Aggregate (Hoboken, N.J.)最新文献

{"title":"Stable Hydrogen-Bonded Cobalt-porphyrin Framework for High-Performance Electrochemical Detection of Carcinoembryonic Antigen","authors":"Youfa Wang,&nbsp;Jie Han,&nbsp;Geoffrey I. N. Waterhouse,&nbsp;Huiwen Gu,&nbsp;Rui Wang,&nbsp;Shuang Wu,&nbsp;Pengfei Dong,&nbsp;Vijaya Raghavan,&nbsp;Jin Wang","doi":"10.1002/agt2.702","DOIUrl":"https://doi.org/10.1002/agt2.702","url":null,"abstract":"<p>The accurate and sensitive detection of low-abundance cancer-related biomarkers in blood remains a key technical challenge in clinical applications. Herein, a simple and accurate sandwich-type electrochemical immunosensor based on a stable hydrogen-bonded cobalt-porphyrin framework (Co-HOF) was successfully developed for the ultrasensitive detection of the cancer-related biomarker, carcinoembryonic antigen (CEA). The antibody-modified Co-HOF forms a sandwich structure with the CEA aptamer electrode exclusively in the presence of CEA, enabling the specific electrochemical detection of CEA. The electrochemical signal increased linearly with the concentration of CEA, demonstrating a wide linear range (0.001–50 ng mL⁻¹) and a low detection limit (0.22 pg mL⁻¹), surpassing the performance of commercial ELISA kits and most reported detection methods. The sensor was successfully employed for CEA detection in spiked human serum, with recoveries ranging from 85.04% to 105.20%. Additionally, we collected blood samples from colorectal cancer patients and healthy individuals to clinically validate the sensor, observing that CEA levels increased with cancer progression. The sensor detection results showed strong consistency (<i>R</i>² = 0.995) with those obtained from commercial ELISA kits, demonstrating the proposed sensor's practicality for clinical detection of CEA and related cancer biomarkers.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.702","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143688688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing Aggregation-Induced Emission-Derived Biomaterials in Viral, Tuberculosis, and Fungal Infectious Diseases","authors":"Wei Wang,&nbsp;Junjie Wang,&nbsp;Ziwei Hu,&nbsp;Xiaowei Yan,&nbsp;Qiuxia Gao,&nbsp;Xiaoxue Li,&nbsp;Judun Zheng,&nbsp;Bin Li,&nbsp;Yunxia Wu,&nbsp;Yuhui Liao","doi":"10.1002/agt2.715","DOIUrl":"https://doi.org/10.1002/agt2.715","url":null,"abstract":"<p>Contagious diseases caused by different types of highly contagious pathogens, such as SARS-CoV-2, monkeypox virus, <i>Mycobacterium tuberculosis</i>, and human immunodeficiency virus, could trigger global outbreaks and bring a huge public health burden. Advanced diagnostic, therapeutic, and preventive strategies are urgently needed to deal with the epidemic of contagious diseases. Aggregation-induced emission (AIE) has emerged as one of the promising candidates that exhibit tunable photophysical properties, high biocompatibility, exceptional photostability, and a distinguishing aggregation-enhanced fluorescence. As a result, they offer effective strategies for the diagnosis, treatment, and prevention of contagious diseases. This review systematically outlined the latest research progress of AIE-based biomaterials and mechanisms in contagious diseases. The versatility of AIE molecules, as well as highly efficient fluorescence properties, has the potential to offer innovative strategies to combat these health challenges. Thanks to recent advances in materials science and a better understanding of aggregation-induced emission luminogens (AIEgens), AIEgens have great potential to provide better solutions for the treatment, detection, and prevention of contagious diseases. By reviewing state-of-the-art methods for the killing, detection, and prevention of contagious agents and highlighting promising technological developments, this outlook aims to promote the development of new means for the prevention and control of emerging, re-emerging, and major contagious diseases as well as further research and development activities in this critical area of research.