Xiaofei Niu, Xinwen Ou, Shizhe Ren, Ke Wang, Fengyan Song, Xiaobin Dong, Wu-Jie Guo, Hui-Qing Peng, Zujin Zhao, Jacky W. Y. Lam, Yong Sheng Zhao, Fei Li, Shu-Yan Yu, Ben Zhong Tang
{"title":"Inside Front Cover: Circularly Polarized Luminescence Inversion in AIE-Active Crystal Enabled by Solvent-Induced Transition Dipole Moment Regulation","authors":"Xiaofei Niu, Xinwen Ou, Shizhe Ren, Ke Wang, Fengyan Song, Xiaobin Dong, Wu-Jie Guo, Hui-Qing Peng, Zujin Zhao, Jacky W. Y. Lam, Yong Sheng Zhao, Fei Li, Shu-Yan Yu, Ben Zhong Tang","doi":"10.1002/agt2.70065","DOIUrl":"https://doi.org/10.1002/agt2.70065","url":null,"abstract":"<p>This study elucidates a novel phenomenon in chiral AIEgens crystalline materials, demonstrating solvent-induced circularly polarized luminescence (CPL) sign inversion while maintaining identical helical configuration and molecular chirality in the crystalline state. The observed CPL reversal originates from non-bonding interactions between co-crystallized solvent molecules and AIEgens, which modulate the <i>θ</i><sub>μ,m</sub> (S<sub>1</sub>→S<sub>0</sub>) of electric and magnetic transition dipole moments within the unit cell. The findings establish a unique mechanism for chiroptical property manipulation through supramolecular engineering of non-covalent interactions in crystalline systems (e70003).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 5","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70065","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lihan Lai, Yun Su, Cong Hu, Zehong Peng, Wei Xue, Liang Dong, Tony Y. Hu
{"title":"Back Cover: Integrating Aggregate Materials and Machine Learning Algorithms: Advancing Detection of Pathogen-Derived Extracellular Vesicles","authors":"Lihan Lai, Yun Su, Cong Hu, Zehong Peng, Wei Xue, Liang Dong, Tony Y. Hu","doi":"10.1002/agt2.70064","DOIUrl":"https://doi.org/10.1002/agt2.70064","url":null,"abstract":"<p>This review highlights cutting-edge strategies for enhancing the detection of pathogen-derived extracellular vesicles, including novel aggregate materials and machine learning approaches. Pathogen-derived vesicles are pivotal in host-pathogen interactions and possess significant diagnostic promise, as their unique cargo offers a rich repository of potential biomarkers. Enhancing vesicle detection may ultimately pave the way for transformative clinical applications (e70018).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 5","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70064","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jun Wei, Xiangzhou Zhang, Xiaojia Wang, Yeqi Liu, Yuhai Zhang
{"title":"Inside Back Cover: New Transparent Rare-Earth-Based Hybrid Glasses: Synthesis, Luminescence, and X-Ray Imaging Application","authors":"Jun Wei, Xiangzhou Zhang, Xiaojia Wang, Yeqi Liu, Yuhai Zhang","doi":"10.1002/agt2.70066","DOIUrl":"https://doi.org/10.1002/agt2.70066","url":null,"abstract":"<p>A desolvation method below 140 °C was reported for a rapid synthesis of RE(NO<sub>3</sub>)<sub>3</sub>(C<sub>5</sub>H<sub>2</sub>N<sub>4</sub>)<sub>2</sub> hybrid glasses within an hour. The glasses containing the whole library of rare-earth ions exhibited a high transparency, which opened up a pathway to explore the elusive interactions between metals and organic linker, providing new insights for the design of rare-earth glasses (e70021).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 5","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70066","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Back Cover: Revolutionizing Bone Regeneration: Vascularized Bone Tissue Engineering with Advanced 3D Printing Technology","authors":"Jiaxuan Fan, Zichuan Ding, Yongrui Cai, Yahao Lai, Chao Huang, Boyi Jiang, Zongke Zhou, Zeyu Luo","doi":"10.1002/agt2.70038","DOIUrl":"https://doi.org/10.1002/agt2.70038","url":null,"abstract":"<p>This study describes the progress in the design and application of 3D printing technology for vascularized bone repair scaffolds. The ultimate goal is to fabricate vascularized bone repair scaffolds with structure and function similar to natural bone tissue for repairing bone defects due to various causes through the design and development of 3D printing technology, printing ink and bioactive factors (e731).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 4","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70038","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yandi Zhang, Wenjun Wang, Xiaoru Yang, Xuanmeng An, Xiaoyi Liu, Weiwei Zhao, Lina Zhu, Ting Wang, Ying Wang, Yi Chen, Junkun Feng, Jinlong Shao, Xuedong Zhou, Ben Zhong Tang, Shaohua Ge, Jianhua Li
