Aggregate (Hoboken, N.J.)最新文献

{"title":"Oxygen-driven cuproptosis synergizes with radiotherapy to potentiate tumor immunotherapy","authors":"Pei Pei,&nbsp;Yuhong Wang,&nbsp;Wenhao Shen,&nbsp;Qing He,&nbsp;Xiangming Han,&nbsp;Chonghai Zhang,&nbsp;Yuyuan Xie,&nbsp;Guangming Zhou,&nbsp;Ye Zhao,&nbsp;Lin Hu,&nbsp;Kai Yang","doi":"10.1002/agt2.484","DOIUrl":"10.1002/agt2.484","url":null,"abstract":"<p>The immunological implications of cuproptosis, a form of cell death highly sensitive to oxygen presence, remain largely unexplored in the context of tumor immunotherapy. Herein, we initially investigate the positive correlation between cuproptosis and tumor immunotherapy through bioinformatics analysis. Subsequently, an oxygen generator loaded with copper ions (^Cu/APH-M) has been constructed, which serves as an effective carrier of copper ions and crucially enhances the oxygenation of the tumor microenvironment. Importantly, ^Cu/APH-M-mediated dual strengthening of cuproptosis and radiotherapy could not only trigger a powerful antitumor immunity related to immunogenic cell death by RNA-sequencing analysis, but also effectively inhibit the growth of both distal and in situ low rectal tumors after combined immunotherapy, creating a robust immune memory effect. Our work reveals the beneficial effects of enhanced cuproptosis in radio-immunotherapy and elucidates its underlying mechanisms, which provides a novel approach for the synergistic integration of cuproptosis with immunotherapy and radiotherapy, broadening the scope of cuproptosis-mediated tumor therapy.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.484","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139095955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An in situ dressing material containing a multi-armed antibiotic for healing irregular wounds","authors":"Ruihua Dong,&nbsp;Mian Chen,&nbsp;Yuexiao Jia,&nbsp;Hao Tang,&nbsp;Ziyin Xiong,&nbsp;Yunze Long,&nbsp;Xingyu Jiang","doi":"10.1002/agt2.493","DOIUrl":"10.1002/agt2.493","url":null,"abstract":"<p>Acute and infected wounds resulting from accidents, battlefield trauma, or surgical interventions have become a global healthcare burden due to the complex bacterial infection environment. However, conventional gauze dressings present insufficient contact with irregular wounds and lack antibacterial activity against multi-drug-resistant bacteria. In this study, we develop in situ nanofibrous dressings tailored to fit wounds of various shapes and sizes while providing nanoscale comfort and excellent antibacterial properties. Our approach involves the fabrication of these dressings using a handheld electrospinning device that allows for the direct deposition of nanofiber dressings onto specific irregular wound sites, resulting in perfect conformal wound closure without any mismatch in 2 min. The nanofibrous dressings are loaded with multi-armed antibiotics that exhibit outstanding antibacterial activity against <i>Staphylococcus aureus</i> (<i>S. aureus</i>) and methicillin-resistant <i>S. aureus</i>. Compared to conventional vancomycin, this in situ nanofibrous dressing shows great antibacterial performance against up to 98% of multi-drug-resistant bacteria. In vitro and in vivo experiments demonstrate the ability of in situ nanofibrous dressings to prevent multi-drug-resistant bacterial infection, greatly alleviate inflammation, and promote wound healing. Our findings highlight the potential of these personalized nanofibrous dressings for clinical applications, including emergency, accident, and surgical healthcare treatment.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.493","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139096221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermally activated delayed fluorescence Au-Ag-oxo nanoclusters: From photoluminescence to radioluminescence","authors":"Peng Yuan,&nbsp;Hansong Zhang,&nbsp;Yang Zhou,&nbsp;Tengyue He,&nbsp;Sami Malola,&nbsp;Luis Gutiérrez-Arzaluz,&nbsp;Yingwei Li,&nbsp;Guocheng Deng,&nbsp;Chunwei Dong,&nbsp;Renwu Huang,&nbsp;Xin Song,&nbsp;Boon K. Teo,&nbsp;Omar F. Mohammed,&nbsp;Hannu Häkkinen,&nbsp;Osman. M. Bakr,&nbsp;Nanfeng Zheng","doi":"10.1002/agt2.475","DOIUrl":"10.1002/agt2.475","url":null,"abstract":"<p>Thermally activated delayed fluorescence (TADF) materials have numerous applications