Aggregate (Hoboken, N.J.)最新文献_第5页

Harnessing the Biological Responses Induced by Nanomaterials for Enhanced Cancer Therapy 利用纳米材料诱导的生物反应增强癌症治疗

IF 13.7

Aggregate (Hoboken, N.J.) Pub Date : 2025-06-24 DOI: 10.1002/agt2.70080

Liting Wang, Hao Fu, Jiangtao Lin, Meng Zhao, Chuanrong Chen, Hongze Liao, Yourong Duan

{"title":"Harnessing the Biological Responses Induced by Nanomaterials for Enhanced Cancer Therapy","authors":"Liting Wang, Hao Fu, Jiangtao Lin, Meng Zhao, Chuanrong Chen, Hongze Liao, Yourong Duan","doi":"10.1002/agt2.70080","DOIUrl":"https://doi.org/10.1002/agt2.70080","url":null,"abstract":"Nanomaterials (NMs) have garnered decades of research interest owing to their unique physicochemical properties and unparalleled advantages in diverse applications. However, these distinctive characteristics simultaneously raise concerns regarding their biosafety. Recent advancements in understanding NMs–organism interactions have led to innovative strategies for mitigating their intrinsic toxicity. Notably, emerging studies reveal that through rational design and precise manipulation, the inherent toxicological effects of NMs can be strategically repurposed for cancer therapeutics. For instance, functionalized NMs may disrupt oxidative homeostasis, activate programmed cell death pathways, modulate immune responses, or regulate ion channel activities. Despite these promising discoveries, the systematic exploitation of NMs-induced biological responses in oncological interventions remains underexplored. Therefore, this review provides, for the first time, a comprehensive introduction to NM-mediated biological process modulation, focusing on their mechanisms and therapeutic potential in cancer treatment. We have summarized (1) key pathways through which NMs elicit cytotoxic effects, including redox homeostasis regulation, immunogenic cell death activation, and so on; (2) design principles for engineering NMs with controllable bio-interactions; and (3) innovative applications leveraging NM-triggered physical effects (e.g., photothermal conversion, reactive oxygen species generation) as targeted therapeutic modalities. Furthermore, we also highlight the translational significance of harnessing NM-specific bioactivities while discussing current challenges in clinical adaptation and possible solutions. By bridging the gap between nanotoxicology and therapeutic innovation, this manuscript offers novel perspectives for developing next-generation nanomedicine platforms with enhanced efficacy and safety profiles.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 9","pages":""},"PeriodicalIF":13.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70080","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Photothermal-Photocatalytic Textile With Efficient Thermal Management for Boosting Ciprofloxacin Purification 高效热管理的光热-光催化织物促进环丙沙星净化

IF 13.7

Aggregate (Hoboken, N.J.) Pub Date : 2025-06-24 DOI: 10.1002/agt2.70091

Yuge Wang, Lipei Ren, Yan Zhuang, Dongfang Liu, Zhixun Zhang, Lei Zhuo, Qian Zhang, Xiwei Guo, Xingfang Xiao, He Zhu

{"title":"A Photothermal-Photocatalytic Textile With Efficient Thermal Management for Boosting Ciprofloxacin Purification","authors":"Yuge Wang, Lipei Ren, Yan Zhuang, Dongfang Liu, Zhixun Zhang, Lei Zhuo, Qian Zhang, Xiwei Guo, Xingfang Xiao, He Zhu","doi":"10.1002/agt2.70091","DOIUrl":"https://doi.org/10.1002/agt2.70091","url":null,"abstract":"Photocatalysis is a renewable and eco-friendly process with great potential for the purification of ciprofloxacin (CIP) in water. However, conventional methods tend to focus on the design of photocatalysts, which pays less attention to the photothermal performance, resulting in a limited purification rate. Here, we propose a photothermal-photocatalytic textile based on carbon fiber felts decorated with homogeneous titanium dioxide films to efficiently purify CIP in water. The carbon fiber felts decorated with titanium dioxide films show high solar absorption (∼93 %) for solar water evaporation and simultaneous photocatalytic degradation for CIP purification. Notably, the enhancement of local wettability by titanium dioxide films on carbon fiber felts promotes photothermal efficiency. The carbon fiber felts decorated with titanium dioxide films demonstrate an evaporation rate of 1.19 kg m−2 h−1, achieving an efficiency of 72.5 % under 1 sun. The experimental results reveal that the local thermal effect can effectively enhance catalytic degradation. CIP is almost completely degraded under sunlight, whereas the degradation efficiency under UV light is 55.8%. Specifically, we observe that CIP can be effectively degraded in purified water and condensed water. Moreover, the carbon fiber felts decorated with titanium dioxide films exhibit multidirectional degradation performance and stable physical and chemical properties, maintaining stable photothermal and photocatalytic performance even after prolonged sunlight exposure and repeated use. This work provides a paradigm for harnessing the abundant sunlight for antibiotic degradation.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 9","pages":""},"PeriodicalIF":13.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70091","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Back Cover: Size-dependent Stability and Luminescence Property in Organic Aggregates 封底：有机聚集体的尺寸依赖性稳定性和发光特性

