Aggregate (Hoboken, N.J.)最新文献

{"title":"Regulating the Interaction Between Near-Infrared Dye and Endogenous Albumin for Concurrent Imaging Skin Inflammation and Neovascularization After Flap Transplantation","authors":"Yijing Du,&nbsp;Xue Zheng,&nbsp;Yanli Gao,&nbsp;Zetao Dang,&nbsp;Yuewei Zhang,&nbsp;Shoujun Zhu","doi":"10.1002/agt2.70114","DOIUrl":"https://doi.org/10.1002/agt2.70114","url":null,"abstract":"<p>Concurrent imaging of skin inflammation and neovascularization is crucial for diagnosing and monitoring skin conditions, especially in flap transplantation. However, current imaging modalities in the clinic are often non-intuitive, have low resolution, or lack the ability to specifically target skin inflammation. Given that albumin can serve as a biomarker for the disruption of skin-vessel barrier (SVB), probes targeting skin inflammation typically need to specifically bind to endogenous albumin, which often results in high background signals. In this study, we screen a series of near-infrared (NIR) dyes for their in vivo covalent binding capabilities with endogenous albumin, and identify the optimal dye for achieving high-contrast imaging of skin inflammation in models of SVB disruption, with minimal interference from other tissues or organs (e.g., skin and muscle). Moreover, by utilizing an albumin-targeting dye with another albumin-escaping NIR-II dye with a non-overlapping emission wavelength, this work explores the concurrent imaging of skin inflammation and neovascularization after flap transplantation, affording to simultaneously assess skin inflammation and the restoration of blood supply.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 9","pages":""},"PeriodicalIF":13.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70114","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface Tailoring on Atomically Precise Gold Nanocluster for Aggregation-Induced Emission and Bioimaging Application","authors":"Yongbo Song,&nbsp;Yu Chen,&nbsp;Tingting Xu,&nbsp;Haipeng Fang,&nbsp;Xiaxi Lei,&nbsp;Jie Kong,&nbsp;Fangyu Fu,&nbsp;Meng Zhou,&nbsp;Wen Wu Xu","doi":"10.1002/agt2.70113","DOIUrl":"https://doi.org/10.1002/agt2.70113","url":null,"abstract":"<p>Aggregation-induced emission (AIE) is not only considered a key strategy for effectively enhancing the luminescence of atomically precise metal nanoclusters (MNCs) but can also broaden their applications. However, the synthesis of MNCs with AIE performance still poses significant challenges. Herein, a strategy of specific-site “surgery” was employed to tailor surface motifs of Au₂₄(SR)₂₀ NC by a two-step ligand-exchange method, in which the outmost two Au₄S₅ motifs were tailored into two S─Au─P and two P atoms, resulting in an [Au₁₈(TBBT)₁₂(TFPP)₄]²⁺ NC (where TBBT is 4-tert-butylphenthiophenol, TFPP is tri-(4-fluorophenyl) phosphine) with the Au₈@(Au₄S₅)₂(SAuP)₂P₂ construction. This precise surgery endows this <b>Au₁₈</b> NC with dual emission (645 and 810 nm) in the aggregated state but no emission in the soluble solution at room temperature. Furthermore, the AIE photophysical behavior was systematically studied through a combination of experimental and theoretical investigations. The results reveal that the high-energy emission band (645 nm) primarily originates from the restricted intramolecular rotation and vibration of surface ligands and motifs. In contrast, the low-energy emission at 810 nm is predominantly attributed to intermolecular interactions in the aggregated state. Benefiting from its distinct AIE characteristics, the <b>Au₁₈</b> NC shows excellent potential as a high-performance fluorescent probe for lysosome-targeted bioimaging. This work presents a novel approach for constructing AIE-active MNCs, paving the way for their future biological applications.