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IF 23.2 2区材料科学 Q1 MATERIALS SCIENCE, COMPOSITES

Advanced Composites and Hybrid Materials Pub Date : 2025-03-18 DOI:10.1007/s42114-025-01271-8

Hui Chen, Zihan Li, Qianqian Yu, Weichang Li, Lisha Gu

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引用次数: 0

摘要

假牙口腔炎（DS）是假牙佩戴者的一大健康问题，它是由白色念珠菌过度生长引起的，并导致上颌假牙下方发炎。目前的治疗方案，包括抗真菌药物和义齿消毒剂，往往受到不良反应和疗效降低的限制。为了应对这些挑战，本研究旨在开发一种新型假牙树枝状聚合物涂层，其中包含疏水性季铵盐（QAS）、亲水性儿茶酚官能团和聚集诱导发射（AIE）荧光团。QAS 以其广谱抗菌活性而著称，它被整合到涂层中，以增强附着力和抗菌性能。树枝状聚合物结构中丰富的儿茶酚官能团有助于提高涂层的稳定性和附着力，这对于在动态口腔环境中长期发挥功效至关重要。此外，AIE 荧光团还能实时监测涂层的完整性，克服了传统荧光染料的局限性。研究的重点是优化涂层构造技术，重点是增强附着力、抗菌功能和实时监测能力。对涂层抗菌机理的研究旨在阐明其抗击 DS 的潜力，并为治疗性假牙提供解决方案。这种方法为目前的治疗方法提供了一种很有前景的替代方案，满足了义齿相关口腔炎对有效、持久的抗真菌疗法的迫切需求。

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Antimicrobial and adhesive dendritic polymer coatings with real-time in situ monitoring via aggregation-induced emission

Denture stomatitis (DS) is a significant health concern among denture wearers, caused by the overgrowth of Candida albicans and leading to inflammation beneath maxillary dentures. Current treatment options, including antifungal medications and denture disinfectants, are often limited by adverse effects and reduced efficacy. To address these challenges, this study aims to develop a novel dendritic polymer coating for dentures, which incorporates hydrophobic quaternary ammonium salts (QAS), hydrophilic catechol functional groups, and aggregation-induced emission (AIE) fluorophores. QAS, known for their broad-spectrum antimicrobial activity, are integrated into the coating to enhance the adhesion and antimicrobial properties. Catechol functional groups, rich in the dendritic polymer structure, contribute to improved stability and adhesion of the coating, which is crucial for long-term efficacy in the dynamic oral environment. Additionally, AIE fluorophores enable real-time monitoring of coating integrity, overcoming limitations of traditional fluorescent dyes. The study focuses on optimizing coating construction techniques, with an emphasis on enhancing adhesion, antimicrobial functionality, and real-time monitoring capabilities. Investigations into the antimicrobial mechanism of the coating aim to elucidate its potential in combating DS and offering solutions for therapeutic dentures. This approach presents a promising alternative to current treatments, addressing the urgent need for effective and durable antifungal therapies for denture-related stomatitis.

Graphical abstract

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来源期刊

Advanced Composites and Hybrid Materials Multiple-

CiteScore

26.00

自引率

21.40%

发文量

185

期刊介绍： Advanced Composites and Hybrid Materials is a leading international journal that promotes interdisciplinary collaboration among materials scientists, engineers, chemists, biologists, and physicists working on composites, including nanocomposites. Our aim is to facilitate rapid scientific communication in this field. The journal publishes high-quality research on various aspects of composite materials, including materials design, surface and interface science/engineering, manufacturing, structure control, property design, device fabrication, and other applications. We also welcome simulation and modeling studies that are relevant to composites. Additionally, papers focusing on the relationship between fillers and the matrix are of particular interest. Our scope includes polymer, metal, and ceramic matrices, with a special emphasis on reviews and meta-analyses related to materials selection. We cover a wide range of topics, including transport properties, strategies for controlling interfaces and composition distribution, bottom-up assembly of nanocomposites, highly porous and high-density composites, electronic structure design, materials synergisms, and thermoelectric materials. Advanced Composites and Hybrid Materials follows a rigorous single-blind peer-review process to ensure the quality and integrity of the published work.