Aggregate (Hoboken, N.J.)最新文献_第5页

Back Cover: Microtubule polymerization induced by iridium-fullerene photosensitizers for cancer immunotherapy via dual-reactive oxygen species regulation strategy 封底：铱-富勒烯光敏剂通过双重活性氧调节策略诱导微管聚合用于癌症免疫疗法

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2024-12-15 DOI: 10.1002/agt2.719

Xiao-Xiao Chen, Kun Peng, Xi Chen, Zheng-Yin Pan, Qing-Hua Shen, Yu-Yi Ling, Jian-Zhang Zhao, Cai-Ping Tan

引用次数: 0

Inside Back Cover: The careful selection of zwitterionic nanoparticle coating results in rapid and efficient cell labeling for imaging-based cell tracking 封底内页：精心选择滋养型纳米粒子涂层，实现快速高效的细胞标记，进行基于成像的细胞追踪

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2024-12-15 DOI: 10.1002/agt2.718

Nicholas D. Calvert, Luciana Yu, Olivia C. Sehl, Julia J. Gevaert, Natasha N. Knier, Angelie Rivera-Rodriguez, Clara S. Goulet, Nitara Fernando, Samantha Flood, Carlos M. Rinaldi-Ramos, Paula J. Foster, Adam J. Shuhendler

引用次数: 0

Intramolecular Aggregation-Induced Surface Coupling of Metal Nanoclusters: Structure Elucidation and Photoluminescence Manipulation 分子内聚集诱导的金属纳米团簇表面耦合：结构解析和光致发光操作

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2024-12-10 DOI: 10.1002/agt2.720

Jian Zhu, Rui Zhao, Honglei Shen, Chen Zhu, Meng Zhou, Xi Kang, Manzhou Zhu

{"title":"Intramolecular Aggregation-Induced Surface Coupling of Metal Nanoclusters: Structure Elucidation and Photoluminescence Manipulation","authors":"Jian Zhu, Rui Zhao, Honglei Shen, Chen Zhu, Meng Zhou, Xi Kang, Manzhou Zhu","doi":"10.1002/agt2.720","DOIUrl":"https://doi.org/10.1002/agt2.720","url":null,"abstract":"The restriction of the molecular motion has been extensively exploited in tailoring the photoluminescence (PL) of metal nanoclusters, while the activation of such a restriction at the molecular level remains highly challenging. In this work, a two-step strategy, that is, surface activating and surface coupling, was proposed to induce the restriction of the molecular motion of nanoclusters at the molecular level, and the corresponding nanoclusters underwent emission appearance and enhancement. The peripheral phosphine ligand functionalization and alkali metal cation introduction gave rise to a series of structural-correlated M+-incorporated Cu14 nanoclusters (M = Li, Na, K, Rb, Cs) with a surface-aggregation characteristic, among which the K+-participating nanocluster displayed the strongest fluorescence intensity in both solution and crystal states. Atomic-level structure–property correlations were investigated to rationalize the PL comparisons. Overall, this work offers a new perspective for regulating the PL of metal nanoclusters via restricting their molecular motions, hopefully providing insight into the fabrication of highly emissive metal nanoclusters and cluster-based nanomaterials.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.720","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143688660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond Molecular Design: Cocrystallization in Hydrogen-Bonded Organic Frameworks for Energy-Conserving Dehydration and Real-Time Luminescent Humidity Detection 超越分子设计：用于节能脱水和实时发光湿度检测的氢键有机框架的共结晶

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2024-12-09 DOI: 10.1002/agt2.721

Wen-Zhu Sun, Wei-Jie Zhang, Ji-Tong Xu, Dan-Qing Liu, Bei-Qi Ou, Ling Chen, Jia-Wen Ye, Xiao-Ming Chen

