Physical entanglement improves the anti-adsorption and super-lubricity properties of polyacrylamide-based hydrogels for biomedical applications

IF 23.2 2区材料科学 Q1 MATERIALS SCIENCE, COMPOSITES

Advanced Composites and Hybrid Materials Pub Date : 2025-03-15 DOI:10.1007/s42114-025-01267-4

Junyu Wang, Yan Xu, Shenglin Li, Luyao Tang, Xiaomin Li, Jian Song, Yuhong Liu

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引用次数: 0

Abstract

Though hydrogels have been widely employed in clinical applications, the bio-fouling problem and poor tribological performance have become one of the crucial limitations. In this study, we innovatively explore physically entangled hydrogels to achieve superior anti-adsorption and lubrication performance and prepare a soft and stretchable hydrogel catheter. The albumin adsorption mass is as low as 0.014 μg/mm², a 97% reduction in protein adsorption mass compared to widely recognized zwitterionic materials. These advantages stem from the numerous physical entanglements in the hydrogel. First, the thicker hydration layer arising from elevated monomer density minimizes contact between proteins and polymer chains; second, binding the soft suspension chain to the hydrogel surface prevents the chains from bonding to proteins in solution. By utilizing physically entangled hydrogels with soft and tough characteristics, the fabricated hydrogel catheters with anti-protein adsorption possess superlubricating properties in serum (friction coefficient: 5.7 × 10⁻³). The physically entangled hydrogel demonstrates a promising approach that can enhance both the anti-adsorption and super-lubricity properties, with the aim of extending the service life of medical devices and improving patient comfort.

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来源期刊

Advanced Composites and Hybrid Materials Multiple-

CiteScore

26.00

自引率

21.40%

发文量

185

期刊介绍： Advanced Composites and Hybrid Materials is a leading international journal that promotes interdisciplinary collaboration among materials scientists, engineers, chemists, biologists, and physicists working on composites, including nanocomposites. Our aim is to facilitate rapid scientific communication in this field. The journal publishes high-quality research on various aspects of composite materials, including materials design, surface and interface science/engineering, manufacturing, structure control, property design, device fabrication, and other applications. We also welcome simulation and modeling studies that are relevant to composites. Additionally, papers focusing on the relationship between fillers and the matrix are of particular interest. Our scope includes polymer, metal, and ceramic matrices, with a special emphasis on reviews and meta-analyses related to materials selection. We cover a wide range of topics, including transport properties, strategies for controlling interfaces and composition distribution, bottom-up assembly of nanocomposites, highly porous and high-density composites, electronic structure design, materials synergisms, and thermoelectric materials. Advanced Composites and Hybrid Materials follows a rigorous single-blind peer-review process to ensure the quality and integrity of the published work.