{"title":"Inside Back Cover: Molecular Diagnosis and Therapy of Dental Caries by Oral Microbiome-Selective Aggregation-Induced Photosensitivity","authors":"Yandi Zhang, Wenjun Wang, Xiaoru Yang, Xuanmeng An, Xiaoyi Liu, Weiwei Zhao, Lina Zhu, Ting Wang, Ying Wang, Yi Chen, Junkun Feng, Jinlong Shao, Xuedong Zhou, Ben Zhong Tang, Shaohua Ge, Jianhua Li","doi":"10.1002/agt2.70035","DOIUrl":"https://doi.org/10.1002/agt2.70035","url":null,"abstract":"<p>This study introduces an aggregation-induced emission probe, MeOTpy, for instant molecular detection and photodynamic treatment of dental caries. MeOTpy exhibited bright fluorescence upon binding to cariogenic pathogens and generating reactive oxygen species under white light irradiation. This aggregation-induced photosensitivity enables rapid assessment of carious disease in human dental plaque samples and prevented dental caries on rat pups (e733).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 4","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70035","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Front Cover: Engineering “Meso-Atom” Bonding: Honeycomb-Network Transitions in Reticular Liquid Crystals","authors":"Christian Anders, Tianyi Tan, Virginia-Marie Fischer, Ruoyu Wang, Mohamed Alaasar, Rebecca Waldecker, Yu Cao, Feng Liu, Carsten Tschierske","doi":"10.1002/agt2.70037","DOIUrl":"https://doi.org/10.1002/agt2.70037","url":null,"abstract":"<p>This research article elucidates the self-assembly of a new type of polyphiles forming complex A15-like cubic network phase with hydrogen-bonded glycerols as “meso-atom”. By aromatic core fluorination, the aggregation of polyphiles is modified to engineer the bond of “meso-atoms”, resulting in the transition between networks and honeycombs, which is of great interests for reticular chemistry (e728).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 4","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhigang Shuai, Qi Sun, Jiajun Ren, Tong Jiang, Weitang Li
{"title":"Inside Front Cover: Excited State Structure and Decay Rates for Aggregates","authors":"Zhigang Shuai, Qi Sun, Jiajun Ren, Tong Jiang, Weitang Li","doi":"10.1002/agt2.70036","DOIUrl":"https://doi.org/10.1002/agt2.70036","url":null,"abstract":"<p>This work presents a novel definition of exciton coherence length, establishing a unique correlation with the radiative decay rate and resolving previous ambiguities. Three-state model and four-state model reveal how intensity borrowing enables emissive H-aggregates. A molecular descriptor is proposed for optimizing both PLQY and mobility, along with a modified energy gap law identifying an optimal J to minimize non-radiative decay loss (e70013).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 4","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70036","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of Host–Emitter Interactions on Light Amplification in Laser Dyes","authors":"Masashi Mamada, Ayano Abe, Takashi Fujihara, Tatsuya Yoshida, Kenichi Goushi, Kiyoshi Miyata, Ken Onda, Chihaya Adachi","doi":"10.1002/agt2.70030","DOIUrl":"https://doi.org/10.1002/agt2.70030","url":null,"abstract":"<p>Organic lasers hold great promise for enabling a new class of future optoelectronics. Consequently, the development of new organic semiconductors as gain media has recently been the subject of significant interest. The molecular design principle based on Einstein coefficients has been validated for achieving high gain, with <i>para</i>-phenylene-vinylene scaffolds recognized as one of the most crucial frameworks. In this study, we develop a stilbene tetramer derivative, QSBCz, which has significantly increased conjugation compared to the highly efficient laser material, BSBCz, resulting in a remarkably high radiative decay rate and a large gain cross-section. However, we find that the optical losses play a significant role in the light amplification of QSBCz. Indeed, a comprehensive understanding and suppression of detrimental optical loss pathways throughout the lasing process are essential, whereas the losses intrinsically associated with molecules have not been well considered. Although host–guest systems are helpful in preventing concentration quenching in aggregated states, this study reveals notable losses when using common host molecules such as 4,4′-bis(9<i>H</i>-carbazol-9-yl)biphenyl (CBP) and mCBP. In contrast, a BSBCz derivative is successfully employed as the host, leading to improved stimulated emission amplification. These findings indicate the importance of host–emitter interactions in lasing properties and highlight the necessity to optimize host materials for developing new laser dyes.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 5","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70030","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lihan Lai, Yun Su, Cong Hu, Zehong Peng, Wei Xue, Liang Dong, Tony Y. Hu
{"title":"Integrating Aggregate Materials and Machine Learning Algorithms: Advancing Detection of Pathogen-Derived Extracellular Vesicles","authors":"Lihan Lai, Yun Su, Cong Hu, Zehong Peng, Wei Xue, Liang Dong, Tony Y. Hu","doi":"10.1002/agt2.70018","DOIUrl":"https://doi.org/10.1002/agt2.70018","url":null,"abstract":"<p>Extracellular vesicles (EVs) are essential for host–pathogen interactions, mediating processes such as immune modulation and pathogen survival. Pathogen-derived EVs hold significant diagnostic potential because of their unique cargo, offering a wealth of potential biomarkers. In this review, we first discuss the roles of EVs derived from various pathogens in host–pathogen interactions and summarize the latest advancements in pathogen detection based on EVs. Then, we highlight innovative strategies, including novel aggregate materials and machine learning approaches, for enhancing EV detection and analysis. Finally, we discuss challenges in the field and future directions for advancing EV-based diagnostics, aiming to translate these insights into clinical applications.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 5","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}