{"title":"Back Cover: Revolutionizing Bone Regeneration: Vascularized Bone Tissue Engineering with Advanced 3D Printing Technology","authors":"Jiaxuan Fan, Zichuan Ding, Yongrui Cai, Yahao Lai, Chao Huang, Boyi Jiang, Zongke Zhou, Zeyu Luo","doi":"10.1002/agt2.70038","DOIUrl":"https://doi.org/10.1002/agt2.70038","url":null,"abstract":"<p>This study describes the progress in the design and application of 3D printing technology for vascularized bone repair scaffolds. The ultimate goal is to fabricate vascularized bone repair scaffolds with structure and function similar to natural bone tissue for repairing bone defects due to various causes through the design and development of 3D printing technology, printing ink and bioactive factors (e731).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 4","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70038","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yandi Zhang, Wenjun Wang, Xiaoru Yang, Xuanmeng An, Xiaoyi Liu, Weiwei Zhao, Lina Zhu, Ting Wang, Ying Wang, Yi Chen, Junkun Feng, Jinlong Shao, Xuedong Zhou, Ben Zhong Tang, Shaohua Ge, Jianhua Li
{"title":"Inside Back Cover: Molecular Diagnosis and Therapy of Dental Caries by Oral Microbiome-Selective Aggregation-Induced Photosensitivity","authors":"Yandi Zhang, Wenjun Wang, Xiaoru Yang, Xuanmeng An, Xiaoyi Liu, Weiwei Zhao, Lina Zhu, Ting Wang, Ying Wang, Yi Chen, Junkun Feng, Jinlong Shao, Xuedong Zhou, Ben Zhong Tang, Shaohua Ge, Jianhua Li","doi":"10.1002/agt2.70035","DOIUrl":"https://doi.org/10.1002/agt2.70035","url":null,"abstract":"<p>This study introduces an aggregation-induced emission probe, MeOTpy, for instant molecular detection and photodynamic treatment of dental caries. MeOTpy exhibited bright fluorescence upon binding to cariogenic pathogens and generating reactive oxygen species under white light irradiation. This aggregation-induced photosensitivity enables rapid assessment of carious disease in human dental plaque samples and prevented dental caries on rat pups (e733).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 4","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70035","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Front Cover: Engineering “Meso-Atom” Bonding: Honeycomb-Network Transitions in Reticular Liquid Crystals","authors":"Christian Anders, Tianyi Tan, Virginia-Marie Fischer, Ruoyu Wang, Mohamed Alaasar, Rebecca Waldecker, Yu Cao, Feng Liu, Carsten Tschierske","doi":"10.1002/agt2.70037","DOIUrl":"https://doi.org/10.1002/agt2.70037","url":null,"abstract":"<p>This research article elucidates the self-assembly of a new type of polyphiles forming complex A15-like cubic network phase with hydrogen-bonded glycerols as “meso-atom”. By aromatic core fluorination, the aggregation of polyphiles is modified to engineer the bond of “meso-atoms”, resulting in the transition between networks and honeycombs, which is of great interests for reticular chemistry (e728).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 4","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhigang Shuai, Qi Sun, Jiajun Ren, Tong Jiang, Weitang Li
{"title":"Inside Front Cover: Excited State Structure and Decay Rates for Aggregates","authors":"Zhigang Shuai, Qi Sun, Jiajun Ren, Tong Jiang, Weitang Li","doi":"10.1002/agt2.70036","DOIUrl":"https://doi.org/10.1002/agt2.70036","url":null,"abstract":"<p>This work presents a novel definition of exciton coherence length, establishing a unique correlation with the radiative decay rate and resolving previous ambiguities. Three-state model and four-state model reveal how intensity borrowing enables emissive H-aggregates. A molecular descriptor is proposed for optimizing both PLQY and mobility, along with a modified energy gap law identifying an optimal J to minimize non-radiative decay loss (e70013).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 4","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70036","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yugyeong Lee, Ji Su Hwang, Ziliang Zhai, Kyungwon Park, Ye Seul Son, Dae-Soo Kim, Seok Chung, Sejoong Kim, Mi-Young Son, Gwang Lee, Sungsu Park
{"title":"Inside Front Cover: Apical-out Tubuloids for Accurate Kidney Toxicity Studies","authors":"Yugyeong Lee, Ji Su Hwang, Ziliang Zhai, Kyungwon Park, Ye Seul Son, Dae-Soo Kim, Seok Chung, Sejoong Kim, Mi-Young Son, Gwang Lee, Sungsu Park","doi":"10.1002/agt2.70026","DOIUrl":"https://doi.org/10.1002/agt2.70026","url":null,"abstract":"<p>This article highlights the development of apical-out tubuloids that accurately mimic drug transport mechanisms. These tubuloids exhibit selective albumin internalization, heightened sensitivity to apically transported colistin, and reduced sensitivity to basally transported tenofovir. Their ability to replicate directional drug transport offers valuable insights into drug delivery and testing models (e697).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Robin Bernhardt, Lukas Rieland, Tianyi Wang, Marvin F. Schumacher, Arne Lützen, Manuela Schiek, Paul H. M. van Loosdrecht
{"title":"Inside Back Cover: Ultrafast Excitonic Transitions in Enantiopure and Racemic Squaraine Thin Films","authors":"Robin Bernhardt, Lukas Rieland, Tianyi Wang, Marvin F. Schumacher, Arne Lützen, Manuela Schiek, Paul H. M. van Loosdrecht","doi":"10.1002/agt2.70027","DOIUrl":"https://doi.org/10.1002/agt2.70027","url":null,"abstract":"<p>Enantiopure ProSQ-C16 thin films exhibit an unusually large excitonic circular dichroism signal. Using steady-state and ultrafast transient absorption spectroscopy, Bernhardt et al. reveal that the optical response and its circular dichroism originate from a single type of predominantly J-like aggregated ProSQ-C16 molecules. A rapid transition to a dark intermediate state via intermolecular charge transfer and exciton-vibration coupling is suggested to be responsible for the suppression of the fluorescence, highlighting the importance of non-Frenkel exciton dynamics (e698).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nadezhda A. Pechnikova, Kalliopi Domvri, Konstantinos Porpodis, Maria S. Istomina, Aleksandra V. Iaremenko, Alexey V. Yaremenko
