Aggregate (Hoboken, N.J.)最新文献

Inside Front Cover: Nozzle Jamming Granularized Blood-Derived Proteins for Bioprinting Cell-Instructive Architectures 内封面：喷嘴干扰颗粒化血源性蛋白质用于生物打印细胞指导结构

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-07-21 DOI: 10.1002/agt2.70107

Lucas S. Ribeiro, João Rocha Maia, Vítor M. Gaspar, Catarina A. Custódio, Emerson R. Camargo, Rita Sobreiro-Almeida, João F. Mano

引用次数: 0

Inside Back Cover: Helically Assembled Rare Earth Fluoride Nanoparticles with Multicolor Circularly Polarized Luminescence for High-Security Anti-Counterfeiting 内后盖：螺旋组装稀土氟化物纳米粒子与多色圆偏振发光高安全防伪

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-07-21 DOI: 10.1002/agt2.70108

Wen Yuan, Shan Lu, Xingjun Li, Zhuo Li, Xiaobo Gu, Xingyang Liu, Zhixiao Ren, Fei Wang, Xueyuan Chen

引用次数: 0

Front Cover: Cell Membrane-Coated Lipid Nanoparticles for Drug Delivery 封面：用于药物递送的细胞膜包被脂质纳米颗粒

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-07-21 DOI: 10.1002/agt2.70106

Moataz B. Zewail, Guangze Yang, Yilong Fan, Yue Hui, Chun-Xia Zhao, Yun Liu

引用次数: 0

Back Cover: Turning on the Heat by Cocrystal Engineering: The Rise of Organic Charge Transfer Photothermal Cocrystals as an Emerging Therapeutic Frontier in Biomedical Application 后盖：通过共晶工程打开热量：有机电荷转移光热共晶的兴起作为生物医学应用的新兴治疗前沿

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-07-21 DOI: 10.1002/agt2.70109

Arshad Khan, Rabia Usman, Shuo Xiang, Yasinalli Tamboli, Muhammad Umair, Awatef M. Alshehri, Ibraheem Bushnak, Yan Deng, Nongyue He

引用次数: 0

Back Cover: Size-dependent Stability and Luminescence Property in Organic Aggregates 封底：有机聚集体的尺寸依赖性稳定性和发光特性

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-06-22 DOI: 10.1002/agt2.70082

Junfang Yang, Jikai Lv, Yuan Jiao, Xiaoyan Zheng, Qian Peng

{"title":"Back Cover: Size-dependent Stability and Luminescence Property in Organic Aggregates","authors":"Junfang Yang, Jikai Lv, Yuan Jiao, Xiaoyan Zheng, Qian Peng","doi":"10.1002/agt2.70082","DOIUrl":"https://doi.org/10.1002/agt2.70082","url":null,"abstract":"This work explores the critical sizes of stable aggregates and their bright luminescence for helical hexaphenylsilole and planar 3-(2-cyano-2-phenylethenyl-Z)-NH-indole aggregation-induced emission luminogens, providing dynamic insights into the aggregation-induced emission (AIE) mechanism and invaluable guidance for optimizing the size of AIE-based nanoparticles in practical bioimaging and sensing applications (e70029).\u0000This review highlights cutting-edge strategies for enhancing the detection of pathogen-derived extracellular vesicles, including novel aggregate materials and machine learning approaches. Pathogen-derived vesicles are pivotal in host-pathogen interactions and possess significant diagnostic promise, as their unique cargo offers a rich repository of potential biomarkers. Enhancing vesicle detection may ultimately pave the way for transformative clinical applications (e70018).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture>\u0000 </div>\u0000 </figure>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 6","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70082","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Front Cover: Hydrogel-Based Smart Materials for Wound Healing and Sensing 封面：用于伤口愈合和传感的基于水凝胶的智能材料

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-06-22 DOI: 10.1002/agt2.70084

Thi Kim Ngan Duong, Thi Thuy Truong, Thi Nhat Linh Phan, Thi Xuan Nguyen, Vu Hoang Minh Doan, Truong Tien Vo, Jaeyeop Choi, Umapada Pal, Prodyut Dhar, Byeongil Lee, Junghwan Oh, Sudip Mondal

引用次数: 0

Inside Front Cover: Development and Application of Organic Sonosensitizers in Cancer Therapy 内封面：有机声敏剂在癌症治疗中的发展与应用

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-06-22 DOI: 10.1002/agt2.70085

Yuhan Ding, Yuchen Yang, Omer Aras, Feifei An, Mengjiao Zhou, Yichao Chai

引用次数: 0

Inside Back Cover: Near-Infrared Organic Room Temperature Phosphorescent Probes Targeting Fibroblast Activation Protein for Surgical Navigation of Liver Cancer 封底内：近红外有机室温磷光探针靶向成纤维细胞激活蛋白用于肝癌手术导航

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-06-22 DOI: 10.1002/agt2.70083