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.715","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143688690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrophobic Carbon Dots Prevent α-Synucleinopathy and Suppress Neuroinflammation to Treat Parkinson's Disease","authors":"Lihua Li,&nbsp;Yao Lu,&nbsp;Xiangling Ye,&nbsp;Chi Zhang,&nbsp;Jialin Liu,&nbsp;Zhongmin Yang,&nbsp;Jianhua Hao","doi":"10.1002/agt2.711","DOIUrl":"https://doi.org/10.1002/agt2.711","url":null,"abstract":"<p>The aggregation of α-synuclein (ɑ-syn) coupled with overexpressed neuroinflammation instigates the degeneration of dopaminergic neurons, thereby aggravating the progression of Parkinson's disease (PD). Herein, we introduced a series of hydrophobic amino acid–based carbon dots (CDs) for inhibiting ɑ-syn aggregation and mitigating the inflammation in PD neurons. Significantly, we show phenylalanine CDs (Phe-CDs) could strongly bind with ɑ-syn monomers and dimers via hydrophobic force, maintain their stability, and inhibit their further aggregates in situ and in vitro, finally conferring neuroprotection in PD by rescuing synaptic loss, ameliorating mitochondrial dysfunctions, and modulating Ca²⁺ flux. Importantly, Phe-CDs demonstrate the ability to penetrate the blood–brain barrier (BBB), significantly improving motor performance in PD mice. Our findings suggest that Phe-CDs hold great promise as a therapeutic agent for PD and the relative neurodegenerative disease.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.711","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143688694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photochemical Synthesis of Polycyclic Phosphonium Salts as Efficient Anticancer and Antibacterial Agents","authors":"Jianqing Li,&nbsp;Zeyan Zhuang,&nbsp;Xiaobin Dong,&nbsp;Zujin Zhao,&nbsp;Ben Zhong Tang","doi":"10.1002/agt2.705","DOIUrl":"https://doi.org/10.1002/agt2.705","url":null,"abstract":"<p>Phosphorus-containing functional materials have diverse applications in optoelectronics and bioscience owing to their unique properties. However, polycyclic π-conjugated phosphonium salts have been rarely explored due to their complex synthesis. In this work, a facile and efficient method for constructing polycyclic π-conjugated phosphonium salts (TBPIMe derivatives) is proposed, based on the photocyclization of phosphindolium salts (TPPIMe derivatives). Systematic experimental and theoretical investigations reveal the changed photophysical and photochemical properties when TPPIMe derivatives are converted to TBPIMe derivatives. Notably, the novel polycyclic π-conjugated phosphonium salt <i>p</i>-MOTBPIMe exhibits improved reactive oxygen species generation ability and much stronger specific affinity toward DNA than phosphindolium salts <i>p</i>-MOTPPIMe. Moreover, in vitro experiments demonstrate that <i>p</i>-MOTPPIMe can also be efficiently converted into <i>p</i>-MOTBPIMe under 405 nm laser irradiation in living cells, accompanied by the migration from cytoplasm to nucleus to enhance the photodynamic effect. Additionally, <i>p</i>-MOTBPIMe shows superior antibacterial activity against not only Gram-positive drug-resistant bacteria but also fungi, by leveraging both dark and light cytotoxicity. This work opens up a new chemical toolkit for novel polycyclic π-conjugated phosphonium salts, which are promising for developing advanced theranostic agents with satisfactory accuracy and efficacy.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.705","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbon Quantum Dots in Biomedical Applications: Advances, Challenges, and Future Prospects","authors":"Nadezhda A. Pechnikova,&nbsp;Kalliopi Domvri,&nbsp;Konstantinos Porpodis,&nbsp;Maria S. Istomina,&nbsp;Aleksandra V. Iaremenko,&nbsp;Alexey V. Yaremenko","doi":"10.1002/agt2.707","DOIUrl":"https://doi.org/10.1002/agt2.707","url":null,"abstract":"<p>Carbon quantum dots (CQDs) represent a rapidly emerging class of nanomaterials with significant potential in biomedical applications due to their tunable fluorescence, high biocompatibility, and versatile functionalization. This review focuses on the recent progress in utilizing CQDs for drug delivery, bioimaging, biosensing, and cancer therapy. With their unique optical properties, such as tunable fluorescence, high quantum yield, and photostability, CQDs enable precise bioimaging and sensitive