in energy conversion and luminescent imaging. However, they are typically achieved as metal-organic complexes or pure organic molecules. Herein, we report the largest Au-Ag-oxo nanoclusters to date, Au₁₈Ag₂₆(R₁COO)₁₂(R₂C≡C)₂₄(<i>μ</i>₄-O)₂(<i>μ</i>₃-O)₂ (<b>Au₁₈Ag₂₆</b>, where R₁ = CH₃-, Ph-, CHOPh- or CF₃Ph-; R₂ = Ph- or FPh-). These nanoclusters exhibit exceptional TADF properties, including a small S₁-T₁ energy gap of 55.5 meV, a high absolute photoluminescence quantum yield of 86.7%, and a microseconds TADF decay time of 1.6 <i>μ</i>s at ambient temperature. Meanwhile, <b>Au₁₈Ag₂₆</b> shows outstanding stability against oxygen quenching and ambient conditions. Atomic level analysis reveals the strong π⋯π and C-H⋯π interactions from the aromatic alkynyl ligands and the enhancement of metal-oxygen-metal interactions by centrally coordinated O²⁻. Modeling of the electronic structure shows spatially separated highest occupied molecular orbital and lowest unoccupied molecular orbital, which promote charge transfer from the ligand shell, predominantly carboxylate ligands, to O²⁻-embedded metal core. Furthermore, TADF Au-Ag-oxo nanoclusters exhibit promising radioluminescence properties, which we demonstrate for X-ray imaging. Our work paves the way for the design of TADF materials based on large metal nanoclusters for light-emission and radioluminescence applications.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.475","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139095962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A panoramic perspective of recent progress in 2D and 3D covalent organic frameworks for drug delivery","authors":"Fariba Mehvari,&nbsp;Vahid Ramezanzade,&nbsp;Parvin Asadi,&nbsp;Nem Singh,&nbsp;Jaewon Kim,&nbsp;Mohammad Dinari,&nbsp;Jong Seung Kim","doi":"10.1002/agt2.480","DOIUrl":"10.1002/agt2.480","url":null,"abstract":"<p>The development of efficient drug delivery systems is essential for improving the efficacy and safety of cancer drugs, particularly for aggressive and difficult-to-treat cancers. Covalent organic frameworks (COFs) are emerging as innovative porous nanomaterials in drug delivery systems (DDS), due to their unique properties, including the metal-free organic skeleton, predetermined structures and pore geometries, high porosity, large surface area, facile surface modification potential, and good biocompatibility. These characteristics make COFs excellent candidates for improving drug delivery by enhancing drug loading capacity and enabling precise encapsulation. This review emphasizes the importance of donor-acceptor-based COFs, which provide channels for charge transportation, and we also explore how the π-conjugated skeleton of COFs enhances its long-acting fluorescent properties and facilitates drug uptake via cell endocytosis. While this review primarily focuses on recent advancements in COF-based targeted DDS, it also acknowledges the challenges posed by the diverse pore geometries in porous materials and discusses potential solutions. Further, it underlines the potential of developing future drug carriers that can successfully and specifically target cancer cells, improving treatment efficiency while reducing adverse side effects.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.480","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139096202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pickering multiphase materials using plant-based cellulosic micro/nanoparticles","authors":"Wei Liu,&nbsp;Bo Pang,&nbsp;Meng Zhang,&nbsp;Jiayi Lv,&nbsp;Ting Xu,&nbsp;Long Bai,&nbsp;Xu-Min Cai,&nbsp;Shuangquan Yao,&nbsp;Siqi Huan,&nbsp;Chuanling Si","doi":"10.1002/agt2.486","DOIUrl":"10.1002/agt2.486","url":null,"abstract":"<p>Pickering multiphase systems stabilized by solid particles have recently attracted increasing attention due to their excellent stability. Among various solid stabilizers, natural and renewable cellulosic micro/nanoparticles that are derived from agricultural and forestry sources have become promising candidates for Pickering stabilization due to their unique morphological features and tunable surface properties. In this review, recent progress on forming and stabilizing Pickering multiphase systems using cellulosic colloidal particles is summarized, including the physicochemical factors affecting their assembly at the interfaces and the preparation methods suitable for producing Pickering emulsions. In addition, relevant application prospects of corresponding Pickering multiphase materials are outlined. Finally, current challenges and future perspectives of such renewable Pickering multiphase systems are presented. This review aims to encourage the utilization of cellulosic micro/nanoparticles as key components in the development of Pickering systems, leading to enhanced performance and unique functionalities.