Aggregate (Hoboken, N.J.)最新文献

{"title":"Inside Front Cover: Excited State Structure and Decay Rates for Aggregates","authors":"Zhigang Shuai,&nbsp;Qi Sun,&nbsp;Jiajun Ren,&nbsp;Tong Jiang,&nbsp;Weitang Li","doi":"10.1002/agt2.70036","DOIUrl":"https://doi.org/10.1002/agt2.70036","url":null,"abstract":"<p>This work presents a novel definition of exciton coherence length, establishing a unique correlation with the radiative decay rate and resolving previous ambiguities. Three-state model and four-state model reveal how intensity borrowing enables emissive H-aggregates. A molecular descriptor is proposed for optimizing both PLQY and mobility, along with a modified energy gap law identifying an optimal J to minimize non-radiative decay loss (e70013).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 4","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70036","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visible-Light-Driven Multifunctional Luminogens With More Than 150 Nm Absorption Band Separation for Dynamic Information Encryption","authors":"Shijie Zhen,&nbsp;Fayun Ma,&nbsp;Hong Chen,&nbsp;Lin Li,&nbsp;Meijing Li,&nbsp;Zujin Zhao,&nbsp;Ben Zhong Tang","doi":"10.1002/agt2.70044","DOIUrl":"https://doi.org/10.1002/agt2.70044","url":null,"abstract":"<p>Information security protection has become a fundamental issue in the human life, national security, and social stability, which is enabled through the use of multi-responsive materials. Ideal multi-responsive materials are operated with visible to near infrared light, exhibit large separation of absorption bands, and are functional by isomerization, posing an unmet challenge. Here, a series of visible-light-operated molecular photoswitches, (<i>E</i>)-1-acetyl-2-((4-(diphenylamino) phenyl) imino) indolin-3-one, and its derivatives (<b>PIO-01/02/03/04/05</b>), featuring near-infrared second aggregation-induced emission (AIE) and impressive acid/base-driven switching, are constructed via twisted intramolecular charge transfer (TICT) and subsequent <i>E</i>/<i>Z</i> isomerization strategies. In addition, protonation not only endows these molecules with large separation (Δ<i>λ</i>_max) of over 100 nm, but also can be used as second independent input altering the light response. Based on calculation studies and advanced spectroscopic techniques, we provide the intricate interplay of the switching behavior of <b>PIO-01/02/03/04/05</b> on their photochemical properties. The optimized compound <b>PIO-01</b> shows significant applications in multi-color, multi-patterning display, transient information recording and erasing, and dual-mode encryption-decryption with ternary code.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 6","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Helically Assembled Rare Earth Fluoride Nanoparticles with Multicolor Circularly Polarized Luminescence for High-Security Anti-Counterfeiting","authors":"Wen Yuan,&nbsp;Shan Lu,&nbsp;Xingjun Li,&nbsp;Zhuo Li,&nbsp;Xiaobo Gu,&nbsp;Xingyang Liu,&nbsp;Zhixiao Ren,&nbsp;Fei Wang,&nbsp;Xueyuan Chen","doi":"10.1002/agt2.70042","DOIUrl":"https://doi.org/10.1002/agt2.70042","url":null,"abstract":"<p>Multicolor circularly polarized luminescence (CPL) materials show considerable potential in the field of advanced anti-counterfeiting. However, it remains challenging to achieve stable inorganic materials with multicolor CPL. In this work, for the first time, chiroptical rare earth (RE) fluoride nanoparticles induced by helical silica are obtained through a facile in situ assembly strategy. The influence of assembly ratio and morphological structure on the luminescence dissymmetry factor (g_lum) has been systematically investigated, leading to an optimized g_lum value of 4.7 × 10⁻³. By adjusting the types and concentrations of RE dopants (Ce³⁺, Tb³⁺, Eu³⁺), the nanocomposites exhibit multicolor CPL and time-resolved photoluminescence characteristics. Remarkably, these nanocomposites retain their CPL activity even after calcination at 400°C. Leveraging the visible multicolor emissions, along with the hidden dynamic and chiroptical signals, the nanocomposites are successfully applied in high-security anti-counterfeiting patterns and multilevel optical encryption codes.