Aggregate (Hoboken, N.J.)最新文献

{"title":"Front Cover: Molecular Aggregates of Wheat Starch–Protein Systems: Structural Disruption and Engineered Digestibility via Non-Covalent Synergy","authors":"Cuihong Dai,&nbsp;Dongling Qiao,&nbsp;Bowen Li,&nbsp;Fengwei Xie,&nbsp;Binjia Zhang","doi":"10.1002/agt2.70165","DOIUrl":"https://doi.org/10.1002/agt2.70165","url":null,"abstract":"<p>This study deciphers how wheat proteins (gliadin/glutelin) form non-covalent aggregates with starch, disrupting its molecular order via hydrophobic and electrostatic forces. Integrating experiments and simulations, we reveal how these aggregates inhibit enzymatic digestion and enhance resistant starch content—enabling tailored glycemic control. The cover visualizes protein-starch synergy for engineering low-digestibility food matrices (e70115).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 9","pages":""},"PeriodicalIF":13.7,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70165","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Front Cover: Achieving Intrinsic Luminescence of Pure Organic Mono- and Di-Radicals in Aggregated States","authors":"Jiahao Guan,&nbsp;Zihao Zhu,&nbsp;Quanquan Gou,&nbsp;Jingmin Wang,&nbsp;Zhiyuan Kuang,&nbsp;Lintao Zhang,&nbsp;Xuewei Zhang,&nbsp;Xin Ai,&nbsp;Alim Abdurahman,&nbsp;Qiming Peng","doi":"10.1002/agt2.70162","DOIUrl":"https://doi.org/10.1002/agt2.70162","url":null,"abstract":"<p>This study presents a novel design strategy involving sterically demanding 2,4,6-triisopropylphenyl (TPP)-substituted tris(2,4,6-trichlorophenyl)methyl (TTM) radicals and diradicals, achieving bright intrinsic emission in crystalline, powder, and amorphous states without doping or matrix assistance. Single-crystal analysis combined with theoretical calculations reveals that bulky substituents significantly suppress intermolecular interactions, providing valuable insights into the mechanism of radical-based solid-state luminescence (e70100).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 9","pages":""},"PeriodicalIF":13.7,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70162","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145110779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Back Cover: Harnessing the Biological Responses Induced by Nanomaterials for Enhanced Cancer Therapy","authors":"Liting Wang,&nbsp;Hao Fu,&nbsp;Jiangtao Lin,&nbsp;Meng Zhao,&nbsp;Chuanrong Chen,&nbsp;Hongze Liao,&nbsp;Yourong Duan","doi":"10.1002/agt2.70163","DOIUrl":"https://doi.org/10.1002/agt2.70163","url":null,"abstract":"<p>This concept is inspired by the fictional work The Monkey King: Uproar in Heaven. The magician symbolizes the harnessing of nanomaterials (represented by the Monkey King in the alchemy furnace), while the cell engulfed in flames within the furnace reflects the manipulation of nanomaterial-induced biological responses. Together, they prepare to combat the looming threat of tumors, symbolized by the soldiers assembling in the clouds (e70080).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 9","pages":""},"PeriodicalIF":13.7,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70163","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Back Cover: Lung-Penetrating Biomimetic Extracellular Vesicle Spherical Nucleic Acids for Pulmonary Fibrosis Therapy Through ROS Scavenging and Anti-Inflammatory Effects","authors":"Saiyun Lou,&nbsp;Jiangpo Ma,&nbsp;Pan Fu,&nbsp;Lin Li,&nbsp;Jingyun Huang,&nbsp;Fangxue Jing,&nbsp;Yuhui Wang,&nbsp;Sihua Qian,&nbsp;Jianping Zheng,&nbsp;Jiang Li,&nbsp;Zhaoxing Dong,&nbsp;Kaizhe Wang","doi":"10.1002/agt2.70164","DOIUrl":"https://doi.org/10.1002/agt2.70164","url":null,"abstract":"<p>This study presents a biomimetic extracellular vesicle-spherical nucleic acid (BEV-SNA) platform for treating idiopathic pulmonary fibrosis (IPF). BEV-SNA combines MSC-derived nanovesicles with cholesterol-modified ssDNA, forming a negatively charged nanostructure that enhances lung delivery. It exhibits multifunctional therapeutic effects, including ROS scavenging, anti-inflammatory activity, and anti-fibrotic action, effectively mitigating fibrosis (e70086).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 9","pages":""},"PeriodicalIF":13.7,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70164","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Back Cover: Self-Assembly of Hydration-Dependent Quasi-Spherical Mixed Micelles into Selective Mesoscale Complex Crystalline Structures","authors":"Young-Jin Yoon,&nbsp;Tae-Hwan Kim","doi":"10.1002/agt2.70135","DOIUrl":"https://doi.org/10.1002/agt2.70135","url":null,"abstract":"<p>This study reveals the self-assembly of complex mesoscale liquid crystalline structures from nonionic amphiphiles (C₁₆EO₂₀ and EO₅PO₄₉EO₅) in aqueous solution. Quantitative small-angle X-ray scattering analyses, including Le Bail refinements and electron density reconstruction, elucidate hydration-dependent quasi-spherical micelle packing into diverse superlattices such as Frank–Kasper phases, providing mechanistic insights into soft matter crystallization and the design of hierarchical nanostructured materials (e70049).