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Inside Back Cover: Revealing enhanced dilution effect of conjugated polymers in partially miscible blends
IF 13.9
Aggregate (Hoboken, N.J.) Pub Date : 2025-01-21 DOI: 10.1002/agt2.738
Hongbo Chen, Ming Hu, Yuehua Zhao, Kaixuan Lyu, Yushuai Xu, Yuansheng Sun, Zhiyuan Xie, Jinying Huang, Dapeng Wang
{"title":"Inside Back Cover: Revealing enhanced dilution effect of conjugated polymers in partially miscible blends","authors":"Hongbo Chen,&nbsp;Ming Hu,&nbsp;Yuehua Zhao,&nbsp;Kaixuan Lyu,&nbsp;Yushuai Xu,&nbsp;Yuansheng Sun,&nbsp;Zhiyuan Xie,&nbsp;Jinying Huang,&nbsp;Dapeng Wang","doi":"10.1002/agt2.738","DOIUrl":"https://doi.org/10.1002/agt2.738","url":null,"abstract":"<p>A counterintuitive optimized dilution effect is unveiled for conjugated polymers in blends. In partially miscible blends, these polymers are more dilute in the majority phase; however, in fully miscible blends, the high miscibility fosters extended chain conformations that undermine dilution. These revelations will inform the design of future generations of polymer light-emitting diodes (e649).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 1","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.738","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143117885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Back Cover: Droplets Cas13a-RPA measurement delineates potential role for plasma circWDR37 in colorectal cancer
IF 13.9
Aggregate (Hoboken, N.J.) Pub Date : 2025-01-21 DOI: 10.1002/agt2.739
Jingsong Xu, Li Cao, Shuang Yang, Ying Jian, Yu Liu, Zhen Shen, Qian Liu, Xiang Chen, Min Li, Shun Li, Xiaolei Zuo, Min Li, Hua Wang
{"title":"Back Cover: Droplets Cas13a-RPA measurement delineates potential role for plasma circWDR37 in colorectal cancer","authors":"Jingsong Xu,&nbsp;Li Cao,&nbsp;Shuang Yang,&nbsp;Ying Jian,&nbsp;Yu Liu,&nbsp;Zhen Shen,&nbsp;Qian Liu,&nbsp;Xiang Chen,&nbsp;Min Li,&nbsp;Shun Li,&nbsp;Xiaolei Zuo,&nbsp;Min Li,&nbsp;Hua Wang","doi":"10.1002/agt2.739","DOIUrl":"https://doi.org/10.1002/agt2.739","url":null,"abstract":"<p>This study identified circWDR37 as a promising biomarker for the early diagnosis and prognostic prediction of colorectal cancer (CRC). A detection platform, termed μDCR, was developed utilizing polyethylene glycol 8000 and dextran-10 to enhance fluorescence and improve detection sensitivity. It is anticipated that μDCR will serve as an optimal method for noninvasive CRC screening (e663).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 1","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.739","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143117356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metal-Organic Frameworks: A Potential Platform From Enzyme Immobilization to Mimetic Enzyme
IF 13.9
Aggregate (Hoboken, N.J.) Pub Date : 2024-12-26 DOI: 10.1002/agt2.724
Geling Kuang, Zichen Wang, Muhammad Bilal, Ziyuan Wang, Yuxiao Feng, Yingjie Du, Jiandong Cui
{"title":"Metal-Organic Frameworks: A Potential Platform From Enzyme Immobilization to Mimetic Enzyme","authors":"Geling Kuang,&nbsp;Zichen Wang,&nbsp;Muhammad Bilal,&nbsp;Ziyuan Wang,&nbsp;Yuxiao Feng,&nbsp;Yingjie Du,&nbsp;Jiandong Cui","doi":"10.1002/agt2.724","DOIUrl":"https://doi.org/10.1002/agt2.724","url":null,"abstract":"<p>Metal-organic frameworks (MOFs) are a new class of organic-inorganic hybrid materials that have been widely studied in the past two decades for their potential in catalysis. (1) In this review, we comprehensively summarize the synthesis, application, and potential advancements of MOFs in enzyme immobilization and mimetic enzymes. (2) We also discuss the design principles behind various MOF-based biocatalysts, such as enzyme@MOF composites, and explore their utility in various reactions. (3) Additionally, we highlight the advantages of MOF materials as enzyme mimetics and provide a perspective on potential solutions to current challenges in MOF catalysis. (4) Ultimately, this review provides a general overview of the most recent advances in MOF-based catalyst platforms, including enzyme@MOF biocatalysts and MOF-based nanozymes, in various applications.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.724","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Vanillin-Derived Inhibitor of Aggregates via Targeting Intrinsically Disordered Regions of Phytoviral Nucleocapsid Protein