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.486","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139095961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing mesenchymal aggregation for engineered organ-level regeneration: Recent progress and perspective","authors":"Chen-Xi Zheng,&nbsp;Bing-Dong Sui,&nbsp;Yan Jin","doi":"10.1002/agt2.497","DOIUrl":"10.1002/agt2.497","url":null,"abstract":"<p>Stem cells, especially mesenchymal progenitors or mesenchymal stem cells (MSCs), possess an intrinsic property to form compact spheroid-like assemblies, a phenomenon known as cell aggregation. In recent years, a growing body of researches have uncovered that this is a cross-species conserved developmental event essential for initiating organogenesis in a variety of organs. Moreover, the self-assembly property also contributes to the regenerative capacities of MSC aggregates in vivo with broad range of applications in tissue engineering. In this review, the principles of self-assembled mesenchymal aggregation and its involvement in physiological organogenesis, as well as the construction approaches of engineering MSC aggregates and its application for organ regeneration are discussed. The authors aim to provide a speculative overview of the current understanding and the recent findings of cell aggregation, from both the developmental and the engineering perspectives, and thus offer insights into the understanding of stem cell biology and the establishment of novel organ regeneration strategies.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.497","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139065152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Front Cover: Cellular journey of nanomaterials: Theories, trafficking, and kinetics","authors":"Xiangrui Wang,&nbsp;Wen-Xiong Wang","doi":"10.1002/agt2.490","DOIUrl":"https://doi.org/10.1002/agt2.490","url":null,"abstract":"<p>Subcellular distribution of engineered nanomaterials is always along with conversion of endosomal-lysosomal system, which is highly dynamic depending on intracellular trafficking between different compartments. Understanding the cellular fate of nanomaterials is critical for targeting ideal organelles to minimize the adverse effect of nanomedicine. Advanced technologies for probing the nano-cell interaction with high temporal-spatial resolution are expected to provide new insights (e372).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.490","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138739894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Back Cover: Tough PEG-only hydrogels with complex 3D structure enabled by digital light processing of “all-PEG” resins","authors":"Safira Noor Anindita,&nbsp;Riccardo Conti,&nbsp;Doris Zauchner,&nbsp;Nevena Paunović,&nbsp;Wanwan Qiu,&nbsp;Marina Green Buzhor,&nbsp;Adva Krivitsky,&nbsp;Zhi Luo,&nbsp;Ralph Müller,&nbsp;Hansjörg Grützmacher,&nbsp;Xiao-Hua Qin,&nbsp;Jean-Christophe Leroux,&nbsp;Yinyin Bao","doi":"10.1002/agt2.491","DOIUrl":"https://doi.org/10.1002/agt2.491","url":null,"abstract":"<p>Creating tough PEG hydrogels with complex 3D structure is a challenging task. We present a 3D printing method that offers precise production of these hydrogels, leveraging heat-assisted digital light processing and a unique dual-macromonomer “all-PEG” resin that includes a four-arm macrophotoinitiator. We fabricated porous hydrogel scaffolds resembling trabecular structures with good bioactivity, underscoring the promise of our approach in the realm of tissue regeneration (e368).