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 8","pages":""},"PeriodicalIF":13.7,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70135","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144881399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Front Cover: From Passive Monitoring to Active Control: Aggregation-induced Emission-driven Antimicrobial Nanotechnology for Long-duration Spaceflight","authors":"Feiyi Sun,&nbsp;Nuomin Li,&nbsp;Zheng Zhao,&nbsp;Zicong Zhang,&nbsp;Zuowan Zhou,&nbsp;Xiaoling Xu,&nbsp;Congwen Liu,&nbsp;Qihuan Xiong,&nbsp;Jianmin Tang,&nbsp;Chunhua Yang,&nbsp;Shiyong Yu,&nbsp;Ying Zhang,&nbsp;Ben Zhong Tang,&nbsp;Yulin Deng","doi":"10.1002/agt2.70137","DOIUrl":"https://doi.org/10.1002/agt2.70137","url":null,"abstract":"<p>On July 15, 2025, Tianzhou-9 cargo craft was launched, carrying key scientific supplies for China's space station including the anti-bacterial modules based on aggregation-induced emission (AIE) technology. The modules enable real-time microbial monitoring and sterilization with high sensitivity, fast response, easy operation, and strong stability, providing an innovative solution to meet the needs of microbial prevention and control in the special environment of the space station (e70132).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 8","pages":""},"PeriodicalIF":13.7,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70137","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144881430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Front Cover: Exactly Restricting the Phenyl Ring Rotation in Metal-Organic Framework for Ultra-Sensitive and Specific Ratiometric Fluorescent Sensing of Sarin","authors":"Cong Lyu,&nbsp;Chuanfang Zhao,&nbsp;Meimei Wang,&nbsp;Jiawen Li,&nbsp;Zhenzhen Cai,&nbsp;Xincun Dou,&nbsp;Baiyi Zu","doi":"10.1002/agt2.70138","DOIUrl":"https://doi.org/10.1002/agt2.70138","url":null,"abstract":"<p>A goal-oriented MOF design strategy is proposed to realize the ultra-sensitive and specific detection of sarin through the rotation restricted emission mechanism. The hydrogen bonding and hydrophobic interaction between Eu-MOF and sarin efficiently lead to a dramatic change in molecular configuration, significantly enhancing the fluorescence intensity and realizing the ratiometric detection of sarin. This strategy would provide new insights for functional sensing material exploration (e70053).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 8","pages":""},"PeriodicalIF":13.7,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70138","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144881431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Back Cover: A General Strategy to Fine-Tune Group 14 Rhodamines for Ultrahigh Signal-to-Noise Ratio Labeling In Vivo by Nano-Aggregation","authors":"Ning Wang,&nbsp;Ting Wang,&nbsp;Mengting Fan,&nbsp;Chen Li,&nbsp;Yue Tian,&nbsp;Xiaoyan Cui","doi":"10.1002/agt2.70136","DOIUrl":"https://doi.org/10.1002/agt2.70136","url":null,"abstract":"<p>This work developed a general strategy to fine-tune fluorogenicity in group 14 rhodamines for ultrahigh signal-to-noise ratio (SNR) labeling <i>in vivo</i>. The fluorogenicity of substituted rhodamines was preciously tuned by both their chemical and physical states. The development of fluorescent probes has enabled the tracking of complex dynamics in live systems with enhanced resolution and sensitivity (e70077).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 8","pages":""},"PeriodicalIF":13.7,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70136","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144881432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Passive Monitoring to Active Control: Aggregation-induced Emission-driven Antimicrobial Nanotechnology for Long-duration Spaceflight","authors":"Feiyi Sun,&nbsp;Nuomin Li,&nbsp;Zheng Zhao,&nbsp;Zicong Zhang,&nbsp;Zuowan Zhou,&nbsp;Xiaoling Xu,&nbsp;Congwen Liu,&nbsp;Qihuan Xiong,&nbsp;Jianmin Tang,&nbsp;Chunhua Yang,&nbsp;Shiyong Yu,&nbsp;Ying Zhang,&nbsp;Ben Zhong Tang,&nbsp;Yulin Deng","doi":"10.1002/agt2.70132","DOIUrl":"https://doi.org/10.1002/agt2.70132","url":null,"abstract":"<p>Humanity has entered a new phase of space exploration in which long-term orbital habitats are becoming routine. Within these permanently inhabited, hermetically sealed modules, microbial safety has emerged as a pivotal determinant of crew health and mission reliability. Closed circulation of air and water, together with the altered physiology and virulence of microorganisms in micro-gravity, renders conventional, Earth-based control measures insufficient and calls for space-specific innovations. Against this backdrop, China's rapid progress in astronautics, exemplified by the successful assembly and sustained operation of the Tiangong Space Station, has become a powerful catalyst for the development of next-generation microbial monitoring and abatement technologies.</p><p>To tackle this challenge, a landmark research programme has been initiated, which is supported by the “Space Station Program Technology Demonstration Experiments” initiative and led by Professors Yulin Deng and Ying Zhang from Beijing Institute of Technology. A central component is the “aggregation-induced emission (AIE)-armed bionic nanostructure module,” a cutting-edge integrated system that merges multidisciplinary expertise. Its key subsystems are the product of collaboration among three leading teams: AIE fluorophores, developed by Academician Ben Zhong Tang's group at The Chinese University of Hong Kong (Shenzhen); Bionic nanostructures, engineered by Professors Zuowan Zhou and Xiaoling Xu at Southwest Jiaotong University; The intelligent antimicrobial control logic was developed by the engineering team led by Mr. Qihuan Xiong at Changsha XiangJi-Hiden Technology Co., Ltd.and Dr. Chunhua Yang at Beijing Genxin Technology Co., Ltd.