Aggregate (Hoboken, N.J.)最新文献_第4页

Molecular Engineering-Boosted High-Performance AIE Sonosensitizer for Cancer Sonodynamic-Augmented Immunotherapy 分子工程-增强高性能AIE声敏剂用于癌症声动力增强免疫治疗

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-05-07 DOI: 10.1002/agt2.70058

Chao Fu, Wei Zhao, Xionglei Wang, Xia He, Yuting Yin, Jiayi Li, Qiyun Deng, Caihong Yan, Yuli Yin, Zhiming Wang, Rong Hu

{"title":"Molecular Engineering-Boosted High-Performance AIE Sonosensitizer for Cancer Sonodynamic-Augmented Immunotherapy","authors":"Chao Fu, Wei Zhao, Xionglei Wang, Xia He, Yuting Yin, Jiayi Li, Qiyun Deng, Caihong Yan, Yuli Yin, Zhiming Wang, Rong Hu","doi":"10.1002/agt2.70058","DOIUrl":"https://doi.org/10.1002/agt2.70058","url":null,"abstract":"Immunogenic cell death (ICD) has been demonstrated as a reliable approach to improve therapeutic effect in cancer treatment by triggering antitumor immunity. However, the trigger of ICD on the basis of chemotherapy and phototherapy meets the obstacles of serious side effect and poor penetration ability, which seriously impedes the therapeutic effect. The development of sonodynamic immunotherapy with the evoking of ICD presents high promise for cancer treatment with high efficacy. Herein, high performance aggregation-induced emission (AIE) sonosensitizer is constructed on the basis of the engineering structure modulation for sonodynamic-augmented immunotherapy. By regulating the intermolecular interaction and pull-push electronic effect, sonosensitizer bearing AIE feature and amplified sono-sensitizing effect is developed. In addition, in vitro observation demonstrated that thiolate-substituted segment incorporation endows the molecules with enhanced cellular uptake efficiency and improved tumor cell eradication ability. More importantly, the developed sonosensitizer could efficiently evoke ICD upon the trigger of ultrasound, which allows for the efficient tumor eradication both at cellular level and in solid tumor. The inhibition of primary tumor and further boost systemic immunity response with the complete elimination toward the distant tumor is achieved. The investigation highlights the promise of utilizing AIE sonosensitizers in sonodynamic immunotherapy to conquer the current limitation of immunotherapy in solid tumor treatment.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 6","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70058","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell Membrane-Coated Lipid Nanoparticles for Drug Delivery 用于药物递送的细胞膜包被脂质纳米颗粒

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-05-05 DOI: 10.1002/agt2.70054

Moataz B. Zewail, Guangze Yang, Yilong Fan, Yue Hui, Chun-Xia Zhao, Yun Liu

{"title":"Cell Membrane-Coated Lipid Nanoparticles for Drug Delivery","authors":"Moataz B. Zewail, Guangze Yang, Yilong Fan, Yue Hui, Chun-Xia Zhao, Yun Liu","doi":"10.1002/agt2.70054","DOIUrl":"https://doi.org/10.1002/agt2.70054","url":null,"abstract":"Cell membrane coating (CMC) of nanoparticles (NPs) has emerged as a prominent strategy that has gained significant attention and achieved notable progress across various therapeutic sectors. Coating NPs with natural cell membranes endows them with various functions and addresses various challenges in drug delivery, such as prolonging circulation time, reducing immunogenicity, and improving targeting efficiency and cellular communication. Among the different NPs, lipid nanoparticles (LNPs) have revolutionized the field of nanomedicine by providing various advantageous features for drug delivery. The versatile characteristics of LNPs synergize well with cell membranes’ biomimetic properties, creating hybrid structures with enhanced functionalities for diverse biomedical applications. A more advanced form of LNPs with significantly enhanced capabilities can be achieved through CMC. However, significant opportunities remain for further advancements, with ongoing efforts focused on discovering innovative applications and fully harnessing the potential of this promising combination. This article provides a critical review of recent progress in cell membrane coated-LNPs (CMC-LNPs). First, different LNP types, their preparation methods, and coating strategies are summarized. The development, properties, functions, and applications of CMC-LNPs are then discussed. Last, their advantages, limitations, challenges, and future perspectives are presented.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 7","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70054","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “[Droplets Cas13a-RPA Measurement Delineates Potential Role For Plasma CircWDR37 in Colorectal Cancer]” 更正“[液滴Cas13a-RPA测量描述血浆CircWDR37在结直肠癌中的潜在作用]”

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-05-01 DOI: 10.1002/agt2.70056