{"title":"Beyond Molecular Design: Cocrystallization in Hydrogen-Bonded Organic Frameworks for Energy-Conserving Dehydration and Real-Time Luminescent Humidity Detection","authors":"Wen-Zhu Sun, Wei-Jie Zhang, Ji-Tong Xu, Dan-Qing Liu, Bei-Qi Ou, Ling Chen, Jia-Wen Ye, Xiao-Ming Chen","doi":"10.1002/agt2.721","DOIUrl":"https://doi.org/10.1002/agt2.721","url":null,"abstract":"Luminescent probes attract increasing attentions for the unique superiorities like visually real-time detecting. However, for optical humidity sensing, it is still quite challenging to attain facile dehydration/activation in sensing materials, due to the high polarity of water molecules, which limits their applications in real-time detection and energy-conserving applications. Here, we report two fluorescent hydrogen-bonded organic frameworks (HOFs), HPISF-H2O and TPISF. HPISF-H2O achieves water absorption in low humidity, but needs an energy-intensive step (heating to ∼92°C in air) to dehydrate. Conversely, despite only a hydroxyl group being replaced, TPISF cannot bind to H2O at all. In other words, real-time detection is not readily achieved through straightforward molecular design. Therefore, we propose a cocrystallization strategy to adjust their water-binding capacity. As a result, the HOF cocrystals are adjusted to have both good H2O absorptivity and very gentle desorbing operation without heating (dry gas blowing or vacuuming). Benefiting from this strategy, appreciable advantages for an effective humidity sensor are realized, including real-time detection (second-scale response/recovery) and distinguishing fluorescence variation. Efficient sensing across a broad relative humidity (RH) range (10.0%–80.0%) was further achieved. Moreover, the mechanistic insight of fluorescent sensing was ascertained through detailed analyses of structural transformation, spectroscopic data, and theoretical approach.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.721","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143688689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stable Hydrogen-Bonded Cobalt-porphyrin Framework for High-Performance Electrochemical Detection of Carcinoembryonic Antigen 稳定氢键钴卟啉框架高效电化学检测癌胚抗原

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2024-12-09 DOI: 10.1002/agt2.702

Youfa Wang, Jie Han, Geoffrey I. N. Waterhouse, Huiwen Gu, Rui Wang, Shuang Wu, Pengfei Dong, Vijaya Raghavan, Jin Wang

{"title":"Stable Hydrogen-Bonded Cobalt-porphyrin Framework for High-Performance Electrochemical Detection of Carcinoembryonic Antigen","authors":"Youfa Wang, Jie Han, Geoffrey I. N. Waterhouse, Huiwen Gu, Rui Wang, Shuang Wu, Pengfei Dong, Vijaya Raghavan, Jin Wang","doi":"10.1002/agt2.702","DOIUrl":"https://doi.org/10.1002/agt2.702","url":null,"abstract":"The accurate and sensitive detection of low-abundance cancer-related biomarkers in blood remains a key technical challenge in clinical applications. Herein, a simple and accurate sandwich-type electrochemical immunosensor based on a stable hydrogen-bonded cobalt-porphyrin framework (Co-HOF) was successfully developed for the ultrasensitive detection of the cancer-related biomarker, carcinoembryonic antigen (CEA). The antibody-modified Co-HOF forms a sandwich structure with the CEA aptamer electrode exclusively in the presence of CEA, enabling the specific electrochemical detection of CEA. The electrochemical signal increased linearly with the concentration of CEA, demonstrating a wide linear range (0.001–50 ng mL−1) and a low detection limit (0.22 pg mL−1), surpassing the performance of commercial ELISA kits and most reported detection methods. The sensor was successfully employed for CEA detection in spiked human serum, with recoveries ranging from 85.04% to 105.20%. Additionally, we collected blood samples from colorectal cancer patients and healthy individuals to clinically validate the sensor, observing that CEA levels increased with cancer progression. The sensor detection results showed strong consistency (R2 = 0.995) with those obtained from commercial ELISA kits, demonstrating the proposed sensor's practicality for clinical detection of CEA and related cancer biomarkers.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.702","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143688688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing Aggregation-Induced Emission-Derived Biomaterials in Viral, Tuberculosis, and Fungal Infectious Diseases 在病毒、肺结核和真菌感染性疾病中推进聚合诱导排放衍生生物材料

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2024-12-02 DOI: 10.1002/agt2.715

Wei Wang, Junjie Wang, Ziwei Hu, Xiaowei Yan, Qiuxia Gao, Xiaoxue Li, Judun Zheng, Bin Li, Yunxia Wu, Yuhui Liao