IF 13.9
Aggregate (Hoboken, N.J.) Pub Date : 2024-12-22 DOI: 10.1002/agt2.725
Yanju Wang, Yuqin Luo, Xin Li, Feifei Chen, Xingjie Zhang, Lu Yu, Runjiang Song, Baoan Song
{"title":"A Vanillin-Derived Inhibitor of Aggregates via Targeting Intrinsically Disordered Regions of Phytoviral Nucleocapsid Protein","authors":"Yanju Wang,&nbsp;Yuqin Luo,&nbsp;Xin Li,&nbsp;Feifei Chen,&nbsp;Xingjie Zhang,&nbsp;Lu Yu,&nbsp;Runjiang Song,&nbsp;Baoan Song","doi":"10.1002/agt2.725","DOIUrl":"https://doi.org/10.1002/agt2.725","url":null,"abstract":"<p>Phase separation (PS) plays a fundamental role in organizing aggregates during the viral lifecycle, providing significant opportunities for in viral disease treatment by inhibiting PS. Intrinsically disordered regions (IDRs) have been extensively studied and found to be critical for PS. However, the discovery of small molecules that target residues within IDRs remains underexplored, particularly in the field of pesticides. Herein, we report a novel phytovirucide compound <b>29</b>, which was screened from a series of vanillin derivatives designed with sulfonylpiperazine motifs. The inactivation efficacy of compound <b>29</b> against <i>tomato spotted wilt virus</i> (TSWV) was significantly superior to that of the control agents <b>vanisulfane</b> and <b>ribavirin</b>. Mechanistically, compound <b>29</b> binds to the TSWV nucleocapsid protein (NP) at residues Lys68 (K68), Thr92 (T92), and Arg94 (R94), with T92 and R94 located in the IDRs of NP. Mutations at these sites impair the ability to form aggregates. Furthermore, a host factor, GTP (Guanosine Triphosphate)-binding nuclear protein Ran-like (Niben101scf08341g01001, NbRANL), which interacts with NP and promotes its aggregation, was identified. Compound <b>29</b> also suppresses the expression of <i>NbRANL</i>, resulting in the dual inhibition of ribonucleoprotein complexes (RNPs) formation. This unique mechanism of action provides insights into IDRs-based virucide discovery.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.725","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-Performance Broad-Spectrum Photodetector by Suppressing Stray Electrons by Adopting a Hybrid CQD/Organic Architecture
IF 13.9
Aggregate (Hoboken, N.J.) Pub Date : 2024-12-19 DOI: 10.1002/agt2.722
Jiawei Qiao, Qian Wang, Jingjing Wang, Junwei Liu, Wenqing Zhang, Xunfan Liao, Long Ye, Hang Yin, Xiaotao Hao
{"title":"High-Performance Broad-Spectrum Photodetector by Suppressing Stray Electrons by Adopting a Hybrid CQD/Organic Architecture","authors":"Jiawei Qiao,&nbsp;Qian Wang,&nbsp;Jingjing Wang,&nbsp;Junwei Liu,&nbsp;Wenqing Zhang,&nbsp;Xunfan Liao,&nbsp;Long Ye,&nbsp;Hang Yin,&nbsp;Xiaotao Hao","doi":"10.1002/agt2.722","DOIUrl":"https://doi.org/10.1002/agt2.722","url":null,"abstract":"<p>Broad-spectrum photodetectors (PDs) are essential for various health monitoring, night vision, and telecommunications applications, but their detectivity in a wide absorbance region is limited by undesirable electronic response properties. Colloidal quantum dots (CQDs) are a promising system for broad-spectrum detection, whereas their practical potential is hindered by suboptimal dark current characteristics. To overcome these challenges, we propose a layered architecture comprising CQDs and a bulk heterojunction (BHJ) organic film as a hole transport layer. The integration of PbS CQDs offers multiple benefits, including bandgap tuning for minimizing thermal carriers, surface passivation to reduce recombination rates, and the formation of high-quality interfaces with organic layers, which collectively contribute to suppressing dark current leakage and thermal excitations by suppressing stray electrons. By integrating ITIC into the BHJ film, the device detectability is significantly enhanced, reaching 10<sup>13</sup> Jones in the 400–1000 nm spectral range. This improvement is attributed to the higher lowest unoccupied molecular orbital (LUMO) of ITIC molecules, which effectively hinders electron injection. Additionally, J-aggregation-induced molecular stacking and optimized phase separation of BHJ films contribute to the enhanced performance. The integration of diverse materials offers greater flexibility in device design and functionality, enabling the development of more advanced and sophisticated optoelectronic devices. Furthermore, this approach could significantly enhance the theoretical and practical understanding of optoelectronic device engineering, leading to the development of more advanced optoelectronic devices.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.722","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143688680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fluorescent Nanoparticles Achieve Efficient Photothermal Conversion and Enhanced Antitumor Efficacy Through Intermolecular Aggregation-Caused Quenching
