封底：肺穿透型仿生细胞外囊泡球形核酸通过清除活性氧和抗炎作用治疗肺纤维化

IF 13.7 Q1 CHEMISTRY, MULTIDISCIPLINARY

Aggregate (Hoboken, N.J.) Pub Date : 2025-09-21 DOI:10.1002/agt2.70164

Saiyun Lou, Jiangpo Ma, Pan Fu, Lin Li, Jingyun Huang, Fangxue Jing, Yuhui Wang, Sihua Qian, Jianping Zheng, Jiang Li, Zhaoxing Dong, Kaizhe Wang

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引用次数: 0

摘要

本研究提出了一种用于治疗特发性肺纤维化（IPF）的仿生细胞外囊泡球形核酸（BEV-SNA）平台。BEV-SNA结合msc衍生的纳米囊泡和胆固醇修饰的ssDNA，形成带负电荷的纳米结构，增强肺输送。它具有多种治疗作用，包括清除ROS，抗炎活性和抗纤维化作用，有效减轻纤维化（e70086）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Back Cover: Lung-Penetrating Biomimetic Extracellular Vesicle Spherical Nucleic Acids for Pulmonary Fibrosis Therapy Through ROS Scavenging and Anti-Inflammatory Effects

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Back Cover: Lung-Penetrating Biomimetic Extracellular Vesicle Spherical Nucleic Acids for Pulmonary Fibrosis Therapy Through ROS Scavenging and Anti-Inflammatory Effects

This study presents a biomimetic extracellular vesicle-spherical nucleic acid (BEV-SNA) platform for treating idiopathic pulmonary fibrosis (IPF). BEV-SNA combines MSC-derived nanovesicles with cholesterol-modified ssDNA, forming a negatively charged nanostructure that enhances lung delivery. It exhibits multifunctional therapeutic effects, including ROS scavenging, anti-inflammatory activity, and anti-fibrotic action, effectively mitigating fibrosis (e70086).

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来源期刊

Aggregate (Hoboken, N.J.)

CiteScore

17.40

自引率

0.00%

发文量

审稿时长

7 weeks