Aggregate (Hoboken, N.J.)最新文献

{"title":"Nozzle Jamming Granularized Blood-Derived Proteins for Bioprinting Cell-Instructive Architectures","authors":"Lucas S. Ribeiro,&nbsp;João Rocha Maia,&nbsp;Vítor M. Gaspar,&nbsp;Catarina A. Custódio,&nbsp;Emerson R. Camargo,&nbsp;Rita Sobreiro-Almeida,&nbsp;João F. Mano","doi":"10.1002/agt2.70041","DOIUrl":"https://doi.org/10.1002/agt2.70041","url":null,"abstract":"<p>Exploring the natural availability and intrinsic bioactivity of blood-derived proteins opens new avenues for fabricating bioactive and patient-specific solutions for biomedical applications. Despite their several advantages, their use as inks for 3D printing is limited due to suboptimal rheological properties. To address this, we propose a dual-step strategy based on the initial generation of blood protein-based bulk hydrogels encompassing pristine and photo-responsive protein mixtures to allow their mechanical granularization followed by jamming, establishing injectable and printable granular inks. In this study, two globular-based protein matrices—human platelet lysates (PL) and bovine serum albumin (BSA)—were used as granular inks for 3D printing. We hypothesize that nozzle jamming—in contrast to the typically employed centrifugal jamming—would render optimized results for the granular protein inks’ processability. Printability was evaluated in filaments, scaffold grids, and convoluted structures. Taking advantage of the previously introduced photocurable moieties, post-printing photocrosslinking was used for the annealing of the microgels, leading to increased scaffold mechanical stability and robustness. The nozzle jamming methodology imparted the best print performance and reproducibility, where PLMA-based inks outperformed the BSAMA-based. In addition, the microgel granular constructs allowed primary human-derived adipose stem cells to adhere and proliferate, whereas the PLMA-based ink demonstrated higher cell affinity and enhanced biological performance. We further demonstrated that bioinks could be developed from PLMA-based inks, showcasing high viability without compromising 3D printing performance. Overall, this study gives clear insights into the importance of the jamming process as well as the granularization outcome requirements for the obtention of highly reproducible granular inks for 3D printing.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 7","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70041","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Front Cover: Achieving Multi-Color Emissive Organic Light-Emitting Diodes With Single-Component Molecule Through Conformational Regulation","authors":"Xiang Long,&nbsp;Zhiwei Ma,&nbsp;Hui Dai,&nbsp;Yuyuan Wang,&nbsp;Haozhi Xie,&nbsp;Xiangyu Ge,&nbsp;Zhan Yang,&nbsp;Juan Zhao,&nbsp;Wei Hong,&nbsp;Zhenguo Chi","doi":"10.1002/agt2.70067","DOIUrl":"https://doi.org/10.1002/agt2.70067","url":null,"abstract":"<p>This article constructs an efficient single-component multi-color emitter Bppy-PTZ through intramolecular hydrogen bonding facilitated by the pyridine ring. By changing the doping concentration, Bppy-PTZ based OLEDs exhibit tunable emissions, including blue, yellow and adjustable white light, highlighting its promising applications in display and lighting fields (e70006).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 5","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70067","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Back Cover: New Transparent Rare-Earth-Based Hybrid Glasses: Synthesis, Luminescence, and X-Ray Imaging Application","authors":"Jun Wei,&nbsp;Xiangzhou Zhang,&nbsp;Xiaojia Wang,&nbsp;Yeqi Liu,&nbsp;Yuhai Zhang","doi":"10.1002/agt2.70066","DOIUrl":"https://doi.org/10.1002/agt2.70066","url":null,"abstract":"<p>A desolvation method below 140 °C was reported for a rapid synthesis of RE(NO₃)₃(C₅H₂N₄)₂ hybrid glasses within an hour. The glasses containing the whole library of rare-earth ions exhibited a high transparency, which opened up a pathway to explore the elusive interactions between metals and organic linker, providing new insights for the design of rare-earth glasses (e70021).