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-06-22 DOI: 10.1002/agt2.70082

Junfang Yang, Jikai Lv, Yuan Jiao, Xiaoyan Zheng, Qian Peng

{"title":"Back Cover: Size-dependent Stability and Luminescence Property in Organic Aggregates","authors":"Junfang Yang, Jikai Lv, Yuan Jiao, Xiaoyan Zheng, Qian Peng","doi":"10.1002/agt2.70082","DOIUrl":"https://doi.org/10.1002/agt2.70082","url":null,"abstract":"This work explores the critical sizes of stable aggregates and their bright luminescence for helical hexaphenylsilole and planar 3-(2-cyano-2-phenylethenyl-Z)-NH-indole aggregation-induced emission luminogens, providing dynamic insights into the aggregation-induced emission (AIE) mechanism and invaluable guidance for optimizing the size of AIE-based nanoparticles in practical bioimaging and sensing applications (e70029).\u0000This review highlights cutting-edge strategies for enhancing the detection of pathogen-derived extracellular vesicles, including novel aggregate materials and machine learning approaches. Pathogen-derived vesicles are pivotal in host-pathogen interactions and possess significant diagnostic promise, as their unique cargo offers a rich repository of potential biomarkers. Enhancing vesicle detection may ultimately pave the way for transformative clinical applications (e70018).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture>\u0000 </div>\u0000 </figure>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 6","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70082","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Front Cover: Hydrogel-Based Smart Materials for Wound Healing and Sensing 封面：用于伤口愈合和传感的基于水凝胶的智能材料

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-06-22 DOI: 10.1002/agt2.70084

Thi Kim Ngan Duong, Thi Thuy Truong, Thi Nhat Linh Phan, Thi Xuan Nguyen, Vu Hoang Minh Doan, Truong Tien Vo, Jaeyeop Choi, Umapada Pal, Prodyut Dhar, Byeongil Lee, Junghwan Oh, Sudip Mondal

引用次数: 0

Inside Front Cover: Development and Application of Organic Sonosensitizers in Cancer Therapy 内封面：有机声敏剂在癌症治疗中的发展与应用

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-06-22 DOI: 10.1002/agt2.70085

Yuhan Ding, Yuchen Yang, Omer Aras, Feifei An, Mengjiao Zhou, Yichao Chai

引用次数: 0

Inside Back Cover: Near-Infrared Organic Room Temperature Phosphorescent Probes Targeting Fibroblast Activation Protein for Surgical Navigation of Liver Cancer 封底内：近红外有机室温磷光探针靶向成纤维细胞激活蛋白用于肝癌手术导航

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-06-22 DOI: 10.1002/agt2.70083

Jinghua Li, Juqing Gu, Liangxuan Ding, Xiaomian Li, Peng Xia, Fusheng Liu, Xi Chen, Weijie Ma, Yong He, Qianqian Li, Zhen Li, Yufeng Yuan

引用次数: 0

Pathway Complexity in Supramolecular Polymerization of Porphyrin Dyads for Kinetic Control of Helicity 卟啉对体超分子聚合的路径复杂性及其对螺旋度的动力学控制

IF 13.7

Aggregate (Hoboken, N.J.) Pub Date : 2025-06-16 DOI: 10.1002/agt2.70090

Hosoowi Lee, Yongho Lee, Minhyeong Lee, Dae Eun Kang, Jiwon Kim, Dong Ha Kim, Woo-Dong Jang