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 7","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70042","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Efficient Heat and Peroxynitrite Generating Nanoplatform for Multimodal Imaging-guided Precision Tumor Phototherapy","authors":"Ziyi Xu,&nbsp;Mingkun Lv,&nbsp;Jingkai Yang,&nbsp;Tingting Li,&nbsp;Jiahui Lv,&nbsp;Jiaxin Li,&nbsp;Hongjun Xiao,&nbsp;Yicheng Yang,&nbsp;Siyu Zhou,&nbsp;Xuan Tan,&nbsp;Li Cheng,&nbsp;Heng Guo,&nbsp;Lei Xi,&nbsp;Pan-Lin Shao,&nbsp;Bo Zhang","doi":"10.1002/agt2.70040","DOIUrl":"https://doi.org/10.1002/agt2.70040","url":null,"abstract":"<p>Near-infrared II (NIR-II) fluorescent nanoparticles (NPs) based on aggregation-induced emission (AIE) have attracted significant attention due to their multimodal imaging capabilities as well as the combined photothermal and photodynamic therapeutic effects in cancer therapy. Reported herein is the rational designed AIE molecule (BPT), via incorporating phenothiazine units with strong electron-donating and reactive oxygen species (ROS) generation capabilities into the classical AIE scaffold tetraphenylethylene, further coupled with a strong electron-acceptor named benzo[1,2-c:4,5-c']bis[1,2,5]thiadiazole. The BPT NPs exhibited maximum NIR-II fluorescence emission at 1083 nm, a fluorescence quantum yield of 1.53%, photothermal conversion efficiency of 63%, and photoacoustic imaging capabilities, alongside considerable type I ROS generation ability. Additionally, when a kind of nitric oxide (NO) donor named O₂-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl) piperazin-1-yl]diazen-1-ium-1,2-diolate (JSK) was incorporated, the corresponding JSK-BPT NPs could generate O₂⁻, NO, and peroxynitrite to induce phototoxicity. By applying it to the 4T1 breast tumor model, JSK-BPT NPs achieved high-quality multimodal imaging of the vasculature and tumor regions in mice. Under the multimodal imaging guidance, the 4T1 tumor could be ablated completely after a single dose of JSK-BPT NPs and under the irradiation of an 808 nm laser.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 6","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70040","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Application of Organic Sonosensitizers in Cancer Therapy","authors":"Yuhan Ding,&nbsp;Yuchen Yang,&nbsp;Omer Aras,&nbsp;Feifei An,&nbsp;Mengjiao Zhou,&nbsp;Yichao Chai","doi":"10.1002/agt2.70032","DOIUrl":"https://doi.org/10.1002/agt2.70032","url":null,"abstract":"<p>Sonodynamic therapy (SDT) is an innovative cancer therapy modality that harnesses the energy of ultrasound to activate sonosensitizers for producing reactive oxygen species (ROS), culminating in the eradication of tumor cells. Compared with photodynamic therapy, SDT has the capacity to penetrate deeply into biological tissues, thereby holding significant promise for addressing deeply situated or surgically inaccessible tumors. The effectiveness of SDT is greatly dependent on the characteristics of the sonosensitizers, and unlike inorganic sonosensitizers, organic sonosensitizers offer a more controlled synthesis process and have excellent biocompatibility. This review presents a meticulous undertaking to categorize organic sonosensitizers and elucidate their mechanisms of action and therapeutic effects in the context of SDT. Design strategies for sonosensitizers are also summarized, and we emphasize the critical role of nanotechnology in tumor localization, imaging, and multimodal synergistic therapy, offering an innovative approach for achieving precise tumor targeting. In addition, the synergistic impact of SDT is delineated when integrated with other oncological modalities, such as photothermal therapy and photodynamic therapy, to enhance therapeutic efficacy. Finally, the review also discusses challenges and future perspectives for the advancement of clinical SDT within the realm of oncology.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 6","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70032","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional Biomimetic Nanotherapeutics for Anti-Oxidative and Anti-Inflammatory Synergistic Therapy of Corneal Neovascularization","authors":"Shundong Cai,&nbsp;Mengdie Li,&nbsp;Jinfa Ye,&nbsp;Mingyou Zhang,&nbsp;Jingbin Zhuang,&nbsp;Yuhang Cheng,&nbsp;Hongjin Li,&nbsp;Lang Ke,&nbsp;Xingyuan Wei,&nbsp;Yun Han,&nbsp;Huanhuan Liu,&nbsp;Gang Liu,&nbsp;Chengchao Chu","doi":"10.1002/agt2.70034","DOIUrl":"https://doi.org/10.1002/agt2.70034","url":null,"abstract":"<p>Corneal neovascularization (CNV) is a debilitating ocular surface disease