Aggregate (Hoboken, N.J.)最新文献

{"title":"Back Cover: Special RCA based sensitive point-of-care detection of HPV mRNA for cervical cancer screening","authors":"Yi Long,&nbsp;Shurui Tao,&nbsp;Dongni Shi,&nbsp;Xingyu Jiang,&nbsp;Tian Yu,&nbsp;Yingxi Long,&nbsp;Libing Song,&nbsp;Guozhen Liu","doi":"10.1002/agt2.656","DOIUrl":"https://doi.org/10.1002/agt2.656","url":null,"abstract":"<p>In the newly developed MSS-RCA technique, a circular template with minimal secondary structure was designed to achieve the higher amplification efficiency compared with conventional RCA technique. The linear structure of the MSS-RCA product provides the highest signal binding efficiency. Integration with a blood glucose meter, MSS-RCA technique was suitable for point-of-care detection of HPV mRNA for cervical cancer screening (e569).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":13.9,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.656","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142013562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Back Cover: Aggregation and aging of nanoparticle–protein complexes at interfaces studied by evanescent-light scattering microscopy","authors":"Wei Liu,&nbsp;Yuwei Zhu,&nbsp;Hang Jiang,&nbsp;Lidan Zhou,&nbsp;Yinan Li,&nbsp;Jiahao Wu,&nbsp;Jie Han,&nbsp;Cheng Yang,&nbsp;Jianzhong Jiang,&nbsp;To Ngai","doi":"10.1002/agt2.655","DOIUrl":"https://doi.org/10.1002/agt2.655","url":null,"abstract":"<p>Aggregation and aging of nanoparticle–protein complexes at interfaces are resolved via an evanescent-light scattering microscopy. Time- and space-resolved measurements by correlation functions show that aging of such soft materials is out-of-equilibrium, stretched and compressed exponential decays can coexist in one aging process. Corona formation, inner stress and inter-connection are key for the aggregation and aging dynamics (e538).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":13.9,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.655","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142013561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Front Cover: Exploring and leveraging aggregation effects on reactive oxygen species generation in photodynamic therapy","authors":"Zeyan Zhuang,&nbsp;Jianqing Li,&nbsp;Pingchuan Shen,&nbsp;Zujin Zhao,&nbsp;Ben Zhong Tang","doi":"10.1002/agt2.654","DOIUrl":"https://doi.org/10.1002/agt2.654","url":null,"abstract":"<p>This paper focuses on the aggregation effects on the reactive oxygen species generation, highlighting the significant variations among isolated and various nano-aggregated states. It provides a consolidated overview on the fundamental principles, discusses current research methodologies, and reviews present research status concerning the aggregation effects on ROS generation, aiming to drive continuous progress in aggregate-level phototheranostic platforms (e540).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":13.9,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.654","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142013630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Front Cover: Rhein-based Pickering emulsion for hepatocellular carcinoma: Shaping the metabolic signaling and immunoactivation in transarterial chemoembolization","authors":"Xiaoliu Liang,&nbsp;Hui Liu,&nbsp;Hu Chen,&nbsp;Xuqi Peng,&nbsp;Zhenjie Li,&nbsp;Minglei Teng,&nbsp;Yisheng Peng,&nbsp;Jiwei Li,&nbsp;Linyu Ding,&nbsp;Jingsong Mao,&nbsp;Chengchao Chu,&nbsp;Hongwei Cheng,&nbsp;Gang Liu","doi":"10.1002/agt2.653","DOIUrl":"https://doi.org/10.1002/agt2.653","url":null,"abstract":"<p>This study identifies metabolic reprogramming and immunosuppression as key factors in transarterial chemoembolization (TACE) refractoriness. Rhein is optimized as a glycolytic inhibitor and immunoactivator to enhance tumor response to TACE. An oil-in-water lipiodol emulsion stabilized with Rhein nanogel holds enhanced mechanical stability, ensuring effective embolization, prolonged drug release, and potent anti-tumor immunity, presenting a new approach for TACE (e552).