Animal microbiome最新文献

{"title":"Host-microbiome interplay supports heat stress resilience in zebu calves.","authors":"Brijesh Yadav, Goutam Banerjee, Anandita Srivastava, Arun Kumar Madan, Ravindra Kumar, Pratik Banerjee","doi":"10.1186/s42523-026-00539-8","DOIUrl":"10.1186/s42523-026-00539-8","url":null,"abstract":"","PeriodicalId":72201,"journal":{"name":"Animal microbiome","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13064310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-dependent gut microbiota associated with intramuscular fat deposition in Longdong cashmere goats.","authors":"Heyu Chai, Haowen Cheng, Jiayang Sun, Yuzhu Luo, Bingang Shi, Jiqing Wang, Shaobin Li, Jing Luo, Fangfang Zhao","doi":"10.1186/s42523-026-00530-3","DOIUrl":"10.1186/s42523-026-00530-3","url":null,"abstract":"<p><p>Intramuscular fat (IMF) is a key determinant of meat quality, influencing tenderness, juiciness, and flavor. Previous studies have reported that the deposition of IMF is controlled by various factors. However, there is a shortage of research exploring the variations in IMF deposition across age groups from a microbial perspective. This study evaluated the differences in IMF deposition between yearling (1-year-old) and mature (4-year-old) Longdong Cashmere goats and analyzed its association with gut microbiota. The results revealed that the IMF content in shoulder meat and blood lipid levels increased with age (p < 0.05). Conversely, the contents of lipoprotein lipase (LPL) in the liver and duodenum significantly decreased with age. Microbial diversity differed between the two age groups, with specific microbiota identified from the gut of goats involved in the lipid metabolism pathway. The concentrations of valeric and isovaleric acids in the rumen, as well as acetic, propionic and isovaleric acids in the colon, were higher in yearling goats than in mature goats (p < 0.05). Spearman correlation analysis of IMF deposition indicators with gut microbiota revealed that, within the rumen, the abundances of CAG-791 and Sodaliphilus were positively correlated with IMF content in shoulder meat and TG levels, while exhibiting a negative correlation with the contents of valeric acids. Furthermore, the abundance of Clostridium_R showed a positive association with IMF content in shoulder meat and with the abundances of CAG-791and Sodaliphilus. In contrast, the abundance of Bact_11 was negatively correlated with IMF content in shoulder meat, TG levels, and the abundances of CAG-791, Sodaliphilus and Clostridium_R. Within the abomasum, the abundances of UMGS and Hylemonella_582308 were correlated with IMF content in the shoulder meat, as well as serum LDL and VLDL levels. This study provides significant insights into the age-dependent gut microbiota associated with intramuscular fat deposition in goats and identifies several potential gut microbiota for further research on their impacts on IMF deposition.</p>","PeriodicalId":72201,"journal":{"name":"Animal microbiome","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13049821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147319161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacillus velezensis alleviates PM_2.5-induced intestinal injury and dysbiosis in broilers via the \"lung-gut axis\".","authors":"Xuan Liu, Xunbozan Zhang, Christopher Peterson Daniel, Dadan Liu, Liang Chen, Hongfu Zhang","doi":"10.1186/s42523-026-00529-w","DOIUrl":"10.1186/s42523-026-00529-w","url":null,"abstract":"<p><strong>Background: </strong>This study investigated how tracheal instillation of Bacillus velezensis mitigates PM_2.5-induced lung injury and counteracts its adverse effects on distal intestinal health in broilers via the \"lung-gut axis\".</p><p><strong>Results: </strong>Five groups were randomly selected from among seventy-five 14-day-old AA broilers: Control, Saline, PM2.5, B. velezensis, and B. velezensis + PM2.5. Results showed that compared with the Saline group, PM_2.5 exposure disrupted lung structure and significantly upregulated TLR4, MyD88, NF-κB, IL-18, and IFN-γ related inflammatory factors via the TLR4/MyD88/NF-κB signaling axis (P < 0.05). In addition, it significantly reduced jejunal villus height through the action of the \"lung-gut axis\" (P < 0.05), decreased the levels of IL-10, Claudin-1, and Occludin while increasing that of IL-22 (P < 0.05). Analysis of the cecal microbiota found that PM_2.5 reduced the Shannon index of bacterial communities and raised the relative abundance of Bacteroidota, Pseudomonadota, and Flavonifractor. Co-treatment with B. velezensis + PM_2.5 reversed the above changes, significantly improved lung and intestinal morphology, enhanced jejunal barrier function, reduced lung and jejunal inflammatory responses, and increased the relative abundance of Faecalibacterium. Based on KEGG functional prediction, the PM_2.5 group was enriched in microbial metabolic pathways, such as two-component systems and ABC transporters.