Aggregate (Hoboken, N.J.)最新文献

{"title":"Revolutionizing Bone Regeneration: Vascularized Bone Tissue Engineering with Advanced 3D Printing Technology","authors":"Jiaxuan Fan,&nbsp;Zichuan Ding,&nbsp;Yongrui Cai,&nbsp;Yahao Lai,&nbsp;Chao Huang,&nbsp;Boyi Jiang,&nbsp;Zongke Zhou,&nbsp;Zeyu Luo","doi":"10.1002/agt2.731","DOIUrl":"https://doi.org/10.1002/agt2.731","url":null,"abstract":"<p>The repair and functional reconstruction of bone defects resulting from trauma, surgical resection, degenerative diseases, and congenital malformations are major clinical challenges. Bone tissue engineering has significant advantages in the treatment of severe bone defects. Vascularized bone repair scaffolds are gradually attracting attention and development because of their excellent biomimetic properties and efficient repair efficiency. Three-dimensional (3D) printing technology, which can be used to fabricate structures at different scales using a wide range of materials, has been used in the production of vascularized bone repair scaffolds. This review discusses the research progress in 3D printing for vascularized bone repair scaffolds. Angiogenesis-osteogenesis coupling in the bone regeneration process is first introduced, followed by a summary of the 3D printing technologies, printing inks, and bioactive factors used to fabricate vascularized bone repair scaffolds. Notably, this review focuses on structural design strategies for vascularized bone repair scaffolds. Finally, the application of vascularized bone repair scaffolds in medicine, as well as challenges and outlooks for future development, are described.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 4","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.731","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infinite Coordination Polymer Polydopamine Nanocomposites Dual-Pathway Multistep Induction of Long-Term Hyperimmunity Combined With Photothermal-Chemo Synergistic Therapy Colorectal Cancer","authors":"Xiaojiang Zhang,&nbsp;Yujie Zhang,&nbsp;Pengqian Wang,&nbsp;Feiyu Shi,&nbsp;Siyuan Du,&nbsp;Zhe Zhang,&nbsp;Daocheng Wu,&nbsp;Junjun She,&nbsp;Ya Wang","doi":"10.1002/agt2.730","DOIUrl":"https://doi.org/10.1002/agt2.730","url":null,"abstract":"<p>To improve the long-term therapeutic efficacy of colorectal cancer, we propose a synergistic treatment strategy involving dual-pathway, multistep induction of long-term hyperimmunity combined with photothermal-chemotherapy. To implement this strategy, infinite coordination polymer nanoparticles (SN38-Mn(II)-EGCG ICP NPs) were prepared by coordinating SN38, EGCG, and Mn²⁺. These nanoparticles were then coated with polydopamine (PDA) and grafted with folate-PEG-thiol (FA-PEG-SH) onto their surfaces, producing tumor-targeting folate-modified PDA infinite coordination polymer nanocomposites (ICP@FA-PDA nanocomposites). These nanocomposites exhibit a particle size of 94.9 ± 1.6 nm with a high drug loading capacity (83.3% ± 1.5%), drug release under acidic conditions while maintaining stability in physiological environments. Furthermore, each component within the nanocomposites serves multiple functions. Notably, the incorporation of multiple components triggers a powerful antitumor immune effect and establishes enduring immune memory through a dual-pathway and multistep approach, which is produced with the activation of the cGAS-STING pathway and immunogenic cell death (ICD) by a four-component multistep process. Under a low-dose regimen, this approach induces dual-pathway hyperimmunity effect and generates ultra-long immunological memory, marked by a ninefold increase in CD8⁺ T cell infiltration, a fourfold increase in CD4⁺ T lymphocytes, a fourfold reduction in Treg cells, and a fivefold increase in memory T cells. The remarkable therapy efficacy is achieved by hyperimmunity effect combination of SN38 and EGCG chemotherapy and photothermal therapy. In vivo studies demonstrated that mice treated with ICP@FA-PDA nanocomposites achieved complete eradication of cancer within 21 days, with no recurrence observed within 60 days. These nanocomposites hold significant promise and potential for future clinical translation.