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.491","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138739895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Front Cover: Movable typing of full-lumen personalized Vein-Chips to model cerebral venous sinus thrombosis","authors":"Yunduo Charles Zhao,&nbsp;Yingqi Zhang,&nbsp;Arian Nasser,&nbsp;Tianbo Hong,&nbsp;Zihao Wang,&nbsp;Allan Sun,&nbsp;Laura Moldovan,&nbsp;Leon S Edwards,&nbsp;Freda Passam,&nbsp;Ken S Butcher,&nbsp;Timothy Ang,&nbsp;Lining Arnold Ju","doi":"10.1002/agt2.489","DOIUrl":"https://doi.org/10.1002/agt2.489","url":null,"abstract":"<p>Zhao et al. have developed an innovative patient-specific Vein-Chip, inspired by the traditional Chinese Movable Typing. The novel injection soft-lithography and assembly techniques enable a cost-efficient platform for personalized cerebral venous sinus thrombosis analysis. These chips hold the potential to serve as pre-clinical diagnostic tools to thoroughly assess personalized Virchow's triad, including hyper-coagulation, altered blood flow, and endothelial dysfunction (e386).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.489","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138739893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Newly elected members of the Chinese Academy of Sciences (chemistry division) in 2023","authors":"","doi":"10.1002/agt2.479","DOIUrl":"https://doi.org/10.1002/agt2.479","url":null,"abstract":"<p>In November 2023, the Chinese Academy of Sciences (CAS) announced the newly elected members. In this Profile column, we introduce 10 Chinese and five foreign members in the chemistry division of the CAS. Congratulations to all the elected academicians!</p><p></p><p><b>Junbiao Chang</b>\u0000 <i>Zhengzhou University, Zhengzhou, China</i>Junbiao Chang is a Professor and the Vice President of Zhengzhou University. He obtained his Ph.D. degree in 1996 from the Institute of Materia Medica, Chinese Academy of Medical Sciences. Then he conducted postdoctoral research at the University of Georgia and later at GNF (USA). Currently, he holds positions as the Director of the State Key Laboratory of Antiviral Drugs and President of the Henan Pharmaceutical Association. He has received awards including the National Natural Science Award (2nd class), the Patent Gold Award from both the World Intellectual Property Organization and the China National Intellectual Property Administration, and so on. His research interests involve designing and synthesizing new small-molecule drugs to treat viral infections, cancer, and cerebral vascular diseases. He has successfully developed several drug candidates that have advanced into clinical trials. Notably, he successfully developed a new drug called Azvudine for AIDS treatment which obtained official approval from the National Medical Products Administration for marketing purposes. Furthermore, Azvudine has been approved in China and Russia for treating coronavirus disease 2019. To date, he has published over 300 peer-reviewed papers in prestigious journals such as <i>Science</i> and <i>Nature</i>, filed more than 40 patents in China along with 8 patents in the United States and 5 patents in Europe, additionally securing multiple patents across countries including Russia and Japan.</p><p></p><p><b>Chunying Chen</b>\u0000 <i>National Center for Nanoscience and Technology, Beijing, China</i>Chunying Chen is a Professor at the National Center for Nanoscience and Technology of China. She received her bachelor's degree in Chemistry (1991) and Ph.D. degree in Biomedical Engineering (1996) from Huazhong University of Science and Technology. Her research interests include analytical techniques for nano−protein corona and the transformation and fate of nanomaterials in biota that provided fundamental insights for the rational design of precision nanomedicine. With the development of quantitative approaches, she also contributed to the understanding of nano-bio interaction and therefore enhancing the therapeutic efficacy against malignant tumors and infectious diseases using theranostic nanomedicine and vaccine nanoadjuvant innovation. She has published over 380 peer-reviewed articles on <i>Nat. Nanotech</i>., <i>Nat. Methods</i>, <i>Nat. Protocols</i>, <i>Nat. Commun</i>., <i>PNAS</i>, <i>J. Am. Chem. Soc</i>., <i>Angew. Chem</i>., <i>Anal. Chem</i>., etc., with over 48,700 citations and an H-index of 119. She serv","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.479","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138739688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}