Advanced Composites and Hybrid Materials最新文献

{"title":"Nanocomposites of sequential dual curing of thiol-epoxy systems with Fe3O4 nanoparticles for remote/in situ applications: thermomechanical, shape memory, and induction heating properties","authors":"I. Collado,&nbsp;A. Vázquez-López,&nbsp;M. Fernández,&nbsp;J. de la Vega,&nbsp;A. Jiménez-Suárez,&nbsp;S. G. Prolongo","doi":"10.1007/s42114-025-01264-7","DOIUrl":"10.1007/s42114-025-01264-7","url":null,"abstract":"<div><p>Sequential dual-curing epoxy composites, such as the thiol-epoxy system, can potentially open new capabilities for end-products in the composite industry. This system remains stable after the initial curing and can undergo further reactions when exposed to a second stimulus, such as the use of magnetic induction: a remote and energy-efficient alternative. This study reports the first dual-curing thiol-epoxy resin reinforced with magnetic nanoparticles Fe₃O₄. The addition of Fe₃O₄ nanoparticles endows the polymer matrix with dual-stimuli shape memory, triggered by both conventional heating and the use of a magnetic field, broadening potential applications. The study examined various manufacturing conditions and loadings of Fe₃O_4, which improved the mechanical properties of the composites. The dual-response shape memory was evaluated by heating the polymer with both a conventional heat source and magnetic fields, resulting in a ~ 100% shape fixation and recovery ratio for either stimulus source, with superior performance under the magnetic field. Furthermore, under moderate magnetic fields, the system was able to reach temperatures as high as 160 °C, and the influence of various parameters on the efficiency of magnetic induction heating was studied by statistical analysis of design of experiments. Additionally, two proofs of concept were presented. In the first, the second curing step was performed under the in situ heating generated by the magnetic field, successfully fixing the temporary shape into the permanent form of the sample. In the second concept, the system was utilized as a smart switch or a threshold temperature sensor.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 2","pages":""},"PeriodicalIF":23.2,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42114-025-01264-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143553650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cu–Zn@HA bimetallic nanozymes: a novel approach for ROS clearance and macrophage polarization in colitis therapy","authors":"Lin Cheng,&nbsp;Yun-kai Dai,&nbsp;Ningyi Zhang,&nbsp;Xiaotong Ye,&nbsp;Yuan Liao,&nbsp;Chun-hua Fan,&nbsp;Wen-ying Zhu,&nbsp;Shu-ling Xu,&nbsp;Liang Guo,&nbsp;Toujun Zou,&nbsp;Dongling Dai,&nbsp;Yu-jin Wu,&nbsp;Dan Liu","doi":"10.1007/s42114-025-01285-2","DOIUrl":"10.1007/s42114-025-01285-2","url":null,"abstract":"<div><p>Inflammatory bowel disease (IBD) presents significant clinical challenges due to its multifaceted pathogenesis and the limited efficacy of existing therapies. This study investigates the therapeutic potential of Cu–Zn@HA bimetallic nanozymes for the treatment of colitis. Through in vivo experiments, we demonstrated that these nanozymes exhibit sustained retention in the colon, facilitating effective modulation of gut microbiota composition and diversity. Notably, Cu–Zn@HA nanozymes significantly enhanced α-diversity and induced distinct alterations in microbial community structure across treatment groups. While no marked differences were observed in the Firmicutes/Bacteroidetes ratio, our biomarker analyses indicated critical shifts in bacterial populations associated with gut health and inflammatory responses. Additionally, Cu–Zn@HA nanozymes effectively scavenged reactive oxygen species (ROS) and promoted macrophage polarization, contributing to an anti-inflammatory microenvironment. Importantly, our studies confirmed the excellent safety profile of these nanozymes. Collectively, these findings underscore the promising role of Cu–Zn@HA bimetallic nanozymes as a novel therapeutic strategy for IBD, paving the way for future investigations into their clinical efficacy and safety.