{"title":"Advancing Aggregation-Induced Emission-Derived Biomaterials in Viral, Tuberculosis, and Fungal Infectious Diseases","authors":"Wei Wang, Junjie Wang, Ziwei Hu, Xiaowei Yan, Qiuxia Gao, Xiaoxue Li, Judun Zheng, Bin Li, Yunxia Wu, Yuhui Liao","doi":"10.1002/agt2.715","DOIUrl":"https://doi.org/10.1002/agt2.715","url":null,"abstract":"Contagious diseases caused by different types of highly contagious pathogens, such as SARS-CoV-2, monkeypox virus, Mycobacterium tuberculosis, and human immunodeficiency virus, could trigger global outbreaks and bring a huge public health burden. Advanced diagnostic, therapeutic, and preventive strategies are urgently needed to deal with the epidemic of contagious diseases. Aggregation-induced emission (AIE) has emerged as one of the promising candidates that exhibit tunable photophysical properties, high biocompatibility, exceptional photostability, and a distinguishing aggregation-enhanced fluorescence. As a result, they offer effective strategies for the diagnosis, treatment, and prevention of contagious diseases. This review systematically outlined the latest research progress of AIE-based biomaterials and mechanisms in contagious diseases. The versatility of AIE molecules, as well as highly efficient fluorescence properties, has the potential to offer innovative strategies to combat these health challenges. Thanks to recent advances in materials science and a better understanding of aggregation-induced emission luminogens (AIEgens), AIEgens have great potential to provide better solutions for the treatment, detection, and prevention of contagious diseases. By reviewing state-of-the-art methods for the killing, detection, and prevention of contagious agents and highlighting promising technological developments, this outlook aims to promote the development of new means for the prevention and control of emerging, re-emerging, and major contagious diseases as well as further research and development activities in this critical area of research.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.715","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143688690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrophobic Carbon Dots Prevent α-Synucleinopathy and Suppress Neuroinflammation to Treat Parkinson's Disease 疏水碳点预防α-突触核蛋白病和抑制神经炎症治疗帕金森病

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2024-12-02 DOI: 10.1002/agt2.711

Lihua Li, Yao Lu, Xiangling Ye, Chi Zhang, Jialin Liu, Zhongmin Yang, Jianhua Hao

引用次数: 0

Photochemical Synthesis of Polycyclic Phosphonium Salts as Efficient Anticancer and Antibacterial Agents 光化学合成多环磷酸盐的高效抗癌和抗菌作用

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2024-11-29 DOI: 10.1002/agt2.705

Jianqing Li, Zeyan Zhuang, Xiaobin Dong, Zujin Zhao, Ben Zhong Tang

{"title":"Photochemical Synthesis of Polycyclic Phosphonium Salts as Efficient Anticancer and Antibacterial Agents","authors":"Jianqing Li, Zeyan Zhuang, Xiaobin Dong, Zujin Zhao, Ben Zhong Tang","doi":"10.1002/agt2.705","DOIUrl":"https://doi.org/10.1002/agt2.705","url":null,"abstract":"Phosphorus-containing functional materials have diverse applications in optoelectronics and bioscience owing to their unique properties. However, polycyclic π-conjugated phosphonium salts have been rarely explored due to their complex synthesis. In this work, a facile and efficient method for constructing polycyclic π-conjugated phosphonium salts (TBPIMe derivatives) is proposed, based on the photocyclization of phosphindolium salts (TPPIMe derivatives). Systematic experimental and theoretical investigations reveal the changed photophysical and photochemical properties when TPPIMe derivatives are converted to TBPIMe derivatives. Notably, the novel polycyclic π-conjugated phosphonium salt p-MOTBPIMe exhibits improved reactive oxygen species generation ability and much stronger specific affinity toward DNA than phosphindolium salts p-MOTPPIMe. Moreover, in vitro experiments demonstrate that p-MOTPPIMe can also be efficiently converted into p-MOTBPIMe under 405 nm laser irradiation in living cells, accompanied by the migration from cytoplasm to nucleus to enhance the photodynamic effect. Additionally, p-MOTBPIMe shows superior antibacterial activity against not only Gram-positive drug-resistant bacteria but also fungi, by leveraging both dark and light cytotoxicity. This work opens up a new chemical toolkit for novel polycyclic π-conjugated phosphonium salts, which are promising for developing advanced theranostic agents with satisfactory accuracy and efficacy.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.705","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carbon Quantum Dots in Biomedical Applications: Advances, Challenges, and Future Prospects 碳量子点在生物医学中的应用：进展、挑战和未来展望

