StemCurCol – 3D printed scaffold for diabetic wound regeneration

Q3 Medicine

Annals of 3D printed medicine Pub Date : 2025-05-01 DOI:10.1016/j.stlm.2025.100203

Henrique Luis Piva , Mariana Santos de Queiroz , Flavia Sayuri Matsuo , Hiago Salge Borges , Mariana Kiomy Osako , Antonio Claudio Tedesco

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Abstract

Diabetic wounds, particularly diabetic foot ulcers, pose a significant challenge for treatment due to impaired healing and susceptibility to complications. The complex pathophysiology of wounds involves dysregulated cellular and molecular processes. Advanced therapeutic strategies are needed to address the different stages of wound healing. Curcumin, a natural polyphenol, has been shown to enhance epidermal re-epithelialization, mobilize cellular participants in wound repair, and improve different stages of wound healing. In this work curcumin-chitosan nanoparticles have been prepared and characterized, and incorporated in collagen with stem cells and were implanted into normal and diabetic mice with induced wounds and their effects on wound healing were evaluated over 14 days. Animals treated with StemCurCol scaffolds presented faster closure rates and enhanced re-epithelialization than the controls, and the cells contributed to regeneration by forming new tissues, and rapidly closing wounds.

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StemCurCol - 3D打印糖尿病伤口再生支架

糖尿病性伤口，特别是糖尿病足溃疡，由于愈合受损和易发生并发症，对治疗构成重大挑战。创伤的复杂病理生理涉及细胞和分子过程的失调。需要先进的治疗策略来解决伤口愈合的不同阶段。姜黄素是一种天然多酚，已被证明可以促进表皮再上皮化，动员细胞参与伤口修复，并改善伤口愈合的不同阶段。本研究制备并表征了姜黄素-壳聚糖纳米颗粒，并将其与干细胞结合于胶原蛋白中，植入正常和糖尿病小鼠创面，观察其对创面愈合的影响。使用StemCurCol支架治疗的动物比对照组具有更快的闭合率和增强的再上皮化，并且细胞通过形成新组织和快速闭合伤口来促进再生。

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