</p></div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 2","pages":""},"PeriodicalIF":23.2,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42114-025-01285-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143553660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling unexpected mechanical softening/stiffening in carbon nanotube composites under cyclic deformation: experiments and predictive modeling","authors":"Dong-Kwan Lee,&nbsp;Ohnyoung Hur,&nbsp;Eunsong Kim,&nbsp;Byung-Ho Kang,&nbsp;Sung Hoon Kang,&nbsp;Kyoungmin Min,&nbsp;Sung-Hoon Park","doi":"10.1007/s42114-025-01291-4","DOIUrl":"10.1007/s42114-025-01291-4","url":null,"abstract":"<div><p>Observation and prediction of the electrical and mechanical properties of nanocomposites under dynamic deformation conditions are critical for wearable devices and soft electronics. Despite extensive research, a comprehensive understanding of the mechanical characteristics of composites subjected to various repetitive deformations remains limited. The intrinsic mechanical properties of a composite undergo significant changes after cyclic deformation, and these changes are strongly influenced by the magnitude of deformation, type and content of fillers, and other variables. This study identified softening and unexpected stiffening effects in carbon nanotube-based composites after repeated tensile deformation. The Mullins effect was evident during cyclic stretching within the pre-strain region; however, a stiffening effect occurred beyond this region. To understand this behavior, we quantitatively evaluated three key factors—filler aspect ratio, pre-strain level, and number of cycles—to determine the mechanical properties of the composite under cyclic deformation. This was achieved using systematic experiments and molecular dynamics simulations. Existing theoretical models that predict the mechanical properties of composites fail to account for the property changes under dynamic deformation. To address this limitation, we developed a formula using symbolic regression to predict the tensile strength of the composites after cyclic deformation, demonstrating its robustness and broad applicability.</p></div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 2","pages":""},"PeriodicalIF":23.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42114-025-01291-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of high-entropy materials with their unique applications","authors":"Juanna Ren,&nbsp;Vilas Y. Kumkale,&nbsp;Hua Hou,&nbsp;Vishal S. Kadam,&nbsp;Chaitali V. Jagtap,&nbsp;Prasad E. Lokhande,&nbsp;Habib M. Pathan,&nbsp;Aricson Pereira,&nbsp;Hanhui Lei,&nbsp;Terence Xiaoteng Liu","doi":"10.1007/s42114-025-01275-4","DOIUrl":"10.1007/s42114-025-01275-4","url":null,"abstract":"<div><p>High-entropy materials (HEMs) constitute an innovative category of advanced materials distinguished by their distinctive atomic arrangements and remarkable multifunctional attributes. This thorough overview critically analyzes the core principles, synthesis methods, and novel applications of HEMs, emphasizing their transformative potentials in electromagnetic and biological fields. This study examines how the high configurational entropy effect, lattice distortion, and slow diffusion mechanisms facilitate the stabilization of single-phase systems including numerous primary elements. Recent advancements in HEM development have demonstrated exceptional skills in electromagnetic wave absorption, attaining reflection losses of up to − 35.10 dB via nano-domain designs and synergistic dielectric-magnetic loss mechanisms. Including rare-earth elements has substantially affected magnetic ordering and transition temperatures, with La-based compounds displaying spontaneous magnetization of approximately 15.2 emu/g. In biomedical applications, innovative HEM formulations have attained improved biocompatibility with a diminished Young’s modulus (69–140 GPa) and exceptional corrosion resistance. This review provides a detailed roadmap for researchers and engineers focused on the practical application of advanced materials, through a methodical analysis of current developments in energy storage, catalysis, electromagnetic shielding, and biological applications. We emphasize the significance of composition design and processing parameters in attaining customized features for specific technological applications while recognizing key difficulties and future research avenues in this swiftly advancing sector.