引用次数: 0

An NIR-III 3P Excitable AIE Nanoprobe for High-Quality Intravital Deep-Brain Angiography 用于高质量活体脑深部血管造影的NIR-III 3P可激发AIE纳米探针

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-05-01 DOI: 10.1002/agt2.70055

Zhijun Zhang, Hui Cheng, Zengming Yang, Xiangquan Deng, Miaomiao Kang, Ping Qiu, Ke Wang, Dong Wang, Ben Zhong Tang

{"title":"An NIR-III 3P Excitable AIE Nanoprobe for High-Quality Intravital Deep-Brain Angiography","authors":"Zhijun Zhang, Hui Cheng, Zengming Yang, Xiangquan Deng, Miaomiao Kang, Ping Qiu, Ke Wang, Dong Wang, Ben Zhong Tang","doi":"10.1002/agt2.70055","DOIUrl":"https://doi.org/10.1002/agt2.70055","url":null,"abstract":"Three-photon (3P) fluorescence imaging (FLI) utilizing excitation wavelengths within the near-infrared-III (NIR-III, 1600–1870 nm) window has emerged as a transformative modality for intravital imaging, owing to its combined advantages of excellent spatiotemporal resolution and remarkable tissue penetration. High-performance fluorescent probes are the cornerstone of high-quality NIR-III 3P FLI. However, the construction of such probes is often hindered by inherent trade-offs in molecular design principles, posing significant challenges for their performance optimization and practical application. Here, we propose a straightforward and effective strategy based on π-bridge manipulation to reconcile those competing molecular design parameters and substantially enhance 3P fluorescence properties. Leveraging this approach, a robust AIE-active small molecule, named TSSID, was developed, which exhibits bright NIR-I (700–950 nm) emission under 1665 nm NIR-III 3P excitation when formulated into nanoparticles (NPs). Remarkably, upon retro-orbital injection into mice following craniotomy, TSSID NPs achieved the best performance in deep-brain angiography among all reported organic 3P materials in terms of vascular imaging depth, signal-to-background ratio, spatial resolution, and hemodynamic imaging depth. Additionally, TSSID NPs demonstrated outstanding biocompatibility through systematic biosafety evaluations. This study provides an excellent imaging agent and useful molecular design philosophy, facilitating the development of advanced organic 3P FLI probes.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 7","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70055","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Refined Dual-Fiber Network Morphology as Printable Hole Transport Layers for High-Performance Perovskite Solar Mini-Modules 一种精细的双光纤网络形态作为高性能钙钛矿太阳能微型组件的可打印空穴传输层

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-04-30 DOI: 10.1002/agt2.70017

Zhihui Yao, Qiyuan Xia, Jin Li, Xiangchuan Meng, Zengqi Huang, Muhammad Bilal Khan Niazi, Shaohua Zhang, Xiaotian Hu, Yiwang Chen

{"title":"A Refined Dual-Fiber Network Morphology as Printable Hole Transport Layers for High-Performance Perovskite Solar Mini-Modules","authors":"Zhihui Yao, Qiyuan Xia, Jin Li, Xiangchuan Meng, Zengqi Huang, Muhammad Bilal Khan Niazi, Shaohua Zhang, Xiaotian Hu, Yiwang Chen","doi":"10.1002/agt2.70017","DOIUrl":"https://doi.org/10.1002/agt2.70017","url":null,"abstract":"In the contemporary preparation of perovskite solar cells (PSCs), the prevalent issue of hole transport layers (HTLs) materials is frequently incompatible with large-area deposition techniques. As the area increases, this results in nonuniform preparation of the HTLs, which significantly reduces the efficiency and reliability of the device at the module level. To tackle this significant challenge, we propose a strategy for a dual-fiber network structure based on polymer HTLs. This strategy involves the use of organic solar cell polymer donor material (PM6) and poly(3-hexylthiophene) (P3HT), which are spontaneously interwoven into micron-sized fiber crystals to establish efficient carrier transport channels. This unique structure not only accelerates charge extraction but also takes advantage of the inherent benefits of polymers, such as excellent printability and homogeneous film formation while enhancing the protection of the perovskite layers. The resulting devices demonstrate a VOC of 1.18 V and a champion PCE of 24.90%, which is higher than the pristine devices (the PCE is 22.87%). Moreover, due to the improved printing characteristics, the PSMs prepared by blade-coating also demonstrate a high PCE of 15.15% within an aperture area of 100 cm2. Additionally, this strategy significantly improves the operational stability, thermal stability, and humidity stability of the devices.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 6","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced Synergistic Photothermal–Chemotherapy in Bacterial Keratitis Treatment Using Halogen-Bonded Organic Frameworks (XOFs) Based on N⋯Br+⋯N Bonds 基于N， Br+， N键的卤素键有机框架（XOFs）在细菌性角膜炎治疗中的增效光热化疗