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 9","pages":""},"PeriodicalIF":13.7,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70113","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Aggregates of Wheat Starch–Protein Systems: Structural Disruption and Engineered Digestibility via Non-Covalent Synergy","authors":"Cuihong Dai,&nbsp;Dongling Qiao,&nbsp;Bowen Li,&nbsp;Fengwei Xie,&nbsp;Binjia Zhang","doi":"10.1002/agt2.70115","DOIUrl":"https://doi.org/10.1002/agt2.70115","url":null,"abstract":"<p>Designing starch-based foods with controlled digestibility is critical for addressing global health challenges like diabetes, yet the molecular mechanisms underlying starch–protein interactions remain poorly quantified. Here, we investigate how wheat starch (WS) interacts with distinct protein fractions—wheat globulin (Glo), gliadin (Gli), and glutelin (Glu)—to form molecular aggregates that modulate digestion. By integrating experimental analyses (FTIR, XRD, rheology) with molecular dynamics (MD) simulations, we demonstrate that Gli and Glu exhibit stronger non-covalent binding to starch than Glo, driven by hydrophobic forces and hydrogen bonding. These interactions disrupt starch chain entanglement, reduce short- and long-range structural order, and inhibit α-amylase activity. At a 50:9 starch-to-protein ratio, Gli and Glu increased resistant starch content by 6.74% and 6.91%, respectively, outperforming Glo (2.96%). MD simulations quantified binding free energies (−107.67 kcal/mol for Gli, −99.50 kcal/mol for Glu), revealing electrostatic contributions from Glu's lysine/arginine residues and hydrophobic interactions in Gli. Notably, Glo and Glu synergistically inhibit amylase via mixed competitive/non-competitive mechanisms. This work establishes a predictive framework for starch–protein aggregate design, bridging molecular interactions to functional outcomes. By elucidating how protein composition dictates digestibility, we advance strategies for engineering low-glycemic-index foods, offering transformative potential for nutrition and food science.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 9","pages":""},"PeriodicalIF":13.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70115","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supramolecular Probe for Monitoring Lysosomal Ferritinophagy to Facilitate the Early Diagnosis of Parkinson's Disease","authors":"Shiqin Zhou,&nbsp;Bo Xiao,&nbsp;Jiamin Chen,&nbsp;Jinming Zhu,&nbsp;Xia Ran,&nbsp;Zuoji Liu,&nbsp;Chaozhong Li,&nbsp;Li Wang,&nbsp;Xinai Cui,&nbsp;Rong Li,&nbsp;Guangwei Feng,&nbsp;Jian Feng","doi":"10.1002/agt2.70120","DOIUrl":"https://doi.org/10.1002/agt2.70120","url":null,"abstract":"<p>Lysosomal iron overload, resulting from dysregulated ferritinophagy, is a significant early event in the progression of Parkinson's disease (PD). This condition causes iron accumulation within cells, triggering oxidative stress and ferroptosis, along with mitochondrial dysfunction and α-synuclein (α-syn) aggregation, ultimately damaging dopaminergic neurons irreversibly. However, tools for real-time monitoring of Fe³⁺ dynamics in vivo are limited. In this study, we introduce TPE-4B/4Q[7], a supramolecular fluorescent probe designed for selective and stable tracking of Fe³⁺ changes within lysosomes. This probe exhibits excellent photostability, low cytotoxicity, and a detection limit of 1.23 × 10⁻⁶ M. In cellular models of PD, TPE-4B/4Q[7] effectively monitors lysosomal ferritinophagy-induced Fe³⁺ overload, allowing for the assessment of oxidative stress, mitochondrial function, and the levels of key biomarkers such as α-syn and tyrosine hydroxylase. Additionally, this probe can track iron accumulation linked to neurodegenerative lesions in <i>Caenorhabditis elegans</i> and MPTP-induced PD mouse models, with signal changes correlating closely with neurodegenerative phenotypes and molecular pathology. Notably, TPE-4B/4Q[7] enables non-invasive brain imaging via nasal delivery. TPE-4B/4Q[7] is a sensitive molecular indicator for early risk assessment and monitoring of PD progression. It is anticipated to be an effective instrument for the early diagnosis of PD.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 9","pages":""},"PeriodicalIF":13.