</p></div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 2","pages":""},"PeriodicalIF":23.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42114-025-01275-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symmetric bimetallic active sites Prussian blue catalysts for photo-reforming biomass to formic acid","authors":"Junming Shi,&nbsp;Can Jin,&nbsp;Shuai Chen,&nbsp;Yulong An,&nbsp;Guoyang Gao,&nbsp;Zhanhua Huang,&nbsp;Guanjie He","doi":"10.1007/s42114-025-01282-5","DOIUrl":"10.1007/s42114-025-01282-5","url":null,"abstract":"<div><p>Photo-reforming biomass is a promising way to alleviate the energy crisis. In the research on Prussian blue analogs as photocatalysts, there are issues such as single catalytic active site, single carbon source reaction substrate, and insufficient substrate conversion. Here, the Prussian blue analogs with symmetric bimetallic active sites are designed, and the effect of the embedding of different metal sites on the reaction activity is explored. Embedding Ni metal in the Prussian blue skeleton resulted in an increased photo-response of the catalyst, an increased current density, and an enhanced catalytic efficiency of the active sites. In addition, the feasibility of photo-reforming fructose to formic acid is demonstrated, which, in combination with natural photosynthesis, explains the occurrence of decarboxylation at the C1 position of fructose to produce formic acid as well as the downstream products CO and CH₄. This work provides ideas for elucidating the photo-reforming of cellulose to high-value-added platform compounds.</p></div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 2","pages":""},"PeriodicalIF":23.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42114-025-01282-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143521722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and properties of epoxy semi-coated quartz sand proppant decorated with stearic acid functionalized TiO2 nanoparticles","authors":"Jiang Guo,&nbsp;Jiajing Xie,&nbsp;Baoqiang Lv,&nbsp;Longqiao Hu,&nbsp;Yukun Sun,&nbsp;Yu Duan,&nbsp;Wenling Wu,&nbsp;Fujian Zhou,&nbsp;Jianfeng Zhu","doi":"10.1007/s42114-025-01251-y","DOIUrl":"10.1007/s42114-025-01251-y","url":null,"abstract":"<div><p>In this work, the hydrophobic and oleophilic epoxy semi-coated quartz sand proppant decorated with stearic acid functionalized TiO₂ nanoparticles is successfully prepared. The unique semi-coated structure is characterized by SEM, SDF, and TEM. Compared with raw quartz sand proppant, the water contact angle of the epoxy semi-coated quartz sand proppant can even reach 141.6°, which is due to the rough surface and hydrophobic coating induced by semi-coated epoxy and hydrophobic stearic acid-modified TiO₂. Meanwhile, the water contact angle could be adjusted by controlling the weight content of quartz sand. Moreover, the semi-coated proppant can maintain its hydrophobicity after treated by boiling water for 4 h, indicating improved thermal stability. The physical properties including bulk density (1.44 g/cm³), apparent density (1.40 g/cm³), acid solubility (3.43%), and breakage rate (1.26%) of the semi-coated proppant decorated with stearic acid functionalized TiO₂ nanoparticles are improved. The thermal stability, acid solubility, and flow conductivity are analyzed as well. This work could provide a new idea for the preparation of quartz sand proppant to enhance the petroleum and gas production through hydraulic fracturing technology.</p></div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 2","pages":""},"PeriodicalIF":23.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42114-025-01251-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143521720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Sn insertion on hydrogen storage performance of Pd-modified silicon-based nanosheets","authors":"Fei Liu,&nbsp;Ruifei Hao,&nbsp;Yanliang Zhao,&nbsp;Chenpan Zheng,&nbsp;Ahmed M. Fallatah,&nbsp;A. Alhadhrami,&nbsp;Qian Wang,&nbsp;Yiwei Wang,&nbsp;Feng Wang,&nbsp;Zhongmin Wang,&nbsp;Terence X. Liu","doi":"10.1007/s42114-024-01198-6","DOIUrl":"10.1007/s42114-024-01198-6","url":null,"abstract":"<div><p>Metal modified silicon based nanosheets (SNS) are a promising type of composite material for hydrogen storage and transportation applications. The