</p><p>This innovative module achieves a critical breakthrough: it simultaneously enables real-time microbial imaging and active pathogen eradication, thus addressing the dual challenge of rapid detection and effective suppression of microorganisms in the space environment.</p><p>Launched at 05:34 CST on 15 July 2025 from the Wenchang Space Launch Center, the Tianzhou-9 cargo spacecraft delivered the first batch of in-orbit experimental materials for this microbial monitoring and protection project. Beyond its immediate technical goals, this mission symbolises China's strategic commitment to solving the fundamental biosafety challenges of long-duration space habitation through convergent, state-of-the-art technological solutions—paving the way for safer, more sustainable human presence in orbit and beyond.</p><p>Although the space environment is inherently inimical to most terrestrial microorganisms, complete sterility aboard orbiting platforms remains unattainable. Contaminants accompany every launch vehicle, propagate via crew activities, and are introduced through experimental payloads, thereby establishing complex microbial consortia within the closed ecological loops of a space station. Once established, these communities give rise to thre","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 8","pages":""},"PeriodicalIF":13.7,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70132","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144881157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Condensed Matter: More Is Different","authors":"Yan Zhou,&nbsp;Dapeng Yu","doi":"10.1002/agt2.70131","DOIUrl":"https://doi.org/10.1002/agt2.70131","url":null,"abstract":"&lt;p&gt;To the Editor,&lt;/p&gt;&lt;p&gt;Half a century ago, one of the most important theoretical physicists who shaped the field of condensed matter physics, Professor Philip Anderson, expressed in his landmark article “More is Different” [&lt;span&gt;1&lt;/span&gt;] that “…the behavior of large and complex aggregates of elementary particles, it turns out, is not to be understood in terms of a simple extrapolation of the properties of a few particles. Instead, at each level of complexity entirely new properties appear…”. The concept “More is Different” emphasized the significance of emergence in complex systems, where emergent behaviors and properties that cannot be found from the individual parts. Professor Anderson's own research in condensed matter physics also reflects the importance of emergence and complexity science. He was most concerned about how complex phenomena emerge from simple systems [&lt;span&gt;2, 3&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;In recent years, Professor Ben Zhong Tang and his team at the Chinese University of Hong Kong (Shenzhen) have proposed the concept of aggregate science, building on their pioneering research on aggregation-induced emission (AIE). AIE is a phenomenon in which certain organic luminophores exhibit stronger emission of light in their aggregated or solid state compared to when they are in solution [&lt;span&gt;4&lt;/span&gt;]. While molecular science usually focuses on the study of free isolated particles that are not affected by interactions between molecules, the object of study of aggregate science is a complex system where various interactions influence each other. Therefore, aggregate matter could be viewed as a special type of complex system, in which increased and enhanced interactions give rise to distinct physical and chemical properties—an idea that aligns with Professor Anderson's concept of “More is Different”.&lt;/p&gt;&lt;p&gt;To showcase the recent developments in the study of aggregate matter in condensed matter physics, &lt;i&gt;Aggregate&lt;/i&gt; has organized a Special Collection:Condensed Matter featuring topics such as proliferation and aggregation of topological spin textures, designs of multiresonant thermally activated delayed fluorescence emitters that suppress severe aggregation-caused quenching, multiple-phase aggregation process of Si and C atoms, and voltage-induced hysteresis resistance in nematic order.&lt;/p&gt;&lt;p&gt;Zhang et al. [&lt;span&gt;5&lt;/span&gt;] theoretically show that the proliferation and aggregation effects of topologically nontrivial bimerons in chiral magnets can be induced by magnetic fields and electric currents. They find that small damping and a relatively large nonadiabatic spin-transfer torque could lead to more pronounced bimeron proliferation and aggregation. They analyze the micromagnetic energy terms during the proliferation and aggregation of bimerons. These results may help to understand the mechanism for the proliferation and aggregation of bimerons and motivate the development of new aggregate science.&lt;/p&gt;&lt;p&gt;Ye et al. [&lt;span&gt;6&lt;/span&gt;] develop a new","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 9","pages":""},"PeriodicalIF":13.7,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70131","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145110811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}