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70120","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-Situ Functional Crosslinking Enables Facile Construction of Rigid Poly(Ethylene Oxide) Network for High Performance All-Solid-State Batteries","authors":"Liang Shan,&nbsp;Bitian Chen,&nbsp;Yunhan Hu,&nbsp;Xiangqin Gan,&nbsp;Han Si,&nbsp;Yongqi Wang,&nbsp;Zhaojun Chen,&nbsp;Yiyong Zhang,&nbsp;Yinbo Zhou,&nbsp;Liming Ding,&nbsp;Junqiao Ding","doi":"10.1002/agt2.70117","DOIUrl":"https://doi.org/10.1002/agt2.70117","url":null,"abstract":"<p>Poly(ethylene oxide) (PEO) based electrolytes have garnered considerable attention in all-solid-state lithium metal batteries with superior safety and energy density, but suffer from low-ion conductivity and poor cycling stability. Herein, a novel in-situ functional crosslinking strategy is proposed to overcome these limitations simultaneously, where a two-in-one bis-diazirine molecule (C1) is not only used as a rigid cross-linker, but also functions as an electron-withdrawing inducer. Benefitting from such an integration of two functionalities into one cross-linker, a rigid PEO electrolyte network can be facilely constructed, while exhibiting disrupted crystallization, robust mechanical strength, loosened Li─O binding to boost the Li⁺ transport, and anion-rich Li⁺ coordinated structure to favor the generation of a stable LiF-rich solid electrolyte interface. As a result, a remarkable ion conductivity of 1.4 × 10⁻³ S cm⁻¹ is achieved at 60°C together with a Li⁺ transference number of 0.63. And the corresponding LiFePO₄||Li and NCM811||Li filled batteries present significantly improved rate performance and capacity retention cycling life compared with the pristine PEO electrolyte, highlighting the great potential of in-situ functional crosslinking for high performance all-solid-state batteries.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 9","pages":""},"PeriodicalIF":13.7,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70117","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ostwald Ripening as a Tool for Controlling Dynamic Nanomaterials","authors":"Stephen D. P. Fielden","doi":"10.1002/agt2.70116","DOIUrl":"https://doi.org/10.1002/agt2.70116","url":null,"abstract":"<p>This editorial highlights the potential of controlling Ostwald ripening, the net diffusion of material from smaller to larger particles. Ostwald ripening can occur in any dispersed system and therefore has the potential to be a powerful tool for both creating new nanomaterials and introducing mechanisms of time dependent behavior.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 9","pages":""},"PeriodicalIF":13.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70116","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interfacial Modification of High-Voltage LiCoO2 Materials via Ti/Mg Doping Strategy for Inhibiting Harmful Phase Transition Effect","authors":"Peng Shi,&nbsp;Tao Zhou,&nbsp;Teng Wang,&nbsp;Xuan Du,&nbsp;Jingfeng Wang,&nbsp;Yinwei Liu,&nbsp;Guo Gao","doi":"10.1002/agt2.70105","DOIUrl":"https://doi.org/10.1002/agt2.70105","url":null,"abstract":"<p>Developing high voltage lithium cobalt oxide (LiCoO₂, LCO) is crucial for attaining the enhanced capacity and energy density of lithium-ion batteries. However, severe interface and structural instability lead to rapid degradation of LCO under the condition of high voltage. Herein, a successful strategy for modifying the interface of LCO is developed using a one-step high temperature process. By coating LCO with Li₃TiMg(PO₄)₃ (LTMP), the obtained phosphate can stabilize the surface crystal structure and boost the mechanical stability of LCO. The high temperature process enables the successful doping of Ti/Mg into the LCO lattice, effectively inhibiting the harmful phase transition effect across various voltage ranges. Compared to commercial LCO and the reported studies, the modified LCO@LTMP performs outstanding electrochemical performance. It delivers an initial discharge specific capacity of 216.4 mAh·g⁻¹ at 0.1 C and 189.98 mAh·g⁻¹ at 1 C. After 250 cycles at 1 C, it preserves 87.46% of its initial capacity, manifesting excellent cycling stability. Moreover, it provides a discharge specific capacity of 115.9 mAh·g⁻¹ at 5 C, demonstrating outstanding rate performance. This work holds great potential for practical applications and offers valuable guidance for developing other high performance cathode materials in rechargeable batteries.