hydrogen storage capacity and hydrogen diffusion ability determined by the metal loading amount and uniform dispersion on the surface of silicon-based nanosheets are very important. Here, a series of Pd-Sn/SNS composite materials with different structures and properties were synthesized, and X-ray diffraction (XRD), scanning electron microscope (SEM), transmission electron microscope (TEM), X-ray photoelectron spectroscopy (XPS), pressure–composition–temperature (PCT), and electrochemical workstations were used to investigate the structure, morphology, electronic structure, hydrogen adsorption and desorption capacity, hydrogen diffusion ability, and cycling stability. The research results indicate that the insertion of Sn broaden the internal space of the SNS layers and increase the active sites for metal Pd deposition, raising the amount of metal deposition while ensuring the uniform distribution of metal Pd particles. This result leads to the promotion of electron transfers from the deposited metal to the substrate. The local electric field effect is enhanced, and the Kubas effect is boosted, which all improve the material’s hydrogen storage capacity. The maximum adsorption capacity is 4.91 wt% achieved by 15 wt% deposition sample at 450 K, and the diffusion coefficients of hydrogen D_H is 6.25 × 10^–6 cm²/s. At the same time, the cyclic stability of the material is also improved. The result of density functional theory (DFT) calculation showed that the insertion of Sn can promote the interaction between Pd deposited on the surface and H. Among them, the electron transfer number of 15 wt% Pd-Sn/SNS is the largest of 3.79 e, and the binding energy of metal atom Pd and the substrate is the largest. The H adsorption energy of 15 wt% Pd-Sn/SNS is the biggest of 0.52 eV.\u0000</p></div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 2","pages":""},"PeriodicalIF":23.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143521691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MOF-derived carbon-coated NiS/NiS2 yolk-shell spheres as a satisfactory positive electrode material for hybrid supercapacitors","authors":"Jing Wang,&nbsp;Shuo Li,&nbsp;Ning Fu,&nbsp;Dayong Tian,&nbsp;Yong Zheng,&nbsp;Fang Wang,&nbsp;Chao Liu,&nbsp;Xiaolong Wang,&nbsp;Zhongyuan Zhou,&nbsp;Yongsheng Niu,&nbsp;Hao Liu,&nbsp;Guoxiu Wang,&nbsp;Shichun Mu,&nbsp;Jiahuan Luo","doi":"10.1007/s42114-025-01257-6","DOIUrl":"10.1007/s42114-025-01257-6","url":null,"abstract":"<div><p>Optimizing the performance of electrode materials to improve the energy density of supercapacitors is the focus of current research. Construction and design with complex yolk-shell structure, as a supercapacitor electrode material, are of great significance and challenging. Herein, a self-sacrificing template strategy was used to construct uniform carbon-modified NiS/NiS₂ yolk-shell spheres using a Ni-based metal–organic framework (Ni-soc-MOF) as the precursors. Especially, the carbon shells produced by the pyrolysis of the organic ligand can improve mechanical stability and electron conductivity. Therefore, the as-obtained NiS/NiS₂@C nanocomposites display a high specific capacity (1082 C g⁻¹at 1 A g⁻¹) and outstanding cycling stability (85% capacity retention after 5000 cycles). In addition, a hybrid supercapacitor device based on the yolk-shell NiS/NiS₂@C nanocomposite and porous carbon can deliver a high energy density of 56.2 Wh kg⁻¹ at 800 W kg⁻¹, while exhibiting an excellent capacity retention of 86% after 10,000 charge/discharge cycles, demonstrating the promising potential of yolk-shell NiS/NiS₂@C nanocomposites via Ni-soc-MOF-derived route in practical application.</p></div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 2","pages":""},"PeriodicalIF":23.