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 4","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.730","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Wine in Old Bottles: Fully Substituted Arylthio Effect Realizes High-Efficiency Purely Organic Phosphorescence Light-Emitting Diode With Single and Ultra-Stable Spectra Under 2000 cd m−2","authors":"Baijun Zhang,&nbsp;Baoxi Li,&nbsp;Han Zhang,&nbsp;Bingzhu Ma,&nbsp;Jingli Lou,&nbsp;Xiaobin Dong,&nbsp;Dezhi Yang,&nbsp;Ben Zhong Tang,&nbsp;Zhiming Wang","doi":"10.1002/agt2.726","DOIUrl":"https://doi.org/10.1002/agt2.726","url":null,"abstract":"<p>Organic light-emitting diodes (OLEDs) based on purely organic room-temperature phosphorescence (RTP) materials often encounter issues of relatively low efficiency and spectral instability. To overcome these limitations, three (arylthio)benzene derivatives (4S, 5S, and 6S) with gradually increased RTP component are designed and compared. Theoretical calculation and photophysical investigation reveal that the fully substituted arylthio effect could enhance the aggregation-induced phosphorescence, enlarge the spin orbital coupling, and reduce the energy gap between S₁ and T₁ as much as possible. As a result, 6S can exhibit single spectra in films with a high phosphorescence efficiency of up to 76.7%, and its doped RTP-OLED furnishes a high maximum external quantum efficiency (EQE) of 15.3% and ultra-stable spectra with the brightness raised from 30 to 2000 cd m⁻². Furthermore, serving 6S as the sensitizer, the RTP-sensitized-fluorescent OLEDs based on fluorescence dopant TBRb and multiple resonance type dopant BN3 both show near three times improvement in electroluminescence performance, with EQE values of 11.3% and 25.6%, respectively. These results demonstrate the feasibility of fully substituted arylthio effect in designing RTP materials and could advance the development of high-performance RTP OLEDs.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 4","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.726","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metal-Organic Frameworks: A Potential Platform From Enzyme Immobilization to Mimetic Enzyme","authors":"Geling Kuang,&nbsp;Zichen Wang,&nbsp;Muhammad Bilal,&nbsp;Ziyuan Wang,&nbsp;Yuxiao Feng,&nbsp;Yingjie Du,&nbsp;Jiandong Cui","doi":"10.1002/agt2.724","DOIUrl":"https://doi.org/10.1002/agt2.724","url":null,"abstract":"<p>Metal-organic frameworks (MOFs) are a new class of organic-inorganic hybrid materials that have been widely studied in the past two decades for their potential in catalysis. (1) In this review, we comprehensively summarize the synthesis, application, and potential advancements of MOFs in enzyme immobilization and mimetic enzymes. (2) We also discuss the design principles behind various MOF-based biocatalysts, such as enzyme@MOF composites, and explore their utility in various reactions. (3) Additionally, we highlight the advantages of MOF materials as enzyme mimetics and provide a perspective on potential solutions to current challenges in MOF catalysis. (4) Ultimately, this review provides a general overview of the most recent advances in MOF-based catalyst platforms, including enzyme@MOF biocatalysts and MOF-based nanozymes, in various applications.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.724","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering “Meso-Atom” Bonding: Honeycomb-Network Transitions in Reticular Liquid Crystals","authors":"Christian Anders,&nbsp;Tianyi Tan,&nbsp;Virginia-Marie Fischer,&nbsp;Ruoyu Wang,&nbsp;Mohamed Alaasar,&nbsp;Rebecca Waldecker,&nbsp;Yu Cao,&nbsp;Feng Liu,&nbsp;Carsten Tschierske","doi":"10.1002/agt2.728","DOIUrl":"https://doi.org/10.1002/agt2.728","url":null,"abstract":"<p>A library of rod-like bolapolyphiles with sticky hydrogen-bonded glycerol groups at their ends and having highly branched side chains with a carbosilane-based four-way branching point, all based on the same oligo(phenylene ethynylene) core, has been synthesized and investigated. For these compounds, a A15-type Frank–Kasper phase is formed upon side-chain elongation in the steric frustration range at the transition from the triangular to the much larger square honeycombs. In contrast to the previously known tetrahedral sphere packings the A15 phase is in this case formed by tetrahedral networks of aggregates of parallelly organized π-conjugated rods. This allows the design of compounds with wide ranges of the A15 network down to room temperature. However, its formation becomes strongly disfavored by core fluorination that is attributed to a changing mode of core–core interaction that also modifies the square honeycombs by deformation of the squares into rectangular or rhombic cells, either with or without emergence of tilt of the rods.