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 9","pages":""},"PeriodicalIF":13.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NIR-II AIEgens for High-Contrast Intravital Fluorescence Angiography: Recent Advances and Prospects","authors":"Zhijun Zhang,&nbsp;Xue Li,&nbsp;Hao Yang,&nbsp;Caifa You,&nbsp;Kui Ren,&nbsp;Zengming Yang,&nbsp;Miaomiao Kang,&nbsp;Dong Wang,&nbsp;Ben Zhong Tang","doi":"10.1002/agt2.70102","DOIUrl":"https://doi.org/10.1002/agt2.70102","url":null,"abstract":"<p>The vasculature, as the essential biological network for oxygen and nutrients delivery and the dynamic regulatory center for physiological processes, is fundamentally important for maintaining human health and life quality. Accurate visualization of vascular structures, as well as real-time monitoring of hemodynamic parameters and molecular profiles associated with vascular function, are therefore crucial for early diagnosis and preventive interventions of vascular diseases. Fluorescence imaging technology, particularly in the second near-infrared window (NIR-II; 1000–1700 nm), offers distinct advantages for these demanding imaging requirements not only due to its high sensitivity, excellent spatial resolution, and real-time monitoring capability but also thanks to the superior signal-to-background ratio and large tissue penetration depth of NIR-II fluorescence. Among diverse NIR-II fluorescent probes, aggregation-induced emission luminogens (AIEgens) stand out for their intrinsic organic nature and, more importantly, for their unique aggregation-enhanced emission properties, which clearly differentiates them from traditional fluorophores and enable high-resolution imaging. Currently, a series of high-performance NIR-II AIEgens featuring relatively high fluorescence brightness and long emission wavelengths with emission tails even extending into the NIR-IIa (1300–1400 nm) and NIR-IIb (1500–1700 nm) subwindows have been reported and demonstrated encouraging results in intravital fluorescence angiography. This minireview summarizes recent advances in NIR-II AIEgens for various vascular imaging applications, categorized by anatomical locations, including cerebral, abdominal, hindlimb, ear, axillary, renal, and tumor angiography. The molecular design strategies and nanoengineering approaches to achieve longer emission wavelengths, higher fluorescence brightness, and improved bioavailability are highlighted. Finally, the remaining challenges and future directions are discussed from the aspects of materials engineering, application scenarios expansion, and clinical translation.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 8","pages":""},"PeriodicalIF":13.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70102","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144881517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Strategy Enabling Combined Fluorescence Imaging of Individual Tuberculous Granulomas and Precise Photothermal Therapy of Tuberculosis With Lesion- and Pathogen-Targeting Capabilities of the Nanoparticles","authors":"Dongxia Zhu,&nbsp;Martin R. Bryce","doi":"10.1002/agt2.70110","DOIUrl":"https://doi.org/10.1002/agt2.70110","url":null,"abstract":"&lt;p&gt;Tuberculosis (TB) infection, caused by &lt;i&gt;Mycobacterium tuberculosis&lt;/i&gt;, reveals tens of millions of new cases and causes millions of deaths each year. The traditional clinical treatment for TB is long-term and combined usage of antibiotics but suffers from poor lesion and pathogen targeting, insufficient efficacy, high systemic toxicity, and ineffectiveness against drug-resistant &lt;i&gt;M. tuberculosis&lt;/i&gt;. As