{"title":"Pathway Complexity in Supramolecular Polymerization of Porphyrin Dyads for Kinetic Control of Helicity","authors":"Hosoowi Lee, Yongho Lee, Minhyeong Lee, Dae Eun Kang, Jiwon Kim, Dong Ha Kim, Woo-Dong Jang","doi":"10.1002/agt2.70090","DOIUrl":"https://doi.org/10.1002/agt2.70090","url":null,"abstract":"The supramolecular polymerization of porphyrin dyad (PD) shows the pathway complexity leading to the formation of kinetically metastable nanoparticles (PDParticle) through rapid cooling and thermodynamically stable fibrous supramolecular polymers (PDFiber) through slow cooling. The kinetically metastable PDParticle is gradually transformed to the thermodynamically stable PDFiber. Due to the inherent achirality of PD, AFM images exhibited a random distribution of both M and P helices. Introducing chiral alkyl chains achieved a predominant helicity in PDFiber, with (S)-PD favoring M helices and (R)-PD favoring P helices. The addition of chiral 2-methyl pyrrolidine (MePy) further influences this transformation by retarding the transition from PDParticle to PDFiber through axial coordination with the zinc porphyrin units, affecting the helicity of the resulting supramolecular polymer. By manipulating the cooling rates and environmental conditions, we demonstrate the reversible control over circular dichroism (CD) and circularly polarized luminescence (CPL), providing insight into the relationship between structural chirality and optical activity.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 8","pages":""},"PeriodicalIF":13.7,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70090","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144881337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Smart Ru-Locked Chemiluminescence Probe via Bioorthogonal Activation for Highly Selective, Real-Time and Noninvasive In Vivo Imaging of Thiol Dysregulation 一种基于生物正交激活的智能ru锁定化学发光探针，用于高选择性、实时和无创的硫醇失调体内成像

IF 13.7

Aggregate (Hoboken, N.J.) Pub Date : 2025-06-13 DOI: 10.1002/agt2.70076

Dongnan Guo, Dan Xu, Xiaofeng Wei, Chunying Fan, Bobo Wang, Laifu Li, Haixia Song, Wenguang Yang, Yujie Wang, Zhaojia Wang, Xiaofang Hou, Sicen Wang

{"title":"A Smart Ru-Locked Chemiluminescence Probe via Bioorthogonal Activation for Highly Selective, Real-Time and Noninvasive In Vivo Imaging of Thiol Dysregulation","authors":"Dongnan Guo, Dan Xu, Xiaofeng Wei, Chunying Fan, Bobo Wang, Laifu Li, Haixia Song, Wenguang Yang, Yujie Wang, Zhaojia Wang, Xiaofang Hou, Sicen Wang","doi":"10.1002/agt2.70076","DOIUrl":"https://doi.org/10.1002/agt2.70076","url":null,"abstract":"Bioorthogonal cleavage chemistry (BCC) has been extensively applied to fluorescence-based imaging in cancer diagnostics. Its potential in chemiluminescence imaging is to be explored. In this study, a smart ruthenium (Ru)-catalyzed bioorthogonal activation chemiluminescence (BAC) probe is developed by integrating BCC with a phenoxy-adamantyl-1,2-dioxetane (PAD) for real-time in vivo imaging of thiol-containing metabolites, particularly hydrogen sulfide (H₂S), associated with thiol dysregulation in the tumor microenvironment. The BAC probe overcomes many limitations that existed in other chemiluminescence probes via a highly selective “Ru-locked” mechanism to achieve light-independent, thiol-triggered activation in the complex tumor microenvironment. This mechanism enables rapid activation (1 min), high sensitivity (LOD = 0.243 µM), and stable luminescence with a half-life of 18.5 h, as determined in vitro, across a broad emission range (400–800 nm). The probe also demonstrates enhanced selectivity for thiol-containing metabolites, particularly H₂S, and exhibits low toxicity both in vitro and in vivo. In a breast cancer mouse model, the probe successfully visualizes endogenous H₂S with high spatial precision, supporting its utility in tumor localization and image-guided surgery. In addition, the PAD scaffolds are developed via an efficient synthetic route, significantly lowering production costs (300- to 400-fold) and increasing yields from 40% to 95%. Furthermore, our BAC probe holds a broad potential for noninvasive diagnosis and real-time monitoring of thiol dysregulation and pathophysiological processes.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 8","pages":""},"PeriodicalIF":13.7,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70076","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144881016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carbon–Nitrogen Axial Chirality as a Novel Chiral Framework Design Strategy for Circularly Polarized Luminescence Materials 碳氮轴向手性：一种新的圆极化发光材料手性框架设计策略

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-06-13 DOI: 10.1002/agt2.70069

Lei Zeng, Chen-Hao Guo, Chensen Li, Ziwei Deng, Yi Lu, Lin Lu, Peng Meng, Shuaijun Sun, Zijie Qiu, Meng Li, Yu Xiong, Zheng Zhao, Chuan-Feng Chen, Ben Zhong Tang