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":13.9,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.653","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142013629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Front Cover: Supramolecular phthalocyanine assemblies-enhanced synergistic photodynamic and photothermal therapy guided by photoacoustic imaging","authors":"Yuan-Yuan Zhao,&nbsp;Xiaojun Zhang,&nbsp;Zixuan Chen,&nbsp;Yihui Xu,&nbsp;Heejeong Kim,&nbsp;Hyunsun Jeong,&nbsp;You Rim Lee,&nbsp;Jiah Lee,&nbsp;Xingshu Li,&nbsp;Juyoung Yoon","doi":"10.1002/agt2.616","DOIUrl":"https://doi.org/10.1002/agt2.616","url":null,"abstract":"<p>In this work, Yoon and co-workers developed a nanostructured supramolecular phototherapeutic agent based on Förster resonance energy transfer mechanism. Such nanostructured phototherapeutic agent can enable the visualization of a tumor with a photoacoustic signal-to-liver ratio as high as 11.9, and ultimately achieving a notable therapeutic effect in a preclinical model at a low dose through the photodynamic and photothermal synergistic therapy (e514).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.616","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141424854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Back Cover: Twins-like nanodrugs synchronously transport in blood and coalesce inside tumors for sensitive ultrasound imaging and triggerable penetrative drug delivery","authors":"Yujun Cai,&nbsp;Gengjia Chen,&nbsp;Minzhao Lin,&nbsp;Bo Li,&nbsp;Huihai Zhong,&nbsp;Tan Li,&nbsp;Zecong Xiao,&nbsp;Yong Wang,&nbsp;Xintao Shuai","doi":"10.1002/agt2.617","DOIUrl":"https://doi.org/10.1002/agt2.617","url":null,"abstract":"<p>A novel strategy for nanoparticle size enlargement is developed by constructing a pair of similar nanodrugs, referred to as “twins-like nanodrugs (TLNs)”. The TLNs synchronously transport in blood, coalesce inside tumor and achieve particle aggregation for ultrasound-triggerable penetrative drug delivery (e476).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.617","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141424855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Front Cover: Near-infrared aggregation-induced emission materials: Bibliometric analysis and their application in biomedical field","authors":"Qian He,&nbsp;Meiyiming Wang,&nbsp;Li Zhao,&nbsp;Bin Xu,&nbsp;Wenjing Tian,&nbsp;Liyun Zhang","doi":"10.1002/agt2.615","DOIUrl":"https://doi.org/10.1002/agt2.615","url":null,"abstract":"<p>Aggregation-induced emission (AIE) materials emitting near-infrared (NIR) light offer advantages like deep tissue penetration, minimal background interference, and negligible tissue damage. Consequently, NIR-AIE holds great promise in biomedical applications, including cell and living imaging, photothermal and photodynamic therapy, making it a prominent research focus (e505).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.615","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141424849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Back Cover: A core–shell-structured zeolitic imidazolate framework@cationic antimicrobial agent templated silica nanocomposite for tackling antibiotic resistant bacteria infection","authors":"Qihui Kan,&nbsp;Yaping Song,&nbsp;Yining Yao,&nbsp;Jun Zhang,&nbsp;He Xian,&nbsp;Dan Cheng,&nbsp;Yue Wang,&nbsp;Liang Mao,&nbsp;Meiyan Wang,&nbsp;Chengzhong Yu","doi":"10.1002/agt2.618","DOIUrl":"https://doi.org/10.1002/agt2.618","url":null,"abstract":"<p>An anti-drug-resistant bacteria core-shell structure is designed, containing antibacterial zeolitic imidazolate framework-8 (ZIF-8) as the core and bactericidal benzalkonium chloride (BAC) templated rough-surface mesostructured silica nanocomposite (RMSN) as the shell. The resultant ZIF-8@RMSN nanocomposite exhibits sustained release of BAC and zinc ions, leading to enhanced antibacterial and biofilm elimination properties against drug-resistant bacterial. In addition, ZIF-8@RMSN modified antibacterial band-aid possesses excellent anti-drug-resistant bacterial infection properties both in vitro and in vivo (e523).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.618","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141424856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aggregation-induced emission (AIE) luminescent materials boosting optical storage into the new era of petabit-level capacity","authors":"Siwei Zhang,&nbsp;Pengfei Zhang,&nbsp;Ben Zhong Tang","doi":"10.1002/agt2.605","DOIUrl":"https://doi.org/10.1002/agt2.605","url":null,"abstract":"<p>The recording of information stands as the most significant milestone in human civilization. Historically, the recording and storage of information have undergone a technological evolution from paintings to carvings, scribing, and digitization. The invention of optical compact discs (CDs) was one of the major landmarks in digital information technology. Over the past half-century, scientists have endeavored to enhance optical storage capacity by improving both optical