that severely compromises visual function and carries a significant risk of vision loss. Despite its clinical impact, the development of effective and safe pharmacological treatments for CNV remains an unmet medical need. The pathogenesis of CNV is largely driven by inflammation and excessive oxidative stress. In this study, we introduce a novel nanotherapeutic strategy utilizing vanadium carbide quantum dots (V₂C QDs) with intrinsic nanozyme properties, co-encapsulated with a plasmid encoding interleukin-10 (IL-10) within a biomimetic metal-organic framework (MOF) for the treatment of CNV. To enhance targeting and biocompatibility, the nanoparticles (NPs) are further coated with mesenchymal stem cell (MSC)-derived cell membrane vesicles (CMVs), yielding the final nanomedicine designated as MOF-V₂C-Plasmid@CMVs (MVPC). In vitro studies demonstrate that MVPC NPs effectively scavenge reactive oxygen species (ROS) induced by <i>tert</i>-butyl hydroperoxide (tBOOH), mitigating oxidative stress. Moreover, the successful delivery and expression of the IL-10 plasmid in RAW264.7 cells result in elevated IL-10 secretion, showcasing robust anti-inflammatory activity. The CMV coating facilitates targeted delivery, enabling the efficient accumulation of MVPC NPs in the CNV region following topical administration via eye drops. In vivo experiments in CNV model rats reveal that MVPC nanotherapeutics significantly suppress neovascularization without inducing adverse effects. Collectively, this study provides proof of concept for a multifunctional nanotherapeutic platform targeting CNV, offering a promising and clinically translatable approach for the treatment of this challenging ocular disease.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 6","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70034","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Near-Infrared Organic Room Temperature Phosphorescent Probes Targeting Fibroblast Activation Protein for Surgical Navigation of Liver Cancer","authors":"Jinghua Li,&nbsp;Juqing Gu,&nbsp;Liangxuan Ding,&nbsp;Xiaomian Li,&nbsp;Peng Xia,&nbsp;Fusheng Liu,&nbsp;Xi Chen,&nbsp;Weijie Ma,&nbsp;Yong He,&nbsp;Qianqian Li,&nbsp;Zhen Li,&nbsp;Yufeng Yuan","doi":"10.1002/agt2.70031","DOIUrl":"https://doi.org/10.1002/agt2.70031","url":null,"abstract":"<p>Hepatectomy is a critical treatment for liver cancer, but achieving complete tumor removal remains challenging. The development of tumor-targeting probes capable of accurately identifying tumor locations and providing real-time intraoperative navigation is of significant clinical importance. We synthesize a tumor-targeted probe by conjugating a fibroblast activation protein inhibitor (FAPI) with near-infrared organic room temperature phosphorescence (RTP) material. We then analyze its surgical navigation performance in the liver cancer model and its imaging performance in fresh patient-derived samples. In vivo validation reveals that the probe exhibits optimal phosphorescence intensity within 48 h (8.53 × 10⁵ p s⁻¹ cm⁻² sr⁻¹) and an average signal-to-noise ratio of 16. The probe could effectively identify FAP-positive samples from liver cancer patients. The successful application of phosphorescence-guided surgery suggests that the near-infrared RTP probe holds significant clinical translational value and could serve as an auxiliary tool for the surgical treatment of liver cancer.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 6","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluorescence Color Gradient Immunochromatographic Assay for Highly-Sensitive, Quantitative, and Simultaneous Detection of Small-Molecule Pollutants","authors":"Shu Wang,&nbsp;Changyue Xu,&nbsp;Xiaosong Wu,&nbsp;Tao Zhang,&nbsp;Jiahuan Zhang,&nbsp;Wenlong Bai,&nbsp;Shuai Zheng,&nbsp;Bing Gu,&nbsp;Chongwen Wang","doi":"10.1002/agt2.70033","DOIUrl":"https://doi.org/10.1002/agt2.70033","url":null,"abstract":"<p>Rapid on-site screening of small-molecule pollutants in complex samples is essential but remains unachieved. In this study, we introduce a universal fluorescence color gradient immunochromatographic assay (FCGICA) utilizing dual-signal superposition to enable ultra-sensitive, wide-range, and simultaneous quantitative detection of multiple small molecules. A red fluorescent nanomembrane (GTQD@Si) is synthesized by the continuous self-assembly of multilayer quantum dots and a SiO₂ shell on a graphene oxide