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Inside Front Cover: Apical-out Tubuloids for Accurate Kidney Toxicity Studies
IF 13.9
Aggregate (Hoboken, N.J.) Pub Date : 2025-03-24 DOI: 10.1002/agt2.70026
Yugyeong Lee, Ji Su Hwang, Ziliang Zhai, Kyungwon Park, Ye Seul Son, Dae-Soo Kim, Seok Chung, Sejoong Kim, Mi-Young Son, Gwang Lee, Sungsu Park
{"title":"Inside Front Cover: Apical-out Tubuloids for Accurate Kidney Toxicity Studies","authors":"Yugyeong Lee,&nbsp;Ji Su Hwang,&nbsp;Ziliang Zhai,&nbsp;Kyungwon Park,&nbsp;Ye Seul Son,&nbsp;Dae-Soo Kim,&nbsp;Seok Chung,&nbsp;Sejoong Kim,&nbsp;Mi-Young Son,&nbsp;Gwang Lee,&nbsp;Sungsu Park","doi":"10.1002/agt2.70026","DOIUrl":"https://doi.org/10.1002/agt2.70026","url":null,"abstract":"<p>This article highlights the development of apical-out tubuloids that accurately mimic drug transport mechanisms. These tubuloids exhibit selective albumin internalization, heightened sensitivity to apically transported colistin, and reduced sensitivity to basally transported tenofovir. Their ability to replicate directional drug transport offers valuable insights into drug delivery and testing models (e697).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inside Back Cover: Ultrafast Excitonic Transitions in Enantiopure and Racemic Squaraine Thin Films 封底内页对映体和外消旋水杨酸薄膜中的超快激子跃迁
IF 13.9
Aggregate (Hoboken, N.J.) Pub Date : 2025-03-24 DOI: 10.1002/agt2.70027
Robin Bernhardt, Lukas Rieland, Tianyi Wang, Marvin F. Schumacher, Arne Lützen, Manuela Schiek, Paul H. M. van Loosdrecht
{"title":"Inside Back Cover: Ultrafast Excitonic Transitions in Enantiopure and Racemic Squaraine Thin Films","authors":"Robin Bernhardt,&nbsp;Lukas Rieland,&nbsp;Tianyi Wang,&nbsp;Marvin F. Schumacher,&nbsp;Arne Lützen,&nbsp;Manuela Schiek,&nbsp;Paul H. M. van Loosdrecht","doi":"10.1002/agt2.70027","DOIUrl":"https://doi.org/10.1002/agt2.70027","url":null,"abstract":"<p>Enantiopure ProSQ-C16 thin films exhibit an unusually large excitonic circular dichroism signal. Using steady-state and ultrafast transient absorption spectroscopy, Bernhardt et al. reveal that the optical response and its circular dichroism originate from a single type of predominantly J-like aggregated ProSQ-C16 molecules. A rapid transition to a dark intermediate state via intermolecular charge transfer and exciton-vibration coupling is suggested to be responsible for the suppression of the fluorescence, highlighting the importance of non-Frenkel exciton dynamics (e698).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Back Cover: Carbon Quantum Dots in Biomedical Applications: Advances, Challenges, and Future Prospects
IF 13.9
Aggregate (Hoboken, N.J.) Pub Date : 2025-03-24 DOI: 10.1002/agt2.70028
Nadezhda A. Pechnikova, Kalliopi Domvri, Konstantinos Porpodis, Maria S. Istomina, Aleksandra V. Iaremenko, Alexey V. Yaremenko
{"title":"Back Cover: Carbon Quantum Dots in Biomedical Applications: Advances, Challenges, and Future Prospects","authors":"Nadezhda A. Pechnikova,&nbsp;Kalliopi Domvri,&nbsp;Konstantinos Porpodis,&nbsp;Maria S. Istomina,&nbsp;Aleksandra V. Iaremenko,&nbsp;Alexey V. Yaremenko","doi":"10.1002/agt2.70028","DOIUrl":"https://doi.org/10.1002/agt2.70028","url":null,"abstract":"<p>Carbon quantum dots (CQDs) illuminate a new frontier in biomedicine with their fluorescence-driven multifunctionality and biocompatibility. This review highlights CQDs as potent tools for targeting cancer cells, delivering drugs, combating pathogens, and generating reactive oxygen species for advanced therapies like photodynamic and photothermal treatment. These nanomaterials promise breakthroughs in imaging, diagnostics, and personalized medicine, overcoming biomedical challenges through innovative design (e707).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Front Cover: Long-Term In Vivo Fluorescence Analyses and Imaging-Guided Tumor Surgery in the Second Near-Infrared Window Using a Supramolecular Metallacage 封面：利用超分子金属骨架在第二近红外窗口进行长期体内荧光分析和成像引导的肿瘤手术
IF 13.9
Aggregate (Hoboken, N.J.) Pub Date : 2025-03-24 DOI: 10.1002/agt2.70025
Yi Qin, Niu Niu, Xue Li, Xueke Yan, Shuai Lu, Zhikai Li, Yixiong Gui, Jun-Long Zhu, Lin Xu, Xiaopeng Li, Dong Wang, Ben Zhong Tang