biosensing. Their small size, biocompatibility, and ease of surface functionalization allow for the development of targeted drug delivery systems, enhancing therapeutic precision and minimizing side effects. In cancer therapy, CQDs have shown potential in photodynamic and photothermal treatments by generating reactive oxygen species under light exposure, selectively targeting cancer cells while sparing healthy tissues. Furthermore, CQDs’ ability to penetrate biological barriers including the blood–brain barrier opens new possibilities for delivering therapeutic agents to hard-to-reach areas, such as tumors or diseased tissues. However, challenges such as optimizing synthesis, ensuring long-term stability, and addressing safety concerns in biological environments remain critical hurdles. This review discusses current efforts to overcome these barriers and improve CQD performance in clinical settings, including scalable production methods and enhanced biocompatibility. As research progresses, CQDs are expected to play an important role in improving healthcare by offering more targeted treatment options and contributing to advancements in personalized medicine.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.707","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gram-Negative Bacteria Targeting AIE Photosensitizer for Selective Photodynamic Killing of Vibrio vulnificus","authors":"Hao-Tian Xin,&nbsp;Qiao-Wen Lin,&nbsp;Simin Sun,&nbsp;Yu-Ying Wang,&nbsp;Bing Liu,&nbsp;Wen-Jin Wang,&nbsp;Zong-Wan Mao,&nbsp;Kang-Nan Wang","doi":"10.1002/agt2.709","DOIUrl":"https://doi.org/10.1002/agt2.709","url":null,"abstract":"<p><i>Vibrio vulnificus</i> is a highly virulent Gram-negative bacterium exhibiting extensive resistance to various antibiotics, presenting significant challenges for efficient and selective eradication. Recently, photosensitizer (PS)-based photodynamic therapy has emerged as an effective strategy against bacteria and biofilms. However, traditional PS struggles to penetrate the unique membrane structure of Gram-negative bacteria such as <i>V. vulnificus</i>, while avoiding traversal of the membrane barrier of eukaryotic cells. To address this issue, herein, a PS named BDTP with aggregation-induced emission properties was developed. BDTP can specifically target the DNA of <i>V. vulnificus</i>, but integrate into the cell membrane, preventing damage to the contents in eukaryotic cells due to its hydrophilic/lipophilic “Y-shaped” structural characteristics. In dark conditions, BDTP functions as an antibiotic, inhibiting bacterial proliferation. Upon white light stimulation, BDTP can induce phototoxic damage to the DNA of <i>V. vulnificus</i> and effectively inhibit/clear <i>V. vulnificus</i> biofilms. Additionally, the eukaryotic cell membrane barrier significantly reduces PS-induced damage to its nucleic acids. This strategy significantly promotes the healing of infected wounds in <i>V. vulnificus</i>-infected mice. Our work introduces the first PS targeting <i>V. vulnificus</i>-associated infections, demonstrating efficacy both in vitro and in vivo.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.709","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term In Vivo Fluorescence Analyses and Imaging-Guided Tumor Surgery in the Second Near-Infrared Window Using a Supramolecular Metallacage","authors":"Yi Qin,&nbsp;Niu Niu,&nbsp;Xue Li,&nbsp;Xueke Yan,&nbsp;Shuai Lu,&nbsp;Zhikai Li,&nbsp;Yixiong Gui,&nbsp;Jun-Long Zhu,&nbsp;Lin Xu,&nbsp;Xiaopeng Li,&nbsp;Dong Wang,&nbsp;Ben Zhong Tang","doi":"10.1002/agt2.708","DOIUrl":"https://doi.org/10.1002/agt2.708","url":null,"abstract":"<p>Long-term in vivo fluorescence analysis is growing into a sparkling frontier in gaining deep insights into various biological processes. Exploration of such fluorophores with high performance still remains an appealing yet significantly challenging task. In this study, we have elaborately integrated a second near-infrared (NIR-II) emissive fluorophore with the metal Pt into a self-assembled prism-like metallacage M-DBTP, which enables the intravital long-term tracking of the metal Pt through NIR-II fluorescence imaging technologies. In addition, the intravital bioimaging of the metallacage-loaded nanoparticles (NPs) indicated an extraordinary photographic performance on the mice blood vessels and the rapid clearance of M-DBTP NPs from the blood within 7 h. The subsequent transfer to the bones and the retention of NPs in the bone marrow region for up to 35 days was revealed by long-term fluorescence analysis, which was confirmed by the distribution and metabolism of Pt through an inductively coupled plasma optical emission spectrometer. Moreover, the bright emission of M-DBTP NPs in the NIR-II region enables them to well perform on fluorescence imaging-guided tumor surgery.