IF 13.9
Aggregate (Hoboken, N.J.) Pub Date : 2024-12-19 DOI: 10.1002/agt2.723
Jundong Lin, Xiaoxia Cai, Fen Zou, Wenjie Xie, Zhihao Zou, Muqi Chen, Yixun Zhang, Huichan He, Qianfeng Xu, Guowei Zhong, Shanghua Cai, Zhenjie Wu, Jianming Lu, Jianheng Ye, Yingke Liang, Yaqiang Huang, Yangjia Zhuo, Huikang Yang, Weide Zhong
{"title":"Fluorescent Nanoparticles Achieve Efficient Photothermal Conversion and Enhanced Antitumor Efficacy Through Intermolecular Aggregation-Caused Quenching","authors":"Jundong Lin,&nbsp;Xiaoxia Cai,&nbsp;Fen Zou,&nbsp;Wenjie Xie,&nbsp;Zhihao Zou,&nbsp;Muqi Chen,&nbsp;Yixun Zhang,&nbsp;Huichan He,&nbsp;Qianfeng Xu,&nbsp;Guowei Zhong,&nbsp;Shanghua Cai,&nbsp;Zhenjie Wu,&nbsp;Jianming Lu,&nbsp;Jianheng Ye,&nbsp;Yingke Liang,&nbsp;Yaqiang Huang,&nbsp;Yangjia Zhuo,&nbsp;Huikang Yang,&nbsp;Weide Zhong","doi":"10.1002/agt2.723","DOIUrl":"https://doi.org/10.1002/agt2.723","url":null,"abstract":"<p>The efficacy of photothermal therapy (PTT) in antitumor applications is often limited by inadequate tumor targeting and low photothermal conversion efficiency (PCE) of photosensitizers. In this study, we designed a photothermal nanoparticle, MPF@IR780, to enhance photosensitizers' targeting and PCE. First, MPF@IR780 improves the delivery of photosensitizers to tumor tissue through the enhanced permeability and retention (EPR) effect. Furthermore, hydrophobic ferrocene was incorporated into the nanoparticle core to increase structural compactness, leading to a strong aggregation-caused quenching (ACQ) effect and an improved PCE of the photosensitizer under near-infrared (NIR) irradiation. Mechanistically, MPF@IR780 induces PANoptosis and ferroptosis in cancer cells through thermal damage and oxidative stress, providing an efficient approach for oncotherapy. This strategy of amplifying the effects of PTT by enhancing the ACQ of photosensitizers offers a promising method for advancing the next generation of PTT.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.723","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143688946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inside Front Cover: Complexity made easy: Aggregation-induced emission small molecules for cancer diagnosis and phototherapies 内封面：复杂变得简单：聚集诱导发射小分子用于癌症诊断和光疗
IF 13.9
Aggregate (Hoboken, N.J.) Pub Date : 2024-12-15 DOI: 10.1002/agt2.717
Luojia Chen, Si-Ling Chen, Yuncong Yuan, Xiang Leng, Xiaoyu Xu, Jingyuan Chen, Jiayi Shi, Kun Qian, Yuanlong Xie, Qihang Ding, Zhen Cheng, Meijia Gu
{"title":"Inside Front Cover: Complexity made easy: Aggregation-induced emission small molecules for cancer diagnosis and phototherapies","authors":"Luojia Chen,&nbsp;Si-Ling Chen,&nbsp;Yuncong Yuan,&nbsp;Xiang Leng,&nbsp;Xiaoyu Xu,&nbsp;Jingyuan Chen,&nbsp;Jiayi Shi,&nbsp;Kun Qian,&nbsp;Yuanlong Xie,&nbsp;Qihang Ding,&nbsp;Zhen Cheng,&nbsp;Meijia Gu","doi":"10.1002/agt2.717","DOIUrl":"https://doi.org/10.1002/agt2.717","url":null,"abstract":"<p>The rising popularity of photosensitizers has greatly transformed traditional cancer diagnosis and phototherapeutic strategies. This review highlights the latest advances in small molecule photosensitizers with aggregation-induced emission (AIE) for cancer theranostics, following the principle of “Complexity made easy.” This study emphasizes on simplicity, expeditiousness, and safety, as it aims to advance cancer research (e657).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"5 6","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.717","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142861097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Front Cover: Reconfigurable liquids enabled by dynamic covalent chemistry 封面：通过动态共价化学实现可重构液体
IF 13.9
Aggregate (Hoboken, N.J.) Pub Date : 2024-12-15 DOI: 10.1002/agt2.716