{"title":"Front Cover: Long-Term In Vivo Fluorescence Analyses and Imaging-Guided Tumor Surgery in the Second Near-Infrared Window Using a Supramolecular Metallacage","authors":"Yi Qin,&nbsp;Niu Niu,&nbsp;Xue Li,&nbsp;Xueke Yan,&nbsp;Shuai Lu,&nbsp;Zhikai Li,&nbsp;Yixiong Gui,&nbsp;Jun-Long Zhu,&nbsp;Lin Xu,&nbsp;Xiaopeng Li,&nbsp;Dong Wang,&nbsp;Ben Zhong Tang","doi":"10.1002/agt2.70025","DOIUrl":"https://doi.org/10.1002/agt2.70025","url":null,"abstract":"<p>A discrete prism-like Pt(II) metallacage with NIR-II emission was constructed via coordination-driven self-assembly, and the brilliant fluorescence of the metallacage-loaded nanoparticles in the NIR-II window enables them well perform on the long-term fluorescence analysis in vivo, which revealed the gradual transfer of nanoparticles into bones from blood and the retention of nanoparticles in the bones for even 35 days (e708).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70025","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inside Back Cover: Mechanism of hierarchical plasmonic biomaterials engineered through peptide-directed self-assembly
IF 13.9
Aggregate (Hoboken, N.J.) Pub Date : 2025-02-19 DOI: 10.1002/agt2.70012
Lubna Amer, Maurice Retout, Zhicheng Jin, Sumathi Kakanar, Jesse V. Jokerst
{"title":"Inside Back Cover: Mechanism of hierarchical plasmonic biomaterials engineered through peptide-directed self-assembly","authors":"Lubna Amer,&nbsp;Maurice Retout,&nbsp;Zhicheng Jin,&nbsp;Sumathi Kakanar,&nbsp;Jesse V. Jokerst","doi":"10.1002/agt2.70012","DOIUrl":"https://doi.org/10.1002/agt2.70012","url":null,"abstract":"<p>The intricate dendritic structures highlight the controlled coalescence of silver nanoparticles into micron-sized aggregates. This process is a consequence of diffusion-limited aggregation driven by non-covalent interactions between peptides and the particle surface. This study explores how different amino acids guide coalescence, thus tuning the material properties. The resulting dynamic, tunable fractal patterns underscore their potential for applications in biosensing (e677).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 2","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143446870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Front Cover: Engineered Platelets for Cancer Therapy
IF 13.9
Aggregate (Hoboken, N.J.) Pub Date : 2025-02-19 DOI: 10.1002/agt2.70010
Kai Zhang, Hongyang Li, Zhaoyu Ma, Wenbin Zhong, Yongkang Yu, Yanli Zhao
{"title":"Front Cover: Engineered Platelets for Cancer Therapy","authors":"Kai Zhang,&nbsp;Hongyang Li,&nbsp;Zhaoyu Ma,&nbsp;Wenbin Zhong,&nbsp;Yongkang Yu,&nbsp;Yanli Zhao","doi":"10.1002/agt2.70010","DOIUrl":"https://doi.org/10.1002/agt2.70010","url":null,"abstract":"<p>This review article highlights various types of engineered platelets used to inhibit tumor growth and prevent postoperative tumor recurrence and metastasis. The challenges faced by engineered platelets in clinical translation are discussed, aiming to provide insights into the development of advanced platelet-based therapeutics in cancer treatment (e704).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 2","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143446873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inside Front Cover: Intrinsic role of alkyl side chains in disorder, aggregates, and carrier mobility of nonfullerene acceptors for organic solar cells: A multiscale theoretical study
IF 13.9
Aggregate (Hoboken, N.J.) Pub Date : 2025-02-19 DOI: 10.1002/agt2.70011
Rongkun Zhou, Chao Li, Zihao Wen, Chen Zhang, Yijie Shi, Hao Hou, Xiaoqing Chen, Qian Kang, Yongzhe Zhang, Hui Yan, Han Yu, Yi Zhao, Zilong Zheng, He Yan
{"title":"Inside Front Cover: Intrinsic role of alkyl side chains in disorder, aggregates, and carrier mobility of nonfullerene acceptors for organic solar cells: A multiscale theoretical study","authors":"Rongkun Zhou,&nbsp;Chao Li,&nbsp;Zihao Wen,&nbsp;Chen Zhang,&nbsp;Yijie Shi,&nbsp;Hao Hou,&nbsp;Xiaoqing Chen,&nbsp;Qian Kang,&nbsp;Yongzhe Zhang,&nbsp;Hui Yan,&nbsp;Han Yu,&nbsp;Yi Zhao,&nbsp;Zilong Zheng,&nbsp;He Yan","doi":"10.1002/agt2.70011","DOIUrl":"https://doi.org/10.1002/agt2.70011","url":null,"abstract":"<p>Although the aggregates of Y6-type acceptors with long linear side-chains enhance the molecular stacking order, the conjugated backbones are enveloped by the side-chains. This hinders the formation of continuous conductive network in organic solar cells. In contrast, the use of branched side-chains mitigates this issue, strengthening electronic coupling between the backbones and thereby improving the electron mobility in Y6-type domains (e664).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 2","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143446869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Back Cover: Au···I coinage bonds: Boosting photoluminescence efficiency and solid-state molecular motion