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.708","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring toward a Broader Space: The Upcoming New Voyage of Aggregate","authors":"Ben Zhong Tang","doi":"10.1002/agt2.714","DOIUrl":"https://doi.org/10.1002/agt2.714","url":null,"abstract":"&lt;p&gt;Developing a top-notch journal is a great yet challenging voyage. To sail steadily and speedily toward the ultimate destination, the ship of &lt;i&gt;Aggregate&lt;/i&gt; needs a compass and an engine. The compass is the original aspiration of publishing high-quality research accomplishments on aggregate science, and the engine is the enthusiastic support from the scientific community, including the authors, reviewers, readers, and editorial board members.&lt;/p&gt;&lt;p&gt;In the past four years, &lt;i&gt;Aggregate&lt;/i&gt; enjoyed a successful takeoff followed by high-speed sailing. Now it has arrived at the transition point of the next-stage shipping line, where we should summarize the previous performance and envision the upcoming new voyage toward a broader space.&lt;/p&gt;&lt;p&gt;In 2024, &lt;i&gt;Aggregate&lt;/i&gt; received the 2nd Journal Impact Factor (JIF) of 13.9, maintaining a Q1 ranking in three categories: “Chemistry, Multidisciplinary”, “Chemistry, Physical”, and “Materials Science, Multidisciplinary” based on the Journal Citation Reports (JCR) 2024 published by Clarivate Analytics. For the first time, &lt;i&gt;Aggregate&lt;/i&gt; received a CiteScore&lt;sup&gt;TM&lt;/sup&gt; of 17.4, ranking top 5% and 6% in the categories of “Chemistry: Chemistry (Miscellaneous)” and “Materials Science, Materials Chemistry,” respectively.&lt;/p&gt;&lt;p&gt;Besides the impressive journal metrics mentioned above, 2024 is a year of rapid expansion for &lt;i&gt;Aggregate&lt;/i&gt; in terms of a significant increase in the numbers of manuscript submissions and paper publications, a broader scope of the journal, a stronger editorial board team, and a wider range of authors and reviewers (Figure 1). So proud to say that the “compass” is upgraded, and the “engine” is further empowered!&lt;/p&gt;&lt;p&gt;To date, &lt;i&gt;Aggregate&lt;/i&gt; has received manuscript submissions from international authors in 38 countries/regions. In 2024, &lt;i&gt;Aggregate&lt;/i&gt; has published 185 papers until November 13, 2024 (Figure 1A). Considering the continuous increase in the number of published papers, we have decided to shift &lt;i&gt;Aggregate&lt;/i&gt; from the current bimonthly journal to a monthly journal from 2025. To maintain high quality with increased quantity, we will set a higher standard for prescreening, while keeping our tradition of fast and fair peer review. In the past 12 months, the acceptance rate has gradually dropped and the average times from the submission to the first and final decisions have been shortened to 12 and 25 days, respectively.&lt;/p&gt;&lt;p&gt;&lt;i&gt;Aggregate&lt;/i&gt; aims to grow into a comprehensive and multidisciplinary journal in the area of aggregate science, covering significant advancements and innovative breakthroughs in a wide range of research fields, including chemistry, materials science, physics, engineering, nanotechnology, biology, life science, and so on. &lt;i&gt;Aggregate&lt;/i&gt; encourages paradigm shift in research philosophy and promotes the study of complex systems and processes at higher structural hierarchy across disciplinary boundaries. We emphasize that all the studies beyond","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"5 6","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.714","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142861865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellulose-Based