</p><p><strong>Conclusions: </strong>Tracheal instillation of B. velezensis can improve the expression of genes associated with lung injury via the TLR4/MyD88/NF-κB signaling axis and effectively alleviate PM_2.5-induced distal jejunal damage, barrier dysfunction, inflammatory response, and dysbiosis by mediating the \"lung-gut axis\". This could provide a theoretical support and scientific basis for seeking probiotics to improve PM_2.5 harm.</p>","PeriodicalId":72201,"journal":{"name":"Animal microbiome","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13049975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147319133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disordered colonic microbiota as a potential contributor to inflammation in diarrheal Jinhua weaned piglets.","authors":"Jiaheng Li, Chengzeng Luo, Fangfang Lou, Xiaojun Zhang, Jiujun Duan, Zeou Wei, Xujin Hu, Pingguang Tu, Xizhong Du, Ruqing Zhong, Liang Chen, Hongfu Zhang","doi":"10.1186/s42523-026-00525-0","DOIUrl":"10.1186/s42523-026-00525-0","url":null,"abstract":"","PeriodicalId":72201,"journal":{"name":"Animal microbiome","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13049971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147319135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of fermented grape pomace on growth performance and intestinal health of weaned piglets.","authors":"Mingyu Wang, Qi Li, Ao Guo, Jiaqi Yue, Lin Zhang, Guangquan Lv, Taiyong Yu","doi":"10.1186/s42523-025-00507-8","DOIUrl":"10.1186/s42523-025-00507-8","url":null,"abstract":"<p><p>The improvement of forage quality through proper fermentation is well documented. Grape pomace (GP), an economically valuable by-product, remains underutilized despite its potential benefits. This study explores the effects of fermented GP (FGP) supplementation on weaned piglets, focusing on immune and antioxidant capacity, intestinal flora homeostasis, growth performance, and diarrhea reduction. We first analyzed and compared the nutritional composition of GP before and after fermentation. Subsequently, a diet supplemented with 5% FGP was formulated. From an initial pool of 480 weaned piglets, 120 healthy animals (28 days old, average weight 8.42 ± 0.19 kg) were randomly assigned to two groups: a control group (CON) fed a basal diet and an experimental group receiving the 5% FGP-supplemented diet. The results demonstrated that fermentation significantly enhanced the levels of key nutrients and amino acids (e.g., Ca, P, Glu) in GP (P < 0.05). Dietary supplementation with FGP significantly improved feed efficiency, as indicated by a reduced feed-to-gain ratio (F/G), and decreased the incidence of diarrhea (P < 0.05). Additionally, FGP exhibited notable antioxidant activity, reflected by reduced serum malondialdehyde (MDA) levels and mitigation of oxidative stress (P < 0.05). Immunomodulatory benefits were also observed, including elevated serum immunoglobulin G (IgG) and interleukin-10 (IL-10), along with decreased tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels (P < 0.05). Morphological improvements in intestinal architecture were evident, with increased villus height (VH) in the duodenum, jejunum, and ileum, as well as an enhanced villus height-to-crypt depth ratio (V/C) (P < 0.05). In conclusion, dietary inclusion of FGP enhances disease resistance in piglets by improving antioxidant capacity, modulating immune responses, enhancing intestinal morphology, and enriching microbial diversity. These findings support FGP as a viable nutritional strategy for boosting health and optimizing the utilization of grape processing by-products.