Jinghua Li, Juqing Gu, Liangxuan Ding, Xiaomian Li, Peng Xia, Fusheng Liu, Xi Chen, Weijie Ma, Yong He, Qianqian Li, Zhen Li, Yufeng Yuan

引用次数: 0

Carbon–Nitrogen Axial Chirality as a Novel Chiral Framework Design Strategy for Circularly Polarized Luminescence Materials 碳氮轴向手性：一种新的圆极化发光材料手性框架设计策略

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-06-13 DOI: 10.1002/agt2.70069

Lei Zeng, Chen-Hao Guo, Chensen Li, Ziwei Deng, Yi Lu, Lin Lu, Peng Meng, Shuaijun Sun, Zijie Qiu, Meng Li, Yu Xiong, Zheng Zhao, Chuan-Feng Chen, Ben Zhong Tang

{"title":"Carbon–Nitrogen Axial Chirality as a Novel Chiral Framework Design Strategy for Circularly Polarized Luminescence Materials","authors":"Lei Zeng, Chen-Hao Guo, Chensen Li, Ziwei Deng, Yi Lu, Lin Lu, Peng Meng, Shuaijun Sun, Zijie Qiu, Meng Li, Yu Xiong, Zheng Zhao, Chuan-Feng Chen, Ben Zhong Tang","doi":"10.1002/agt2.70069","DOIUrl":"https://doi.org/10.1002/agt2.70069","url":null,"abstract":"Circularly polarized luminescence (CPL) materials are essential for advanced optoelectronic applications, yet efficient chiral design strategies remain challenging. Axial chirality has been widely employed in the construction of CPL materials due to its unique rigid structure. However, the focus has been primarily on the derivatives of carbon–carbon axial chirality. We herein propose a strategy for constructing carbon–nitrogen (C─N) axially chiral molecular frameworks to fully exploit the excellent chromophoric properties of nitrogen-containing heterocycles (such as carbazole). A pair of chiral emitters, (S/R)-AI-2TCFC, was designed and synthesized, exhibiting an emission peak at 578 nm both in the toluene solution and in the neat film state. It possessed typical aggregation-induced emission (AIE), thermally activated delayed fluorescence (TADF), and a luminescence dissymmetry factor (glum) of 10−3, demonstrating its potential for high-performance device applications. These materials were successfully applied in circularly polarized organic light-emitting diodes (CP-OLEDs), demonstrating promising electroluminescence performance. This innovative strategy not only expands the design toolbox for CPL materials but also paves the way for next-generation high-performance optoelectronic devices.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 7","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70069","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selenium-Containing Polyurethane Thermo-Sensitive Hydrogel Accelerates Diabetic Wound Healing by Activating Unfolded Protein Response 含硒聚氨酯热敏水凝胶通过激活未折叠蛋白反应加速糖尿病伤口愈合

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-06-04 DOI: 10.1002/agt2.70074

Mo Zhai, Zilun Huang, Banruo Xianyu, Xiaoqiang Bai, Zhuqing Wan, Yang Fu, Huaping Xu, Longwei Lv, Yongsheng Zhou

{"title":"Selenium-Containing Polyurethane Thermo-Sensitive Hydrogel Accelerates Diabetic Wound Healing by Activating Unfolded Protein Response","authors":"Mo Zhai, Zilun Huang, Banruo Xianyu, Xiaoqiang Bai, Zhuqing Wan, Yang Fu, Huaping Xu, Longwei Lv, Yongsheng Zhou","doi":"10.1002/agt2.70074","DOIUrl":"https://doi.org/10.1002/agt2.70074","url":null,"abstract":"Diabetic wound healing impairment, a common complication of diabetes, has limited clinical treatment options and poor therapeutic outcomes, causing significant physical pain and psychological burden for patients. This study aims to accelerate wound healing by modulating cellular stress responses, offering a safe and efficient new therapeutic strategy. Herein, a selenium-containing polyurethane (SePU) thermo-sensitive hydrogel was synthesized, and its mechanism for promoting diabetic wound healing by activating the unfolded protein response (UPR) was elucidated. Hydroxybutyl chitosan (HBC) offers a more convenient application for SePU, with its high hydroxybutyl substitution enabling the hydrogel to undergo a rapid sol–gel transition at physiological temperatures. In vitro experiments showed that SePU thermo-sensitive hydrogel (SePU/HBC), at appropriate concentrations, significantly promoted the proliferation, spreading, migration, and adhesion of human skin fibroblasts (HSFs), while inhibiting inflammation. In vivo diabetic mouse model, SePU/HBC exhibited a significant wound-healing effect, promoting re-epithelialization, collagen formation and maturation. Mechanistic studies revealed that SePU/HBC alleviated endoplasmic reticulum stress under hyperglycemic conditions by activating the UPR-related gene ATF6 to alleviate endoplasmic reticulum stress (ERS) and inhibit apoptosis. This study offers a novel strategy for diabetic wound treatment using SePU/HBC, which activates the UPR and inhibits apoptosis, demonstrating promising clinical applications for wound healing.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 7","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70074","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0