Switchable Circularly Polarized Light Emitter: Photo-Actuated Chiral Assemblies With Azobenzene Polymers","authors":"Wenye Sun,&nbsp;Bing Tian,&nbsp;Bang An,&nbsp;Rui Teng,&nbsp;Mingcong Xu,&nbsp;Chunhui Ma,&nbsp;Zhijun Chen,&nbsp;Haipeng Yu,&nbsp;Jian Li,&nbsp;Wei Li,&nbsp;Siqi Huan,&nbsp;Shouxin Liu,&nbsp;Orlando J. Rojas","doi":"10.1002/agt2.712","DOIUrl":"https://doi.org/10.1002/agt2.712","url":null,"abstract":"<p>Circularly polarized luminescent materials find extensive applications in 3D displays, information encryption, and photoinduced supramolecular chirality. However, controlling the handedness of circularly polarized luminescence remains a significant challenge in advancing optical technologies. In this study, we present a Janus circularly polarized light emitter comprising a fluorescent film combined with chiral nematic cellulose with switchable chirality. The emitter achieves maximum luminescence dissymmetry factors (0.28 and −0.65) through mode switching. In addition, we show the emitter's versatility in inducing chiral helices in azobenzene polymers with varying polar groups, resulting in significant chiral signals. Importantly, the chirality of these polymers can be switched by altering the luminescence mode of the emitter. These results are expected to facilitate the efficient design of chiral luminescent materials and photoinduction devices.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.712","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RAFT Copolymerization of Pt(II) Pincer Complexes With Water-Soluble Polymer as an Efficient Way to Obtain Micellar-Type Nanoparticles With Aggregation-Induced NIR Emission","authors":"Roman A. Shilov,&nbsp;Vadim A. Baigildin,&nbsp;Kristina S. Kisel,&nbsp;Ekaterina E. Galenko,&nbsp;Alexander S. Gubarev,&nbsp;Mariya E. Mikhailova,&nbsp;Olga S. Vezo,&nbsp;Nikolai V. Tsvetkov,&nbsp;Andrey A. Shtyrov,&nbsp;Mikhail N. Ryazantsev,&nbsp;Julia R. Shakirova,&nbsp;Sergey P. Tunik","doi":"10.1002/agt2.713","DOIUrl":"https://doi.org/10.1002/agt2.713","url":null,"abstract":"<p>The idea of preparation a water-soluble Pt-containing AIEgen was successfully realized by direct reversible addition-fragmentation transfer copolymerization of a Pt(II) complex (<b>LPtPV</b>) containing a vinyl group and polyvinylpyrrolidone (<b>p(VP)</b>). The resulting block-copolymer <b>p(VP-<i>b</i>-LPtPV)</b> containing 5–8 Pt(II) chromophores exhibits intriguing photophysical properties—strong solvent and concentration dependence of absorption and emission characteristics. Various physicochemical and analytical methods (NMR spectroscopy, XRD analysis, ESI-MS, AUC, DLS, ICP-OES, GPC, viscometry, TEM) were used to characterize the initial complex, its binuclear analogs, <b>p(VP)</b> and <b>p(VP-<i>b</i>-LPtPV)</b>. The obtained data indicate that the photophysical properties of the latter are dictated by the type of aggregation process rather than solvatochromic effects. It is shown that at low concentration in organic solvents, the platinum chromophores aggregation is either absent (dimethylformamide) or occurs predominantly at intramolecular level (MeCN), whereas in aqueous media, <b>p(VP-<i>b</i>-LPtPV)</b> readily aggregates into micellar-type nanoparticles with a hydrophilic p(VP) corona and a hydrophobic Pt-containing core, in which strong intra- and intermolecular Pt···Pt and/or π···π interactions result in a significant red shift of absorption and emission down to 600 and 816 nm, respectively. Despite of emission shift into NIR area where emission is commonly quenched by nonradiative vibrational relaxation, an increase in the emission quantum yield occurs in complete agreement with the typical aggregation-induced emission (AIE) emitters’ behavior. Quantum mechanics/molecular mechanics simulations of aggregation processes also confirm the trends in the relationship between aggregation mode and photophysical behavior, particularly, in the variations of energy gaps between the ground state of the AIEgens and their excited singlet and triplet states.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.713","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}