a characteristic lesion of TB, granulomas have a compact construction, which greatly limits the access of small-molecule antibiotics to the necrotic area to kill &lt;i&gt;M. tuberculosis&lt;/i&gt; [&lt;span&gt;1&lt;/span&gt;]. Moreover, &lt;i&gt;M. tuberculosis&lt;/i&gt; bacilli, which are quiescent within the granulomas, are phenotypically resistant to traditional antibiotics. These factors contribute to the poor outcomes of conventional antibiotic regimens. So far, several types of nanodrugs including PEGylated liposomes, PEGylated quantum dots, and polymer micelles have been studied with the aim of granuloma targeting [&lt;span&gt;2, 3&lt;/span&gt;]. However, these nanoparticles (NPs) cannot achieve specific targeting of &lt;i&gt;M. tuberculosis&lt;/i&gt;. Therefore, the development of lesion–pathogen dual-targeting formulations that can successfully track granulomas, penetrate their compact structures to reach the necrotic region, and bind specifically to the internal &lt;i&gt;M. tuberculosis&lt;/i&gt; is highly desirable to enhance anti-TB efficiency.&lt;/p&gt;&lt;p&gt;Wang and coworkers [&lt;span&gt;4, 5&lt;/span&gt;] have recently reported an ingenious and simple design for the precise theranostic treatment of TB, that is, a mycobacterium pre-activated macrophage-like biomimetic nanoparticle (BNP) strategy. As depicted in Figure 1a, macrophages display abundant expression of pathogen-specific receptors on their surface after mycobacterium stimulation; thus, &lt;i&gt;M. tuberculosis&lt;/i&gt; targeting can be realized through the specific binding of these receptors to the corresponding ligands of &lt;i&gt;M. tuberculosis&lt;/i&gt;. Next, cell membranes are isolated from these pre-activated macrophages and coated onto drug-loaded polymer NPs to form advanced BNPs called BBTD@PM NPs. The propeller-shaped tetraphenylethylene substituents of TPE-BT-BBTD ensure that the drug does not suffer from aggregation-caused quenching of emission; instead, encapsulated BBTD@PM NPs are aggregation-induced emission (AIE)-active with near-infrared region IIb (NIR-IIb) fluorescence from the extended heteroaromatic π-system upon excitation by 1064-nm laser light. Moreover, the NPs have strong photothermal (light-to-heat) conversion efficiency (33.8%) which facilitates fluorescence imaging of lesions/pathogens, as well as photothermal killing of &lt;i&gt;M. tuberculosis&lt;/i&gt;. Photoinduced heating of NPs in the NIR region is an effective targeted treatment using simple procedures with minimal damage to the surrounding healthy tissues.&lt;/p&gt;&lt;p&gt;The authors applied BBTD@PM NPs to a mouse model of pulmonary TB. Upon intravenous injection into TB mice, BBTD@PM NPs rapidly accumulate in g","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 8","pages":""},"PeriodicalIF":13.7,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70110","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144881168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Front Cover: Nozzle Jamming Granularized Blood-Derived Proteins for Bioprinting Cell-Instructive Architectures","authors":"Lucas S. Ribeiro,&nbsp;João Rocha Maia,&nbsp;Vítor M. Gaspar,&nbsp;Catarina A. Custódio,&nbsp;Emerson R. Camargo,&nbsp;Rita Sobreiro-Almeida,&nbsp;João F. Mano","doi":"10.1002/agt2.70107","DOIUrl":"https://doi.org/10.1002/agt2.70107","url":null,"abstract":"<p>This study explores the availability and intrinsic bioactivity of blood-derived proteins, namely human platelet lysates (hPL), for developing granular bioinks. Bulk hydrogels are generated from pristine/photo-responsive hPL following their mechanical granularization, and microgel jamming. It provides novel insights into rheological requirements and jamming methodologies of patient-derived products, where nozzle jamming outperformed, accounting for its simplicity and reproducible outcomes (e70041).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 7","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70107","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}