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 4","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.728","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Vanillin-Derived Inhibitor of Aggregates via Targeting Intrinsically Disordered Regions of Phytoviral Nucleocapsid Protein","authors":"Yanju Wang,&nbsp;Yuqin Luo,&nbsp;Xin Li,&nbsp;Feifei Chen,&nbsp;Xingjie Zhang,&nbsp;Lu Yu,&nbsp;Runjiang Song,&nbsp;Baoan Song","doi":"10.1002/agt2.725","DOIUrl":"https://doi.org/10.1002/agt2.725","url":null,"abstract":"<p>Phase separation (PS) plays a fundamental role in organizing aggregates during the viral lifecycle, providing significant opportunities for in viral disease treatment by inhibiting PS. Intrinsically disordered regions (IDRs) have been extensively studied and found to be critical for PS. However, the discovery of small molecules that target residues within IDRs remains underexplored, particularly in the field of pesticides. Herein, we report a novel phytovirucide compound <b>29</b>, which was screened from a series of vanillin derivatives designed with sulfonylpiperazine motifs. The inactivation efficacy of compound <b>29</b> against <i>tomato spotted wilt virus</i> (TSWV) was significantly superior to that of the control agents <b>vanisulfane</b> and <b>ribavirin</b>. Mechanistically, compound <b>29</b> binds to the TSWV nucleocapsid protein (NP) at residues Lys68 (K68), Thr92 (T92), and Arg94 (R94), with T92 and R94 located in the IDRs of NP. Mutations at these sites impair the ability to form aggregates. Furthermore, a host factor, GTP (Guanosine Triphosphate)-binding nuclear protein Ran-like (Niben101scf08341g01001, NbRANL), which interacts with NP and promotes its aggregation, was identified. Compound <b>29</b> also suppresses the expression of <i>NbRANL</i>, resulting in the dual inhibition of ribonucleoprotein complexes (RNPs) formation. This unique mechanism of action provides insights into IDRs-based virucide discovery.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.725","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Performance Broad-Spectrum Photodetector by Suppressing Stray Electrons by Adopting a Hybrid CQD/Organic Architecture","authors":"Jiawei Qiao,&nbsp;Qian Wang,&nbsp;Jingjing Wang,&nbsp;Junwei Liu,&nbsp;Wenqing Zhang,&nbsp;Xunfan Liao,&nbsp;Long Ye,&nbsp;Hang Yin,&nbsp;Xiaotao Hao","doi":"10.1002/agt2.722","DOIUrl":"https://doi.org/10.1002/agt2.722","url":null,"abstract":"<p>Broad-spectrum photodetectors (PDs) are essential for various health monitoring, night vision, and telecommunications applications, but their detectivity in a wide absorbance region is limited by undesirable electronic response properties. Colloidal quantum dots (CQDs) are a promising system for broad-spectrum detection, whereas their practical potential is hindered by suboptimal dark current characteristics. To overcome these challenges, we propose a layered architecture comprising CQDs and a bulk heterojunction (BHJ) organic film as a hole transport layer. The integration of PbS CQDs offers multiple benefits, including bandgap tuning for minimizing thermal carriers, surface passivation to reduce recombination rates, and the formation of high-quality interfaces with organic layers, which collectively contribute to suppressing dark current leakage and thermal excitations by suppressing stray electrons. By integrating ITIC into the BHJ film, the device detectability is significantly enhanced, reaching 10¹³ Jones in the 400–1000 nm spectral range. This improvement is attributed to the higher lowest unoccupied molecular orbital (LUMO) of ITIC molecules, which effectively hinders electron injection. Additionally, J-aggregation-induced molecular stacking and optimized phase separation of BHJ films contribute to the enhanced performance. The integration of diverse materials offers greater flexibility in device design and functionality, enabling the development of more advanced and sophisticated optoelectronic devices. Furthermore, this approach could significantly enhance the theoretical and practical understanding of optoelectronic device engineering, leading to the development of more advanced optoelectronic devices.