Back Cover: Lung-Penetrating Biomimetic Extracellular Vesicle Spherical Nucleic Acids for Pulmonary Fibrosis Therapy Through ROS Scavenging and Anti-Inflammatory Effects
Saiyun Lou, Jiangpo Ma, Pan Fu, Lin Li, Jingyun Huang, Fangxue Jing, Yuhui Wang, Sihua Qian, Jianping Zheng, Jiang Li, Zhaoxing Dong, Kaizhe Wang
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Abstract
This study presents a biomimetic extracellular vesicle-spherical nucleic acid (BEV-SNA) platform for treating idiopathic pulmonary fibrosis (IPF). BEV-SNA combines MSC-derived nanovesicles with cholesterol-modified ssDNA, forming a negatively charged nanostructure that enhances lung delivery. It exhibits multifunctional therapeutic effects, including ROS scavenging, anti-inflammatory activity, and anti-fibrotic action, effectively mitigating fibrosis (e70086).
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