em> &lt; 0.001) and behavioural intention to use (<em>p</em> &lt; 0.001).</div></div><div><h3>Findings</h3><div>This study demonstrated that a brief introduction to the technology increased perceptual factors which may be related to the initial phase of adoption of such technology. An inference from the findings is that for HCPs with low previous experience of 3D printing, this may be a suitable model to provide education on the technology and potentially increase the adoption of 3D printing in the clinical setting. Increased perception is expected to contribute to increased likelihood of eventual adoption in healthcare.</div></div><div><h3>Originality/value</h3><div>This study addresses a literature gap in adopting 3D printing within healthcare. The study demonstrated that even brief educational interventions can substantially shift perceptions among HCPs. This suggests that the SEV is a scalable and cost-effective strategy to initially promote the adoption of 3D printing within healthcare.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"19 ","pages":"Article 100205"},"PeriodicalIF":0.0,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144069685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}