</p>","PeriodicalId":72201,"journal":{"name":"Animal microbiome","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13041460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamics of the milk microbial community during subacute ruminal acidosis with or without intramammary lipopolysaccharide challenge in dairy cows.","authors":"Viktoria Neubauer, Siska Aditya, Narciso M Quijada, Stefanie Urimare Wetzels, Monika Dzieciol, Poulad Pourazad, Qendrim Zebeli, Evelyne Selberherr","doi":"10.1186/s42523-025-00499-5","DOIUrl":"10.1186/s42523-025-00499-5","url":null,"abstract":"","PeriodicalId":72201,"journal":{"name":"Animal microbiome","volume":"8 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12937525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Composition of microbiota from chicken caecal mucosa considerably differs from microbiota in the caecal lumen.","authors":"Jiri Volf, Daniela Karasova, Magdalena Crhanova, Marcela Faldynova, Hana Prikrylova, Michal Zeman, Vladimir Babak, Jana Rajova, Pavel Kulich, Ivan Rychlik","doi":"10.1186/s42523-026-00536-x","DOIUrl":"10.1186/s42523-026-00536-x","url":null,"abstract":"<p><strong>Background: </strong>Despite the importance of microbiota at mucosal surfaces of the gut and their different composition in comparison to those colonising the gut lumen, only a few papers specifically addressed this topic. In this study, we therefore defined mucosa-associated and lumen-associated microbiota from the chicken caecum.</p><p><strong>Results: </strong>To identify mucosa-adapted microbiota members, caeca from adult hens instead of chicks should be analysed. Mucosa-adapted microbiota included Treponema-like species, Brachyspira innocens, Mucispirillum sp., Helicobacter pullorum, Desulfovibrio sp. and Anaerobiospirillum sp. On the other hand, representatives of Bacteroidota were enriched in the caecal lumen. Reduced colonization of the mucosal surface in one-week-old chicks was a consequence of the lack of appropriate microbiota source in chicks obtained from hatcheries since when the chicks were raised in the presence of adult hens, they were efficiently colonised by mucosa-adapted microbiota within the first week of life. The identified mucosa-associated bacteria were of helical shape, chemotactic and motile, and expressed type VI secretion system in vivo. Brachyspira innocens and Anaerobiospirillum fermented carbohydrates while Mucispirillum sp. and Helicobacter pullorum preferred amino-acid fermentation.</p><p><strong>Conclusions: </strong>Here, we defined mucosal microbiota of chicken caecum, microbiota which are in closer contact with chicken host than the luminal microbiota and may therefore considerably affect the behaviour of chickens.</p>","PeriodicalId":72201,"journal":{"name":"Animal microbiome","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13040750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Faecal microbiome profiling uncovers putative biomarkers for piglets resilient to post-weaning diarrhoea.","authors":"Mattia Pirolo, Moiz Khan Sherwani, Carmen Espinosa-Gongora, Esben Østergaard Eriksen, Clara Tassinato, Antton Alberdi, Luca Guardabassi","doi":"10.1186/s42523-026-00522-3","DOIUrl":"10.1186/s42523-026-00522-3","url":null,"abstract":"","PeriodicalId":72201,"journal":{"name":"Animal microbiome","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13040825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147286347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large-scale genomic analysis of jumbo phages: coevolution, genome architecture, and host interaction mechanisms.","authors":"Chao Wei, Zhe Chen, Yaxiang Wang, Lusheng Huang, Congying Chen","doi":"10.1186/s42523-026-00534-z","DOIUrl":"10.1186/s42523-026-00534-z","url":null,"abstract":"","PeriodicalId":72201,"journal":{"name":"Animal microbiome","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13037316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147286395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ecological insights into the cross-domain microbiome interactions in the hematophagous bat Desmodus rotundus.","authors":"Nicolas Luna, Carolina Hernández, Angie L Ramírez, Plutarco Urbano, Karen Barragán, Catalina Ariza, Marina Muñoz, Luz H Patiño, Juan David Ramírez","doi":"10.1186/s42523-025-00504-x","DOIUrl":"10.1186/s42523-025-00504-x","url":null,"abstract":"","PeriodicalId":72201,"journal":{"name":"Animal microbiome","volume":"8 1","pages":"22"},"PeriodicalIF":4.4,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12922381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146228685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}