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 5","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70066","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional Framework Nucleic Acid Vehicle for Antibiotic Sensitization and Treatment of Methicillin-Resistant Staphylococcus aureus","authors":"Yicheng Zhao,&nbsp;Jingyi Si,&nbsp;Shisong Jing,&nbsp;Bingmei Wang,&nbsp;Yueshan Xu,&nbsp;Jiyu Guan,&nbsp;Quan Liu,&nbsp;Jianlei Shen,&nbsp;Min Lv,&nbsp;Li Wang,&nbsp;Changfeng Zhu","doi":"10.1002/agt2.70059","DOIUrl":"https://doi.org/10.1002/agt2.70059","url":null,"abstract":"<p>The increasing prevalence of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) due to antibiotic misuse necessitates novel therapeutic strategies to counter multidrug-resistant infections. Here, we introduce a self-assembling, aggregation-enhanced tetrahedral DNA nanostructure (tFNA) platform that achieves targeted drug delivery through controlled aggregation and sustained release, effectively restoring MRSA susceptibility to β-lactam antibiotics. These tetrahedral frameworks, termed tFNAs-ASOs-ceftriaxone sodium (TACs), serve as a dual-functional system that co-encapsulates antisense oligonucleotides (ASOs) targeting the <i>mecA</i> gene and the β-lactam antibiotic ceftriaxone sodium (Cef). Aggregation of TACs plays a pivotal role in maximizing drug retention and stability, prolonging the localized release of both ASOs and antibiotics while maintaining high bioavailability at the infection site. Characterization studies, including size distribution, zeta potential, and fluorescence quenching assays, confirm their robust aggregation stability and encapsulation efficiency, ensuring controlled drug kinetics and prolonged therapeutic effects. Upon interaction with bacterial cells, the locally concentrated TACs facilitate efficient ASO-mediated <i>mecA</i> silencing, thereby disrupting PBP2a expression and re-sensitizing MRSA to β-lactams. Simultaneously, the aggregated ceftriaxone sodium reservoir ensures sustained inhibition of bacterial cell wall synthesis, leading to effective bacterial clearance. In addition, TACs display potent antibiofilm activity by penetrating the biofilm matrix and delivering therapeutics directly to the embedded bacterial population, thereby overcoming the diffusion barriers. In vivo, TACs exhibit superior therapeutic efficacy in an MRSA-induced pneumonia mouse model, significantly improving survival rates, reducing bacterial burden, and mitigating lung tissue damage. These findings highlight the transformative potential of tFNAs as an intelligent drug aggregation and release system, offering a novel paradigm for optimizing antibiotic therapy against multidrug-resistant pathogens.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 7","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70059","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interfacial Engineering of Pillararene-Modified Ceria Nanoparticles for Regulable Enhanced Sonodynamic Therapy","authors":"Congcong Wang,&nbsp;Yanan Guo,&nbsp;Guoying Tan,&nbsp;Wanrong Kang,&nbsp;Wenjia Guo,&nbsp;Nan Song,&nbsp;Yu Tang","doi":"10.1002/agt2.70062","DOIUrl":"https://doi.org/10.1002/agt2.70062","url":null,"abstract":"<p>Sonodynamic therapy (SDT) has emerged as an advanced technology for treatment of malignant tumors. Many organic and inorganic sonosensitizers have been reported but they still have the respective limitations. Constructing the materials to integrate the superiorities of organic and inorganic sonosensitizers is expected to be a good method to enhance the efficiency of SDT. Herein, we report an intelligent sonosensitizer (TPA–OS⊂CP5@CeO<i>_x</i>), integrating the organic (TPA–OS) and inorganic sonosensitizers (CP5@CeO<i>_x</i>) via host–guest interaction. The modification of carboxyl-pillar[5]arene (CP5) on CeO<i>_x</i> constructs the supramolecular interface by coupling of CP5 and oxygen vacancies. The band gap of CeO<i>_x</i> is reduced and the ratio of Ce⁴⁺/Ce³⁺ is increased to regulate tumor microenvironment. Thus, the SDT performance of CP5@CeO_<i>x</i> can be improved. Furthermore, the synergistic effect of TPA–OS with aggregation-induced emission can further regulate and enhance the SDT efficiency. The cellular experiments demonstrate that TPA–OS⊂CP5@CeO<i>_x</i> exhibits the synergistic therapeutic effect in double organelle of lysosome and mitochondria. The in vivo experiments suggest TPA–OS⊂CP5@CeO<i>_x</i> has imaging-guided enhanced SDT performance to achieve tumor inhibition. This study contributes to the construction of novel intelligent sonosensitizers, indicating that supramolecular interface engineering is promising to realize the customized treatments with minimal side effects.