IF 13.9
Aggregate (Hoboken, N.J.) Pub Date : 2025-02-19 DOI: 10.1002/agt2.70009
Xueqian Zhao, Junyi Gong, Zikang Li, Herman H. Y. Sung, Ian D. Williams, Jacky W. Y. Lam, Zheng Zhao, Ben Zhong Tang, Wai-Yeung Wong, Linli Xu
{"title":"Back Cover: Au···I coinage bonds: Boosting photoluminescence efficiency and solid-state molecular motion","authors":"Xueqian Zhao,&nbsp;Junyi Gong,&nbsp;Zikang Li,&nbsp;Herman H. Y. Sung,&nbsp;Ian D. Williams,&nbsp;Jacky W. Y. Lam,&nbsp;Zheng Zhao,&nbsp;Ben Zhong Tang,&nbsp;Wai-Yeung Wong,&nbsp;Linli Xu","doi":"10.1002/agt2.70009","DOIUrl":"https://doi.org/10.1002/agt2.70009","url":null,"abstract":"<p>This paper describes an AIE-active Au(I) complex, ITCPAu, characterized by Au···I coinage bonds that enhance photoluminescence efficiency and facilitate solid-state molecular motion. The study highlights its multiswitchable behavior, nearly pure white-light emission, and versatility as a carrier for solvent molecules. These findings provide valuable insights into Au···I noncovalent interactions for smart material development (e686).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 2","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143446871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inside Front Cover: Fluorescence imaging-guided lipid droplets-localized photodynamic therapy
IF 13.9
Aggregate (Hoboken, N.J.) Pub Date : 2025-01-21 DOI: 10.1002/agt2.737
Shan Wang, Qiang Wang, Yang Lv, Zhe Liu, Kippeum Lee, Dongeun Kim, Miae Won, Jianliang Shen, Jong Seung Kim
{"title":"Inside Front Cover: Fluorescence imaging-guided lipid droplets-localized photodynamic therapy","authors":"Shan Wang,&nbsp;Qiang Wang,&nbsp;Yang Lv,&nbsp;Zhe Liu,&nbsp;Kippeum Lee,&nbsp;Dongeun Kim,&nbsp;Miae Won,&nbsp;Jianliang Shen,&nbsp;Jong Seung Kim","doi":"10.1002/agt2.737","DOIUrl":"https://doi.org/10.1002/agt2.737","url":null,"abstract":"<p>This review focuses on the lipid droplets (LDs)-localized chemical chromophores for photodynamic therapy. It highlights the design principles, performance, and biomedical applications of these photosensitizers (PSs). Especially, the cell death pathways induced by these tools are introduced. These targetable PSs guard our health by destroying the LDs of cancer cells, just as soldiers protect our cities from alien invasion by destroying the energy cores of alien airships (e665).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 1","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.737","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143117747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Front Cover: Near-room-temperature π-conjugated nematic liquid crystals in molecules with a flexible seven-membered ring structure
IF 13.9
Aggregate (Hoboken, N.J.) Pub Date : 2025-01-21 DOI: 10.1002/agt2.736
Riki Iwai, Hiroyuki Yoshida, Yuki Arakawa, Shunsuke Sasaki, Yuuto Iida, Kazunobu Igawa, Tsuneaki Sakurai, Satoshi Suzuki, Masatoshi Tokita, Junji Watanabe, Gen-ichi Konishi
{"title":"Front Cover: Near-room-temperature π-conjugated nematic liquid crystals in molecules with a flexible seven-membered ring structure","authors":"Riki Iwai,&nbsp;Hiroyuki Yoshida,&nbsp;Yuki Arakawa,&nbsp;Shunsuke Sasaki,&nbsp;Yuuto Iida,&nbsp;Kazunobu Igawa,&nbsp;Tsuneaki Sakurai,&nbsp;Satoshi Suzuki,&nbsp;Masatoshi Tokita,&nbsp;Junji Watanabe,&nbsp;Gen-ichi Konishi","doi":"10.1002/agt2.736","DOIUrl":"https://doi.org/10.1002/agt2.736","url":null,"abstract":"<p>This study provides a novel molecular design methodology that dramatically decreases the isotropization temperature of π-conjugated nematic liquid crystals (NLC). In addition, a large-area electric-field-responsive fluorescent switch device with a sub-millisecond response time is demonstrated using a luminescent NLC and a liquid crystal display cell. The era of alignment of liquid crystalline organic semiconductors as desired has begun (e660).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 1","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.736","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143117746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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