{"title":"Back Cover: Carbon Quantum Dots in Biomedical Applications: Advances, Challenges, and Future Prospects","authors":"Nadezhda A. Pechnikova, Kalliopi Domvri, Konstantinos Porpodis, Maria S. Istomina, Aleksandra V. Iaremenko, Alexey V. Yaremenko","doi":"10.1002/agt2.70028","DOIUrl":"https://doi.org/10.1002/agt2.70028","url":null,"abstract":"<p>Carbon quantum dots (CQDs) illuminate a new frontier in biomedicine with their fluorescence-driven multifunctionality and biocompatibility. This review highlights CQDs as potent tools for targeting cancer cells, delivering drugs, combating pathogens, and generating reactive oxygen species for advanced therapies like photodynamic and photothermal treatment. These nanomaterials promise breakthroughs in imaging, diagnostics, and personalized medicine, overcoming biomedical challenges through innovative design (e707).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yi Qin, Niu Niu, Xue Li, Xueke Yan, Shuai Lu, Zhikai Li, Yixiong Gui, Jun-Long Zhu, Lin Xu, Xiaopeng Li, Dong Wang, Ben Zhong Tang
{"title":"Front Cover: Long-Term In Vivo Fluorescence Analyses and Imaging-Guided Tumor Surgery in the Second Near-Infrared Window Using a Supramolecular Metallacage","authors":"Yi Qin, Niu Niu, Xue Li, Xueke Yan, Shuai Lu, Zhikai Li, Yixiong Gui, Jun-Long Zhu, Lin Xu, Xiaopeng Li, Dong Wang, Ben Zhong Tang","doi":"10.1002/agt2.70025","DOIUrl":"https://doi.org/10.1002/agt2.70025","url":null,"abstract":"<p>A discrete prism-like Pt(II) metallacage with NIR-II emission was constructed via coordination-driven self-assembly, and the brilliant fluorescence of the metallacage-loaded nanoparticles in the NIR-II window enables them well perform on the long-term fluorescence analysis in vivo, which revealed the gradual transfer of nanoparticles into bones from blood and the retention of nanoparticles in the bones for even 35 days (e708).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70025","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dual-Targeted Protein MRI Contrast Agent for Early Detection of Micrometastases","authors":"Ruofan Hu, Zhiyang Wang, Tinghui Shen, Qianwen Yang, Weizhi Chen, Xiqun Jiang","doi":"10.1002/agt2.732","DOIUrl":"https://doi.org/10.1002/agt2.732","url":null,"abstract":"<p>Tumor metastasis accounts for the major portion of cancer-related deaths. Magnetic resonance imaging (MRI) is a valuable imaging modality for tumor diagnosis in clinical applications, offering detailed soft tissue images with excellent spatial resolution and good biosafety. However, the low sensitivity and the lack of specificity to disease sites limit the application of MRI contrast agents in early and precise detection of small primary and metastatic cancers. Therefore, there is an urgent need for innovative MRI contrast agents with enhanced relaxivity, target ability, and pharmacokinetics to improve imaging sensitivity and widen the detection window in the meantime. Here, we reported a dual-targeting protein MRI contrast agent (EPR-DTPA-Gd) fused by a nanobody against epidermal growth factor receptor 1 (EGFR), integrin α<sub>v</sub>β<sub>3</sub>-binding cyclic nonapeptide, and elastin-like polypeptide. We found that this protein contrast agent exhibited high sensitivity and specificity for the tumor overexpressed EGFR and integrin α<sub>v</sub>β<sub>3</sub> in MRI. Furthermore, EPR-DTPA-Gd had high longitudinal relaxation rate (<i>r</i><sub>1</sub>) (68.76 mM<sup>−1</sup> s<sup>−1</sup> per molecule) and an improved pharmacokinetics behavior for tumor imaging. Using T1-weighted imaging, EPR-DTPA-Gd successfully detected a series of early metastases with the smallest 0.012 mm<sup>2</sup> (213 µm × 58 µm) in a liver metastasis model of human cervical carcinoma HeLa cells, which cannot be detected by the clinically approved T1-weighted contrast agent. The heightened detection sensitivity intrinsic to EPR-DTPA-Gd facilitates precise imaging of tumor lesions, supporting sophisticated image-guided interventions and early management in high-risk patient cohorts.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 4","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.732","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lubna Amer, Maurice Retout, Zhicheng Jin, Sumathi Kakanar, Jesse V. Jokerst
{"title":"Inside Back Cover: Mechanism of hierarchical plasmonic biomaterials engineered through peptide-directed self-assembly","authors":"Lubna Amer, Maurice Retout, Zhicheng Jin, Sumathi Kakanar, Jesse V. Jokerst","doi":"10.1002/agt2.70012","DOIUrl":"https://doi.org/10.1002/agt2.70012","url":null,"abstract":"<p>The intricate dendritic structures highlight the controlled coalescence of silver nanoparticles into micron-sized aggregates. This process is a consequence of diffusion-limited aggregation driven by non-covalent interactions between peptides and the particle surface. This study explores how different amino acids guide coalescence, thus tuning the material properties. The resulting dynamic, tunable fractal patterns underscore their potential for applications in biosensing (e677).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 2","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143446870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}