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 7","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunostimulatory DNA Tetrahedron-Based Nanovaccine Combined With Immune Checkpoint PD-1 Blockade for Boosting Systemic Immune Responses Against Oral Squamous Cell Carcinoma","authors":"Xueting Yang,&nbsp;Yun Wang,&nbsp;Yan Yang,&nbsp;Sicheng Zhang,&nbsp;Dianri Wang,&nbsp;Yi Luo,&nbsp;Chunyan Shui,&nbsp;Yongcong Cai,&nbsp;Ruoyi Yang,&nbsp;Shuang Dong,&nbsp;Mu Yang,&nbsp;Yunfeng Lin,&nbsp;Chao Li","doi":"10.1002/agt2.70061","DOIUrl":"https://doi.org/10.1002/agt2.70061","url":null,"abstract":"<p>Despite advancements in immune checkpoint blockade (ICB) therapies for treating various tumors, the immunosuppressive environment in oral squamous cell carcinoma (OSCC) significantly limits therapeutic efficacy. Tumor vaccines, which offer great potential for cancer immunotherapy, still face challenges like potential mutation risks, rapid elimination, and low in vivo delivery efficiency. In this study, we fabricate an immunostimulatory nanovaccine using tetrahedral framework nucleic acids (tFNAs) as a carrier for stable and efficient delivery of CpG oligonucleotide. Then an intensive tumor immunotherapeutic strategy by combining tFNA-CpG nanovaccine with PD-1 inhibitor is used in OSCC tumor-bearing mice. Intravenous administration of the tFNA-CpG nanovaccine effectively activates the antigen-presenting cells (APCs), resulting in an increased proportion of M1-like macrophages and mature dendritic cells, accompanied by heightened production of inflammatory cytokines IL-1β, IL-12, and IL-6. When combined with ICB therapy, the anti-PD-1 drug inhibits the PD-1/PD-L1 interaction within tumor microenvironment. Subsequently, the APCs activated by tFNA-CpG facilitate the phenotypic differentiation of T cells, resulting in a substantial boost in infiltration of cytotoxic T cells (expressing IFN-γ and Granzyme B) in both lymph nodes and tumor tissues, thereby executing a potent antitumor effect and inhibiting the progression of OSCC tumors in C3H mouse. Therefore, this study presents an attractive approach to overcoming current ICB limitations in OSCC immunotherapy and provides new avenues for future clinical practice.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 7","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging the Gap Between Traditional and Nontraditional Luminogens With Strong Non-Aromatic Through-Bond Conjugation and Through-Space Conjugation","authors":"Xiaomi Zhang,&nbsp;Yunhao Bai,&nbsp;Junwen Deng,&nbsp;Xuanshu Zhong,&nbsp;Jinsheng Xiao,&nbsp;Wendi Xie,&nbsp;Huiliang Wang","doi":"10.1002/agt2.70063","DOIUrl":"https://doi.org/10.1002/agt2.70063","url":null,"abstract":"<p>The development of nontraditional luminogens (NTLs) with superior photoluminescence (PL) properties is of great scientific and practical significance and has drawn rapidly growing interest in recent years. An extremely important but unresolved question is that if there are any distinct differences in the structures and PL mechanisms between traditional luminogens (TLs) and NTLs. In this work, four dihydropyridine derivatives with strong non-aromatic through-bond conjugation (TBC) were designed and synthesized, and the influence of strong non-aromatic TBC and through-space conjugation (TSC) effects on their PL behaviors was studied. These compounds in solutions show significant concentration-dependent emission (CDE) and excitation-dependent emission (EDE), which are typical PL behaviors of NTLs. In solid state, the compounds show wide excitation spectra while narrow emission spectra, with high quantum yields up to 57.4%, but they do not show significant EDE, similar to TLs. And very impressively, two kinds of crystals also exhibit optical waveguide property, which is the first report in NTLs. The UV–vis spectra, crystal structures, and theoretical calculations prove the presence of large non-aromatic TBC interactions in these NTLs, and strong non-aromatic TSC can be formed among the molecules that are in a planar conformation and stacked into layers through intermolecular hydrogen bonding and π⋅⋅⋅π interactions. The combined effect of strong non-aromatic TBC and TSC endows the compounds unique PL behaviors that are between those of TLs and NTLs, thus bridging the gap between TLs and NTLs.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 6","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chiral Amplification and Regulation: Design and Applications of Circularly Polarized Luminescence-Active Materials Derived From Macrocyclic Compounds","authors":"Wei Zhang,&nbsp;Mao-Qin Liu,&nbsp;Yang Luo","doi":"10.1002/agt2.70039","DOIUrl":"https://doi.org/10.1002/agt2.70039","url":null,"abstract":"<p>Chirality is a fundamental property in molecules and biological systems, characterized by asymmetric configurational features. Circularly polarized luminescence (CPL) materials have gained significant attention due to their unique optical activities, with applications in 3D displays, chiral sensors, asymmetric catalysis, and more. Chiral transfer and amplification typically involve the generation of chirality in the excited state, facilitated by interactions like energy transfer, electron transfer, or chiral induction. Supramolecular self-assembly strategies, particularly macrocyclic compounds, enable chiral amplification by linking chiral and achiral luminescent