surface. This nanomembrane exhibits high stability in complex environments and provides superior fluorescence along with a larger reactive interface for sensing. The integration of GTQD@Si with green fluorescent microspheres embedded in the test line generates a broad fluorescence color gradient based on variations in target molecule concentrations, thereby significantly enhancing the sensitivity, stability, and quantitative range of the immunochromatographic assay (ICA). By directly reading the ratio of red and green image signals, the proposed FCGICA enables simultaneous, high-sensitivity, and quantitative detection of three different types of small-molecule pollutants including fumonisin B1, imidacloprid, and clenbuterol within 15 min, with a detection range improved by 2–3 orders of magnitude compared with traditional methods. Moreover, the powerful practicality of FCGICA has been verified through comprehensive testing on various real samples, demonstrating its great potential in on-site detection of small molecules.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 6","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70033","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Host–Emitter Interactions on Light Amplification in Laser Dyes","authors":"Masashi Mamada,&nbsp;Ayano Abe,&nbsp;Takashi Fujihara,&nbsp;Tatsuya Yoshida,&nbsp;Kenichi Goushi,&nbsp;Kiyoshi Miyata,&nbsp;Ken Onda,&nbsp;Chihaya Adachi","doi":"10.1002/agt2.70030","DOIUrl":"https://doi.org/10.1002/agt2.70030","url":null,"abstract":"<p>Organic lasers hold great promise for enabling a new class of future optoelectronics. Consequently, the development of new organic semiconductors as gain media has recently been the subject of significant interest. The molecular design principle based on Einstein coefficients has been validated for achieving high gain, with <i>para</i>-phenylene-vinylene scaffolds recognized as one of the most crucial frameworks. In this study, we develop a stilbene tetramer derivative, QSBCz, which has significantly increased conjugation compared to the highly efficient laser material, BSBCz, resulting in a remarkably high radiative decay rate and a large gain cross-section. However, we find that the optical losses play a significant role in the light amplification of QSBCz. Indeed, a comprehensive understanding and suppression of detrimental optical loss pathways throughout the lasing process are essential, whereas the losses intrinsically associated with molecules have not been well considered. Although host–guest systems are helpful in preventing concentration quenching in aggregated states, this study reveals notable losses when using common host molecules such as 4,4′-bis(9<i>H</i>-carbazol-9-yl)biphenyl (CBP) and mCBP. In contrast, a BSBCz derivative is successfully employed as the host, leading to improved stimulated emission amplification. These findings indicate the importance of host–emitter interactions in lasing properties and highlight the necessity to optimize host materials for developing new laser dyes.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 5","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70030","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Aggregate Materials and Machine Learning Algorithms: Advancing Detection of Pathogen-Derived Extracellular Vesicles","authors":"Lihan Lai,&nbsp;Yun Su,&nbsp;Cong Hu,&nbsp;Zehong Peng,&nbsp;Wei Xue,&nbsp;Liang Dong,&nbsp;Tony Y. Hu","doi":"10.1002/agt2.70018","DOIUrl":"https://doi.org/10.1002/agt2.70018","url":null,"abstract":"<p>Extracellular vesicles (EVs) are essential for host–pathogen interactions, mediating processes such as immune modulation and pathogen survival. Pathogen-derived EVs hold significant diagnostic potential because of their unique cargo, offering a wealth of potential biomarkers. In this review, we first discuss the roles of EVs derived from various pathogens in host–pathogen interactions and summarize the latest advancements in pathogen detection based on EVs. Then, we highlight innovative strategies, including novel aggregate materials and machine learning approaches, for enhancing EV detection and analysis. Finally, we discuss challenges in the field and future directions for advancing EV-based diagnostics, aiming to translate these insights into clinical applications.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 5","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}