{"title":"Carbon–Nitrogen Axial Chirality as a Novel Chiral Framework Design Strategy for Circularly Polarized Luminescence Materials","authors":"Lei Zeng, Chen-Hao Guo, Chensen Li, Ziwei Deng, Yi Lu, Lin Lu, Peng Meng, Shuaijun Sun, Zijie Qiu, Meng Li, Yu Xiong, Zheng Zhao, Chuan-Feng Chen, Ben Zhong Tang","doi":"10.1002/agt2.70069","DOIUrl":"https://doi.org/10.1002/agt2.70069","url":null,"abstract":"Circularly polarized luminescence (CPL) materials are essential for advanced optoelectronic applications, yet efficient chiral design strategies remain challenging. Axial chirality has been widely employed in the construction of CPL materials due to its unique rigid structure. However, the focus has been primarily on the derivatives of carbon–carbon axial chirality. We herein propose a strategy for constructing carbon–nitrogen (C─N) axially chiral molecular frameworks to fully exploit the excellent chromophoric properties of nitrogen-containing heterocycles (such as carbazole). A pair of chiral emitters, (S/R)-AI-2TCFC, was designed and synthesized, exhibiting an emission peak at 578 nm both in the toluene solution and in the neat film state. It possessed typical aggregation-induced emission (AIE), thermally activated delayed fluorescence (TADF), and a luminescence dissymmetry factor (glum) of 10−3, demonstrating its potential for high-performance device applications. These materials were successfully applied in circularly polarized organic light-emitting diodes (CP-OLEDs), demonstrating promising electroluminescence performance. This innovative strategy not only expands the design toolbox for CPL materials but also paves the way for next-generation high-performance optoelectronic devices.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 7","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70069","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lung-Penetrating Biomimetic Extracellular Vesicle Spherical Nucleic Acids for Pulmonary Fibrosis Therapy Through ROS Scavenging and Anti-Inflammatory Effects 肺穿透仿生细胞外囊泡球形核酸通过清除活性氧和抗炎作用治疗肺纤维化

IF 13.7

Aggregate (Hoboken, N.J.) Pub Date : 2025-06-12 DOI: 10.1002/agt2.70086

Saiyun Lou, Jiangpo Ma, Pan Fu, Lin Li, Jingyun Huang, Fangxue Jing, Yuhui Wang, Sihua Qian, Jianping Zheng, Jiang Li, Zhaoxing Dong, Kaizhe Wang

{"title":"Lung-Penetrating Biomimetic Extracellular Vesicle Spherical Nucleic Acids for Pulmonary Fibrosis Therapy Through ROS Scavenging and Anti-Inflammatory Effects","authors":"Saiyun Lou, Jiangpo Ma, Pan Fu, Lin Li, Jingyun Huang, Fangxue Jing, Yuhui Wang, Sihua Qian, Jianping Zheng, Jiang Li, Zhaoxing Dong, Kaizhe Wang","doi":"10.1002/agt2.70086","DOIUrl":"https://doi.org/10.1002/agt2.70086","url":null,"abstract":"Idiopathic pulmonary fibrosis (IPF) is an irreversible and fatal lung disease characterized by persistent alveolar epithelial cell injury and extracellular matrix deposition. Early dual modulation of oxidative stress and inflammation may offer a promising therapeutic opportunity. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) offer therapeutic promise but face challenges in scalability and efficient lung delivery. Here, we developed a biomimetic extracellular vesicle-spherical nucleic acid (BEV-SNA) platform for IPF therapy. BEV-SNA were constructed by integrating mechanically extruded BEVs from primary MSCs with cholesterol-modified ssDNA through hydrophobic co-assembly. In stemness-maintained P0-P1 MSCs, the production of BEVs increased by 17.2-fold compared to natural EVs. Benefiting from a three-dimensionally dense and negatively charged DNA shell, BEV-SNA reduce airway adhesion, enabling deep pulmonary delivery and efficient cellular uptake. In IPF models, BEV-SNA demonstrated multiphase therapeutic effects, including protection of alveolar epithelial cells from ROS, anti-inflammatory activity, and late-stage anti-fibrotic action, effectively halting fibrosis progression and achieving a 50% survival rate in mice. This study presents a novel therapeutic platform combining the natural biomimicry of EVs with the functional adaptability of SNAs, proposing an innovative strategy for pulmonary drug delivery and the treatment of respiratory diseases.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 9","pages":""},"PeriodicalIF":13.7,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70086","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0