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-04-29 DOI: 10.1002/agt2.70050

Zhennan Tian, Shirui Zhou, Yao Qu, Qian Yang, Xuguan Bai, Jiahao Zhao, Hongqiang Dong, Ya Lu, Nan Deng, Lu Wang, Limin Pi, Yang Cheng, Shigui Chen, Wei Liu

{"title":"Enhanced Synergistic Photothermal–Chemotherapy in Bacterial Keratitis Treatment Using Halogen-Bonded Organic Frameworks (XOFs) Based on N⋯Br+⋯N Bonds","authors":"Zhennan Tian, Shirui Zhou, Yao Qu, Qian Yang, Xuguan Bai, Jiahao Zhao, Hongqiang Dong, Ya Lu, Nan Deng, Lu Wang, Limin Pi, Yang Cheng, Shigui Chen, Wei Liu","doi":"10.1002/agt2.70050","DOIUrl":"https://doi.org/10.1002/agt2.70050","url":null,"abstract":"The swift progression of bacterial keratitis necessitates expeditious therapeutic intervention. Present therapeutic methodologies are characterized by their protracted duration and invasiveness, which often result in suboptimal antibiotic therapy. Consequently, there is an imperative requirement for the development of novel therapeutic approaches for the management of bacterial keratitis. In this study, we present two types of XOFs connected by [N···Br+···N] interactions. These frameworks were characterized using 1H NMR, IR, XPS, SAXS, and HR-TEM. Two-dimensional (2D) structural models were established based on PXRD data and theoretical simulations. The application of these XOFs as novel antibacterial agents for the treatment of bacterial keratitis were explored, and the effects of different connection knots and hydrophilicity on the antibacterial efficacy of XOFs were compared. As expected, the therapeutic effect of XOFs based on [N···Br+···N] interactions are superior to XOFs based on [N···I+···N] interactions. The therapeutic effect of TPPA-based XOFs with good hydrophilicity is better than TPPE-based XOFs. In addition, a photothermal agent (IR820) was loaded onto XOF(Br)-TPPA for combined photothermal and chemotherapy, with experimental results indicating a substantial enhancement in therapeutic efficacy. This work not only deepens our understanding of halogen-bonded organic frameworks but also paves the way for the application of XOFs in biomedical materials.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 6","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70050","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “Advancing Self-Healing Soy Protein Hydrogel With Dynamic Schiff Base and Metal–Ligand Bonds for Diabetic Chronic Wound Recovery” 更正“推进具有动态希夫碱和金属配体键的自愈大豆蛋白水凝胶用于糖尿病慢性伤口恢复”

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-04-28 DOI: 10.1002/agt2.70057

引用次数: 0

Turning on the Heat by Cocrystal Engineering: The Rise of Organic Charge Transfer Photothermal Cocrystals as an Emerging Therapeutic Frontier in Biomedical Application 通过共晶工程打开热量：有机电荷转移光热共晶的兴起作为生物医学应用的新兴治疗前沿

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-04-24 DOI: 10.1002/agt2.70045

Arshad Khan, Rabia Usman, Shuo Xiang, Yasinalli Tamboli, Muhammad Umair, Awatef M. Alshehri, Ibraheem Bushnak, Yan Deng, Nongyue He

{"title":"Turning on the Heat by Cocrystal Engineering: The Rise of Organic Charge Transfer Photothermal Cocrystals as an Emerging Therapeutic Frontier in Biomedical Application","authors":"Arshad Khan, Rabia Usman, Shuo Xiang, Yasinalli Tamboli, Muhammad Umair, Awatef M. Alshehri, Ibraheem Bushnak, Yan Deng, Nongyue He","doi":"10.1002/agt2.70045","DOIUrl":"https://doi.org/10.1002/agt2.70045","url":null,"abstract":"The field of molecular charge transfer cocrystals (CTCs) has advanced rapidly in recent years, with much work focused on their use in optoelectronic devices, photoacoustic imaging, photothermal therapy (PTT), optical waveguides, seawater desalination, and more. Organic photothermal CTCs are of particular interest because of their unique phototherapeutic effects in phototherapy and their remarkable imaging capabilities in fluorescence, magnetic resonance, and photoacoustic imaging, further enhancing their significance in medical applications. However, the use of photothermal CTCs in biomedicine has been limited, with few reported biological applications. Hence, there is a growing interest in CT-derived functional photothermal cocrystals potential contenders for targeted and controlled biomedical applications such as bacteria inhibition, cancer eradication, and tissue regeneration. This review offers insight into the recent advancements in crafting and producing CT-based materials with biomedical attributes. In addition, it outlines the current obstacles and future prospects in this burgeoning research domain, aiming to propel the continued advancement of CT-based biomaterials toward enhanced biomedical utilities. Overall, cocrystal-based near-infrared (NIR) photothermal materials have the potential to revolutionize a wide range of medical and technological applications and are an active area of research in chemistry, materials science, and nanotechnology.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 7","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrogel-Based Smart Materials for Wound Healing and Sensing 基于水凝胶的伤口愈合和传感智能材料