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2024-11-28 DOI: 10.1002/agt2.707

Nadezhda A. Pechnikova, Kalliopi Domvri, Konstantinos Porpodis, Maria S. Istomina, Aleksandra V. Iaremenko, Alexey V. Yaremenko

{"title":"Carbon Quantum Dots in Biomedical Applications: Advances, Challenges, and Future Prospects","authors":"Nadezhda A. Pechnikova, Kalliopi Domvri, Konstantinos Porpodis, Maria S. Istomina, Aleksandra V. Iaremenko, Alexey V. Yaremenko","doi":"10.1002/agt2.707","DOIUrl":"https://doi.org/10.1002/agt2.707","url":null,"abstract":"Carbon quantum dots (CQDs) represent a rapidly emerging class of nanomaterials with significant potential in biomedical applications due to their tunable fluorescence, high biocompatibility, and versatile functionalization. This review focuses on the recent progress in utilizing CQDs for drug delivery, bioimaging, biosensing, and cancer therapy. With their unique optical properties, such as tunable fluorescence, high quantum yield, and photostability, CQDs enable precise bioimaging and sensitive biosensing. Their small size, biocompatibility, and ease of surface functionalization allow for the development of targeted drug delivery systems, enhancing therapeutic precision and minimizing side effects. In cancer therapy, CQDs have shown potential in photodynamic and photothermal treatments by generating reactive oxygen species under light exposure, selectively targeting cancer cells while sparing healthy tissues. Furthermore, CQDs’ ability to penetrate biological barriers including the blood–brain barrier opens new possibilities for delivering therapeutic agents to hard-to-reach areas, such as tumors or diseased tissues. However, challenges such as optimizing synthesis, ensuring long-term stability, and addressing safety concerns in biological environments remain critical hurdles. This review discusses current efforts to overcome these barriers and improve CQD performance in clinical settings, including scalable production methods and enhanced biocompatibility. As research progresses, CQDs are expected to play an important role in improving healthcare by offering more targeted treatment options and contributing to advancements in personalized medicine.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.707","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gram-Negative Bacteria Targeting AIE Photosensitizer for Selective Photodynamic Killing of Vibrio vulnificus 革兰氏阴性菌靶向AIE光敏剂选择性光动力杀灭创伤弧菌

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2024-11-26 DOI: 10.1002/agt2.709

Hao-Tian Xin, Qiao-Wen Lin, Simin Sun, Yu-Ying Wang, Bing Liu, Wen-Jin Wang, Zong-Wan Mao, Kang-Nan Wang

{"title":"Gram-Negative Bacteria Targeting AIE Photosensitizer for Selective Photodynamic Killing of Vibrio vulnificus","authors":"Hao-Tian Xin, Qiao-Wen Lin, Simin Sun, Yu-Ying Wang, Bing Liu, Wen-Jin Wang, Zong-Wan Mao, Kang-Nan Wang","doi":"10.1002/agt2.709","DOIUrl":"https://doi.org/10.1002/agt2.709","url":null,"abstract":"Vibrio vulnificus is a highly virulent Gram-negative bacterium exhibiting extensive resistance to various antibiotics, presenting significant challenges for efficient and selective eradication. Recently, photosensitizer (PS)-based photodynamic therapy has emerged as an effective strategy against bacteria and biofilms. However, traditional PS struggles to penetrate the unique membrane structure of Gram-negative bacteria such as V. vulnificus, while avoiding traversal of the membrane barrier of eukaryotic cells. To address this issue, herein, a PS named BDTP with aggregation-induced emission properties was developed. BDTP can specifically target the DNA of V. vulnificus, but integrate into the cell membrane, preventing damage to the contents in eukaryotic cells due to its hydrophilic/lipophilic “Y-shaped” structural characteristics. In dark conditions, BDTP functions as an antibiotic, inhibiting bacterial proliferation. Upon white light stimulation, BDTP can induce phototoxic damage to the DNA of V. vulnificus and effectively inhibit/clear V. vulnificus biofilms. Additionally, the eukaryotic cell membrane barrier significantly reduces PS-induced damage to its nucleic acids. This strategy significantly promotes the healing of infected wounds in V. vulnificus-infected mice. Our work introduces the first PS targeting V. vulnificus-associated infections, demonstrating efficacy both in vitro and in vivo.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.709","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0