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42114-025-01257-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143496877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustainable prospects of lignocellulosic wood and natural fiber-based materials in 3D and 4D printing","authors":"K. M. Faridul Hasan,&nbsp;Md Mazedur Rahman,&nbsp;Fatema Khanum Rima,&nbsp;Jakiya Sultana,&nbsp;Muhammad Abu Taher,&nbsp;Péter György Horváth,&nbsp;József Garab,&nbsp;László Bejó,&nbsp;Tibor Alpár","doi":"10.1007/s42114-025-01273-6","DOIUrl":"10.1007/s42114-025-01273-6","url":null,"abstract":"<div><p>The sustainable options for 3D/4D printing, utilizing lignocellulosic materials derived from wood and natural fibers, have gained significant attention in the pursuit of building a greener and more environmentally friendly world. As environmental concerns continue to grow, there is an increasing focus on greener materials and manufacturing processes. The utilization of these environmentally friendly alternatives as substitutes for synthetic fiber filled polymer matrices in 3D/4D printing is driven by the objective of enhancing the material properties of printed items while reducing material costs. 3D/4D printing, also known as additive manufacturing, represents a promising frontier in environmentally friendly manufacturing. Recent progress and advancements in 3D/4D printing technology have expanded its capabilities beyond prototyping to the rapid fabrication of finished goods. This review explores the characteristics, processing techniques, mechanical and physical properties, applications, and future possibilities of sustainable 3D/4D printed products developed from wood and natural fibers. Architectural design and polymer selection have the potential to yield materials with improved functionality, mechanical characteristics, porosity, and stability. Additionally, the multifunctional polymer-based 3D/4D printing product development has enabled the production of biomedical devices, electrical products, and aerospace-related items. The challenges associated with utilizing these products for large-scale production and other aspects of sustainable 3D/4D printing will also be discussed, along with recommendations for future solutions. Overall, this work offers valuable insights that can guide future research, development, and implementation of lignocellulosic-based 3D/4D printed composites. By exploring the potential of these sustainable materials in 3D/4D printing, it contributes to the advancement of environmentally friendly manufacturing practices and promotes the adoption of greener alternatives across various industries.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 2","pages":""},"PeriodicalIF":23.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42114-025-01273-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143496963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glutamic acid-loaded separable microneedle composite for long-acting hair regeneration treatment","authors":"Bricard Mbituyimana,&nbsp;Lina Fu,&nbsp;Hao Wang,&nbsp;Fuyu Qi,&nbsp;Yuchi Jiang,&nbsp;Fanbo Meng,&nbsp;Min Wu,&nbsp;Zhijun Shi,&nbsp;Guang Yang","doi":"10.1007/s42114-025-01287-0","DOIUrl":"10.1007/s42114-025-01287-0","url":null,"abstract":"<div><p>Androgenetic alopecia (AGA) is the most common type of hair loss frequently observed in clinics. Right now, there are no effective treatments for AGA. Here, we developed a biodegradable microneedle (MN) patch made of polylactic-co-glycolic acid (PLGA) loaded with glutamic acid (GA) that improves sustainable drug release and effective hair regeneration treatment. Once the patch has penetrated the skin, the GA-loaded MNs (GA-MNs) are quickly separated from their base and enter the skin. These MNs then serve as drug storage tanks inside the skin, releasing the therapeutics gradually for over 4 weeks. The sustained release of GA from long-acting biodegradable needles could lead to endocytosis by dermal papilla cells (DPCs), promoting the proliferation of cells. Compared with topical minoxidil, which requires daily treatment, animal studies have shown that GA-MNs can increase hair regeneration more effectively with lower dose frequency; the number of hair follicles in the GA-MNs group reached 83.68 ± 4.52%, which was significantly higher than that of the minoxidil group (56.93 ± 3.21%). This transdermal technology of biodegradable MNs shows considerable promise in clinical applications and offers a straightforward, safe, and effective therapy approach for clinical hair regeneration treatment.</p></div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 2","pages":""},"PeriodicalIF":23.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42114-025-01287-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143489560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}