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-04-22 DOI: 10.1002/agt2.70047

Thi Kim Ngan Duong, Thi Thuy Truong, Thi Nhat Linh Phan, Thi Xuan Nguyen, Vu Hoang Minh Doan, Truong Tien Vo, Jaeyeop Choi, Umapada Pal, Prodyut Dhar, Byeongil Lee, Junghwan Oh, Sudip Mondal

{"title":"Hydrogel-Based Smart Materials for Wound Healing and Sensing","authors":"Thi Kim Ngan Duong, Thi Thuy Truong, Thi Nhat Linh Phan, Thi Xuan Nguyen, Vu Hoang Minh Doan, Truong Tien Vo, Jaeyeop Choi, Umapada Pal, Prodyut Dhar, Byeongil Lee, Junghwan Oh, Sudip Mondal","doi":"10.1002/agt2.70047","DOIUrl":"https://doi.org/10.1002/agt2.70047","url":null,"abstract":"Recent advancements in hydrogel-based flexible materials have revolutionized wound healing and monitoring strategies. These materials offer promising solutions for medical treatment and real-time diagnostics. Their rich water content, biocompatibility, and tunable properties closely mimic the natural extracellular matrix, supporting wound regeneration. Unlike traditional wound healing materials, hydrogel-based systems address critical issues such as material stability and toxicity while integrating advanced monitoring devices. This review highlights the latest innovations in hydrogel-based wound healing materials. It focuses on flexibility, biocompatibility, and potential for integration with smart monitoring systems. The review covers design principles and fabrication techniques for hydrogel-based nanofibers, elastomers, and conducting polymers. It also discusses the development of electronic skin and innovative wound dressings. In addition, the review explains how sensing capabilities, stimuli-responsive functions, and antibacterial agents are incorporated into these materials. Finally, the article examines challenges and future directions in the field. It emphasizes the transformative potential of multifunctional hydrogel-based materials for improving wound healing and continuous monitoring.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 6","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70047","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Full-Color Tunable Fluorescent Polysiloxanes Driven by Structure Evolution and Aggregation From Amine–Aldehyde Reaction 胺醛反应中结构演化和聚集驱动的全彩可调荧光聚硅氧烷

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-04-22 DOI: 10.1002/agt2.70048

Cheng Huang, Xinyu Cao, Xianpeng Fan, Lvyin Wang, Jingnan Zhang, Gang Ye, Haijiao Xie, Yongmei Ma

{"title":"Full-Color Tunable Fluorescent Polysiloxanes Driven by Structure Evolution and Aggregation From Amine–Aldehyde Reaction","authors":"Cheng Huang, Xinyu Cao, Xianpeng Fan, Lvyin Wang, Jingnan Zhang, Gang Ye, Haijiao Xie, Yongmei Ma","doi":"10.1002/agt2.70048","DOIUrl":"https://doi.org/10.1002/agt2.70048","url":null,"abstract":"Nonconventional fluorescent materials, which are nonaromatic or consist of isolated aromatic systems, have attracted extensive attention because of their aggregation-induced emission properties. The mechanism of nonconventional fluorescence remains incompletely understood, hindering the prediction and modulation of its emission color. Achieving full-color tunability in such systems, particularly within elastomers, is highly challenging. Herein, fluorescent cross-linked polysiloxanes are synthesized using aliphatic amino-terminated polysiloxane and glutaraldehyde, exhibiting full-color emission that can be continuously tuned through thermal treatments within a single material system. Thermal treatment of cross-linked polysiloxanes enables precise control over the structural evolution of fluorophores from imines to 3-(2-piperidyl)pyridinium derivatives and their aggregation states. It enables the continuous and wide-range modulation of the emission color. Additionally, the intramolecular and intermolecular charge transfers of the novel unconventional fluorophore, 3-(2-piperidyl)pyridinium derivatives, have been identified, which are of great significance for aggregation-induced bathochromic fluorescence. Prepared from all commercial chemicals, these cross-linked polysiloxanes show great potential for large-scale production and applications, especially as flexible fluorescent light-conversion layers and solvent-responsive smart materials. Furthermore, our research is expected to inspire the innovation of unconventional fluorophores in multiple dimensions.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 6","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70048","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0