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.722","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143688680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluorescent Nanoparticles Achieve Efficient Photothermal Conversion and Enhanced Antitumor Efficacy Through Intermolecular Aggregation-Caused Quenching","authors":"Jundong Lin,&nbsp;Xiaoxia Cai,&nbsp;Fen Zou,&nbsp;Wenjie Xie,&nbsp;Zhihao Zou,&nbsp;Muqi Chen,&nbsp;Yixun Zhang,&nbsp;Huichan He,&nbsp;Qianfeng Xu,&nbsp;Guowei Zhong,&nbsp;Shanghua Cai,&nbsp;Zhenjie Wu,&nbsp;Jianming Lu,&nbsp;Jianheng Ye,&nbsp;Yingke Liang,&nbsp;Yaqiang Huang,&nbsp;Yangjia Zhuo,&nbsp;Huikang Yang,&nbsp;Weide Zhong","doi":"10.1002/agt2.723","DOIUrl":"https://doi.org/10.1002/agt2.723","url":null,"abstract":"<p>The efficacy of photothermal therapy (PTT) in antitumor applications is often limited by inadequate tumor targeting and low photothermal conversion efficiency (PCE) of photosensitizers. In this study, we designed a photothermal nanoparticle, MPF@IR780, to enhance photosensitizers' targeting and PCE. First, MPF@IR780 improves the delivery of photosensitizers to tumor tissue through the enhanced permeability and retention (EPR) effect. Furthermore, hydrophobic ferrocene was incorporated into the nanoparticle core to increase structural compactness, leading to a strong aggregation-caused quenching (ACQ) effect and an improved PCE of the photosensitizer under near-infrared (NIR) irradiation. Mechanistically, MPF@IR780 induces PANoptosis and ferroptosis in cancer cells through thermal damage and oxidative stress, providing an efficient approach for oncotherapy. This strategy of amplifying the effects of PTT by enhancing the ACQ of photosensitizers offers a promising method for advancing the next generation of PTT.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.723","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143688946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Front Cover: Complexity made easy: Aggregation-induced emission small molecules for cancer diagnosis and phototherapies","authors":"Luojia Chen,&nbsp;Si-Ling Chen,&nbsp;Yuncong Yuan,&nbsp;Xiang Leng,&nbsp;Xiaoyu Xu,&nbsp;Jingyuan Chen,&nbsp;Jiayi Shi,&nbsp;Kun Qian,&nbsp;Yuanlong Xie,&nbsp;Qihang Ding,&nbsp;Zhen Cheng,&nbsp;Meijia Gu","doi":"10.1002/agt2.717","DOIUrl":"https://doi.org/10.1002/agt2.717","url":null,"abstract":"<p>The rising popularity of photosensitizers has greatly transformed traditional cancer diagnosis and phototherapeutic strategies. This review highlights the latest advances in small molecule photosensitizers with aggregation-induced emission (AIE) for cancer theranostics, following the principle of “Complexity made easy.” This study emphasizes on simplicity, expeditiousness, and safety, as it aims to advance cancer research (e657).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"5 6","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.717","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142861097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Front Cover: Reconfigurable liquids enabled by dynamic covalent chemistry","authors":"Kaijuan Li,&nbsp;Yuzheng Luo,&nbsp;Yunhui Wen,&nbsp;Wenrui Shan,&nbsp;Shaowei Shi","doi":"10.1002/agt2.716","DOIUrl":"https://doi.org/10.1002/agt2.716","url":null,"abstract":"<p>The formation, assembly and jamming of nanoparticle surfactants (NPS) by the co-assembly between polydopamine nanoparticles and poly(styrene-<i>co</i>-methacrylamidophenylboronic acid) at the oil-water interface is presented. Taking advantage of the photothermal property of PDA NPs, the thermal responsiveness of NPSs can be triggered upon near-infrared irradiation, allowing the welding of droplets and offering a straightforward to construct modular droplet devices (e621).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"5 6","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.716","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142861098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}