Kaijuan Li, Yuzheng Luo, Yunhui Wen, Wenrui Shan, Shaowei Shi
{"title":"Front Cover: Reconfigurable liquids enabled by dynamic covalent chemistry","authors":"Kaijuan Li,&nbsp;Yuzheng Luo,&nbsp;Yunhui Wen,&nbsp;Wenrui Shan,&nbsp;Shaowei Shi","doi":"10.1002/agt2.716","DOIUrl":"https://doi.org/10.1002/agt2.716","url":null,"abstract":"<p>The formation, assembly and jamming of nanoparticle surfactants (NPS) by the co-assembly between polydopamine nanoparticles and poly(styrene-<i>co</i>-methacrylamidophenylboronic acid) at the oil-water interface is presented. Taking advantage of the photothermal property of PDA NPs, the thermal responsiveness of NPSs can be triggered upon near-infrared irradiation, allowing the welding of droplets and offering a straightforward to construct modular droplet devices (e621).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"5 6","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.716","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142861098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Back Cover: Microtubule polymerization induced by iridium-fullerene photosensitizers for cancer immunotherapy via dual-reactive oxygen species regulation strategy 封底：铱-富勒烯光敏剂通过双重活性氧调节策略诱导微管聚合用于癌症免疫疗法
IF 13.9
Aggregate (Hoboken, N.J.) Pub Date : 2024-12-15 DOI: 10.1002/agt2.719
Xiao-Xiao Chen, Kun Peng, Xi Chen, Zheng-Yin Pan, Qing-Hua Shen, Yu-Yi Ling, Jian-Zhang Zhao, Cai-Ping Tan
{"title":"Back Cover: Microtubule polymerization induced by iridium-fullerene photosensitizers for cancer immunotherapy via dual-reactive oxygen species regulation strategy","authors":"Xiao-Xiao Chen,&nbsp;Kun Peng,&nbsp;Xi Chen,&nbsp;Zheng-Yin Pan,&nbsp;Qing-Hua Shen,&nbsp;Yu-Yi Ling,&nbsp;Jian-Zhang Zhao,&nbsp;Cai-Ping Tan","doi":"10.1002/agt2.719","DOIUrl":"https://doi.org/10.1002/agt2.719","url":null,"abstract":"<p>The constructive chemical combination of iridium(III) complexes and C<sub>60</sub> moiety endows <b>Ir-C<sub>60</sub>1</b> with dual reactive oxygen species (ROS) regulation abilities and promising antitumor photo-immunotherapeutic activities. In the dark, <b>Ir-C<sub>60</sub>1</b> serves as ROS scavengers to reverse dysfunctional T cells. Upon photo irradiation, <b>Ir-C<sub>60</sub>1</b> can produce various ROS and oxidize tubulin to exert efficient photo-immunotherapeutic effects through multiple antitumor pathways (e623).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"5 6","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.719","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142861100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inside Back Cover: The careful selection of zwitterionic nanoparticle coating results in rapid and efficient cell labeling for imaging-based cell tracking 封底内页：精心选择滋养型纳米粒子涂层，实现快速高效的细胞标记，进行基于成像的细胞追踪
IF 13.9
Aggregate (Hoboken, N.J.) Pub Date : 2024-12-15 DOI: 10.1002/agt2.718
Nicholas D. Calvert, Luciana Yu, Olivia C. Sehl, Julia J. Gevaert, Natasha N. Knier, Angelie Rivera-Rodriguez, Clara S. Goulet, Nitara Fernando, Samantha Flood, Carlos M. Rinaldi-Ramos, Paula J. Foster, Adam J. Shuhendler
{"title":"Inside Back Cover: The careful selection of zwitterionic nanoparticle coating results in rapid and efficient cell labeling for imaging-based cell tracking","authors":"Nicholas D. Calvert,&nbsp;Luciana Yu,&nbsp;Olivia C. Sehl,&nbsp;Julia J. Gevaert,&nbsp;Natasha N. Knier,&nbsp;Angelie Rivera-Rodriguez,&nbsp;Clara S. Goulet,&nbsp;Nitara Fernando,&nbsp;Samantha Flood,&nbsp;Carlos M. Rinaldi-Ramos,&nbsp;Paula J. Foster,&nbsp;Adam J. Shuhendler","doi":"10.1002/agt2.718","DOIUrl":"https://doi.org/10.1002/agt2.718","url":null,"abstract":"<p>In the current work, superparamagnetic iron oxide nanoparticles coated with zwitterionic ligands improved cell loading and retention for Magnetic Particle Imaging. The best-performing surface coating enabled high cell uptake with short incubation times and stable in vivo imaging over 7 days. These advancements improve the sensitivity and duration of cell tracking by enhancing nanoparticle loading into a variety of cell types (e609).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"5 6","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.718","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142861099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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