units through intermolecular interactions. Macrocyclic hosts—cyclodextrins, calix[<i>n</i>]arenes, pillar[<i>n</i>]arenes, chiral cyclophanes, and cucurbit[<i>n</i>]urils—are especially promising due to their stable structures and adjustable cavities for guest encapsulation. These compounds induce unique photophysical properties through host–guest complexation, making them ideal for constructing chiral transfer, amplification, and CPL-active materials. This review summarizes their advancements in multicolor CPL materials, chiral sensing, induction, asymmetric catalysis, and separation, highlighting their potential in supramolecular chiral material design. The challenges and future directions of this field are also discussed, aiming to guide further research and application in supramolecular chiral systems.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 6","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70039","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of Active Sites-Accessible Au8 Clusters for Intensive Tumor Pyroptosis","authors":"Qiu-Xu Zang,&nbsp;Wei-Tong Chen,&nbsp;Wenjing Zhang,&nbsp;Zhao-Yang Wang,&nbsp;Xi-Yan Dong,&nbsp;Runping Han,&nbsp;Yanjuan Sang,&nbsp;Xiaoyuan Chen,&nbsp;Shuang-Quan Zang","doi":"10.1002/agt2.70046","DOIUrl":"https://doi.org/10.1002/agt2.70046","url":null,"abstract":"<p>Atomically precise gold nanoclusters (NCs), possessing characteristics of molecules and nanoparticles, offer a promising solution to the challenges faced by existing pyroptosis inducers. Their abilities to catalyze the generation of reactive oxygen species and enhance radiosensitization position them as effective agents for activating pyroptosis. However, their catalytic efficiency is often compromised by limited geometrically accessible spaces around the active sites and the lack of suitable ligands. Leveraging the exposed metal centers in mononuclear organometallic catalysts and the tunable ligand of NCs, herein, ethynylferrocene (EFc) was utilized to amplify the peroxidase (POD)-like activity of gold NCs by establishing the unshielded catalytic center and electron donor-acceptor interaction between EFc and Au core. The resulting Au₈Fe₂ NCs with excellent POD-mimicking activity could efficiently trigger pyroptosis by inducing intracellular oxidative stress. Moreover, the Au₈Fe₂ NCs, with their potential to deplete glutathione and enable magnetic resonance imaging, could also induce ferroptosis and serve as a diagnostic tool for tumors. All of these processes can be further potentiated by X-ray radiation, taking advantage of the high atomic number of gold. This work opens new avenues for engineering the catalytic properties of NCs and broadens their potential applications in biomedicine.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 6","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formation of the Most Iodine-Rich Polyiodide [I13]− in Pore-Partitioned Metal-Organic Frameworks for Efficient Iodine Capture","authors":"Feng-Yu Chen,&nbsp;Xin-Xin Lu,&nbsp;Yu-Hui Luo,&nbsp;Jie Li,&nbsp;Dong-En Zhang,&nbsp;Yong Yan","doi":"10.1002/agt2.70051","DOIUrl":"https://doi.org/10.1002/agt2.70051","url":null,"abstract":"<p>Radioactive iodine produced from nuclear fission in power plants presents substantial environmental risks and requires effective remediation measures. Metal-organic frameworks (MOFs) containing specifically designed pore geometries with stable skeletons that allow dense packing of guest molecules are sought after for iodine capture. Here, 14 new MOFs were developed through reticular chemistry for a comprehensive study of the iodine capture behavior. Remarkably, one of this family of materials, JOU-20(FeCo₂), exhibited an exceptional static vapor iodine uptake capacity of 3.08 g/g at 80°C and a high iodine storage density of 4.69 g/cm³. Significantly, single-crystal X-ray diffraction revealed the adsorbed iodine in JOU-20(FeCo₂) forming an unusual aggregation of the giant trigonal antiprismatic polyiodide anion [I₁₃]⁻. To the best of our knowledge, this is the first time that the polyiodide [I₁₃]⁻ was structurally resolved in a crystalline framework, and it represents the most iodine-rich polyiodide species ever discovered experimentally. Combined spectroscopy and theoretical calculation methods demonstrated that nitrogen/sulfur sites and metal nodes play critical roles in stabilizing [I₁₃]⁻. This work introduces a pore partition strategy to create a confined space with specific pore geometry for the formation of unusual polyiodide [I₁₃]⁻, and multiple binding sites for stabilizing it, which significantly enhances the iodine adsorption performance of MOFs.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 6","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}