systems and optical storage materials, as shown in Scheme 1. In terms of commercial products, the storage capacity has increased from 700 MB (CDs) to 27 GB (Blu-ray discs) by optimizing the optical system based on the same optical storage medium (polycarbonate). To surpass the conventional optical diffraction limit, the optical systems have evolved from traditional lasers to nonlinear two-photon absorption (TPA) and stimulated emission depletion (STED), which has minified the laser spot size from microns to approximately tens of nanometers, marking a remarkable achievement. However, luminescent materials are essential to enable TPA and STED technology to be applied in optical storage.</p><p>The traditional photopolymers or photoresists usually possess weak emission, and doped with rare earth phosphors, up-conversion nanoparticles, carbon dots, nanoclusters, and metal nanorods that can lead to enhanced fluorescence intensity, but the inorganic nanoparticles in photopolymers may induce light scattering. Traditional conjugated organic chromophores produce quenching upon solid-state aggregation. The green fluorescent protein (GFP) doped in photoresist achieved a reversibly switchable record and detected sub-diffraction site spacing of approximately 200 nm,^[<span>¹</span>^] but the stability of GFP is far from meeting the requirements of optical storage. The above methods only enhance the fluorescence intensity of photopolymer film but cannot improve the fluorescence contrast of recorded and unrecorded areas. Therefore, the fluorescence signal radiated by the super-resolution point is easily submerged in the background noise, and the information cannot be read correctly.</p><p>Writing in Nature, Zhao et al.^[<span>²</span>^] reported that a photoresist film doped with aggregation-induced emission luminogens (AIEgens) enables a volumetric nanoscale optical storage system, achieving an impressive 1.6 petabit super disk.</p><p>The concept of aggregation-induced emission (AIE) was proposed in the year of 2001.^[<span>³</span>^] AIEgens usually have rotors or isomerizable double bonds, resulting in weak or no emission in single molecular states (dilute solution) and enhanced emission in the aggregate form due to the restriction of intramolecular motion (RIM). After more than two decades of development, thousands of AIEgens have been designed and synthesized, and their emissions cover from ultravio","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.605","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141424850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Special RCA based sensitive point-of-care detection of HPV mRNA for cervical cancer screening","authors":"Yi Long,&nbsp;Shurui Tao,&nbsp;Dongni Shi,&nbsp;Xingyu Jiang,&nbsp;Tian Yu,&nbsp;Yingxi Long,&nbsp;Libing Song,&nbsp;Guozhen Liu","doi":"10.1002/agt2.569","DOIUrl":"10.1002/agt2.569","url":null,"abstract":"<p>Developing the sensitive point-of-care testing (POCT) of oncogenic nucleic acids from human papillomavirus (HPV) infection is essential in preventing cervical cancer, especially in resource-limited settings. Rolling circle amplification (RCA) is attractive in achieving POCT via nucleic acid-based aggregation under isothermal conditions. However, the influence of RCA product structure on the aggregation remains unexplored resulting in limited sensitivity. Here, a minimum secondary structured RCA technique (MSS-RCA) is developed by designing a unique circular template, demonstrating significantly enhanced detection sensitivity with only one amplification step and one primer under isothermal conditions. The amplification efficiency of MSS-RCA could be kinetically manipulated by controlling the secondary structure of the circular template. Introducing the invertase probe to MSS-RCA, <i>HPV16 E6/E7</i> nucleic acid target was detected with a personal glucose meter (PGM) with a sensitivity of 5 f<span>m</span> (50 zmol in 10 µL). This integrated MSS-RCA-PGM detection system was successfully applied to detect <i>HPV16 E6/E7</i> mRNA extracted from 54 cervical swab samples reaching a positive predictive value of 100.00% and negative predictive values of 96.00% (77.77% to 99.40%, 95% CI). MSS-RCA-PGM provides a sensitive POCT platform for the detection of nucleic acid biomarkers for screening of cervical cancer or other diseases.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":13.9,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.569","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140925633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}